Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Rprm | Rat | (S)-naringenin | multiple interactions | ISO | RPRM (Homo sapiens) | 6480464 | [naringenin co-treated with bisphenol A] results in increased expression of RPRM mRNA and [naringenin metabolite co-treated with bisphenol A] results in increased expression of RPRM mRNA | CTD | PMID:36235125 | Rprm | Rat | (S)-naringenin | increases expression | ISO | RPRM (Homo sapiens) | 6480464 | naringenin metabolite results in increased expression of RPRM mRNA and naringenin results in increased expression of RPRM mRNA | CTD | PMID:36235125 | Rprm | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Rprm (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of RPRM mRNA | CTD | PMID:22206623 | Rprm | Rat | 17beta-estradiol | multiple interactions | ISO | RPRM (Homo sapiens) | 6480464 | [Estradiol co-treated with EGF protein] results in decreased expression of RPRM mRNA and [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of RPRM mRNA | CTD | PMID:19619570 and PMID:24758408 | Rprm | Rat | 17beta-estradiol | decreases expression | ISO | RPRM (Homo sapiens) | 6480464 | Estradiol results in decreased expression of RPRM mRNA | CTD | PMID:19619570 more ... | Rprm | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RPRM (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RPRM mRNA | CTD | PMID:19619570 | Rprm | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of RPRM mRNA | CTD | PMID:34747641 | Rprm | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of RPRM mRNA | CTD | PMID:21215274 | Rprm | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RPRM (Homo sapiens) | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of RPRM mRNA | CTD | PMID:19619570 | Rprm | Rat | 2,4,6-trinitrobenzenesulfonic acid | decreases expression | ISO | Rprm (Mus musculus) | 6480464 | Trinitrobenzenesulfonic Acid results in decreased expression of RPRM mRNA | CTD | PMID:17982090 | Rprm | Rat | 2-acetamidofluorene | decreases expression | EXP | | 6480464 | 2-Acetylaminofluorene results in decreased expression of RPRM mRNA | CTD | PMID:19167416 | Rprm | Rat | 2-acetamidofluorene | increases expression | EXP | | 6480464 | 2-Acetylaminofluorene results in increased expression of RPRM mRNA | CTD | PMID:22584684 | Rprm | Rat | 2-acetamidofluorene | multiple interactions | ISO | Rprm (Mus musculus) | 6480464 | TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of RPRM mRNA] | CTD | PMID:17317680 | Rprm | Rat | 3,3',5,5'-tetrabromobisphenol A | increases expression | EXP | | 6480464 | tetrabromobisphenol A results in increased expression of RPRM mRNA | CTD | PMID:28300664 | Rprm | Rat | 5-aza-2'-deoxycytidine | multiple interactions | ISO | Rprm (Mus musculus) | 6480464 | [[Decitabine co-treated with trichostatin A] affects the methylation of RPRM promoter] which affects the expression of RPRM mRNA | CTD | PMID:18836996 | Rprm | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of RPRM mRNA | CTD | PMID:24780913 | Rprm | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of RPRM mRNA | CTD | PMID:30047161 | Rprm | Rat | aflatoxin B1 | increases methylation | ISO | RPRM (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of RPRM gene | CTD | PMID:28458013 | Rprm | Rat | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of RPRM mRNA | CTD | PMID:33354967 | Rprm | Rat | aflatoxin B1 | decreases methylation | ISO | RPRM (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of RPRM gene | CTD | PMID:27153756 | Rprm | Rat | all-trans-retinoic acid | decreases expression | EXP | | 6480464 | Tretinoin results in decreased expression of RPRM mRNA | CTD | PMID:20488242 | Rprm | Rat | all-trans-retinoic acid | increases expression | ISO | RPRM (Homo sapiens) | 6480464 | Tretinoin results in increased expression of RPRM mRNA | CTD | PMID:23724009 | Rprm | Rat | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of RPRM mRNA | CTD | PMID:30047161 | Rprm | Rat | arsenite(3-) | increases methylation | ISO | RPRM (Homo sapiens) | 6480464 | arsenite results in increased methylation of RPRM promoter | CTD | PMID:23974009 | Rprm | Rat | benzo[a]pyrene | increases expression | ISO | Rprm (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of RPRM mRNA | CTD | PMID:19770486 | Rprm | Rat | benzo[a]pyrene | affects methylation | ISO | RPRM (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of RPRM 3' UTR and Benzo(a)pyrene affects the methylation of RPRM promoter | CTD | PMID:27901495 | Rprm | Rat | benzo[a]pyrene | increases methylation | ISO | RPRM (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of RPRM exon | CTD | PMID:27901495 | Rprm | Rat | bis(2-chloroethyl) sulfide | decreases expression | ISO | Rprm (Mus musculus) | 6480464 | Mustard Gas results in decreased expression of RPRM mRNA | CTD | PMID:19778212 | Rprm | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Rprm (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of RPRM mRNA | CTD | PMID:28085963 | Rprm | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of RPRM mRNA | CTD | PMID:25181051 | Rprm | Rat | bisphenol A | multiple interactions | ISO | RPRM (Homo sapiens) | 6480464 | [naringenin co-treated with bisphenol A] results in increased expression of RPRM mRNA and [naringenin metabolite co-treated with bisphenol A] results in increased expression of RPRM mRNA | CTD | PMID:36235125 | Rprm | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of RPRM mRNA | CTD | PMID:30816183 more ... | Rprm | Rat | bisphenol A | increases expression | ISO | Rprm (Mus musculus) | 6480464 | bisphenol A results in increased expression of RPRM mRNA | CTD | PMID:29161229 | Rprm | Rat | bromobenzene | increases expression | EXP | | 6480464 | bromobenzene results in increased expression of RPRM mRNA | CTD | PMID:32479839 | Rprm | Rat | butanal | increases expression | ISO | RPRM (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of RPRM mRNA | CTD | PMID:26079696 | Rprm | Rat | carbon nanotube | affects expression | ISO | Rprm (Mus musculus) | 6480464 | Nanotubes and Carbon affects the expression of RPRM mRNA | CTD | PMID:25554681 | Rprm | Rat | chlorpyrifos | decreases expression | ISO | Rprm (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of RPRM mRNA | CTD | PMID:32715474 | Rprm | Rat | copper atom | multiple interactions | ISO | RPRM (Homo sapiens) | 6480464 | [Copper results in increased activity of TP53 protein] which results in increased expression of RPRM mRNA | CTD | PMID:16391388 | Rprm | Rat | copper(0) | multiple interactions | ISO | RPRM (Homo sapiens) | 6480464 | [Copper results in increased activity of TP53 protein] which results in increased expression of RPRM mRNA | CTD | PMID:16391388 | Rprm | Rat | coumarin | decreases expression | EXP | | 6480464 | coumarin results in decreased expression of RPRM mRNA | CTD | PMID:18480146 | Rprm | Rat | coumestrol | multiple interactions | ISO | RPRM (Homo sapiens) | 6480464 | [Coumestrol co-treated with resveratrol] results in decreased expression of RPRM mRNA | CTD | PMID:19167446 | Rprm | Rat | diazinon | increases expression | EXP | | 6480464 | Diazinon results in increased expression of RPRM mRNA | CTD | PMID:29108742 | Rprm | Rat | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of RPRM mRNA | CTD | PMID:21551480 | Rprm | Rat | dorsomorphin | multiple interactions | ISO | RPRM (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Rprm | Rat | entinostat | increases expression | ISO | RPRM (Homo sapiens) | 6480464 | entinostat results in increased expression of RPRM mRNA | CTD | PMID:26272509 | Rprm | Rat | entinostat | multiple interactions | ISO | RPRM (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RPRM mRNA | CTD | PMID:27188386 | Rprm | Rat | furan | decreases expression | EXP | | 6480464 | furan results in decreased expression of RPRM mRNA | CTD | PMID:25539665 | Rprm | Rat | GW 4064 | decreases expression | ISO | Rprm (Mus musculus) | 6480464 | GW 4064 results in decreased expression of RPRM mRNA | CTD | PMID:26655953 | Rprm | Rat | hexane | increases methylation | EXP | | 6480464 | n-hexane results in increased methylation of RPRM promoter | CTD | PMID:23740543 | Rprm | Rat | iron(III) nitrilotriacetate | increases expression | EXP | | 6480464 | ferric nitrilotriacetate results in increased expression of RPRM mRNA | CTD | PMID:23208426 | Rprm | Rat | maneb | multiple interactions | ISO | Rprm (Mus musculus) | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of RPRM mRNA | CTD | PMID:36117858 | Rprm | Rat | mercury dibromide | increases expression | ISO | RPRM (Homo sapiens) | 6480464 | mercuric bromide results in increased expression of RPRM mRNA | CTD | PMID:26272509 | Rprm | Rat | mercury dibromide | multiple interactions | ISO | RPRM (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RPRM mRNA | CTD | PMID:27188386 | Rprm | Rat | methapyrilene | increases expression | EXP | | 6480464 | Methapyrilene results in increased expression of RPRM mRNA | CTD | PMID:22484513 | Rprm | Rat | methapyrilene | decreases expression | EXP | | 6480464 | Methapyrilene results in decreased expression of RPRM mRNA | CTD | PMID:30467583 | Rprm | Rat | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of RPRM mRNA | CTD | PMID:38685447 | Rprm | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of RPRM mRNA | CTD | PMID:30047161 | Rprm | Rat | methylmercury chloride | increases expression | ISO | RPRM (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of RPRM mRNA | CTD | PMID:28001369 | Rprm | Rat | mifepristone | decreases expression | ISO | RPRM (Homo sapiens) | 6480464 | Mifepristone results in decreased expression of RPRM mRNA | CTD | PMID:17584828 | Rprm | Rat | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | increases expression | ISO | RPRM (Homo sapiens) | 6480464 | N more ... | CTD | PMID:18778698 | Rprm | Rat | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | multiple interactions | ISO | RPRM (Homo sapiens) | 6480464 | TP53 mutant form inhibits the reaction [N more ... | CTD | PMID:18778698 | Rprm | Rat | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of RPRM mRNA | CTD | PMID:19638242 and PMID:25242409 | Rprm | Rat | nevirapine | decreases expression | EXP | | 6480464 | Nevirapine metabolite results in decreased expression of RPRM mRNA | CTD | PMID:23947594 | Rprm | Rat | ochratoxin A | increases expression | EXP | | 6480464 | ochratoxin A results in increased expression of RPRM mRNA | CTD | PMID:23208426 | Rprm | Rat | p-chloromercuribenzoic acid | increases expression | ISO | RPRM (Homo sapiens) | 6480464 | p-Chloromercuribenzoic Acid results in increased expression of RPRM mRNA | CTD | PMID:26272509 | Rprm | Rat | p-chloromercuribenzoic acid | multiple interactions | ISO | RPRM (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RPRM mRNA | CTD | PMID:27188386 | Rprm | Rat | p-toluidine | decreases expression | EXP | | 6480464 | 4-toluidine results in decreased expression of RPRM mRNA | CTD | PMID:27638505 | Rprm | Rat | panobinostat | multiple interactions | ISO | RPRM (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RPRM mRNA | CTD | PMID:27188386 | Rprm | Rat | panobinostat | increases expression | ISO | RPRM (Homo sapiens) | 6480464 | panobinostat results in increased expression of RPRM mRNA | CTD | PMID:26272509 | Rprm | Rat | paracetamol | decreases expression | ISO | RPRM (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of RPRM mRNA | CTD | PMID:22230336 | Rprm | Rat | paraquat | multiple interactions | ISO | Rprm (Mus musculus) | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of RPRM mRNA | CTD | PMID:36117858 | Rprm | Rat | pentanal | increases expression | ISO | RPRM (Homo sapiens) | 6480464 | pentanal results in increased expression of RPRM mRNA | CTD | PMID:26079696 | Rprm | Rat | phenobarbital | decreases