Gene: Slpi (secretory leukocyte peptidase inhibitor) Rattus norvegicus
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Symbol:
Slpi
Name:
secretory leukocyte peptidase inhibitor
RGD ID:
621768
Description:
Predicted to have enzyme binding activity; nucleic acid binding activity; and serine-type endopeptidase inhibitor activity. Involved in negative regulation of inflammatory response. Predicted to localize to Golgi apparatus and extracellular space. Biomarker of chronic obstructive pulmonary disease; endophthalmitis; middle cerebral artery infarction; myocardial infarction; and polycystic ovary syndrome. Orthologous to human SLPI (secretory leukocyte peptidase inhibitor); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
secretory leukocyte protease inhibitor
Orthologs:
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 3 160,799,979 - 160,802,228 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 3 160,799,981 - 160,802,433 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 3 166,981,037 - 166,983,286 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 3 155,373,825 - 155,376,074 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 3 155,279,861 - 155,282,110 (-) NCBI Celera 3 151,693,623 - 151,695,872 (-) NCBI Celera Cytogenetic Map 3 q42 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
type 2 diabetes mellitus ISO RGD:1350976 8554872 ClinVar Annotator: match by term: Diabetes mellitus type 2 ClinVar visual epilepsy ISO RGD:1350976 8554872 ClinVar Annotator: match by term: Seizures ClinVar PMID:32581362
Imported Annotations - CTD
Chemical and Drug Induced Liver Injury ISO RGD:1350976 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17984051 Reperfusion Injury ISO RGD:1350976 11554173 CTD Direct Evidence: therapeutic CTD PMID:8215636
(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1350976 6480464 epigallocatechin gallate inhibits the reaction [Ozone results in decreased secretion of SLPI protein] CTD PMID:22496898 (-)-epigallocatechin 3-gallate increases expression ISO RGD:1350976 6480464 epigallocatechin gallate results in increased expression of SLPI mRNA CTD PMID:22496898 1,2-dichloroethane increases expression ISO RGD:1551752 6480464 ethylene dichloride results in increased expression of SLPI mRNA CTD PMID:28960355 1-chloro-2,4-dinitrobenzene affects expression ISO RGD:1551752 6480464 Dinitrochlorobenzene affects the expression of SLPI mRNA CTD PMID:22302311 17alpha-ethynylestradiol multiple interactions ISO RGD:1551752 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLPI mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of SLPI mRNA CTD PMID:15834898 , PMID:17557909 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of SLPI mRNA CTD PMID:17010207 17beta-estradiol increases expression ISO RGD:1350976 6480464 Estradiol results in increased expression of SLPI mRNA CTD PMID:19619570 17beta-estradiol multiple interactions ISO RGD:1350976 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SLPI mRNA, [Estradiol co-treated with TGFB1 protein] results in decreased expression of SLPI mRNA CTD PMID:19619570 , PMID:30165855 17beta-estradiol decreases expression ISO RGD:1350976 6480464 Estradiol results in decreased expression of SLPI mRNA CTD PMID:23019147 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1551752 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLPI mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1551752 6480464 Tetrachlorodibenzodioxin affects the expression of SLPI mRNA CTD PMID:18343893 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SLPI mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1350976 6480464 Tetrachlorodibenzodioxin results in decreased expression of SLPI mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1350976 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SLPI mRNA CTD PMID:19619570 2,3,7,8-Tetrachlorodibenzofuran affects expression ISO RGD:1551752 6480464 2 more ... CTD PMID:18343893 2,4,6-trinitrobenzenesulfonic acid multiple interactions ISO RGD:1551752 6480464 Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SLPI mRNA] CTD PMID:18200517 2,4,6-trinitrobenzenesulfonic acid increases expression ISO RGD:1551752 6480464 Trinitrobenzenesulfonic Acid results in increased expression of SLPI mRNA CTD PMID:18200517 2,4-diaminotoluene increases expression ISO RGD:1551752 6480464 2, 4-diaminotoluene results in increased expression of SLPI mRNA CTD PMID:20713471 3,3',5,5'-tetrabromobisphenol A increases expression ISO RGD:1551752 6480464 tetrabromobisphenol A results in increased expression of SLPI mRNA CTD PMID:25172293 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1551752 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SLPI mRNA CTD PMID:16054899 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2, 6-dinitrotoluene affects the expression of SLPI mRNA CTD PMID:21346803 4-hydroxyphenyl