Cpped1 (calcineurin-like phosphoesterase domain containing 1) - Rat Genome Database

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Gene: Cpped1 (calcineurin-like phosphoesterase domain containing 1) Rattus norvegicus
Analyze
Symbol: Cpped1
Name: calcineurin-like phosphoesterase domain containing 1
RGD ID: 1306568
Description: Predicted to enable metal ion binding activity and myosin phosphatase activity. Predicted to be located in cytosol and plasma membrane. Orthologous to human CPPED1 (calcineurin like phosphoesterase domain containing 1); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcineurin-like phosphoesterase domain-containing protein 1; LOC302890; RGD1306568; serine/threonine-protein phosphatase CPPED1; similar to C530044N13Rik protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8104,135,601 - 4,328,039 (+)NCBIGRCr8
mRatBN7.2103,701,522 - 3,821,050 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl103,701,459 - 3,821,054 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx108,398,219 - 8,517,727 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01032,048,018 - 32,167,528 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0103,560,671 - 3,680,174 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0103,655,038 - 3,774,887 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl103,655,038 - 3,774,884 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0102,523,592 - 2,643,427 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4103,577,406 - 3,698,276 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1103,577,405 - 3,698,275 (+)NCBI
Celera102,736,337 - 2,853,536 (+)NCBICelera
Cytogenetic Map10q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:23376485  


Genomics

Comparative Map Data
Cpped1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8104,135,601 - 4,328,039 (+)NCBIGRCr8
mRatBN7.2103,701,522 - 3,821,050 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl103,701,459 - 3,821,054 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx108,398,219 - 8,517,727 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01032,048,018 - 32,167,528 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0103,560,671 - 3,680,174 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0103,655,038 - 3,774,887 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl103,655,038 - 3,774,884 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0102,523,592 - 2,643,427 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4103,577,406 - 3,698,276 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1103,577,405 - 3,698,275 (+)NCBI
Celera102,736,337 - 2,853,536 (+)NCBICelera
Cytogenetic Map10q11NCBI
CPPED1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381612,659,799 - 12,803,887 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1612,659,799 - 12,803,887 (-)EnsemblGRCh38hg38GRCh38
GRCh371612,753,656 - 12,897,744 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361612,661,157 - 12,805,245 (-)NCBINCBI36Build 36hg18NCBI36
Celera1612,928,685 - 13,072,599 (-)NCBICelera
Cytogenetic Map16p13.12NCBI
HuRef1612,670,499 - 12,814,452 (-)NCBIHuRef
CHM1_11612,753,540 - 12,897,609 (-)NCBICHM1_1
T2T-CHM13v2.01612,696,825 - 12,840,919 (-)NCBIT2T-CHM13v2.0
Cpped1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391611,621,546 - 11,727,377 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1611,621,585 - 11,727,309 (-)EnsemblGRCm39 Ensembl
GRCm381611,803,684 - 11,909,476 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1611,803,721 - 11,909,445 (-)EnsemblGRCm38mm10GRCm38
MGSCv371611,803,814 - 11,909,516 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361611,717,299 - 11,823,001 (-)NCBIMGSCv36mm8
Celera1612,434,528 - 12,536,877 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map166.61NCBI
Cpped1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554425,897,991 - 6,023,481 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554425,898,055 - 6,023,384 (+)NCBIChiLan1.0ChiLan1.0
CPPED1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21813,201,489 - 13,342,715 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11616,969,098 - 17,113,542 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01611,589,885 - 11,734,701 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11613,016,807 - 13,160,927 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1613,017,311 - 13,160,927 (-)Ensemblpanpan1.1panPan2
CPPED1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1630,150,113 - 30,249,198 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl630,150,166 - 30,247,933 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha631,520,448 - 31,620,164 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0630,322,950 - 30,422,826 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl630,322,962 - 30,422,826 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1630,137,474 - 30,237,488 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0630,012,464 - 30,112,417 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0630,435,037 - 30,535,112 (+)NCBIUU_Cfam_GSD_1.0
Cpped1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344113,241,573 - 113,338,446 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365011,339,098 - 1,436,328 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365011,339,433 - 1,436,280 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPPED1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl330,362,646 - 30,489,143 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1330,362,725 - 30,484,250 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2329,432,771 - 29,554,486 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CPPED1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1512,113,336 - 12,248,964 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl512,110,126 - 12,248,943 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606817,863,212 - 18,001,901 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cpped1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247825,572,182 - 5,701,664 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247825,572,236 - 5,704,482 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cpped1
748 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:127
Count of miRNA genes:103
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000045047
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1549898Neuinf3Neuroinflammation QTL 326.4nervous system integrity trait (VT:0010566)MHC Class II RT1A-positive spinal cord ventral horn area to total spinal cord ventral horn area ratio (CMO:0001980)1034063205387112Rat

Markers in Region
D10Cebr1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2103,774,780 - 3,774,954 (+)MAPPERmRatBN7.2
Rnor_6.0103,728,612 - 3,728,785NCBIRnor6.0
Rnor_5.0102,597,152 - 2,597,325UniSTSRnor5.0
RGSC_v3.4103,652,003 - 3,652,176UniSTSRGSC3.4
Celera102,809,205 - 2,809,378UniSTS
Cytogenetic Map10q11UniSTS
RH133395  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2103,820,811 - 3,821,029 (+)MAPPERmRatBN7.2
Rnor_6.0103,774,649 - 3,774,866NCBIRnor6.0
Rnor_5.0102,643,189 - 2,643,406UniSTSRnor5.0
RGSC_v3.4103,698,038 - 3,698,255UniSTSRGSC3.4
Celera102,853,298 - 2,853,515UniSTS
RH 3.4 Map1046.0UniSTS
Cytogenetic Map10q11UniSTS
RH142467  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2103,782,147 - 3,782,300 (+)MAPPERmRatBN7.2
Rnor_6.0103,735,979 - 3,736,131NCBIRnor6.0
Rnor_5.0102,604,519 - 2,604,671UniSTSRnor5.0
RGSC_v3.4103,659,370 - 3,659,522UniSTSRGSC3.4
Celera102,816,572 - 2,816,724UniSTS
Cytogenetic Map10q11UniSTS
RH144561  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2103,820,577 - 3,820,733 (+)MAPPERmRatBN7.2
Rnor_6.0103,774,415 - 3,774,570NCBIRnor6.0
Rnor_5.0102,642,955 - 2,643,110UniSTSRnor5.0
RGSC_v3.4103,697,804 - 3,697,959UniSTSRGSC3.4
Celera102,853,064 - 2,853,219UniSTS
Cytogenetic Map10q11UniSTS
BE107796  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2103,728,202 - 3,728,363 (+)MAPPERmRatBN7.2
Rnor_6.0103,681,720 - 3,681,880NCBIRnor6.0
Rnor_5.0102,550,274 - 2,550,434UniSTSRnor5.0
RGSC_v3.4103,604,089 - 3,604,249UniSTSRGSC3.4
Celera102,762,664 - 2,762,824UniSTS
RH 3.4 Map1046.5UniSTS
Cytogenetic Map10q11UniSTS
RH141784  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2103,819,985 - 3,820,166 (+)MAPPERmRatBN7.2
Rnor_6.0103,773,823 - 3,774,003NCBIRnor6.0
Rnor_5.0102,642,363 - 2,642,543UniSTSRnor5.0
RGSC_v3.4103,697,212 - 3,697,392UniSTSRGSC3.4
Celera102,852,472 - 2,852,652UniSTS
Cytogenetic Map10q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 30 41 41 2 41 2 7 35 28 3
Low 13 16 17 8 9 67 13 8 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000045047   ⟹   ENSRNOP00000051045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl103,701,459 - 3,821,054 (+)Ensembl
Rnor_6.0 Ensembl103,655,038 - 3,774,884 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113221   ⟹   ENSRNOP00000080567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl103,701,459 - 3,724,076 (+)Ensembl
RefSeq Acc Id: NM_001013963   ⟹   NP_001013985
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8104,208,511 - 4,328,039 (+)NCBI
mRatBN7.2103,701,522 - 3,821,050 (+)NCBI
Rnor_6.0103,655,038 - 3,774,887 (+)NCBI
Rnor_5.0102,523,592 - 2,643,427 (+)NCBI
RGSC_v3.4103,577,406 - 3,698,276 (+)RGD
Celera102,736,337 - 2,853,536 (+)RGD
Sequence:
RefSeq Acc Id: XM_063268855   ⟹   XP_063124925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8104,135,601 - 4,328,039 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001013985 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124925 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH81991 (Get FASTA)   NCBI Sequence Viewer  
  EDL96189 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051045
  ENSRNOP00000051045.3
  ENSRNOP00000080567.1
GenBank Protein Q66H71 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001013985   ⟸   NM_001013963
- UniProtKB: Q66H71 (UniProtKB/Swiss-Prot),   A6K4G7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000051045   ⟸   ENSRNOT00000045047
RefSeq Acc Id: ENSRNOP00000080567   ⟸   ENSRNOT00000113221
RefSeq Acc Id: XP_063124925   ⟸   XM_063268855
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66H71-F1-model_v2 AlphaFold Q66H71 1-312 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696932
Promoter ID:EPDNEW_R7457
Type:initiation region
Name:Cpped1_1
Description:calcineurin-like phosphoesterase domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0103,655,007 - 3,655,067EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306568 AgrOrtholog
BioCyc Gene G2FUF-26179 BioCyc
Ensembl Genes ENSRNOG00000015118 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045047 ENTREZGENE
  ENSRNOT00000045047.4 UniProtKB/Swiss-Prot
  ENSRNOT00000113221.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.21.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7129542 IMAGE-MGC_LOAD
InterPro Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MPP_CSTP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:302890 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94195 IMAGE-MGC_LOAD
NCBI Gene 302890 ENTREZGENE
PANTHER METALLOPHOSPHOESTERASE, CALCINEURIN SUPERFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN PHOSPHATASE CPPED1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Metallophos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cpped1 PhenoGen
RatGTEx ENSRNOG00000015118 RatGTEx
Superfamily-SCOP SSF56300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZR02_RAT UniProtKB/TrEMBL
  A6K4G7 ENTREZGENE, UniProtKB/TrEMBL
  CPPED_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-06-12 Cpped1  calcineurin-like phosphoesterase domain containing 1  RGD1306568  similar to C530044N13Rik protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1306568  similar to C530044N13Rik protein  RGD1306568_predicted  similar to C530044N13Rik protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1306568_predicted  similar to C530044N13Rik protein (predicted)  LOC302890_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC302890_predicted  similar to C530044N13Rik protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL