ADAM8 (ADAM metallopeptidase domain 8) - Rat Genome Database

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Gene: ADAM8 (ADAM metallopeptidase domain 8) Sus scrofa
Analyze
Symbol: ADAM8
Name: ADAM metallopeptidase domain 8
RGD ID: 13932970
Description: ENCODES a protein that exhibits immunoglobulin receptor binding (ortholog); tumor necrosis factor receptor superfamily binding (ortholog); INVOLVED IN cell-cell adhesion (ortholog); signal release (ortholog); ASSOCIATED WITH asthma (ortholog); Chemical and Drug Induced Liver Injury (ortholog); distal 10q deletion syndrome (ortholog); FOUND IN alpha9-beta1 integrin-ADAM8 complex (inferred); cell surface (inferred); cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: disintegrin and metalloproteinase domain-containing protein 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14141,221,198 - 141,232,306 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114141,221,177 - 141,233,728 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214153,183,627 - 153,194,348 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
canonical NF-kappaB signal transduction  (IEA)
cell adhesion  (IEA)
cell morphogenesis  (IEA)
cell-cell adhesion  (IEA,ISO)
cellular response to hypoxia  (IEA)
inflammatory response  (IBA,IEA)
integrin-mediated signaling pathway  (IEA)
leukocyte migration involved in inflammatory response  (IEA)
lymphocyte chemotaxis  (IEA)
negative regulation of neuron apoptotic process  (IEA)
positive regulation of acute inflammatory response  (IEA)
positive regulation of bone resorption  (IEA)
positive regulation of cell adhesion  (IEA)
positive regulation of cellular extravasation  (IBA,IEA)
positive regulation of eosinophil migration  (IEA)
positive regulation of epithelial to mesenchymal transition  (IEA)
positive regulation of fibronectin-dependent thymocyte migration  (IEA)
positive regulation of inflammatory response  (IEA)
positive regulation of innate immune response  (IEA)
positive regulation of MAPK cascade  (IEA)
positive regulation of membrane protein ectodomain proteolysis  (IBA,IEA)
positive regulation of neutrophil extravasation  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of T cell differentiation in thymus  (IEA)
positive regulation of T cell migration  (IEA)
positive regulation of thymocyte apoptotic process  (IEA)
positive regulation of tumor necrosis factor (ligand) superfamily member 11 production  (IEA)
proteolysis  (IBA,IEA)
regulation of cell-cell adhesion  (IBA,IEA)
signal release  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADAM8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14141,221,198 - 141,232,306 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114141,221,177 - 141,233,728 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214153,183,627 - 153,194,348 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810133,262,423 - 133,276,868 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10133,262,420 - 133,276,868 (-)EnsemblGRCh38hg38GRCh38
GRCh3710135,075,927 - 135,090,372 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610134,925,911 - 134,940,362 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410134,964,788 - 134,979,211NCBI
Celera10128,426,024 - 128,440,474 (+)NCBICelera
Cytogenetic Map10q26.3NCBI
HuRef10128,622,621 - 128,637,236 (-)NCBIHuRef
CHM1_110135,357,756 - 135,372,278 (-)NCBICHM1_1
T2T-CHM13v2.010134,218,053 - 134,232,489 (-)NCBIT2T-CHM13v2.0
Adam8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397139,558,845 - 139,573,016 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7139,558,845 - 139,572,475 (-)EnsemblGRCm39 Ensembl
GRCm387139,978,932 - 139,995,207 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7139,978,932 - 139,992,562 (-)EnsemblGRCm38mm10GRCm38
MGSCv377147,164,840 - 147,178,387 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367139,830,261 - 139,843,808 (-)NCBIMGSCv36mm8
Celera7139,782,797 - 139,796,305 (-)NCBICelera
Cytogenetic Map7F4NCBI
cM Map784.96NCBI
Adam8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81204,206,206 - 204,218,988 (-)NCBIGRCr8
mRatBN7.21194,776,559 - 194,789,330 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1194,770,060 - 194,788,801 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01212,317,510 - 212,332,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1212,317,848 - 212,330,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,236,436 - 219,251,059 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41199,780,772 - 199,791,855 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1192,454,105 - 192,468,808 (-)NCBICelera
Cytogenetic Map1q41NCBI
Adam8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547710,895,446 - 10,907,215 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547710,894,288 - 10,906,961 (-)NCBIChiLan1.0ChiLan1.0
ADAM8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28145,386,583 - 145,400,948 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110145,391,940 - 145,406,305 (-)NCBINHGRI_mPanPan1
PanPan1.110134,171,986 - 134,186,221 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10134,172,724 - 134,186,227 (-)Ensemblpanpan1.1panPan2
ADAM8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12840,853,665 - 40,865,604 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2840,855,509 - 40,863,747 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2840,909,672 - 40,921,207 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02841,490,792 - 41,502,283 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2841,490,100 - 41,500,790 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12840,973,551 - 40,985,028 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02840,962,945 - 40,974,543 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02841,365,582 - 41,377,170 (-)NCBIUU_Cfam_GSD_1.0
Adam8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244072136,156,736 - 6,171,452 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648619,391,324 - 19,402,332 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648619,389,925 - 19,403,577 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12653,114,184 - 53,129,650 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2653,114,924 - 53,126,900 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605441,248,757 - 41,264,128 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473713,459,274 - 13,474,686 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ADAM8
238 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system reproductive system respiratory system
High
Medium
Low 9 2 5 1 3
Below cutoff 1 2 3 1 18 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000033889   ⟹   ENSSSCP00000029496
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14141,221,198 - 141,232,306 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000085234   ⟹   ENSSSCP00000059944
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14141,221,198 - 141,231,339 (-)Ensembl
RefSeq Acc Id: XM_021073932   ⟹   XP_020929591
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114141,221,177 - 141,233,728 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020929591   ⟸   XM_021073932
- UniProtKB: A0A4X1V7Q8 (UniProtKB/TrEMBL),   K9IW78 (UniProtKB/TrEMBL),   K7GNP1 (UniProtKB/TrEMBL),   A0A8D1I905 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000059944   ⟸   ENSSSCT00000085234
RefSeq Acc Id: ENSSSCP00000029496   ⟸   ENSSSCT00000033889
Protein Domains
Disintegrin   EGF-like   Peptidase M12B


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010772 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025029157 UniProtKB/TrEMBL
  ENSSSCG00030023023 UniProtKB/TrEMBL
  ENSSSCG00035075969 UniProtKB/TrEMBL
  ENSSSCG00045025381 UniProtKB/TrEMBL
  ENSSSCG00055005364 UniProtKB/TrEMBL
  ENSSSCG00065074377 UniProtKB/TrEMBL
  ENSSSCG00070021999 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000033889 ENTREZGENE
  ENSSSCT00000033889.4 UniProtKB/TrEMBL
  ENSSSCT00000085234.2 UniProtKB/TrEMBL
  ENSSSCT00025039968.1 UniProtKB/TrEMBL
  ENSSSCT00030031998.1 UniProtKB/TrEMBL
  ENSSSCT00035103389.1 UniProtKB/TrEMBL
  ENSSSCT00045043531.1 UniProtKB/TrEMBL
  ENSSSCT00055010540.1 UniProtKB/TrEMBL
  ENSSSCT00065102532.1 UniProtKB/TrEMBL
  ENSSSCT00070043753.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF_extracell UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
NCBI Gene ADAM8 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 8 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PRINTS DISINTEGRIN UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF57552 UniProtKB/TrEMBL
UniProt A0A4X1V7Q8 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2Q7A5_PIG UniProtKB/TrEMBL
  A0A8D1I905 ENTREZGENE, UniProtKB/TrEMBL
  K7GNP1 ENTREZGENE, UniProtKB/TrEMBL
  K9IW78 ENTREZGENE
UniProt Secondary K9IW78 UniProtKB/TrEMBL
VGNC ID VGNC:97866 ENTREZGENE