Mpc2 (mitochondrial pyruvate carrier 2)

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Gene: Mpc2 (mitochondrial pyruvate carrier 2) Rattus norvegicus

Analyze

Symbol:

Mpc2

Name:

mitochondrial pyruvate carrier 2

RGD ID:

1563422

Description:

Predicted to enable identical protein binding activity and pyruvate transmembrane transporter activity. Predicted to be involved in mitochondrial pyruvate transmembrane transport. Predicted to act upstream of or within acetyl-CoA biosynthetic process from pyruvate and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in mitochondrial inner membrane. Orthologous to human MPC2 (mitochondrial pyruvate carrier 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

brain protein 44; Brp44; LOC100359982; LOC289182; protein 0-44; RGD1563422; similar to Brain protein 44; SLC54A2; solute carrier family 54 member 2

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MPC2 (mitochondrial pyruvate carrier 2)	RGD	RGD
Mus musculus (house mouse):	Mpc2 (mitochondrial pyruvate carrier 2)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Mpc2 (mitochondrial pyruvate carrier 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MPC2 (mitochondrial pyruvate carrier 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MPC2 (mitochondrial pyruvate carrier 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mpc2 (mitochondrial pyruvate carrier 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MPC2 (mitochondrial pyruvate carrier 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MPC2 (mitochondrial pyruvate carrier 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mpc2 (mitochondrial pyruvate carrier 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	GPR37L1 (G protein-coupled receptor 37 like 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	MPC2 (mitochondrial pyruvate carrier 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mpc2 (mitochondrial pyruvate carrier 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mpc2 (mitochondrial pyruvate carrier 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MPC2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG32832	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG9396	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG9399	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mpc-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MPC3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	mpc2a	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	mpc2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	77,728,176 - 77,747,664 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	77,728,250 - 77,747,664 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	80,341,634 - 80,361,071 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	81,645,633 - 81,665,070 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	78,891,731 - 78,911,144 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	83,680,527 - 83,700,491 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	83,681,322 - 83,700,213 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	88,559,889 - 88,579,949 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	81,184,656 - 81,203,905 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	13	77,441,619 - 77,461,027 (+)	NCBI		Celera
Cytogenetic Map	13	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

immunodeficiency 25 (ISO)

parathyroid carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-dexrazoxane (ISO)

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (EXP)

5-fluorouracil (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (EXP)

choline (ISO)

cisplatin (ISO)

clobetasol (ISO)

clofibrate (ISO)

cocaine (EXP)

copper(II) sulfate (ISO)

cyclophosphamide (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

diethylstilbestrol (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

enzalutamide (ISO)

fenthion (ISO)

folic acid (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

isotretinoin (ISO)

ivermectin (ISO)

L-methionine (ISO)

lead(0) (ISO)

leflunomide (EXP)

menadione (ISO)

methidathion (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

mitoxantrone (ISO)

nefazodone (EXP)

nimesulide (EXP)

p-menthan-3-ol (EXP)

paracetamol (ISO)

parathion (ISO)

phenylmercury acetate (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sunitinib (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tributylstannane (ISO)

triptonide (ISO)

tungsten (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vinclozolin (EXP)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acetyl-CoA biosynthetic process from pyruvate (ISO)

mitochondrial pyruvate transmembrane transport (IBA,IEA,ISO,ISS)

positive regulation of insulin secretion involved in cellular response to glucose stimulus (ISO)

Cellular Component

mitochondrial inner membrane (IEA,ISO,ISS)

mitochondrion (ISO)

Molecular Function

identical protein binding (ISO)

protein binding (ISO)

pyruvate transmembrane transporter activity (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:3022128	PMID:14651853	PMID:18614015	PMID:21630459	PMID:22628554	PMID:22628558	PMID:24910426	PMID:26316108	PMID:35580702

Genomics

Comparative Map Data

Mpc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	77,728,176 - 77,747,664 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	77,728,250 - 77,747,664 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	80,341,634 - 80,361,071 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	81,645,633 - 81,665,070 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	78,891,731 - 78,911,144 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	83,680,527 - 83,700,491 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	83,681,322 - 83,700,213 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	88,559,889 - 88,579,949 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	81,184,656 - 81,203,905 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	13	77,441,619 - 77,461,027 (+)	NCBI		Celera
Cytogenetic Map	13	q23	NCBI

