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Gene: Amacr (alpha-methylacyl-CoA racemase) Rattus norvegicus
Symbol: Amacr
Name: alpha-methylacyl-CoA racemase
RGD ID: 3048
Description: Exhibits alpha-methylacyl-CoA racemase activity. Involved in bile acid biosynthetic process. Localizes to mitochondrion and peroxisome. Human ortholog(s) of this gene implicated in alpha-methylacyl-CoA racemase deficiency; congenital bile acid synthesis defect 4; and urinary bladder cancer. Orthologous to human AMACR (alpha-methylacyl-CoA racemase); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2-arylpropionyl-CoA epimerase; 2-methylacyl-CoA racemase; Da1-8; Marc1; methylacyl-CoA racemase alpha
Homo sapiens (human) : AMACR (alpha-methylacyl-CoA racemase)  HGNC  Alliance
Mus musculus (house mouse) : Amacr (alpha-methylacyl-CoA racemase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Amacr (alpha-methylacyl-CoA racemase)
Pan paniscus (bonobo/pygmy chimpanzee) : AMACR (alpha-methylacyl-CoA racemase)
Canis lupus familiaris (dog) : AMACR (alpha-methylacyl-CoA racemase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Amacr (alpha-methylacyl-CoA racemase)
Sus scrofa (pig) : AMACR (alpha-methylacyl-CoA racemase)
Chlorocebus sabaeus (African green monkey) : AMACR (alpha-methylacyl-CoA racemase)
Heterocephalus glaber (naked mole-rat) : Amacr (alpha-methylacyl-CoA racemase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0260,949,276 - 60,961,342 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl260,949,256 - 60,961,326 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0283,723,119 - 83,735,166 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4260,332,292 - 60,344,326 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1260,260,524 - 60,272,557 (+)NCBI
Celera258,726,090 - 58,738,137 (-)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Amacr
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3048
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.