Eda2r (ectodysplasin A2 receptor) - Rat Genome Database

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Gene: Eda2r (ectodysplasin A2 receptor) Rattus norvegicus
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Symbol: Eda2r
Name: ectodysplasin A2 receptor
RGD ID: 1564025
Description: Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in cytokine-mediated signaling pathway; positive regulation of JNK cascade; and positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator. Predicted to be active in plasma membrane. Orthologous to human EDA2R (ectodysplasin A2 receptor); PARTICIPATES IN cytokine mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ectodysplasin A2 isoform receptor; LOC296872; RGD1564025; similar to Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor); similar to Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor); tumor necrosis factor receptor superfamily member 27
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X66,225,557 - 66,280,674 (-)NCBIGRCr8
mRatBN7.2X62,224,763 - 62,269,333 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX62,228,229 - 62,269,268 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX63,691,820 - 63,736,363 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X67,192,369 - 67,236,902 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X64,755,977 - 64,800,507 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X66,560,200 - 66,602,509 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX66,561,286 - 66,602,506 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X67,389,639 - 67,430,026 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X85,010,195 - 85,049,670 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX62,627,786 - 62,667,518 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11039935   PMID:12270937   PMID:20434500  


Genomics

Comparative Map Data
Eda2r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X66,225,557 - 66,280,674 (-)NCBIGRCr8
mRatBN7.2X62,224,763 - 62,269,333 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX62,228,229 - 62,269,268 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX63,691,820 - 63,736,363 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X67,192,369 - 67,236,902 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X64,755,977 - 64,800,507 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X66,560,200 - 66,602,509 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX66,561,286 - 66,602,506 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X67,389,639 - 67,430,026 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X85,010,195 - 85,049,670 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX62,627,786 - 62,667,518 (-)NCBICelera
Cytogenetic MapXq22NCBI
EDA2R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X66,595,637 - 66,639,269 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX66,595,637 - 66,639,298 (-)EnsemblGRCh38hg38GRCh38
GRCh37X65,815,479 - 65,859,111 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X65,732,204 - 65,752,598 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X65,598,503 - 65,618,894NCBI
CeleraX66,163,047 - 66,183,441 (-)NCBICelera
Cytogenetic MapXq12NCBI
HuRefX59,642,932 - 59,686,455 (-)NCBIHuRef
CHM1_1X65,708,158 - 65,751,820 (-)NCBICHM1_1
T2T-CHM13v2.0X65,023,365 - 65,067,011 (-)NCBIT2T-CHM13v2.0
Eda2r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X96,375,936 - 96,420,786 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX96,377,446 - 96,420,822 (-)EnsemblGRCm39 Ensembl
GRCm38X97,333,837 - 97,377,234 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX97,333,840 - 97,377,216 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X94,529,180 - 94,572,548 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X93,538,638 - 93,579,891 (-)NCBIMGSCv36mm8
CeleraX84,324,759 - 84,367,800 (-)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX42.74NCBI
Eda2r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554756,087,687 - 6,143,432 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554756,080,153 - 6,143,339 (-)NCBIChiLan1.0ChiLan1.0
EDA2R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X66,194,757 - 66,239,254 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X66,198,397 - 66,242,834 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X55,786,361 - 55,830,798 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X65,851,559 - 65,894,775 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX65,850,306 - 65,894,975 (-)Ensemblpanpan1.1panPan2
Eda2r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X50,538,211 - 50,572,294 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366351,303,858 - 1,337,868 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366351,303,855 - 1,335,766 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDA2R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X52,522,231 - 52,533,080 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
EDA2R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X56,527,838 - 56,574,646 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX56,531,860 - 56,574,448 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660833,894,520 - 3,942,652 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eda2r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624898657,924 - 676,365 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624898643,941 - 679,421 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eda2r
145 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:35
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000017429
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
70221Bp56Blood pressure QTL 564.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X5704214165612192Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat

Markers in Region
EDA2R  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X62,236,334 - 62,237,008 (+)MAPPERmRatBN7.2
Rnor_6.0X66,567,152 - 66,567,825NCBIRnor6.0
Rnor_5.0X67,396,583 - 67,397,256UniSTSRnor5.0
RGSC_v3.4X85,015,294 - 85,015,967UniSTSRGSC3.4
CeleraX62,634,738 - 62,635,411UniSTS
Cytogenetic MapXq31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 11 49 113 75 74 43 25 43 6 197 97 93 42 58 31

Sequence


Ensembl Acc Id: ENSRNOT00000017429   ⟹   ENSRNOP00000017429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX62,228,229 - 62,269,268 (-)Ensembl
Rnor_6.0 EnsemblX66,562,044 - 66,602,506 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076510   ⟹   ENSRNOP00000068211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX66,561,286 - 66,602,458 (-)Ensembl
RefSeq Acc Id: NM_001401114   ⟹   NP_001388043
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X66,236,111 - 66,280,620 (-)NCBI
mRatBN7.2X62,224,775 - 62,269,282 (-)NCBI
RefSeq Acc Id: XM_039100197   ⟹   XP_038956125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X66,236,099 - 66,280,673 (-)NCBI
mRatBN7.2X62,224,763 - 62,269,322 (-)NCBI
RefSeq Acc Id: XM_063279875   ⟹   XP_063135945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X66,225,557 - 66,280,674 (-)NCBI
RefSeq Acc Id: XM_063279876   ⟹   XP_063135946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X66,236,099 - 66,280,671 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001388043 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956125 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135945 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135946 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL95959 (Get FASTA)   NCBI Sequence Viewer  
  EDL95960 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017429.6
Ensembl Acc Id: ENSRNOP00000017429   ⟸   ENSRNOT00000017429
Ensembl Acc Id: ENSRNOP00000068211   ⟸   ENSRNOT00000076510
RefSeq Acc Id: XP_038956125   ⟸   XM_039100197
- Peptide Label: isoform X1
- UniProtKB: A0A096MJP5 (UniProtKB/TrEMBL),   A6IQ53 (UniProtKB/TrEMBL),   D3ZAX4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388043   ⟸   NM_001401114
- UniProtKB: D3ZAX4 (UniProtKB/TrEMBL),   A0A096MJP5 (UniProtKB/TrEMBL),   A6IQ53 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135945   ⟸   XM_063279875
- Peptide Label: isoform X1
- UniProtKB: A0A096MJP5 (UniProtKB/TrEMBL),   A6IQ53 (UniProtKB/TrEMBL),   D3ZAX4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135946   ⟸   XM_063279876
- Peptide Label: isoform X2
- UniProtKB: A0A096MJP5 (UniProtKB/TrEMBL),   A6IQ53 (UniProtKB/TrEMBL),   D3ZAX4 (UniProtKB/TrEMBL)
Protein Domains
TNFR-Cys

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A096MJP5-F1-model_v2 AlphaFold A0A096MJP5 1-298 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701857
Promoter ID:EPDNEW_R12377
Type:multiple initiation site
Name:Eda2r_1
Description:ectodysplasin A2 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X66,602,455 - 66,602,515EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564025 AgrOrtholog
BioCyc Gene G2FUF-2172 BioCyc
Ensembl Genes ENSRNOG00000013018 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017429.8 UniProtKB/TrEMBL
Gene3D-CATH Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/TrEMBL
InterPro TNFR_27 UniProtKB/TrEMBL
  TNFR_Cys_rich_reg UniProtKB/TrEMBL
  TNFRSF27_N UniProtKB/TrEMBL
  TNR19/27/EDAR UniProtKB/TrEMBL
NCBI Gene 296872 ENTREZGENE
PANTHER PTHR12120:SF8 UniProtKB/TrEMBL
  TNFR-CYS DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam TNFR_c6 UniProtKB/TrEMBL
PhenoGen Eda2r PhenoGen
PRINTS TNFACTORR27 UniProtKB/TrEMBL
PROSITE TNFR_NGFR_1 UniProtKB/TrEMBL
  TNFR_NGFR_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013018 RatGTEx
SMART TNFR UniProtKB/TrEMBL
Superfamily-SCOP TNF receptor-like UniProtKB/TrEMBL
UniProt A0A096MJP5 ENTREZGENE, UniProtKB/TrEMBL
  A6IQ53 ENTREZGENE, UniProtKB/TrEMBL
  D3ZAX4 ENTREZGENE
UniProt Secondary D3ZAX4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-17 Eda2r  ectodysplasin A2 receptor  Eda2r  ectodysplasin A2 isoform receptor   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Eda2r  ectodysplasin A2 isoform receptor   Eda2r_predicted  ectodysplasin A2 isoform receptor (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Eda2r_predicted  ectodysplasin A2 isoform receptor (predicted)  RGD1564025_predicted  similar to Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-10 RGD1564025_predicted  similar to Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (predicted)    similar to Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor) (predicted)  Name updated 1299863 APPROVED
2006-03-07 RGD1564025_predicted  similar to Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor) (predicted)  LOC296872  similar to Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC296872  similar to Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor)      Symbol and Name status set to provisional 70820 PROVISIONAL