MPC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	167,916,675 - 167,937,072 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	167,916,675 - 167,937,072 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	167,885,913 - 167,906,310 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	166,153,934 - 166,171,857 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	140,996,568 - 141,015,532 (-)	NCBI		Celera
Cytogenetic Map	1	q24.2	NCBI
HuRef	1	139,131,551 - 139,151,946 (-)	NCBI		HuRef
CHM1_1	1	169,308,123 - 169,328,511 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	167,268,139 - 167,288,538 (-)	NCBI		T2T-CHM13v2.0

Mpc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	165,288,829 - 165,308,787 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	165,288,206 - 165,308,783 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	165,461,260 - 165,481,218 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	165,460,637 - 165,481,214 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	167,391,339 - 167,411,345 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	167,297,883 - 167,317,889 (+)	NCBI		MGSCv36	mm8
Celera	1	167,907,338 - 167,927,350 (+)	NCBI		Celera
Cytogenetic Map	1	H2.3	NCBI
cM Map	1	72.8	NCBI

Mpc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955462	9,177,484 - 9,193,646 (+)	NCBI	ChiLan1.0	ChiLan1.0

MPC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	1	81,496,346 - 81,514,023 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	143,406,611 - 143,424,508 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	147,132,213 - 147,151,648 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	147,132,213 - 147,151,648 (-)	Ensembl	panpan1.1		panPan2

MPC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	30,544,986 - 30,574,102 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	30,545,152 - 30,574,080 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	30,082,089 - 30,110,979 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	30,363,306 - 30,392,420 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	7	30,203,083 - 30,232,134 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	30,234,149 - 30,263,466 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	30,472,383 - 30,501,925 (+)	NCBI		UU_Cfam_GSD_1.0

Mpc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	100,392,453 - 100,412,989 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936481	18,253,929 - 18,259,738 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MPC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	83,069,748 - 83,096,990 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	83,069,914 - 83,091,687 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	90,745,599 - 90,767,335 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MPC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	61,109,742 - 61,128,675 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666055	62,835,049 - 62,854,123 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mpc2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624826	5,915,490 - 5,936,779 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624826	5,919,317 - 5,936,785 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mpc2
131 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	94
Count of miRNA genes:	74
Interacting mature miRNAs:	79
Transcripts:	ENSRNOT00000004206
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	34535218	79535218	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	37262092	82262092	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	37415584	80753406	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	37415584	82415584	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	38433408	83433408	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	39754544	84754544	Rat
12879444	Bp397	Blood pressure QTL 397			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45049404	90049404	Rat
12879471	Bp398	Blood pressure QTL 398			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45514719	90514719	Rat
12879441	Bp396	Blood pressure QTL 396			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45699983	90699983	Rat
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	46088046	91088046	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	46197976	84753113	Rat
1641901	Alcrsp6	Alcohol response QTL 6			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	13	52362171	97362171	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	56056920	101056920	Rat
738026	Lnnr5	Liver neoplastic nodule remodeling QTL 5	3.29		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	59874408	85581182	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	61825626	106807694	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	65103704	106807694	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	65103704	106807694	Rat
8655945	Rf61	Renal function QTL 61	3.6		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	13	69060519	86800898	Rat
1331783	Bp221	Blood pressure QTL 221	3.72886		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	69060519	86800898	Rat
1300166	Kidm6	Kidney mass QTL 6	3.93		kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	13	69060519	86800898	Rat
11530006	Niddm72	Non-insulin dependent diabetes mellitus QTL 72		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	74023918	80753406	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	74023918	97213863	Rat
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	74862117	85581182	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	74862117	101339893	Rat

