Adam8 (ADAM metallopeptidase domain 8) - Rat Genome Database

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Gene: Adam8 (ADAM metallopeptidase domain 8) Ictidomys tridecemlineatus
Analyze
Symbol: Adam8
Name: ADAM metallopeptidase domain 8
RGD ID: 12508840
Description: ENCODES a protein that exhibits calcium ion binding (inferred); cell adhesion molecule binding (inferred); immunoglobulin receptor binding (inferred); INVOLVED IN cell-cell adhesion (ortholog); ASSOCIATED WITH asthma (ortholog); Chemical and Drug Induced Liver Injury (ortholog); distal 10q deletion syndrome (ortholog); FOUND IN alpha9-beta1 integrin-ADAM8 complex (inferred); cell surface (inferred); cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: disintegrin and metalloproteinase domain-containing protein 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244072136,156,736 - 6,171,452 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648619,391,324 - 19,402,332 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648619,389,925 - 19,403,577 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Adam8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244072136,156,736 - 6,171,452 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648619,391,324 - 19,402,332 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648619,389,925 - 19,403,577 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810133,262,423 - 133,276,868 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10133,262,420 - 133,276,868 (-)EnsemblGRCh38hg38GRCh38
GRCh3710135,075,927 - 135,090,372 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610134,925,911 - 134,940,362 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410134,964,788 - 134,979,211NCBI
Celera10128,426,024 - 128,440,474 (+)NCBICelera
Cytogenetic Map10q26.3NCBI
HuRef10128,622,621 - 128,637,236 (-)NCBIHuRef
CHM1_110135,357,756 - 135,372,278 (-)NCBICHM1_1
T2T-CHM13v2.010134,218,053 - 134,232,489 (-)NCBIT2T-CHM13v2.0
Adam8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397139,558,845 - 139,573,016 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7139,558,845 - 139,572,475 (-)EnsemblGRCm39 Ensembl
GRCm387139,978,932 - 139,995,207 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7139,978,932 - 139,992,562 (-)EnsemblGRCm38mm10GRCm38
MGSCv377147,164,840 - 147,178,387 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367139,830,261 - 139,843,808 (-)NCBIMGSCv36mm8
Celera7139,782,797 - 139,796,305 (-)NCBICelera
Cytogenetic Map7F4NCBI
cM Map784.96NCBI
Adam8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81204,206,206 - 204,218,988 (-)NCBIGRCr8
mRatBN7.21194,776,559 - 194,789,330 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1194,770,060 - 194,788,801 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01212,317,510 - 212,332,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1212,317,848 - 212,330,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,236,436 - 219,251,059 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41199,780,772 - 199,791,855 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1192,454,105 - 192,468,808 (-)NCBICelera
Cytogenetic Map1q41NCBI
Adam8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547710,895,446 - 10,907,215 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547710,894,288 - 10,906,961 (-)NCBIChiLan1.0ChiLan1.0
ADAM8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28145,386,583 - 145,400,948 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110145,391,940 - 145,406,305 (-)NCBINHGRI_mPanPan1
PanPan1.110134,171,986 - 134,186,221 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10134,172,724 - 134,186,227 (-)Ensemblpanpan1.1panPan2
ADAM8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12840,853,665 - 40,865,604 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2840,855,509 - 40,863,747 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2840,909,672 - 40,921,207 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02841,490,792 - 41,502,283 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2841,490,100 - 41,500,790 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12840,973,551 - 40,985,028 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02840,962,945 - 40,974,543 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02841,365,582 - 41,377,170 (-)NCBIUU_Cfam_GSD_1.0
ADAM8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14141,221,198 - 141,232,306 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114141,221,177 - 141,233,728 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214153,183,627 - 153,194,348 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12653,114,184 - 53,129,650 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2653,114,924 - 53,126,900 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605441,248,757 - 41,264,128 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473713,459,274 - 13,474,686 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000000001   ⟹   ENSSTOP00000000001
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648619,391,324 - 19,402,332 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000041602   ⟹   ENSSTOP00000025939
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648619,391,324 - 19,401,578 (-)Ensembl
RefSeq Acc Id: XM_040271851   ⟹   XP_040127785
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244072136,156,736 - 6,171,452 (+)NCBI
Protein Sequences
Protein RefSeqs XP_040127785 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000000001.3
  ENSSTOP00000025939.1
GenBank Protein KAG3263822 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_040127785   ⟸   XM_040271851
- UniProtKB: I3LVT4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000000001   ⟸   ENSSTOT00000000001
Ensembl Acc Id: ENSSTOP00000025939   ⟸   ENSSTOT00000041602
Protein Domains
Disintegrin   EGF-like   Peptidase M12B


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000000001 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000000001.3 UniProtKB/TrEMBL
  ENSSTOT00000041602.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
NCBI Gene Adam8 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 8 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PRINTS DISINTEGRIN UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF57552 UniProtKB/TrEMBL
UniProt A0A287CXF5_ICTTR UniProtKB/TrEMBL
  I3LVT4 ENTREZGENE, UniProtKB/TrEMBL