Pc (pyruvate carboxylase) - Rat Genome Database

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Gene: Pc (pyruvate carboxylase) Rattus norvegicus
Analyze
Symbol: Pc
Name: pyruvate carboxylase
RGD ID: 3262
Description: Enables ATP binding activity; biotin binding activity; and pyruvate carboxylase activity. Involved in carboxylic acid metabolic process; gluconeogenesis; and positive regulation of phospholipid biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase); PARTICIPATES IN gluconeogenesis pathway; pyruvate metabolic pathway; alanine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: PCB; Pcx; pyruvate carboxylase, mitochondrial; pyruvic carboxylase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21201,799,374 - 201,898,412 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,804,267 - 201,898,380 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1210,152,085 - 210,251,300 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01217,244,857 - 217,343,799 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01209,935,881 - 210,034,819 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,759,157 - 219,859,854 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,759,183 - 219,859,848 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,626,831 - 226,726,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41207,112,853 - 207,212,737 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11207,266,305 - 207,366,189 (+)NCBI
Celera1199,343,224 - 199,439,273 (+)NCBICelera
RH 3.4 Map11554.4RGD
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-phenylbutyric acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzatropine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium atom  (EXP)
clofibrate  (EXP)
clomipramine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
duvoglustat  (ISO)
elemental selenium  (ISO)
entacapone  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (EXP,ISO)
glycidyl methacrylate  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (EXP)
imipramine  (EXP)
indometacin  (EXP)
inulin  (ISO)
iodide salt  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ethionine  (EXP)
lipopolysaccharide  (ISO)
methapyrilene  (EXP,ISO)
mifepristone  (EXP,ISO)
Muraglitazar  (EXP)
N-hexadecanoylsphingosine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
obeticholic acid  (ISO)
oleic acid  (EXP)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phlorizin  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (EXP,ISO)
Propiverine  (EXP)
resveratrol  (ISO)
rimonabant  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenic acid  (ISO)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP)
tetracycline  (ISO)
thapsigargin  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
tolcapone  (EXP)
triadimefon  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)
zearalenone  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
mitochondrial matrix  (ISO)
mitochondrion  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver. Ballard FJ and Hanson RW, Biochem J. 1967 Sep;104(3):866-71.
2. Amerindian pyruvate carboxylase deficiency is associated with two distinct missense mutations. Carbone MA, etal., Am J Hum Genet 1998 Jun;62(6):1312-9.
3. Intron retention and frameshift mutations result in severe pyruvate carboxylase deficiency in two male siblings. Carbone MA, etal., Hum Mutat. 2002 Jul;20(1):48-56.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Cloning, sequencing and expression of rat liver pyruvate carboxylase. Jitrapakdee S, etal., Biochem J 1996 Jun 1;316 ( Pt 2):631-7.
7. Structure, mechanism and regulation of pyruvate carboxylase. Jitrapakdee S, etal., Biochem J. 2008 Aug 1;413(3):369-87.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Regulation of pyruvate carboxylase activity by calcium in intact rat liver mitochondria. Kimmich GA and Rasmussen H, J Biol Chem. 1969 Jan 10;244(1):190-9.
10. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
11. The sequence of the rat pyruvate carboxylase-encoding cDNA. Lehn DA, etal., Gene 1995 Nov 20;165(2):331-2.
12. Enhanced rat beta-cell proliferation in 60% pancreatectomized islets by increased glucose metabolic flux through pyruvate carboxylase pathway. Liu YQ, etal., Am J Physiol Endocrinol Metab. 2005 Mar;288(3):E471-8. Epub 2004 Oct 26.
13. beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats. Liu YQ, etal., J Biol Chem 2002 Oct 18;277(42):39163-8.
14. Knockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cells. MacDonald MJ, etal., Arch Biochem Biophys. 2013 Apr 1;532(1):23-31. doi: 10.1016/j.abb.2013.01.002. Epub 2013 Jan 25.
15. cDNA cloning of human kidney pyruvate carboxylase. MacKay N, etal., Biochem Biophys Res Commun 1994 Jul 29;202(2):1009-14.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. Pharmacological biotin supplementation maintains biotin status and function in rats administered dietary carbamazepine. Rathman SC, etal., J Nutr. 2003 Sep;133(9):2857-62.
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
26. Induction and suppression of the key enzymes of glycolysis and gluconeogenesis in isolated perfused rat liver in response to glucose, fructose and lactate. Wimhurst JM and Manchester KL, Biochem J. 1973 May;134(1):143-56.
Additional References at PubMed
PMID:3178228   PMID:8687459   PMID:12477932   PMID:12865426   PMID:14651853   PMID:16729965   PMID:16740637   PMID:16752176   PMID:17408383   PMID:18297087   PMID:18614015   PMID:18686030  
PMID:18697738   PMID:18769905   PMID:20001964   PMID:21700703   PMID:23861867   PMID:25054881   PMID:25931508   PMID:26316108   PMID:26767982   PMID:29476059   PMID:30053369   PMID:32357304  


Genomics

Comparative Map Data
Pc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21201,799,374 - 201,898,412 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,804,267 - 201,898,380 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1210,152,085 - 210,251,300 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01217,244,857 - 217,343,799 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01209,935,881 - 210,034,819 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,759,157 - 219,859,854 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,759,183 - 219,859,848 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,626,831 - 226,726,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41207,112,853 - 207,212,737 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11207,266,305 - 207,366,189 (+)NCBI
Celera1199,343,224 - 199,439,273 (+)NCBICelera
RH 3.4 Map11554.4RGD
Cytogenetic Map1q43NCBI
PC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381166,848,420 - 66,958,383 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1166,848,417 - 66,958,386 (-)EnsemblGRCh38hg38GRCh38
GRCh371166,615,891 - 66,725,854 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,372,573 - 66,482,423 (-)NCBINCBI36Build 36hg18NCBI36
Build 341166,372,572 - 66,431,998NCBI
Celera1163,944,403 - 64,054,124 (-)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1162,944,043 - 63,053,644 (-)NCBIHuRef
CHM1_11166,499,596 - 66,607,614 (-)NCBICHM1_1
T2T-CHM13v2.01166,844,694 - 66,952,886 (-)NCBIT2T-CHM13v2.0
Pcx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,560,500 - 4,671,780 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl194,560,500 - 4,671,780 (+)EnsemblGRCm39 Ensembl
GRCm38194,510,472 - 4,621,752 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,510,472 - 4,621,752 (+)EnsemblGRCm38mm10GRCm38
MGSCv37194,510,472 - 4,621,752 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36194,594,346 - 4,621,698 (+)NCBIMGSCv36mm8
Celera194,381,239 - 4,492,934 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.07NCBI
Pc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542218,420,596 - 18,536,436 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542218,421,100 - 18,536,591 (+)NCBIChiLan1.0ChiLan1.0
PC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11169,116,844 - 69,229,111 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01162,205,644 - 62,317,917 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11165,527,285 - 65,639,533 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1165,527,662 - 65,551,396 (-)Ensemblpanpan1.1panPan2
PC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11850,406,994 - 50,507,677 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1850,412,272 - 50,507,669 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1849,016,958 - 49,117,517 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01851,357,399 - 51,457,857 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1851,357,414 - 51,457,857 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11850,541,749 - 50,642,299 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01850,121,287 - 50,221,660 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01850,910,958 - 51,011,409 (+)NCBIUU_Cfam_GSD_1.0
Pc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049476,235,346 - 6,350,686 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365992,677,583 - 2,793,197 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365992,677,770 - 2,793,033 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl25,518,517 - 5,587,797 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.125,566,608 - 5,587,797 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.224,594,815 - 4,609,731 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2p17NCBI
PC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.117,310,738 - 7,418,357 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl17,357,246 - 7,417,998 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038104,598,850 - 104,705,939 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476719,480,522 - 19,614,051 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476719,481,158 - 19,601,036 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pc
392 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:205
Count of miRNA genes:128
Interacting mature miRNAs:151
Transcripts:ENSRNOT00000026316
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1199368955224569684Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1199773958202166723Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat

Markers in Region
D1Got187  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21201,818,238 - 201,818,406 (+)MAPPERmRatBN7.2
Rnor_6.01219,778,018 - 219,778,182NCBIRnor6.0
Celera1199,362,095 - 199,362,261UniSTS
RH 3.4 Map11554.5RGD
RH 3.4 Map11554.5UniSTS
RH 2.0 Map11134.4RGD
Cytogenetic Map1q42UniSTS
RH94624  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21201,898,189 - 201,898,375 (+)MAPPERmRatBN7.2
Rnor_6.01219,859,658 - 219,859,843NCBIRnor6.0
Rnor_5.01226,726,138 - 226,726,323UniSTSRnor5.0
RGSC_v3.41207,212,546 - 207,212,731UniSTSRGSC3.4
Celera1199,439,082 - 199,439,267UniSTS
RH 3.4 Map11554.4UniSTS
Cytogenetic Map1q42UniSTS
BI301314  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21201,845,141 - 201,845,307 (+)MAPPERmRatBN7.2
Rnor_6.01219,805,009 - 219,805,174NCBIRnor6.0
Rnor_5.01226,671,415 - 226,671,580UniSTSRnor5.0
RGSC_v3.41207,159,556 - 207,159,721UniSTSRGSC3.4
Celera1199,389,173 - 199,389,338UniSTS
RH 3.4 Map11555.9UniSTS
Cytogenetic Map1q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 29 57 41 11 41 7 10 74 35 38 9 7
Low 1 14 8 1 1 3 2 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC119332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U32314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U36585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U54551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U54552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U54553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U54554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U54555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U81515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000026316   ⟹   ENSRNOP00000026316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1201,809,771 - 201,898,380 (+)Ensembl
Rnor_6.0 Ensembl1219,759,183 - 219,859,848 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082388   ⟹   ENSRNOP00000075317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1201,804,267 - 201,898,376 (+)Ensembl
Rnor_6.0 Ensembl1219,764,001 - 219,859,844 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087432   ⟹   ENSRNOP00000068757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1201,872,018 - 201,898,380 (+)Ensembl
Rnor_6.0 Ensembl1219,833,299 - 219,859,847 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106490   ⟹   ENSRNOP00000086416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1201,835,211 - 201,898,380 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119641   ⟹   ENSRNOP00000092227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1201,873,788 - 201,898,380 (+)Ensembl
RefSeq Acc Id: NM_012744   ⟹   NP_036876
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21201,799,448 - 201,898,381 (+)NCBI
Rnor_6.01219,759,183 - 219,859,849 (+)NCBI
Rnor_5.01226,626,831 - 226,726,350 (+)NCBI
RGSC_v3.41207,112,853 - 207,212,737 (+)RGD
Celera1199,343,224 - 199,439,273 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230691   ⟹   XP_006230753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21201,799,374 - 201,898,376 (+)NCBI
Rnor_6.01219,759,157 - 219,859,844 (+)NCBI
Rnor_5.01226,626,831 - 226,726,350 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230692   ⟹   XP_006230754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21201,872,078 - 201,898,412 (+)NCBI
Rnor_6.01219,833,584 - 219,859,854 (+)NCBI
Rnor_5.01226,626,831 - 226,726,350 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230693   ⟹   XP_006230755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21201,872,112 - 201,898,412 (+)NCBI
Rnor_6.01219,833,580 - 219,859,854 (+)NCBI
Rnor_5.01226,626,831 - 226,726,350 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101392   ⟹   XP_038957320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21201,803,328 - 201,898,376 (+)NCBI
RefSeq Acc Id: XM_039101393   ⟹   XP_038957321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21201,802,226 - 201,898,376 (+)NCBI
RefSeq Acc Id: XM_039101394   ⟹   XP_038957322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21201,799,374 - 201,898,412 (+)NCBI
RefSeq Acc Id: XM_039101398   ⟹   XP_038957326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21201,804,273 - 201,898,412 (+)NCBI
RefSeq Acc Id: XM_039101401   ⟹   XP_038957329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21201,892,268 - 201,898,402 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_036876   ⟸   NM_012744
- Peptide Label: precursor
- UniProtKB: Q5RKM0 (UniProtKB/Swiss-Prot),   Q64555 (UniProtKB/Swiss-Prot),   P52873 (UniProtKB/Swiss-Prot),   A6HYX8 (UniProtKB/TrEMBL),   A0A8I6A5A2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230753   ⟸   XM_006230691
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QDW8 (UniProtKB/TrEMBL),   A0A8I6A5A2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230755   ⟸   XM_006230693
- Peptide Label: isoform X2
- UniProtKB: Q5RKM0 (UniProtKB/Swiss-Prot),   Q64555 (UniProtKB/Swiss-Prot),   P52873 (UniProtKB/Swiss-Prot),   A6HYX8 (UniProtKB/TrEMBL),   A0A8I6A5A2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230754   ⟸   XM_006230692
- Peptide Label: isoform X2
- UniProtKB: Q5RKM0 (UniProtKB/Swiss-Prot),   Q64555 (UniProtKB/Swiss-Prot),   P52873 (UniProtKB/Swiss-Prot),   A6HYX8 (UniProtKB/TrEMBL),   A0A8I6A5A2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075317   ⟸   ENSRNOT00000082388
RefSeq Acc Id: ENSRNOP00000026316   ⟸   ENSRNOT00000026316
RefSeq Acc Id: ENSRNOP00000068757   ⟸   ENSRNOT00000087432
RefSeq Acc Id: XP_038957322   ⟸   XM_039101394
- Peptide Label: isoform X2
- UniProtKB: Q5RKM0 (UniProtKB/Swiss-Prot),   P52873 (UniProtKB/Swiss-Prot),   Q64555 (UniProtKB/Swiss-Prot),   A6HYX8 (UniProtKB/TrEMBL),   A0A8I6A5A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957321   ⟸   XM_039101393
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QDW8 (UniProtKB/TrEMBL),   A0A8I6A5A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957320   ⟸   XM_039101392
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QDW8 (UniProtKB/TrEMBL),   A0A8I6A5A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957326   ⟸   XM_039101398
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QDW8 (UniProtKB/TrEMBL),   A0A8I6A5A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957329   ⟸   XM_039101401
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000092227   ⟸   ENSRNOT00000119641
RefSeq Acc Id: ENSRNOP00000086416   ⟸   ENSRNOT00000106490
Protein Domains
ATP-grasp   Biotin carboxylation   Biotinyl-binding   Lipoyl-binding   Pyruvate carboxyltransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52873-F1-model_v2 AlphaFold P52873 1-1178 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690626
Promoter ID:EPDNEW_R1150
Type:multiple initiation site
Name:Pc_1
Description:pyruvate carboxylase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01219,759,190 - 219,759,250EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3262 AgrOrtholog
BioCyc Gene G2FUF-56750 BioCyc
BioCyc Pathway PWY66-399 [gluconeogenesis III] BioCyc
Ensembl Genes ENSRNOG00000019372 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026316 ENTREZGENE
  ENSRNOT00000026316.7 UniProtKB/TrEMBL
  ENSRNOT00000082388 ENTREZGENE
  ENSRNOT00000082388.2 UniProtKB/TrEMBL
  ENSRNOT00000087432 ENTREZGENE
  ENSRNOT00000087432.2 UniProtKB/TrEMBL
  ENSRNOT00000106490.1 UniProtKB/TrEMBL
  ENSRNOT00000119641.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1490.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-grasp fold, B domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  pyruvate carboxylase f1077a mutant domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109369 IMAGE-MGC_LOAD
InterPro Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-grasp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP_grasp_subdomain_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BC-like_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_carboxylation_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_COase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylase_cons_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CbamoylP_synth_lsu-like_ATP-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PreATP-grasp_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PYR_CT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyruv_COase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rudment_hybrid_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single_hybrid_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25104 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93035 IMAGE-MGC_LOAD
NCBI Gene 25104 ENTREZGENE
PANTHER PYRUVATE CARBOXYLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PYRUVATE CARBOXYLASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Biotin_carb_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_carb_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPSase_L_D2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMGL-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PYC_OADA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pc PhenoGen
PIRSF Pyruv_carbox UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ATP_GRASP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIOTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIOTINYL_LIPOYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50979 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PYR_CT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019372 RatGTEx
SMART Biotin_carb_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Aldolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione synthetase ATP-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  post-HMGL domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51246 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217253
UniProt A0A0G2JTL5_RAT UniProtKB/TrEMBL
  A0A8I6A5A2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AH57_RAT UniProtKB/TrEMBL
  A0A8L2QDW8 ENTREZGENE, UniProtKB/TrEMBL
  A6HYX8 ENTREZGENE, UniProtKB/TrEMBL
  P52873 ENTREZGENE, UniProtKB/Swiss-Prot
  Q5RKM0 ENTREZGENE
  Q64555 ENTREZGENE
UniProt Secondary Q5RKM0 UniProtKB/Swiss-Prot
  Q64555 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-24 Pc  pyruvate carboxylase  Pcx  pyruvate carboxylase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Pcx  pyruvate carboxylase  Pc  Pyruvate carboxylase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pc  Pyruvate carboxylase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 1178 amino acids; 129.8 kDa 729499