Slpi (secretory leukocyte peptidase inhibitor) - Rat Genome Database

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Gene: Slpi (secretory leukocyte peptidase inhibitor) Rattus norvegicus
Analyze
Symbol: Slpi
Name: secretory leukocyte peptidase inhibitor
RGD ID: 621768
Description: Predicted to enable enzyme binding activity; nucleic acid binding activity; and serine-type endopeptidase inhibitor activity. Predicted to be involved in innate immune response; negative regulation of viral genome replication; and response to bacterium. Predicted to be located in Golgi apparatus. Predicted to be active in extracellular space. Biomarker of chronic obstructive pulmonary disease; endophthalmitis; middle cerebral artery infarction; myocardial infarction; and polycystic ovary syndrome. Orthologous to human SLPI (secretory leukocyte peptidase inhibitor); INTERACTS WITH 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: secretory leukocyte protease inhibitor
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Slpi-ps1   Slpi-ps2  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,501,573 - 173,503,822 (-)NCBIGRCr8
mRatBN7.23153,082,208 - 153,084,457 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,082,369 - 153,084,453 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3156,892,395 - 156,894,639 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,391,330 - 165,393,574 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,136,592 - 163,138,836 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03160,799,979 - 160,802,228 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,799,981 - 160,802,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03166,981,037 - 166,983,286 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,373,825 - 155,376,074 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13155,279,861 - 155,282,110 (-)NCBI
Celera3151,693,623 - 151,695,872 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
1,2-dichloroethane  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-diaminotoluene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-aminosalicylic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
acyclovir  (ISO)
aflatoxin B1  (ISO)
alatrofloxacin  (ISO)
albuterol  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amikacin  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
atropine  (ISO)
benzatropine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bromfenac  (ISO)
butane-2,3-dione  (ISO)
C60 fullerene  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
cefaloridine  (EXP)
chlordecone  (ISO)
cisplatin  (ISO)
clavulanic acid  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corosolic acid  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (ISO)
diclofenac  (ISO)
didanosine  (ISO)
diethylstilbestrol  (EXP,ISO)
dioxygen  (EXP,ISO)
diphenhydramine  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
entacapone  (ISO)
esmolol  (ISO)
ethambutol  (ISO)
ethanol  (ISO)
etodolac  (ISO)
fentin chloride  (EXP)
ferric oxide  (ISO)
Fexofenadine hydrochloride  (ISO)
flavonoids  (EXP)
fludrocortisone  (ISO)
flutamide  (ISO)
fluticasone  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glycerol  (ISO)
hydrogen peroxide  (ISO)
hydroxyzine  (ISO)
Iproniazid  (ISO)
irinotecan  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
isoniazide  (ISO)
isoprenaline  (ISO)
ketoconazole  (EXP,ISO)
ketorolac tromethamine  (ISO)
levofloxacin  (ISO)
lipopolysaccharide  (ISO)
loratadine  (ISO)
lumiracoxib  (ISO)
mebendazole  (ISO)
metaproterenol  (ISO)
methylmercury chloride  (EXP)
minoxidil  (ISO)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
naphthalene  (ISO)
nefazodone  (ISO)
nickel subsulfide  (EXP)
nimesulide  (ISO)
nomifensine  (ISO)
orciprenaline  (ISO)
oxaliplatin  (EXP)
oxybutynin  (ISO)
oxycodone  (EXP)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP)
paraquat  (ISO)
penbutolol  (ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
pirprofen  (ISO)
primaquine  (ISO)
primidone  (ISO)
procyclidine  (ISO)
progesterone  (ISO)
propanal  (ISO)
propane-1,2-diol  (ISO)
protriptyline  (ISO)
rofecoxib  (ISO)
rotenone  (EXP)
Salmeterol xinafoate  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
tienilic acid  (ISO)
titanium dioxide  (ISO)
tolcapone  (ISO)
tolterodine tartrate  (ISO)
tolvaptan  (ISO)
topotecan  (EXP)
trazodone  (ISO)
trichloroethene  (EXP)
Trihexyphenidyl  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
triprolidine  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tungsten  (ISO)
undecane  (EXP)
valproic acid  (ISO)
Y-27632  (ISO)
zafirlukast  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Lard-based high-fat diet increases secretory leukocyte protease inhibitor expression and attenuates the inflammatory response of acute lung injury in endotoxemic rats. Fujiwara M, etal., Clin Nutr. 2014 Nov 8. pii: S0261-5614(14)00263-5. doi: 10.1016/j.clnu.2014.11.001.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Regulatory effects of endogenous protease inhibitors in acute lung inflammatory injury. Gipson TS, etal., J Immunol. 1999 Mar 15;162(6):3653-62.
