Mir20a (microRNA 20a) - Rat Genome Database

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Pathways
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Gene: Mir20a (microRNA 20a) Rattus norvegicus
Analyze
Symbol: Mir20a
Name: microRNA 20a
RGD ID: 2325401
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including negative regulation of macromolecule biosynthetic process; regulation of angiogenesis; and regulation of signal transduction. Predicted to act upstream of or within several processes, including cellular response to forskolin; embryo implantation; and long-term synaptic potentiation. Predicted to be located in extracellular exosome. Predicted to be part of RISC complex. Biomarker of metabolic dysfunction-associated steatotic liver disease. Orthologous to human MIR20A (microRNA 20a); INTERACTS WITH 2,5-hexanedione; 2-acetamidofluorene; 2-methoxyethanol.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-20a; rno-mir-20a
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81598,588,303 - 98,588,387 (+)NCBIGRCr8
mRatBN7.21592,181,084 - 92,181,168 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1592,181,084 - 92,181,168 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1596,087,873 - 96,087,957 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01597,220,739 - 97,220,823 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01594,128,145 - 94,128,229 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015100,180,334 - 100,180,418 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15100,180,334 - 100,180,418 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015103,641,357 - 103,641,441 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1591,045,764 - 91,045,848 (+)NCBICelera
Cytogenetic Map15q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell apoptotic process  (ISO)
cellular response to forskolin  (ISO)
cellular response to hypoxia  (ISO)
cellular response to inorganic substance  (ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
embryo implantation  (ISO)
in utero embryonic development  (ISO)
inflammatory response  (ISO)
long-term synaptic potentiation  (ISO)
lung development  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (ISO)
negative regulation of amyloid precursor protein biosynthetic process  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of cell adhesion molecule production  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of chemokine-mediated signaling pathway  (ISO)
negative regulation of cytokine-mediated signaling pathway  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-17 production  (ISO)
negative regulation of p38MAPK cascade  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of sprouting angiogenesis  (ISO)
negative regulation of stress fiber assembly  (ISO)
negative regulation of toll-like receptor 4 signaling pathway  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of vascular endothelial growth factor production  (ISO)
ossification  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
pre-B cell differentiation  (ISO)
regulation of gene expression  (ISO)
response to bacterium  (ISO)
response to wounding  (ISO)
sensory perception of sound  (ISO)
spinal cord motor neuron differentiation  (ISO)
ventricular septum morphogenesis  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. miR-20a regulates expression of the iron exporter ferroportin in lung cancer. Babu KR and Muckenthaler MU, J Mol Med (Berl). 2016 Mar;94(3):347-59. doi: 10.1007/s00109-015-1362-3. Epub 2015 Nov 12.
2. Association between polymorphisms of MIR17HG and risk of colorectal cancer in the Chinese Han population. Chen P, etal., Mol Genet Genomic Med. 2019 Jun;7(6):e667. doi: 10.1002/mgg3.667. Epub 2019 Apr 3.
3. MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4. Cheng D, etal., Oncotarget. 2016 Jul 19;7(29):45199-45213. doi: 10.18632/oncotarget.9900.
4. Expression of miR-20a: A serum biomarker in the diagnostic approach for hepatocellular carcinoma. Fahim A, etal., J Pak Med Assoc. 2019 Jan;69(1):29-33.
5. Spontaneous combined hyperlipidemia, coronary heart disease and decreased survival in Dahl salt-sensitive hypertensive rats transgenic for human cholesteryl ester transfer protein. Herrera VL, etal., Nat Med. 1999 Dec;5(12):1383-9.
6. HPV 16 E7 inhibits OSCC cell proliferation, invasion, and metastasis by upregulating the expression of miR-20a. Hu J, etal., Tumour Biol. 2016 Jul;37(7):9433-40. doi: 10.1007/s13277-016-4817-4. Epub 2016 Jan 19.
7. Six Serum-Based miRNAs as Potential Diagnostic Biomarkers for Gastric Cancer. Huang Z, etal., Cancer Epidemiol Biomarkers Prev. 2017 Feb;26(2):188-196. doi: 10.1158/1055-9965.EPI-16-0607. Epub 2016 Oct 18.
8. Expression profile of miR-17/92 cluster is predictive of treatment response in rectal cancer. Kral J, etal., Carcinogenesis. 2018 Dec 13;39(11):1359-1367. doi: 10.1093/carcin/bgy100.
9. MicroRNA‑20a promotes inflammation via the nuclear factor‑κB signaling pathway in pediatric pneumonia. Liu Z, etal., Mol Med Rep. 2018 Jan;17(1):612-617. doi: 10.3892/mmr.2017.7899. Epub 2017 Oct 26.
10. The other face of miR-17-92a cluster, exhibiting tumor suppressor effects in prostate cancer. Ottman R, etal., Oncotarget. 2016 Nov 8;7(45):73739-73753. doi: 10.18632/oncotarget.12061.
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Plasma microRNA signature of patients with IgA nephropathy. Wu J, etal., Gene. 2018 Apr 5;649:80-86. doi: 10.1016/j.gene.2018.01.050. Epub 2018 Feb 6.
13. Long Noncoding RNA MIR17HG Promotes Colorectal Cancer Progression via miR-17-5p. Xu J, etal., Cancer Res. 2019 Oct 1;79(19):4882-4895. doi: 10.1158/0008-5472.CAN-18-3880. Epub 2019 Aug 13.
14. Serum miR-20a and miR-486 are potential biomarkers for discriminating colorectal neoplasia: A pilot study. Yang Q, etal., J Cancer Res Ther. 2018;14(7):1572-1577. doi: 10.4103/jcrt.JCRT_1198_16.
15. Knockdown of lncRNA H19 alleviates ox-LDL-induced HCAECs inflammation and injury by mediating miR-20a-5p/HDAC4 axis. Yang Y, etal., Inflamm Res. 2022 Sep;71(9):1109-1121. doi: 10.1007/s00011-022-01604-z. Epub 2022 Jul 19.
16. Plasma miR-17, miR-20a, miR-20b and miR-122 as potential biomarkers for diagnosis of NAFLD in type 2 diabetes mellitus patients. Ye D, etal., Life Sci. 2018 Sep 1;208:201-207. doi: 10.1016/j.lfs.2018.07.029. Epub 2018 Jul 17.
Additional References at PubMed
PMID:14691248   PMID:16381832   PMID:16682203   PMID:16766679   PMID:17604727   PMID:18320040   PMID:18329372   PMID:18556655   PMID:20403161   PMID:20708584   PMID:21338882   PMID:21993888  
PMID:22182733   PMID:23185045   PMID:23646144   PMID:24205035   PMID:25751060   PMID:25858512   PMID:25959411   PMID:30426336   PMID:31397222   PMID:31444671   PMID:31451219   PMID:31465630  
PMID:31490024   PMID:31566731   PMID:32141587   PMID:34570349   PMID:35287147   PMID:35917232   PMID:36214718   PMID:37464223  


