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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ferruginol
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Accession:CHEBI:78274 term browser browse the term
Definition:An abietane diterpenoid that is abieta-8,11,13-triene substituted by a hydroxy group at positions 12.
Synonyms:exact_synonym: abieta-8,11,13-trien-12-ol
 related_synonym: 12-hydroxyabieta-8,11,13-triene;   8,11,13-abietatrien-12-ol;   Formula=C20H30O;   InChI=1S/C20H30O/c1-13(2)15-11-14-7-8-18-19(3,4)9-6-10-20(18,5)16(14)12-17(15)21/h11-13,18,21H,6-10H2,1-5H3/t18-,20+/m0/s1;   InChIKey=QXNWVJOHUAQHLM-AZUAARDMSA-N;   SMILES=CC(C)c1cc2CC[C@H]3C(C)(C)CCC[C@]3(C)c2cc1O
 alt_id: CHEBI:5045
 xref: CAS:514-62-5;   KEGG:C09092;   KNApSAcK:C00003426
 xref_mesh: MESH:C431074
 xref: MetaCyc:CPD-16534;   PMID:16202980;   PMID:18237473;   PMID:18294971;   PMID:23812755;   PMID:24417091;   PMID:24651372;   PMID:24690774;   PMID:24710900;   Reaxys:5275000;   Wikipedia:Ferruginol



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ferruginol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions
increases activity
ISO pyrrolidine dithiocarbamic acid inhibits the reaction [ferruginol results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [ferruginol results in increased activity of CASP3 protein] CTD PMID:30086653 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP ferruginol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein] CTD PMID:32946155 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Il6 interleukin 6 multiple interactions EXP ferruginol inhibits the reaction [Isoproterenol results in increased secretion of IL6 protein] CTD PMID:32946155 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
ISO pyrrolidine dithiocarbamic acid inhibits the reaction [ferruginol results in increased expression of RELA protein]; SB 203580 inhibits the reaction [ferruginol results in increased expression of RELA protein] CTD PMID:30086653 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP ferruginol inhibits the reaction [Isoproterenol results in increased secretion of TNF protein] CTD PMID:32946155 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP ferruginol inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein] CTD PMID:32946155 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions EXP ferruginol inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein] CTD PMID:32946155 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19659
    role 19634
      biological role 19633
        antimicrobial agent 17784
          antibacterial agent 14305
            ferruginol 7
              11,20-dihydroxyferruginol + 0
              11,20-dihydroxysugiol 0
              11-hydroxyferruginol 0
              11-hydroxysugiol + 0
              6beta-hydroxyferruginol 0
              salviol 0
              sugiol + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    main group molecular entity 19649
                      s-block molecular entity 19457
                        hydrogen molecular entity 19450
                          hydrides 18928
                            organic hydride 18546
                              organic fundamental parent 18582
                                hydrocarbon 18313
                                  terpene 13645
                                    terpenoid 13281
                                      diterpenoid 12692
                                        abietane diterpenoid 206
                                          ferruginol 7
                                            11,20-dihydroxyferruginol + 0
                                            11,20-dihydroxysugiol 0
                                            11-hydroxyferruginol 0
                                            11-hydroxysugiol + 0
                                            6beta-hydroxyferruginol 0
                                            salviol 0
                                            sugiol + 0
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