4. Delayed healing and induction of secretory leukocyte protease inhibitor in polycystic ovary syndrome rat skin wounds. Jeong SJ, etal., Int J Mol Med. 2012 Feb;29(2):185-94. doi: 10.3892/ijmm.2011.816. Epub 2011 Oct 20.
5. Rat antigen-induced arthritis: cartilage alterations assessed with iodine-123-antileukoproteinase. Kinne RW, etal., J Nucl Med. 1998 Sep;39(9):1638-45.
6. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
7. Downregulation of secretory leukocyte proteinase inhibitor in chronic obstructive lung disease: the role of TGF-beta/Smads signaling pathways. Luo BL, etal., Arch Med Res. 2008 May;39(4):388-96. doi: 10.1016/j.arcmed.2008.02.002.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Inhibition of SLPI ameliorates disease activity in experimental autoimmune encephalomyelitis. Muller AM, etal., BMC Neurosci. 2012 Mar 21;13:30. doi: 10.1186/1471-2202-13-30.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Attenuation of increased secretory leukocyte protease inhibitor, matricellular proteins and angiotensin II and left ventricular remodeling by candesartan and omapatrilat during healing after reperfused myocardial infarction. Palaniyappan A, etal., Mol Cell Biochem. 2013 Apr;376(1-2):175-88. doi: 10.1007/s11010-013-1565-2. Epub 2013 Jan 30.
12. Induction of secretory leukocyte protease inhibitor (SLPI) in estradiol valerate (EV) induced polycystic ovary. Park JJ, etal., Arch Pharm Res. 2011 Aug;34(8):1389-97. doi: 10.1007/s12272-011-0820-x. Epub 2011 Sep 11.
13. Secretory leukocyte protease inhibitor is an inducible antimicrobial peptide expressed in Staphylococcus aureus endophthalmitis. Reviglio VE, etal., Mediators Inflamm. 2007;2007:93857. doi: 10.1155/2007/93857.
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Secretory leukocyte protease inhibitor suppresses the inflammation and joint damage of bacterial cell wall-induced arthritis. Song X, etal., J Exp Med 1999 Aug 16;190(4):535-42.
18. Up-regulation of secretory leukocyte protease inhibitor (SLPI) in the brain after ischemic stroke: adenoviral expression of SLPI protects brain from ischemic injury. Wang X, etal., Mol Pharmacol. 2003 Oct;64(4):833-40.
19. Endogenous regulation of the acute inflammatory response. Ward PA and Lentsch AB, Mol Cell Biochem 2002 May-Jun;234-235(1-2):225-8.
20. Zhonghua wai ke za zhi [Chinese journal of surgery] Zhao D and Yang BX, Zhonghua Wai Ke Za Zhi. 2009 Mar 1;47(5):373-6.