retinamide decreases expression ISO RGD:1551752 6480464 Fenretinide results in decreased expression of SLPI mRNA CTD PMID:28973697 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of SLPI mRNA CTD PMID:24780913 acetylsalicylic acid decreases expression ISO RGD:1350976 6480464 Aspirin results in decreased expression of SLPI mRNA CTD PMID:15928584 acrylamide increases expression ISO RGD:1551752 6480464 Acrylamide results in increased expression of SLPI mRNA CTD PMID:30807115 aflatoxin B1 increases expression ISO RGD:1551752 6480464 Aflatoxin B1 results in increased expression of SLPI mRNA CTD PMID:19770486 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of SLPI mRNA CTD PMID:16483693 amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of SLPI mRNA CTD PMID:30779732 arsane decreases expression ISO RGD:1551752 6480464 Arsenic results in decreased expression of SLPI mRNA CTD PMID:19654921 arsane multiple interactions ISO RGD:1350976 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of SLPI mRNA CTD PMID:32525701 arsenic atom decreases expression ISO RGD:1551752 6480464 Arsenic results in decreased expression of SLPI mRNA CTD PMID:19654921 arsenic atom multiple interactions ISO RGD:1350976 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of SLPI mRNA CTD PMID:32525701 atrazine affects methylation EXP 6480464 Atrazine affects the methylation of SLPI gene CTD PMID:28931070 benzo[a]pyrene increases expression ISO RGD:1551752 6480464 Benzo(a)pyrene results in increased expression of SLPI mRNA CTD PMID:20127859 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SLPI mRNA CTD PMID:18180321 bisphenol A increases methylation ISO RGD:1551752 6480464 bisphenol A results in increased methylation of SLPI promoter CTD PMID:27312807 bleomycin A2 increases expression ISO RGD:1551752 6480464 Bleomycin results in increased expression of SLPI protein CTD PMID:26345256 butane-2,3-dione affects expression ISO RGD:1350976 6480464 Diacetyl affects the expression of SLPI mRNA CTD PMID:31381966 butane-2,3-dione increases secretion ISO RGD:1350976 6480464 Diacetyl results in increased secretion of SLPI protein CTD PMID:31381966 C60 fullerene increases expression ISO RGD:1551752 6480464 fullerene C60 results in increased expression of SLPI mRNA CTD PMID:20064541 calcitriol increases expression ISO RGD:1350976 6480464 Calcitriol results in increased expression of SLPI mRNA CTD PMID:26485663 carbon nanotube increases expression ISO RGD:1551752 6480464 Nanotubes, Carbon analog results in increased expression of SLPI mRNA, Nanotubes, Carbon results in increased expression of SLPI mRNA CTD PMID:25554681 carmustine affects response to substance ISO RGD:1350976 6480464 SLPI mRNA affects the susceptibility to Carmustine CTD PMID:16365179 cefaloridine increases expression EXP 6480464 Cephaloridine results in increased expression of SLPI mRNA CTD PMID:18500788 cisplatin affects response to substance ISO RGD:1350976 6480464 SLPI protein affects the susceptibility to Cisplatin CTD PMID:16217747 cisplatin decreases expression ISO RGD:1350976 6480464 Cisplatin results in decreased expression of SLPI mRNA CTD PMID:27392435 cobalt dichloride increases expression ISO RGD:1350976 6480464 cobaltous chloride results in increased expression of SLPI mRNA CTD PMID:23052192 copper atom multiple interactions ISO RGD:1350976 6480464 [NSC 689534 binds to Copper] which results in increased expression of SLPI mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:1350976 6480464 [NSC 689534 binds to Copper] which results in increased expression of SLPI mRNA CTD PMID:20971185 crocidolite asbestos increases expression ISO RGD:1551752 6480464 Asbestos, Crocidolite results in increased expression of SLPI mRNA CTD PMID:23917077 crocidolite asbestos decreases expression ISO RGD:1350976 6480464 Asbestos, Crocidolite results in decreased expression of SLPI mRNA CTD PMID:24160326 curcumin multiple interactions ISO RGD:1551752 6480464 Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SLPI mRNA] CTD PMID:18200517 cyclophosphamide decreases expression ISO RGD:1551752 6480464 Cyclophosphamide results in decreased expression of SLPI mRNA CTD PMID:15331540 cyclosporin A decreases expression ISO RGD:1350976 6480464 Cyclosporine results in decreased expression of SLPI mRNA CTD PMID:20106945 , PMID:27989131 dexamethasone multiple interactions ISO RGD:1551752 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SLPI mRNA CTD PMID:16054899 dichlorine increases expression ISO RGD:1551752 6480464 Chlorine results in increased expression of SLPI mRNA CTD PMID:30189237 diethylstilbestrol increases expression ISO RGD:1551752 6480464 Diethylstilbestrol results in increased expression of SLPI mRNA CTD PMID:15171707 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of SLPI mRNA CTD PMID:17010207 dioxygen multiple interactions ISO RGD:1551752 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of SLPI mRNA CTD PMID:30529165 diuron increases expression EXP 6480464 Diuron metabolite results in increased expression of SLPI mRNA CTD PMID:24172598 doxorubicin decreases expression ISO RGD:1350976 6480464 Doxorubicin results in decreased expression of SLPI mRNA CTD PMID:29803840 ethanol multiple interactions ISO RGD:1551752 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of SLPI mRNA CTD PMID:30517762 ferric oxide multiple interactions ISO RGD:1551752 6480464 [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of SLPI mRNA CTD PMID:20540983 flavonoids increases expression EXP 6480464 Flavonoids results in increased expression of SLPI mRNA CTD PMID:18035473 fluticasone multiple interactions ISO RGD:1350976 6480464 [Fluticasone co-treated with Salmeterol Xinafoate] results in increased expression of SLPI mRNA, Salmeterol Xinafoate promotes the reaction [Fluticasone results in increased expression of SLPI mRNA] CTD PMID:15860753 , PMID:15862954 fluticasone increases expression ISO RGD:1350976 6480464 Fluticasone results in increased expression of SLPI mRNA CTD PMID:15860753 fulvestrant multiple interactions ISO RGD:1551752 6480464 fulvestrant inhibits the reaction [Genistein results in increased expression of SLPI mRNA] CTD PMID:22553218 furan increases expression EXP 6480464 furan results in increased expression of SLPI mRNA CTD PMID:27387713 genistein multiple interactions ISO RGD:1551752 6480464 fulvestrant inhibits the reaction [Genistein results in increased expression of SLPI mRNA] CTD PMID:22553218 genistein increases expression ISO RGD:1551752 6480464 Genistein results in increased expression of SLPI mRNA CTD PMID:21810550 more ... gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of SLPI mRNA CTD PMID:22061828 hydrogen peroxide increases expression ISO RGD:1551752 6480464 Hydrogen Peroxide results in increased expression of SLPI mRNA CTD PMID:14729362 , PMID:15003993 hydrogen peroxide affects expression ISO RGD:1350976 6480464 Hydrogen Peroxide affects the expression of SLPI mRNA CTD PMID:20044591 irinotecan affects expression EXP 6480464 Irinotecan affects the expression of SLPI mRNA CTD PMID:20097248 iron atom decreases expression ISO RGD:1350976 6480464 Iron deficiency results in decreased expression of SLPI mRNA CTD PMID:20368581 iron(0) decreases expression ISO RGD:1350976 6480464 Iron deficiency results in decreased expression of SLPI mRNA CTD PMID:20368581 lipopolysaccharide multiple interactions ISO RGD:1551752 6480464 (+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of SLPI mRNA] CTD PMID:25890327 lipopolysaccharide increases expression ISO RGD:1551752 6480464 Lipopolysaccharides results in increased expression of SLPI mRNA CTD PMID:25890327 , PMID:27339419 methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of SLPI mRNA CTD PMID:31378766 monosodium L-glutamate increases expression ISO RGD:1551752 6480464 Sodium Glutamate results in increased expression of SLPI mRNA CTD PMID:22078008 N-methyl-4-phenylpyridinium decreases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of SLPI mRNA CTD PMID:28801915 N-nitrosodiethylamine multiple interactions ISO RGD:1551752 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of SLPI mRNA CTD PMID:24535843 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of SLPI mRNA CTD PMID:28943392 N-nitrosodiethylamine increases expression ISO RGD:1551752 6480464 Diethylnitrosamine results in increased expression of SLPI mRNA CTD PMID:24535843 naphthalene increases expression ISO RGD:1551752 6480464 naphthalene results in increased expression of SLPI mRNA CTD PMID:18978301 nickel subsulfide decreases expression EXP 6480464 nickel subsulfide results in decreased expression of SLPI mRNA CTD PMID:21086188 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of SLPI mRNA CTD PMID:25729387 oxaliplatin increases expression EXP 6480464 oxaliplatin results in increased expression of SLPI mRNA CTD PMID:25729387 oxycodone decreases expression EXP 6480464 Oxycodone results in decreased expression of SLPI mRNA CTD PMID:23439660 ozone decreases secretion ISO RGD:1350976 6480464 Ozone results in decreased secretion of SLPI protein CTD PMID:22496898 ozone multiple interactions ISO RGD:1350976 6480464 epigallocatechin gallate inhibits the reaction [Ozone results in decreased secretion of SLPI protein] CTD PMID:22496898 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of SLPI mRNA CTD PMID:17984051 paraquat increases expression ISO RGD:1551752 6480464 Paraquat results in increased expression of SLPI protein CTD PMID:26345256 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of SLPI mRNA CTD PMID:16221955 phenobarbital multiple interactions ISO RGD:1551752 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of SLPI mRNA, NR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLPI mRNA] CTD PMID:19482888 , PMID:24535843 phenobarbital increases expression ISO RGD:1551752 6480464 Phenobarbital results in increased expression of SLPI mRNA CTD PMID:19482888 PhIP decreases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in decreased expression of SLPI mRNA CTD PMID:15215175 pirinixic acid decreases expression ISO RGD:1551752 6480464 pirinixic acid results in decreased expression of SLPI mRNA CTD PMID:17426115 pirinixic acid increases expression ISO RGD:1551752 6480464 pirinixic acid results in increased expression of SLPI mRNA CTD PMID:20813756 pirinixic acid multiple interactions ISO RGD:1551752 6480464 [pirinixic acid co-treated with PPARA] results in increased expression of SLPI mRNA CTD PMID:20813756 progesterone affects expression ISO RGD:1551752 6480464 Progesterone affects the expression of SLPI mRNA CTD PMID:17251523 propanal decreases expression ISO RGD:1350976 6480464 propionaldehyde results in decreased expression of SLPI mRNA CTD PMID:26079696 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of SLPI mRNA CTD PMID:28374803 Salmeterol xinafoate multiple interactions ISO RGD:1350976 6480464 [Fluticasone co-treated with Salmeterol Xinafoate] results in increased expression of SLPI mRNA, Salmeterol Xinafoate promotes the reaction [Fluticasone results in increased expression of SLPI mRNA] CTD PMID:15860753 , PMID:15862954 serpentine asbestos decreases expression ISO RGD:1350976 6480464 Asbestos, Serpentine results in decreased expression of SLPI mRNA CTD PMID:24160326 serpentine asbestos increases expression ISO RGD:1350976 6480464 Asbestos, Serpentine results in increased expression of SLPI mRNA CTD PMID:24160326 silicon dioxide decreases expression ISO RGD:1350976 6480464 Silicon Dioxide analog results in decreased expression of SLPI mRNA CTD PMID:25895662 silicon dioxide increases expression ISO RGD:1551752 6480464 Silicon Dioxide results in increased expression of SLPI mRNA, Silicon Dioxide results in increased expression of SLPI protein CTD PMID:26345256 silicon dioxide increases expression ISO RGD:1350976 6480464 Silicon Dioxide analog results in increased expression of SLPI mRNA CTD PMID:23806026 sodium arsenate multiple interactions ISO RGD:1350976 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of SLPI mRNA CTD PMID:32525701 succimer multiple interactions ISO RGD:1551752 6480464 [Succimer binds to Magnetite Nanoparticles] which results in increased expression of SLPI mRNA CTD PMID:21641980 temozolomide affects response to substance ISO RGD:1350976 6480464 SLPI mRNA affects the susceptibility to temozolomide CTD PMID:16365179 tert-butyl hydroperoxide decreases response to substance ISO RGD:1551752 6480464 SLPI protein results in decreased susceptibility to tert-Butylhydroperoxide CTD PMID:15003993 tert-butyl hydroperoxide increases expression ISO RGD:1551752 6480464 tert-Butylhydroperoxide results in increased expression of SLPI mRNA CTD PMID:14729362 more ... tetrachloromethane increases expression ISO RGD:1551752 6480464 Carbon Tetrachloride results in increased expression of SLPI mRNA CTD PMID:27339419 , PMID:31919559 tetrachloromethane multiple interactions ISO RGD:1551752 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of SLPI mRNA CTD PMID:30517762 thioacetamide multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of SLPI mRNA CTD PMID:28943392 titanium dioxide increases expression ISO RGD:1551752 6480464 titanium dioxide results in increased expression of SLPI mRNA CTD PMID:19464567 , PMID:23557971 Tolvaptan increases expression ISO RGD:1551752 6480464 tolvaptan results in increased expression of SLPI mRNA, tolvaptan results in increased expression of SLPI protein CTD PMID:28115652 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of SLPI mRNA CTD PMID:25729387 topotecan increases expression EXP 6480464 Topotecan results in increased expression of SLPI mRNA CTD PMID:25729387 trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of SLPI mRNA CTD PMID:17905399 trimellitic anhydride affects expression ISO RGD:1551752 6480464 trimellitic anhydride affects the expression of SLPI mRNA CTD PMID:22302311 triphenyl phosphate decreases expression EXP 6480464 triphenyl phosphate results in decreased expression of SLPI mRNA CTD PMID:30589522 tungsten decreases expression ISO RGD:1551752 6480464 Tungsten results in decreased expression of SLPI mRNA CTD PMID:30912803 undecane decreases expression EXP 6480464 undecane results in decreased expression of SLPI protein CTD PMID:17337753 valproic acid decreases methylation ISO RGD:1350976 6480464 Valproic Acid results in decreased methylation of SLPI gene CTD PMID:29154799 zoledronic acid increases expression ISO RGD:1350976 6480464 zoledronic acid results in increased expression of SLPI mRNA, zoledronic acid results in increased expression of SLPI protein CTD PMID:24714768 , PMID:28871336
Gene-Chemical Interaction Annotations