Genomics

Comparative Map Data
Mir20a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81598,588,303 - 98,588,387 (+)NCBIGRCr8
mRatBN7.21592,181,084 - 92,181,168 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1592,181,084 - 92,181,168 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1596,087,873 - 96,087,957 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01597,220,739 - 97,220,823 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01594,128,145 - 94,128,229 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015100,180,334 - 100,180,418 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15100,180,334 - 100,180,418 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015103,641,357 - 103,641,441 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1591,045,764 - 91,045,848 (+)NCBICelera
Cytogenetic Map15q23NCBI
MIR20A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381391,351,065 - 91,351,135 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1391,351,065 - 91,351,135 (+)EnsemblGRCh38hg38GRCh38
GRCh371392,003,319 - 92,003,389 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361390,801,319 - 90,801,389 (+)NCBINCBI36Build 36hg18NCBI36
Celera1372,850,290 - 72,850,360 (+)NCBICelera
Cytogenetic Map13q31.3NCBI
HuRef1372,599,154 - 72,599,224 (+)NCBIHuRef
CHM1_11391,971,959 - 91,972,029 (+)NCBICHM1_1
T2T-CHM13v2.01390,553,641 - 90,553,711 (+)NCBIT2T-CHM13v2.0
Mir20a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914115,281,589 - 115,281,695 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14115,281,589 - 115,281,695 (+)EnsemblGRCm39 Ensembl
GRCm3814115,044,157 - 115,044,263 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14115,044,157 - 115,044,263 (+)EnsemblGRCm38mm10GRCm38
MGSCv3714115,443,379 - 115,443,485 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera14113,634,725 - 113,634,831 (+)NCBICelera
Cytogenetic Map14E4NCBI
cM Map1459.4NCBI
MIR20A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12242,478,462 - 42,478,520 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2242,478,462 - 42,478,520 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2242,334,150 - 42,334,208 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02242,879,711 - 42,879,769 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2242,879,711 - 42,879,769 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12242,562,184 - 42,562,242 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02242,616,563 - 42,616,621 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02242,617,626 - 42,617,684 (+)NCBIUU_Cfam_GSD_1.0
MIR20A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1160,735,099 - 60,735,196 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11160,735,109 - 60,735,179 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21166,610,513 - 66,610,583 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:10356
Count of gene targets:6039
Count of transcripts:6536
Interacting mature miRNAs:rno-miR-20a-3p, rno-miR-20a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)155559608995018120Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1568327165100062518Rat
1331724Bp223Blood pressure QTL 2233.53715arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)157369051895018228Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)157369051899794247Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)157369065795018120Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1575788062101769107Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1575788062101769107Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1576306099101769107Rat
1300118Bp190Blood pressure QTL 1902.94arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)158226252098288169Rat
1300120Kidm7Kidney mass QTL 73.55kidney mass (VT:0002707)left kidney wet weight to body weight ratio (CMO:0001954)158226252098288169Rat
1581519Cm59Cardiac mass QTL 592.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)158885347095840528Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 6 1
Low 4 18 6 10 6 5 5 10 3 17 8 5
Below cutoff 1 2 2 1 2 2 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000053728
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1592,181,084 - 92,181,168 (+)Ensembl
Rnor_6.0 Ensembl15100,180,334 - 100,180,418 (+)Ensembl
RefSeq Acc Id: NR_031793
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81598,588,303 - 98,588,387 (+)NCBI
mRatBN7.21592,181,084 - 92,181,168 (+)NCBI
Rnor_6.015100,180,334 - 100,180,418 (+)NCBI
Rnor_5.015103,641,357 - 103,641,441 (+)NCBI
Celera1591,045,764 - 91,045,848 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325401 AgrOrtholog
BioCyc Gene G2FUF-12489 BioCyc
Ensembl Genes ENSRNOG00000035605 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053728 ENTREZGENE
miRBase MI0000638 ENTREZGENE
NCBI Gene 100314222 ENTREZGENE
PhenoGen Mir20a PhenoGen
RatGTEx ENSRNOG00000035605 RatGTEx
RNAcentral URS0000574A2C RNACentral
  URS0000759D49 RNACentral
  URS000075DF28 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir20a  microRNA 20a  Mir20a  microRNA mir-20a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir20a  microRNA mir-20a      Symbol and Name status set to provisional 70820 PROVISIONAL