Markers in Region

RH139030

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	77,727,661 - 77,727,801 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	83,680,488 - 83,680,627	NCBI	Rnor6.0
Rnor_5.0	13	88,559,946 - 88,560,085	UniSTS	Rnor5.0
RGSC_v3.4	13	81,184,010 - 81,184,149	UniSTS	RGSC3.4
Celera	13	77,441,031 - 77,441,170	UniSTS
RH 3.4 Map	13	479.8	UniSTS
Cytogenetic Map	13	q23	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001077643	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001322942	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM061478	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215073	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ222522	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224252	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000244	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000004206 ⟹ ENSRNOP00000004206

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	77,728,250 - 77,747,664 (+)	Ensembl
Rnor_6.0 Ensembl	13	83,681,322 - 83,700,213 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000098110 ⟹ ENSRNOP00000094616

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	77,728,250 - 77,747,664 (+)	Ensembl

RefSeq Acc Id:

NM_001077643 ⟹ NP_001071111

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	77,728,250 - 77,747,664 (+)	NCBI
Rnor_6.0	13	83,681,076 - 83,700,491 (+)	NCBI
Rnor_5.0	13	88,559,889 - 88,579,949 (+)	NCBI
Celera	13	77,441,619 - 77,461,027 (+)	NCBI

Sequence:

show sequence

CCCACTCCCGCTCGCAGGGGGCGGGCTGGGGCGGGCTTTTGCTGAGCCTCCACCCCCTCAGCCT
TCTCCGGACTCGGCCTCAAAGTGCTTCACCTCTGGCTGGCAGAGCCAGGGAAGGGCGCCCTAGG
GCGGAGACGGACACCTAGCGCTGTAGAGGGAAAGTGACGAGCCGCCCTTCATTGTCAGCCAGGA
ACGCGGACACAGCGGCGCTCCCACCCAGCTGCAGTGGATCCTTAGGCCGCCGAGATGGCAGCTG
CCGGCGCCCGAGGCCTGCGGGCCACCTACCACCGACTCATGGATAAAGTGGAGTTGTTGCTGCC
AAAGAAATTGAGGCCGCTATACAACCACCCGGCAGGCCCCAGAACAGTTTTTTTCTGGGCTCCG
ATAATGAAGTGGGGATTGGTATGTGCTGGATTAGCTGACATGGCCAGACCTGCAGAGAAACTCA
GCACAGCTCAATCCACTGTGCTGATGGCTACAGGGTTTATTTGGTCAAGGTATTCACTTGTAAT
TATACCAAAAAATTGGAGTTTGTTCGCTGTTAATTTCTTTGTGGGGTCAGCAGGAGCCTCTCAG
CTGTTTCGGATCTGGAAATATAATCAAGAACTCAAATCTAAAGGAATCCAGTAAGAGAGTTCCT
GATCACCTGAACATTCTAGATGTGGACAGAAACATTGAAACCTAGTGTATTTGATTACTGATAA
GGTGATGCTAATATTCTGATAACATTTGAAAAGAACGAAAACAAAATCTAACTGTAATTAATAG
CTAGCACTTGACTTCACAAAAAAAAAATAAATAAAGCAAACTTTTAGTAACAGTCTGTCTTTAC
ATATGCCTCAAGGAACTGTGGATAGCACCAACGTTGTTTTCTACCCTTTGTCCATAATAAATCC
TACTTGGTCATA

hide sequence

RefSeq Acc Id:

NM_001322942 ⟹ NP_001309871

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	77,728,250 - 77,747,664 (+)	NCBI
Rnor_6.0	13	83,681,076 - 83,700,491 (+)	NCBI
Celera	13	77,441,619 - 77,461,027 (+)	NCBI

Sequence:

show sequence

CCCACTCCCGCTCGCAGGGGGCGGGCTGGGGCGGGCTTTTGCTGAGCCTCCACCCCCTCAGCCT
TCTCCGGACTCGGCCTCAAAGTGCTTCACCTCTGGCTGGCAGAGCCAGGGAAGGGCGCCCTAGG
GCGGAGACGGACACCTAGCGCTGTAGAGGGAAAGTGACGAGCCGCCCTTCATTGTCAGCCAGGA
ACGCGGACACAGCGGCGCTCCCACCCAGCTGCAGTGGATCCTTAGGCCGCCGAGATGGCAGCTG
CCGGCGCCCGAGGCCTGCGGGCCACCTACCACCGACTCATGGATAAAGTGGAGTTGTTGCTGCC
AAAGAAATTGAGGCCGCTATACAACCACCCGGCAGGCCCCAGAACAGTTTTTTTCTGGGCTCCG
ATAATGAAGTGGGGATTGGTATGTGCTGGATTAGCTGACATGGCCAGACCTGCAGAGAAACTCA
GCACAGCTCAATCCACTGTGCTGATGGCTACAGATATAATCAAGAACTCAAATCTAAAGGAATC
CAGTAAGAGAGTTCCTGATCACCTGAACATTCTAGATGTGGACAGAAACATTGAAACCTAGTGT
ATTTGATTACTGATAAGGTGATGCTAATATTCTGATAACATTTGAAAAGAACGAAAACAAAATC
TAACTGTAATTAATAGCTAGCACTTGACTTCACAAAAAAAAAATAAATAAAGCAAACTTTTAGT
AACAGTCTGTCTTTACATATGCCTCAAGGAACTGTGGATAGCACCAACGTTGTTTTCTACCCTT
TGTCCATAATAAATCCTACTTGGTCATA

hide sequence

RefSeq Acc Id:

XM_006250126 ⟹ XP_006250188

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	77,728,176 - 77,747,664 (+)	NCBI
Rnor_6.0	13	83,680,527 - 83,700,491 (+)	NCBI
Rnor_5.0	13	88,559,889 - 88,579,949 (+)	NCBI

Sequence:

show sequence

CCCTCACCCTAGGAGAGTAGATTAAGGCCGCTCTAGCCCACTCCTTAATTGTCTATGGATAAAA
GAGTAATGACGGAAGCCGCTGAAATTGTCTCGCTCACGCCTCTCGATTCAAAGGAAAAAAAAAA
CCGGGCGTGATGACTCATGCTTGTAATTCCAGCATTCGGGAGGCTGGACGATGGCAGGATCCAA
AACAGCCTAGGTTACATAGCGAGACACCGACTCGAAAATAATAAGTAAATAAAAGAAACTCCGA
CAGGCGTGCGGCGTCATCTTTAGTTCGGGCGAGGAAAGCCCAGAAAGCTTATTTTAACTACACC
CTTCTTAGTCAAAGTGAGGGACAGGACAGAAGCGCGGCTTCAGTTTCCCCTCTCCAAAATGTCC
TCTAGGACCGGAAGGAGGTGAGAGTCTGACCACGCCTCTTCCGCTCTGTGAGGCCAGCCAATTA
GAGCAGGCCGTTAAGCTTGCGCAATGCCTCGTCCGCCCAGCGCTTGCAGCCCTAGCTCGGCGAC
CTCTTTAGCACCTGTTGCCATGACTCCTCCTCTGTCTCCCACTCCCGCTCGCAGGGGGCGGGCT
GGGGCGGGCTTTTGCTGAGCCTCCACCCCCTCAGCCTTCTCCGGACTCGGCCTCAAAGTGCTTC
ACCTCTGGCTGGCAGAGCCAGGGAAGGGCGCCCTAGGGCGGAGACGGACACCTAGCGCTGTAGA
GGGAAAGTGACGAGCCGCCCTTCATTGTCAGCCAGGAACGCGGACACAGCGGCGCTCCCACCCA
GCTGCAGTGGATCCTTAGGCCGCCGAGATGGCAGCTGCCGGCGCCCGAGGCCTGCGGGCCACCT
ACCACCGACTCATGGATAAAGTGGAGTTGTTGCTGCCAAAGAAATTGAGGCCGCTATACAACCA
CCCGGCAGGCCCCAGAACAGTTTTTTTCTGGGCTCCGATAATGAAGTGGGGATTGGTATGTGCT
GGATTAGCTGACATGGCCAGACCTGCAGAGAAACTCAGCACAGCTCAATCCACTGTGCTGATGG
CTACAGGGTTTATTTGGTCAAGGTATTCACTTGTAATTATACCAAAAAATTGGAGTTTGTTCGC
TGTTAATTTCTTTGTGGGGTCAGCAGGAGCCTCTCAGCTGTTTCGGATCTGGAAGTAAGCCTAC
TACCAAGATATAATCAAGAACTCAAATCTAAAGGAATCCAGTAAGAGAGTTCCTGATCACCTGA
ACATTCTAGATGTGGACAGAAACATTGAAACCTAGTGTATTTGATTACTGATAAGGTGATGCTA
ATATTCTGATAACATTTGAAAAGAACGAAAACAAAATCTAACTGTAATTAATAGCTAGCACTTG
ACTTCACAAAAAAAAAATAAATAAAGCAAACTTTTAGTAACAGTCTGTCTTTACATATGCCTCA
AGGAACTGTGGATAGCACCAACGTTGTTTTCTACCCTTTGTCCATAATAAATCCTACTTGGTCA
TA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001071111	(Get FASTA)	NCBI Sequence Viewer
	NP_001309871	(Get FASTA)	NCBI Sequence Viewer
	XP_006250188	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM09326	(Get FASTA)	NCBI Sequence Viewer
	EDM09327	(Get FASTA)	NCBI Sequence Viewer
	EDM09328	(Get FASTA)	NCBI Sequence Viewer
	P38718	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001071111 ⟸ NM_001077643
- Peptide Label:	isoform 1
- UniProtKB:	P38718 (UniProtKB/Swiss-Prot), A6IDH0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAAGARGLRATYHRLMDKVELLLPKKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPA EKLSTAQSTVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGSAGASQLFRIWKYNQELKSKGIQ hide sequence