expression | EXP | | 6480464 | Phenobarbital results in decreased expression of RPRM mRNA | CTD | PMID:22584684 | Rprm | Rat | phenylmercury acetate | increases expression | ISO | RPRM (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of RPRM mRNA | CTD | PMID:26272509 | Rprm | Rat | phenylmercury acetate | multiple interactions | ISO | RPRM (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RPRM mRNA | CTD | PMID:27188386 | Rprm | Rat | potassium dichromate | decreases expression | ISO | Rprm (Mus musculus) | 6480464 | Potassium Dichromate results in decreased expression of RPRM mRNA | CTD | PMID:23608068 | Rprm | Rat | progesterone | increases expression | ISO | Rprm (Mus musculus) | 6480464 | Progesterone results in increased expression of RPRM mRNA | CTD | PMID:22238285 | Rprm | Rat | resveratrol | multiple interactions | ISO | RPRM (Homo sapiens) | 6480464 | [Coumestrol co-treated with resveratrol] results in decreased expression of RPRM mRNA | CTD | PMID:19167446 | Rprm | Rat | resveratrol | multiple interactions | EXP | | 6480464 | [resveratrol co-treated with Streptozocin] results in increased expression of RPRM mRNA | CTD | PMID:25905778 | Rprm | Rat | SB 431542 | multiple interactions | ISO | RPRM (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Rprm | Rat | sodium arsenite | decreases expression | ISO | Rprm (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of RPRM mRNA | CTD | PMID:37682722 | Rprm | Rat | streptozocin | multiple interactions | EXP | | 6480464 | [resveratrol co-treated with Streptozocin] results in increased expression of RPRM mRNA | CTD | PMID:25905778 | Rprm | Rat | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of RPRM mRNA | CTD | PMID:30047161 | Rprm | Rat | sulforaphane | decreases expression | ISO | Rprm (Mus musculus) | 6480464 | sulforaphane results in decreased expression of RPRM mRNA | CTD | PMID:30529165 | Rprm | Rat | sulforaphane | decreases expression | ISO | RPRM (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of RPRM mRNA | CTD | PMID:31838189 | Rprm | Rat | tetraphene | increases expression | ISO | Rprm (Mus musculus) | 6480464 | benz(a)anthracene results in increased expression of RPRM mRNA | CTD | PMID:26377693 | Rprm | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of RPRM mRNA | CTD | PMID:34492290 | Rprm | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of RPRM mRNA | CTD | PMID:33387578 | Rprm | Rat | trichostatin A | multiple interactions | ISO | Rprm (Mus musculus) | 6480464 | [[decitabine co-treated with trichostatin A] affects the methylation of RPRM promoter] which affects the expression of RPRM mRNA | CTD | PMID:18836996 | Rprm | Rat | trichostatin A | increases expression | ISO | RPRM (Homo sapiens) | 6480464 | trichostatin A results in increased expression of RPRM mRNA | CTD | PMID:24935251 | Rprm | Rat | triphenyl phosphate | decreases expression | EXP | | 6480464 | triphenyl phosphate results in decreased expression of RPRM mRNA | CTD | PMID:30589522 | Rprm | Rat | valdecoxib | decreases expression | EXP | | 6480464 | valdecoxib results in decreased expression of RPRM mRNA | CTD | PMID:24136188 | Rprm | Rat | valproic acid | decreases methylation | ISO | RPRM (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of RPRM gene | CTD | PMID:29154799 | Rprm | Rat | valproic acid | affects expression | ISO | RPRM (Homo sapiens) | 6480464 | Valproic Acid affects the expression of RPRM mRNA | CTD | PMID:25979313 | Rprm | Rat | valproic acid | increases expression | ISO | RPRM (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of RPRM mRNA | CTD | PMID:23179753 more ... | Rprm | Rat | valproic acid | multiple interactions | ISO | RPRM (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RPRM mRNA | CTD | PMID:27188386 | Rprm | Rat | vitamin E | increases expression | ISO | RPRM (Homo sapiens) | 6480464 | Vitamin E results in increased expression of RPRM mRNA | CTD | PMID:19244175 | |