Acmsd (aminocarboxymuconate semialdehyde decarboxylase) - Rat Genome Database

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Gene: Acmsd (aminocarboxymuconate semialdehyde decarboxylase) Rattus norvegicus
Analyze
Symbol: Acmsd
Name: aminocarboxymuconate semialdehyde decarboxylase
RGD ID: 620868
Description: Enables aminocarboxymuconate-semialdehyde decarboxylase activity. Involved in aging and tryptophan catabolic process. Predicted to be active in cytosol. Used to study kidney failure. Orthologous to human ACMSD (aminocarboxymuconate semialdehyde decarboxylase); PARTICIPATES IN kynurenine metabolic pathway; tryptophan metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-nitropropane; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; picolinate carboxylase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21339,200,486 - 39,244,337 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1339,200,314 - 39,245,209 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1341,786,679 - 41,829,829 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01343,074,766 - 43,117,920 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01340,337,153 - 40,381,033 (+)NCBIRnor_WKY
Rnor_6.01344,424,689 - 44,468,734 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1344,424,689 - 44,468,734 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01349,510,444 - 49,553,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41340,547,366 - 40,573,698 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11340,561,408 - 40,587,743 (-)NCBI
Celera1339,577,658 - 39,620,559 (+)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1-nitropropane  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitropropane  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-acetylaminofluorene  (EXP)
4-nitro-1,2-phenylenediamine  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
adenine  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlorpyrifos  (EXP)
clofibric acid  (EXP)
cyclosporin A  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
furan  (EXP,ISO)
gentamycin  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
kojic acid  (ISO)
linoleic acid  (EXP)
metformin  (EXP)
N-nitrosodiethylamine  (EXP)
NAD zwitterion  (EXP)
NAD(+)  (EXP)
nicotinic acid  (EXP)
O-methyleugenol  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
phenformin  (EXP)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
propanal  (ISO)
pyrazine-2-carboxylic acid  (EXP)
quinolinic acid  (EXP)
resveratrol  (EXP)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP)
trichloroethene  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cellular_component  (ND)
cytoplasm  (IBA)
cytosol  (IBA,IEA,ISO,ISS,TAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats. Comai S, etal., Clin Chim Acta. 2005 Oct;360(1-2):67-80. doi: 10.1016/j.cccn.2005.04.013.
2. Tryptophan-niacin metabolism in rat with puromycin aminonucleoside-induced nephrosis. Egashira Y, etal., Int J Vitam Nutr Res. 2006 Jan;76(1):28-33. doi: 10.1024/0300-9831.76.1.28.
3. Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and "quinolinate hypothesis". Fukuoka S, etal., J Biol Chem 2002 Sep 20;277(38):35162-7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The kynurenine pathway and neurodegenerative disease. Maddison DC and Giorgini F, Semin Cell Dev Biol. 2015 Apr;40:134-41. doi: 10.1016/j.semcdb.2015.03.002. Epub 2015 Mar 12.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency. Saito K, etal., Am J Physiol Renal Physiol. 2000 Sep;279(3):F565-72. doi: 10.1152/ajprenal.2000.279.3.F565.
15. Production of L-tryptophan-derived catabolites in hepatocytes from streptozotocin-induced diabetic rats. Sasaki N, etal., Eur J Nutr. 2009 Apr;48(3):145-53. doi: 10.1007/s00394-009-0774-7. Epub 2009 Jan 23.
16. Purification and molecular cloning of rat 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase. Tanabe A, etal., Biochem J 2002 Feb 1;361(Pt 3):567-75.
17. Expression of rat hepatic 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase is affected by a high protein diet and by streptozotocin-induced diabetes. Tanabe A, etal., J Nutr. 2002 Jun;132(6):1153-9. doi: 10.1093/jn/132.6.1153.
Additional References at PubMed
PMID:17288562   PMID:19843166   PMID:23376485   PMID:25289390   PMID:25392945  


Genomics

Comparative Map Data
Acmsd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21339,200,486 - 39,244,337 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1339,200,314 - 39,245,209 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1341,786,679 - 41,829,829 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01343,074,766 - 43,117,920 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01340,337,153 - 40,381,033 (+)NCBIRnor_WKY
Rnor_6.01344,424,689 - 44,468,734 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1344,424,689 - 44,468,734 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01349,510,444 - 49,553,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41340,547,366 - 40,573,698 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11340,561,408 - 40,587,743 (-)NCBI
Celera1339,577,658 - 39,620,559 (+)NCBICelera
Cytogenetic Map13q13NCBI
ACMSD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382134,838,616 - 134,902,034 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2134,838,616 - 134,902,034 (+)EnsemblGRCh38hg38GRCh38
GRCh372135,596,186 - 135,659,604 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362135,312,656 - 135,376,074 (+)NCBINCBI36Build 36hg18NCBI36
Build 342135,429,919 - 135,493,332NCBI
Celera2129,309,109 - 129,372,527 (+)NCBICelera
Cytogenetic Map2q21.3NCBI
HuRef2127,587,573 - 127,651,049 (+)NCBIHuRef
CHM1_12135,600,992 - 135,664,414 (+)NCBICHM1_1
T2T-CHM13v2.02135,278,873 - 135,342,322 (+)NCBIT2T-CHM13v2.0
Acmsd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391127,657,150 - 127,695,301 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1127,657,150 - 127,695,715 (+)EnsemblGRCm39 Ensembl
GRCm381127,729,413 - 127,767,564 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1127,729,413 - 127,767,978 (+)EnsemblGRCm38mm10GRCm38
MGSCv371129,625,990 - 129,664,141 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361129,556,959 - 129,595,110 (+)NCBIMGSCv36mm8
Celera1130,370,820 - 130,409,013 (+)NCBICelera
Cytogenetic Map1E3NCBI
Acmsd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554402,348,396 - 2,412,706 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554402,348,434 - 2,412,706 (+)NCBIChiLan1.0ChiLan1.0
ACMSD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B138,918,281 - 138,978,407 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B138,918,281 - 138,978,407 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B24,958,661 - 25,019,901 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ACMSD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11937,658,999 - 37,725,426 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1937,659,226 - 37,725,172 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1937,899,088 - 37,966,088 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01939,104,331 - 39,171,370 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1939,104,336 - 39,171,359 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11937,746,853 - 37,813,851 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01937,907,821 - 37,974,822 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01939,142,980 - 39,209,976 (+)NCBIUU_Cfam_GSD_1.0
Acmsd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303100,712,913 - 100,760,168 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646940,858,338 - 40,904,807 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493646940,858,338 - 40,904,807 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACMSD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1517,106,724 - 17,163,899 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11517,121,950 - 17,164,005 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21519,522,142 - 19,538,454 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACMSD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11019,063,731 - 19,128,387 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1019,064,115 - 19,129,089 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660613,375,719 - 3,440,136 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acmsd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473234,232,908 - 34,292,898 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473234,232,890 - 34,294,195 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acmsd
236 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:18
Count of miRNA genes:17
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000005206
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
2303030Bp327Blood pressure QTL 327arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133039535141184251Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
2292232Pur16Proteinuria QTL 1617.2urine total protein amount (VT:0000032)urine protein level (CMO:0000591)133615572341961389Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10 10 10 21
Low 10 18 11 7 11 8 7 4
Below cutoff 2 9 11 2 10 2 7 8 9 4 19 7 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005206   ⟹   ENSRNOP00000005206
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1339,200,486 - 39,245,209 (+)Ensembl
Rnor_6.0 Ensembl1344,424,689 - 44,468,734 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097274   ⟹   ENSRNOP00000079363
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1339,200,314 - 39,245,209 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109111   ⟹   ENSRNOP00000081182
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1339,200,314 - 39,245,209 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119830   ⟹   ENSRNOP00000088596
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1339,200,314 - 39,245,209 (+)Ensembl
RefSeq Acc Id: NM_134372   ⟹   NP_599199
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21339,200,486 - 39,244,337 (+)NCBI
Rnor_6.01344,424,689 - 44,468,734 (+)NCBI
Rnor_5.01349,510,444 - 49,553,512 (+)NCBI
RGSC_v3.41340,547,366 - 40,573,698 (-)RGD
Celera1339,577,658 - 39,620,559 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_599199 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB84692 (Get FASTA)   NCBI Sequence Viewer  
  Q8R5M5 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_599199   ⟸   NM_134372
- UniProtKB: Q8R5M5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005206   ⟸   ENSRNOT00000005206
RefSeq Acc Id: ENSRNOP00000081182   ⟸   ENSRNOT00000109111
RefSeq Acc Id: ENSRNOP00000088596   ⟸   ENSRNOT00000119830
RefSeq Acc Id: ENSRNOP00000079363   ⟸   ENSRNOT00000097274
Protein Domains
Amidohydro-rel

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R5M5-F1-model_v2 AlphaFold Q8R5M5 1-336 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698775
Promoter ID:EPDNEW_R9300
Type:multiple initiation site
Name:Acmsd_1
Description:aminocarboxymuconate semialdehyde decarboxylase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01344,424,615 - 44,424,675EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620868 AgrOrtholog
BioCyc Gene G2FUF-18436 BioCyc
BioCyc Pathway PWY-5652 [2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA] BioCyc
Ensembl Genes ENSRNOG00000003884 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000005206.7 UniProtKB/TrEMBL
  ENSRNOP00000079363.1 UniProtKB/TrEMBL
  ENSRNOP00000081182 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000088596.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005206.7 UniProtKB/TrEMBL
  ENSRNOT00000097274.1 UniProtKB/TrEMBL
  ENSRNOT00000109111 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000119830.1 UniProtKB/TrEMBL
InterPro ACMSD UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Amidohydro-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metal_Hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171385 UniProtKB/Swiss-Prot
NCBI Gene 171385 ENTREZGENE
PANTHER PTHR21240 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Amidohydro_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acmsd PhenoGen
Superfamily-SCOP SSF51556 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZMP7_RAT UniProtKB/TrEMBL
  A0A8I6AJ63_RAT UniProtKB/TrEMBL
  A9CMA9_RAT UniProtKB/TrEMBL
  ACMSD_RAT UniProtKB/Swiss-Prot
  F8WFI2_RAT UniProtKB/TrEMBL
  Q8R5M5 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Acmsd  aminocarboxymuconate semialdehyde decarboxylase  Acmsd  2-amino-3-carboxymuconate-6-semialdehyde decarboxylase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Acmsd  2-amino-3-carboxymuconate-6-semialdehyde decarboxylase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 acmsd  2-amino-3-carboxymuconate-6-semialdehyde decarboxylase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease involved in diabetes 70243
gene_expression expressed in liver and kidney only 70243
gene_function converts 2-amino-3-carboxymuconate-6-semialdehyde to 2-aminomuconate-6-semialdehyde 70243
gene_process may function in tryptophan-niacin metabolism 70243