RefSeq Acc Id:	XP_006250188 ⟸ XM_006250126
- Peptide Label:	isoform X1
- UniProtKB:	P38718 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MAAAGARGLRATYHRLMDKVELLLPKKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPA EKLSTAQSTVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGSAGASQLFRIWK hide sequence

RefSeq Acc Id:	NP_001309871 ⟸ NM_001322942
- Peptide Label:	isoform 2
- UniProtKB:	A0A8I6AS07 (UniProtKB/TrEMBL), A6IDG9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAAGARGLRATYHRLMDKVELLLPKKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPA EKLSTAQSTVLMATDIIKNSNLKESSKRVPDHLNILDVDRNIET hide sequence

RefSeq Acc Id:

ENSRNOP00000004206 ⟸ ENSRNOT00000004206

RefSeq Acc Id:

ENSRNOP00000094616 ⟸ ENSRNOT00000098110

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P38718-F1-model_v2	AlphaFold	P38718	1-127	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1563422	AgrOrtholog
BioCyc Gene	G2FUF-17568	BioCyc
Ensembl Genes	ENSRNOG00000003150	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000004206	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000094616	ENTREZGENE
	ENSRNOP00000094616.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000004206	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000098110	ENTREZGENE
	ENSRNOT00000098110.1	UniProtKB/TrEMBL
InterPro	MPC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:100359982	UniProtKB/Swiss-Prot
NCBI Gene	100359982	ENTREZGENE
PANTHER	MITOCHONDRIAL PYRUVATE CARRIER 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UPF0041 BRAIN PROTEIN 44-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	MPC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Mpc2	PhenoGen
UniProt	A0A8I6AS07	ENTREZGENE, UniProtKB/TrEMBL
	A6IDG9	ENTREZGENE, UniProtKB/TrEMBL
	A6IDH0	ENTREZGENE, UniProtKB/TrEMBL
	MPC2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-08-08	Mpc2	mitochondrial pyruvate carrier 2	Brp44	brain protein 44	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-09-08	Brp44	brain protein 44	LOC100359982	similar to brain protein 44	Data Merged	737654	APPROVED
2010-05-06	LOC100359982	brain protein 44			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-04-30	RGD1563422	similar to Brain protein 44	RGD1563422_predicted	similar to Brain protein 44 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1563422_predicted	similar to Brain protein 44 (predicted)	LOC289182	similar to Brain protein 44	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC289182	similar to Brain protein 44			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar