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Gene: Phlda3 (pleckstrin homology-like domain, family A, member 3) Rattus norvegicus

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Symbol:

Phlda3

Name:

pleckstrin homology-like domain, family A, member 3

RGD ID:

1310502

Description:

Predicted to enable phosphatidylinositol phosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of apoptotic process. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human PHLDA3 (pleckstrin homology like domain family A member 3); INTERACTS WITH 1,2-dimethylhydrazine; 1-nitropropane; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC363989; pleckstrin homology-like domain family A member 3; TDAG51/Ipl homolog 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	49,745,003 - 49,748,088 (+)	NCBI		GRCr8
mRatBN7.2	13	47,193,250 - 47,196,335 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	47,193,086 - 47,196,335 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	49,802,074 - 49,805,158 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	51,090,139 - 51,093,225 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	48,353,354 - 48,356,441 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	52,588,917 - 52,592,002 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	52,588,917 - 52,592,001 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	57,637,217 - 57,640,302 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	48,789,678 - 48,793,999 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	48,803,734 - 48,808,041 (+)	NCBI
Celera	13	47,510,714 - 47,513,799 (+)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

familial adult myoclonic epilepsy 5 (ISO)

gastrointestinal stromal tumor (ISO)

Hypokalemic Periodic Paralysis, Type 1 (ISO)

myocardial infarction (ISO)

Myocardial Reperfusion Injury (ISO)

parathyroid carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

(S)-colchicine (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (EXP,ISO)

1,4-dioxane (ISO)

1-nitropropane (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-diaminotoluene (EXP)

2,4-dinitrotoluene (EXP)

2,6-diaminotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-acetamidofluorene (EXP,ISO)

2-hydroxypropanoic acid (ISO)

2-nitro-p-phenylenediamine (EXP)

2-nitrofluorene (EXP)

2-nitropropane (EXP)

4,4'-sulfonyldiphenol (ISO)

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one (EXP)

4-acetylaminofluorene (EXP)

4-nitro-1,2-phenylenediamine (EXP)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

7,12-dimethyltetraphene (ISO)

acetamide (EXP)

adefovir pivoxil (ISO)

adenine (ISO)

aflatoxin B1 (EXP,ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

beta-lapachone (ISO)

beta-naphthoflavone (EXP)

bis(2-chloroethyl) sulfide (EXP,ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

butan-1-ol (ISO)

cadmium dichloride (ISO)

cadmium sulfate (ISO)

caffeine (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chloroacetaldehyde (ISO)

choline (ISO)

chromium(6+) (ISO)

chrysene (ISO)

cidofovir anhydrous (ISO)

cisplatin (ISO)

cobalt atom (ISO)

cobalt dichloride (ISO)

cocaine (EXP)

copper(II) chloride (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

deoxynivalenol (ISO)

dexamethasone (EXP)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

diclofenac (ISO)

dioxygen (EXP,ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethyl methanesulfonate (ISO)

etoposide (ISO)

fenamidone (ISO)

fenofibrate (EXP)

folic acid (ISO)

formaldehyde (ISO)

furan (ISO)

Heptachlor epoxide (ISO)

hydroxyurea (ISO)

ifosfamide (ISO)

indoline (EXP)

inulin (ISO)

iron dichloride (ISO)

iron(III) nitrilotriacetate (EXP)

isoprenaline (ISO)

L-methionine (ISO)

lead(0) (ISO)

leflunomide (EXP,ISO)

linezolid (EXP)

lipopolysaccharide (ISO)

manganese(II) chloride (EXP)

metformin (EXP,ISO)

methapyrilene (EXP)

methyl methanesulfonate (ISO)

mitomycin C (ISO)

MK-2206 (EXP)

N-methyl-4-phenylpyridinium (EXP,ISO)

N-methyl-N-nitrosourea (ISO)

N-nitrosodiethylamine (EXP,ISO)

N-Nitrosopyrrolidine (ISO)

ochratoxin A (EXP)

orphenadrine (EXP)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pinostrobin (ISO)

pirinixic acid (ISO)

propanal (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

Soman (EXP)

tamoxifen (ISO)

temozolomide (ISO)

testosterone (EXP,ISO)

tetrachloromethane (EXP,ISO)

tetraphene (ISO)

thiazoles (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP)

triphenyl phosphate (EXP)

Triptolide (ISO)

trovafloxacin (ISO)

Tungsten carbide (ISO)

tunicamycin (ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vinclozolin (EXP)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (IBA,ISO,ISS)

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IBA,ISO,ISS)

positive regulation of apoptotic process (IBA,ISO,ISS)

Cellular Component

cytoplasm (IEA)

plasma membrane (IBA,ISO,ISS)

Molecular Function

phosphatidylinositol-3,4,5-trisphosphate binding (ISO,ISS)

phosphatidylinositol-3,4-bisphosphate binding (ISO,ISS)

phosphatidylinositol-3,5-bisphosphate binding (ISO,ISS)

phosphatidylinositol-3-phosphate binding (ISO,ISS)

phosphatidylinositol-4,5-bisphosphate binding (ISO,ISS)

phosphatidylinositol-5-phosphate binding (ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:19203586	PMID:23376485	PMID:31426686	PMID:34351043

Genomics

Comparative Map Data

Phlda3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	49,745,003 - 49,748,088 (+)	NCBI		GRCr8
mRatBN7.2	13	47,193,250 - 47,196,335 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	47,193,086 - 47,196,335 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	49,802,074 - 49,805,158 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	51,090,139 - 51,093,225 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	48,353,354 - 48,356,441 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	52,588,917 - 52,592,002 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	52,588,917 - 52,592,001 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	57,637,217 - 57,640,302 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	48,789,678 - 48,793,999 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	48,803,734 - 48,808,041 (+)	NCBI
Celera	13	47,510,714 - 47,513,799 (+)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

PHLDA3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	201,464,278 - 201,469,188 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	201,464,278 - 201,469,237 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	201,433,406 - 201,438,316 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	199,701,245 - 199,704,922 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	198,166,279 - 198,169,956	NCBI
Celera	1	174,558,492 - 174,562,169 (-)	NCBI		Celera
Cytogenetic Map	1	q32.1	NCBI
HuRef	1	172,600,628 - 172,604,316 (-)	NCBI		HuRef
CHM1_1	1	202,856,735 - 202,860,431 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	200,722,059 - 200,726,971 (-)	NCBI		T2T-CHM13v2.0

Phlda3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	135,693,823 - 135,696,872 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	135,693,857 - 135,696,874 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	135,766,085 - 135,769,134 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	135,766,119 - 135,769,136 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	137,662,662 - 137,665,711 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	137,582,544 - 137,585,545 (+)	NCBI		MGSCv36	mm8
Celera	1	138,400,219 - 138,403,272 (+)	NCBI		Celera
Cytogenetic Map	1	E4	NCBI
cM Map	1	59.26	NCBI

Phlda3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	37,579,006 - 37,582,230 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	37,579,006 - 37,582,230 (-)	NCBI	ChiLan1.0	ChiLan1.0

PHLDA3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	47,912,241 - 47,916,187 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	47,876,910 - 47,880,873 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	177,063,775 - 177,067,714 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	181,365,063 - 181,368,638 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	181,367,976 - 181,368,359 (-)	Ensembl	panpan1.1		panPan2

PHLDA3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	1,438,539 - 1,440,701 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	1,488,304 - 1,490,785 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	1,444,885 - 1,447,366 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	1,444,921 - 1,445,304 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	1,432,439 - 1,434,920 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	1,540,393 - 1,542,879 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	1,564,820 - 1,567,301 (+)	NCBI		UU_Cfam_GSD_1.0

Phlda3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	73,746,903 - 73,750,232 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936567	2,981,602 - 2,984,903 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936567	2,981,632 - 2,984,906 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PHLDA3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	23,826,874 - 23,827,245 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	23,824,181 - 23,827,428 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	28,232,722 - 28,235,987 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PHLDA3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	27,945,013 - 27,948,870 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	27,945,608 - 27,945,991 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	28,740,957 - 28,744,831 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Phlda3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624807	9,259,456 - 9,262,531 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624807	9,259,437 - 9,262,528 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Phlda3
16 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	109
Count of miRNA genes:	81
Interacting mature miRNAs:	100
Transcripts:	ENSRNOT00000011999
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	46088046	91088046	Rat
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	34663461	87525369	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	9313465	54313465	Rat
6893344	Cm79	Cardiac mass QTL 79	1.5	0.04	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	43720770	62022792	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	46197976	84753113	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	22301875	67301875	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	37415584	80753406	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	14915655	59915655	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
12879441	Bp396	Blood pressure QTL 396			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45699983	90699983	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	39754544	84754544	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
70170	Eae14	Experimental allergic encephalomyelitis QTL 14		0.0024	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	23203448	68203448	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	17694436	53050594	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	34535218	79535218	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	38433408	83433408	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
4145117	Mcs27	Mammary carcinoma susceptibility QTL 27		0.0001	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	13	43437904	47841255	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	23692969	68692969	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	32284471	77284471	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
2301962	Cm72	Cardiac mass QTL 72	4.12		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	13	31241331	58363171	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	37262092	82262092	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	37415584	82415584	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	23692969	68692969	Rat
12879472	Bp399	Blood pressure QTL 399			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45228358	47841255	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	15158722	60158722	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	9313465	54313465	Rat

Markers in Region

RH133254

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	47,196,079 - 47,196,293 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	52,591,747 - 52,591,960	NCBI	Rnor6.0
Rnor_5.0	13	57,640,047 - 57,640,260	UniSTS	Rnor5.0
RGSC_v3.4	13	48,793,744 - 48,793,957	UniSTS	RGSC3.4
Celera	13	47,513,544 - 47,513,757	UniSTS
RH 3.4 Map	13	148.7	UniSTS
Cytogenetic Map	13	q13	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012206	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC096932	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC087038	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EV766228	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000011999 ⟹ ENSRNOP00000011999

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	47,193,086 - 47,196,335 (+)	Ensembl
Rnor_6.0 Ensembl	13	52,588,917 - 52,592,001 (+)	Ensembl

RefSeq Acc Id:

NM_001012206 ⟹ NP_001012206

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	49,745,003 - 49,748,088 (+)	NCBI
mRatBN7.2	13	47,193,250 - 47,196,335 (+)	NCBI
Rnor_6.0	13	52,588,917 - 52,592,002 (+)	NCBI
Rnor_5.0	13	57,637,217 - 57,640,302 (+)	NCBI
RGSC_v3.4	13	48,789,678 - 48,793,999 (+)	RGD
Celera	13	47,510,714 - 47,513,799 (+)	RGD

Sequence:

show sequence

ATGTAAGGGCACATCCCGCCAGCAGCCGCCCAGCGCGCAGACTGAGTGCAGGGGAGCGGGCGTG
CGGACGGAGAGGCTCAGGGCACCCGGTAGGAGTTCGGGGAGGTCGGAGCGGTGCGCAGGGTACG
GAGCCGGCGGCGAGCGGGTAGCATCCGCACGCGCATCCCGGGTGCCGCTGTCTGCAAGGCGGCC
CCGGCCGCAGGCTCGGCTGGACAGGGAGCAAGGCCAACCAGCCCCAGGGCGCGAGAAGCCGGCG
TTGTAGAGCCGGGAGAGCCGGGACCGCCGCAGCCTCCAGCGCTGTGGGAACCTCGGGGCGCCCA
TGACGGCGGCGGCGACCGTGCTAAAGGAGGGCGTGCTGGAGAAGCGCAGCGGCGGGCTGCTGCA
GCTGTGGAAGCGGAAGCGTTGCGTGCTCACCGAGCGCGGGCTGCAGCTCTTCGAGGCCAAGGGC
ACGGGCGGCCGGCCCAAGGAGCTCAGCTTCTCCCGCATCAAAGCCGTGGAGTGCGTGGAGAGCA
CCGGGCGCCACATCTACTTCACGCTAGTGACCGAAGGCGGGGGCGAGATCGACTTCCGCTGCCC
CCTCGAAGACCCCGGCTGGAACGCTCAGATCACCCTGGGCCTGGTCAAGTTCAAGAATCAACAG
GCCATCCAGACTGTGCGGGCCCGGCAGAGTCTTGGAACTGGGACCCTCGTGTCCTAAACCACGA
GGCATACCATTTTATCCACATGCCCCCCTCCCACCTCCGTGCCCAGAAGACATGCCAGCTTCTC
TGTCCACTTTGGTTGGTTGGGGCCTGATTACATGTGATGTGGCAGAAGCTATCAACATGTGGAA
GACATACCTATCACCATGGAAGGCGCCAACTGGCCGGAGGCAGACAGCAGAAGCCAATAGGGGC
TGAGGATGAAGATTCAGTTCCTGAACACTAAGACTGTTAAGGCCACAGGCCTGGCCTCAAGTAT
CATGATGGAGCACTTGGGCCTTACCTGGCATCAAGGCCCCTCCCACCAGTCTAGCCCTTGGTTC
TGGGTTCTGCAGACTGCTGTTTGGCCTCTGGCTTTGAGACATGCCCAAAGGAGGGCTGTTCTTC
CTGGTGTGCTAAGGCAGTGCCTCAGAACTCAGGAGGCCAGTCTGGGGTCCAAAAGATGACCACC
CTACCTTCAGACAGCCATTGGACTCAAGCTTGTGGAGGGGGATCTGCTGGGCTGGAGGCCTGTG
CCTGGGGGTCTCTTGCTGCTTAGGTCCTTTTGGGACCCCCCACCACCACCATCTGTACCCTTTC
TTTGCACACTTCCTCCCTCACCTCTGTTGCCCTCTCCTCACTTCGGTGTTGGGCTTGGAGGGGG
TGGGGGTGGGGTAAGGGTTGGGCCTTTACCATTTCATGCTTATTCCAGAATGAAGAGGCCCAGT
TCGTGGGCAGTAACCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001012206	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH87038	(Get FASTA)	NCBI Sequence Viewer
	EDM09684	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011999.3
	ENSRNOP00055031156
	ENSRNOP00060021651
	ENSRNOP00065028240
GenBank Protein	Q5PQT7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001012206 ⟸ NM_001012206
- UniProtKB:	Q5PQT7 (UniProtKB/Swiss-Prot), A6ICG3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTAAATVLKEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFSRIKAVECVES TGRHIYFTLVTEGGGEIDFRCPLEDPGWNAQITLGLVKFKNQQAIQTVRARQSLGTGTLVS hide sequence

Ensembl Acc Id:

ENSRNOP00000011999 ⟸ ENSRNOT00000011999

Protein Domains

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5PQT7-F1-model_v2	AlphaFold	Q5PQT7	1-125	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698846

Promoter ID:

EPDNEW_R9371

Type:

initiation region

Name:

Phlda3_1

Description:

pleckstrin homology-like domain, family A, member 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	52,588,948 - 52,589,008	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310502	AgrOrtholog
BioCyc Gene	G2FUF-18193	BioCyc
Ensembl Genes	ENSRNOG00000009068	Ensembl, UniProtKB/Swiss-Prot
	ENSRNOG00055022271	UniProtKB/Swiss-Prot
	ENSRNOG00060015777	UniProtKB/Swiss-Prot
	ENSRNOG00065020722	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000011999.6	UniProtKB/Swiss-Prot
	ENSRNOT00055038266	UniProtKB/Swiss-Prot
	ENSRNOT00060026997	UniProtKB/Swiss-Prot
	ENSRNOT00065035123	UniProtKB/Swiss-Prot
Gene3D-CATH	2.30.29.30	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7096388	IMAGE-MGC_LOAD
InterPro	PH-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PH_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PHLA1/2/3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:363989	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:93690	IMAGE-MGC_LOAD
NCBI Gene	363989	ENTREZGENE
PANTHER	PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY A MEMBER 3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLECKSTRIN HOMOLOGY-LIKE DOMAIN, PQ-RICH PROTEIN	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam	PF00169	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Phlda3	PhenoGen
RatGTEx	ENSRNOG00000009068	RatGTEx
	ENSRNOG00055022271	RatGTEx
	ENSRNOG00060015777	RatGTEx
	ENSRNOG00065020722	RatGTEx
SMART	SM00233	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6ICG3	ENTREZGENE, UniProtKB/TrEMBL
	PHLA3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Phlda3	pleckstrin homology-like domain, family A, member 3	Phlda3_predicted	pleckstrin homology-like domain, family A, member 3 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Phlda3_predicted	pleckstrin homology-like domain, family A, member 3 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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