Additional References at PubMed
PMID:2467900   PMID:3462719   PMID:12526812   PMID:12615907   PMID:15044260   PMID:16352738   PMID:18269849   PMID:18322212   PMID:18714013   PMID:19199708   PMID:19333378   PMID:20551380  
PMID:22041779   PMID:23376485   PMID:23516280   PMID:33370451  


Genomics

Comparative Map Data
Slpi
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,501,573 - 173,503,822 (-)NCBIGRCr8
mRatBN7.23153,082,208 - 153,084,457 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,082,369 - 153,084,453 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3156,892,395 - 156,894,639 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,391,330 - 165,393,574 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,136,592 - 163,138,836 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03160,799,979 - 160,802,228 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,799,981 - 160,802,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03166,981,037 - 166,983,286 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,373,825 - 155,376,074 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13155,279,861 - 155,282,110 (-)NCBI
Celera3151,693,623 - 151,695,872 (-)NCBICelera
Cytogenetic Map3q42NCBI
SLPI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382045,252,239 - 45,254,564 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2045,252,239 - 45,254,564 (-)EnsemblGRCh38hg38GRCh38
GRCh372043,880,880 - 43,883,205 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362043,314,293 - 43,316,620 (-)NCBINCBI36Build 36hg18NCBI36
Build 342043,314,292 - 43,316,620NCBI
Celera2040,589,481 - 40,591,808 (-)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2040,622,786 - 40,625,111 (-)NCBIHuRef
CHM1_12043,783,432 - 43,785,757 (-)NCBICHM1_1
T2T-CHM13v2.02046,988,133 - 46,990,454 (-)NCBIT2T-CHM13v2.0
Slpi
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,195,990 - 164,231,086 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2164,195,990 - 164,231,015 (-)EnsemblGRCm39 Ensembl
GRCm382164,354,070 - 164,356,507 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,354,070 - 164,389,095 (-)EnsemblGRCm38mm10GRCm38
MGSCv372164,179,806 - 164,182,243 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362164,045,511 - 164,064,154 (-)NCBIMGSCv36mm8
Celera2170,287,487 - 170,289,924 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map285.16NCBI
SLPI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22150,985,903 - 51,026,936 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12050,979,011 - 51,020,044 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02041,583,429 - 41,585,773 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12042,673,417 - 42,675,773 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2042,673,417 - 42,675,773 (-)Ensemblpanpan1.1panPan2
SLPI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12432,566,030 - 32,568,406 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2432,566,026 - 32,568,420 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2432,210,966 - 32,213,346 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02433,276,396 - 33,278,776 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2433,276,396 - 33,278,790 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12432,537,713 - 32,540,093 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02432,653,063 - 32,655,444 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02433,196,545 - 33,198,948 (-)NCBIUU_Cfam_GSD_1.0
LOC101960095
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640192,165,015 - 192,167,144 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365147,618,261 - 7,620,912 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365147,618,382 - 7,620,790 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLPI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1747,595,803 - 47,598,387 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11747,595,804 - 47,598,364 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21753,167,238 - 53,169,798 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLPI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,579,549 - 18,581,897 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl218,579,515 - 18,582,076 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605067,222,449 - 67,224,808 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slpi
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247909,235,650 - 9,239,231 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247909,235,830 - 9,238,562 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slpi
55 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:80
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000074757
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145956084157309487Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3145956084161299569Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat

Markers in Region
RH134808  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23153,011,182 - 153,011,849 (+)MAPPERmRatBN7.2
mRatBN7.23153,083,076 - 153,083,735 (+)MAPPERmRatBN7.2
Rnor_6.03160,800,848 - 160,801,506NCBIRnor6.0
Rnor_6.03160,728,752 - 160,729,418NCBIRnor6.0
Rnor_5.03166,981,906 - 166,982,564UniSTSRnor5.0
Rnor_5.03166,912,466 - 166,913,132UniSTSRnor5.0
RGSC_v3.43155,280,634 - 155,281,300UniSTSRGSC3.4
RGSC_v3.43155,374,694 - 155,375,352UniSTSRGSC3.4
Celera3151,694,492 - 151,695,150UniSTS
Celera3151,655,607 - 151,656,273UniSTS
RH 3.4 Map31421.6UniSTS
Cytogenetic Map3q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 18
Medium 21 3 59 27 51 27 9 18 53
Low 90 144 96 96 30 43 23 85 93 24
Below cutoff 24 24 24 24 112 15 28

Sequence


Ensembl Acc Id: ENSRNOT00000076191   ⟹   ENSRNOP00000068012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3153,082,369 - 153,084,225 (-)Ensembl
Rnor_6.0 Ensembl3160,799,981 - 160,802,433 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078398   ⟹   ENSRNOP00000070977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3153,082,369 - 153,084,453 (-)Ensembl
RefSeq Acc Id: NM_053372   ⟹   NP_445824
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83173,501,573 - 173,503,822 (-)NCBI
mRatBN7.23153,082,208 - 153,084,457 (-)NCBI
Rnor_6.03160,799,979 - 160,802,228 (-)NCBI
Rnor_5.03166,981,037 - 166,983,286 (-)NCBI
RGSC_v3.43155,373,825 - 155,376,074 (-)RGD
Celera3151,693,623 - 151,695,872 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445824 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD34035 (Get FASTA)   NCBI Sequence Viewer  
  AAD51758 (Get FASTA)   NCBI Sequence Viewer  
  AAN32722 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068012.2
  ENSRNOP00000070977.2
RefSeq Acc Id: NP_445824   ⟸   NM_053372
- Peptide Label: precursor
- UniProtKB: M0RCZ7 (UniProtKB/TrEMBL),   A6JX77 (UniProtKB/TrEMBL),   Q9R0Z8 (UniProtKB/TrEMBL),   Q9WUQ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068012   ⟸   ENSRNOT00000076191
Ensembl Acc Id: ENSRNOP00000070977   ⟸   ENSRNOT00000078398
Protein Domains
WAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A096MJ68-F1-model_v2 AlphaFold A0A096MJ68 1-131 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692653
Promoter ID:EPDNEW_R3177
Type:single initiation site
Name:Slpi_1
Description:secretory leukocyte peptidase inhibitor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03160,802,236 - 160,802,296EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621768 AgrOrtholog
BioCyc Gene G2FUF-46865 BioCyc
Ensembl Genes ENSRNOG00000046699 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000076191.2 UniProtKB/TrEMBL
  ENSRNOT00000078398.2 UniProtKB/TrEMBL
Gene3D-CATH 4.10.75.10 UniProtKB/TrEMBL
InterPro Elafin-like_sf UniProtKB/TrEMBL
  WAP_four-disulfide_core UniProtKB/TrEMBL
  Whey_acidic_protein_4-diS_core UniProtKB/TrEMBL
KEGG Report rno:84386 UniProtKB/TrEMBL
NCBI Gene 84386 ENTREZGENE
PANTHER ANTILEUKOPROTEINASE UniProtKB/TrEMBL
  WHEY ACDIC PROTEIN WAP UniProtKB/TrEMBL
Pfam WAP UniProtKB/TrEMBL
PhenoGen Slpi PhenoGen
PRINTS 4DISULPHCORE UniProtKB/TrEMBL
PROSITE WAP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046699 RatGTEx
SMART WAP UniProtKB/TrEMBL
Superfamily-SCOP WAP UniProtKB/TrEMBL
UniProt A0A096MJ68_RAT UniProtKB/TrEMBL
  A6JX77 ENTREZGENE, UniProtKB/TrEMBL
  M0RCZ7 ENTREZGENE, UniProtKB/TrEMBL
  Q9R0Z8 ENTREZGENE, UniProtKB/TrEMBL
  Q9WUQ4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Slpi  secretory leukocyte peptidase inhibitor    secretory leukocyte protease inhibitor  Name updated 1299863 APPROVED
2002-08-07 Slpi  secretory leukocyte protease inhibitor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA and protein levels are upregulated in inflamed joint tissues 634208