(20S)-20-hydroxypregn-4-en-3-one multiple interactions EXP 6480464 20-alpha-Dihydroprogesterone inhibits the reaction [docetaxel results in decreased expression of MAL mRNA] CTD PMID:19335538 1,1-dichloroethene decreases expression ISO RGD:10882 6480464 vinylidene chloride results in decreased expression of MAL mRNA CTD PMID:26682919 17alpha-ethynylestradiol affects expression ISO RGD:735676 6480464 Ethinyl Estradiol affects the expression of MAL mRNA CTD PMID:20170705 , PMID:26865667 17beta-estradiol decreases expression ISO RGD:735676 6480464 Estradiol results in decreased expression of MAL mRNA CTD PMID:23019147 17beta-estradiol increases expression ISO RGD:735676 6480464 Estradiol results in increased expression of MAL mRNA CTD PMID:23373633 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:10882 6480464 Tetrachlorodibenzodioxin results in increased expression of MAL mRNA CTD PMID:17035482 2-acetamidofluorene increases expression ISO RGD:10882 6480464 2-Acetylaminofluorene results in increased expression of MAL mRNA CTD PMID:17317680 4,4'-diaminodiphenylmethane increases expression ISO RGD:10882 6480464 4, 4'-diaminodiphenylmethane results in increased expression of MAL mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol increases expression ISO RGD:10882 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of MAL mRNA CTD PMID:30951980 4-hydroxyphenyl retinamide increases expression ISO RGD:10882 6480464 Fenretinide results in increased expression of MAL mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine increases expression ISO RGD:735676 6480464 Decitabine results in increased expression of MAL mRNA CTD PMID:19208741 , PMID:19445022 5-aza-2'-deoxycytidine decreases methylation ISO RGD:735676 6480464 Decitabine results in decreased methylation of MAL promoter CTD PMID:19208741 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of MAL mRNA CTD PMID:24780913 , PMID:25825206 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of MAL mRNA CTD PMID:25378103 all-trans-retinoic acid decreases expression ISO RGD:735676 6480464 Tretinoin results in decreased expression of MAL mRNA CTD PMID:23830798 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of MAL mRNA CTD PMID:16483693 antirheumatic drug decreases expression ISO RGD:735676 6480464 Antirheumatic Agents results in decreased expression of MAL mRNA CTD PMID:24449571 arsenite(3-) increases methylation ISO RGD:735676 6480464 arsenite results in increased methylation of MAL promoter CTD PMID:23974009 benzo[a]pyrene decreases expression ISO RGD:10882 6480464 Benzo(a)pyrene results in decreased expression of MAL mRNA CTD PMID:22228805 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:735676 6480464 Diethylhexyl Phthalate results in decreased expression of MAL mRNA CTD PMID:31163220 bisphenol A affects expression ISO RGD:735676 6480464 bisphenol A affects the expression of MAL mRNA CTD PMID:20170705 bisphenol A increases expression ISO RGD:10882 6480464 bisphenol A results in increased expression of MAL mRNA CTD PMID:25594700 , PMID:30951980 bisphenol F increases expression ISO RGD:10882 6480464 bisphenol F results in increased expression of MAL mRNA CTD PMID:30951980 butanal increases expression ISO RGD:735676 6480464 butyraldehyde results in increased expression of MAL mRNA CTD PMID:26079696 carbon nanotube increases expression ISO RGD:10882 6480464 Nanotubes, Carbon analog results in increased expression of MAL mRNA, Nanotubes, Carbon results in increased expression of MAL mRNA CTD PMID:25554681 cerium trichloride decreases expression ISO RGD:10882 6480464 cerous chloride results in decreased expression of MAL mRNA CTD PMID:23573234 chloroprene decreases expression EXP 6480464 Chloroprene results in decreased expression of MAL mRNA CTD PMID:23125180 choline multiple interactions ISO RGD:10882 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of MAL more ... CTD PMID:20938992 cisplatin affects response to substance ISO RGD:735676 6480464 MAL protein affects the susceptibility to Cisplatin CTD PMID:16217747 clofibrate multiple interactions ISO RGD:10882 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of MAL mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MAL mRNA] CTD PMID:17585979 clozapine decreases expression ISO RGD:10882 6480464 Clozapine results in decreased expression of MAL mRNA CTD PMID:17266109 , PMID:18797397 cobalt atom multiple interactions ISO RGD:735676 6480464 [tungsten carbide binds to Cobalt] which results in decreased expression of MAL mRNA CTD PMID:20105288 cobalt dichloride decreases expression ISO RGD:735676 6480464 cobaltous chloride results in decreased expression of MAL mRNA CTD PMID:20105288 copper atom multiple interactions ISO RGD:10882 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of MAL mRNA CTD PMID:15467011 copper(0) multiple interactions ISO RGD:10882 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of MAL mRNA CTD PMID:15467011 dichlorine multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in increased expression of MAL mRNA CTD PMID:18636392 doxorubicin increases expression ISO RGD:735676 6480464 Doxorubicin results in increased expression of MAL mRNA CTD PMID:29803840 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of MAL mRNA CTD PMID:29391264 ethanol multiple interactions EXP 6480464 [Dronabinol co-treated with Ethanol] results in increased expression of MAL mRNA CTD PMID:17618662 ethanol affects splicing ISO RGD:10882 6480464 Ethanol affects the splicing of MAL mRNA CTD PMID:30319688 ethanol decreases expression ISO RGD:10882 6480464 Ethanol results in decreased expression of MAL mRNA CTD PMID:29018328 ethanol increases expression EXP 6480464 Ethanol results in increased expression of MAL mRNA CTD PMID:17618662 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of MAL mRNA CTD PMID:18035473 folic acid multiple interactions ISO RGD:10882 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of MAL more ... CTD PMID:20938992 furan increases expression EXP 6480464 furan results in increased expression of MAL mRNA CTD PMID:27387713 genistein multiple interactions EXP 6480464 [Genistein co-treated with Methoxychlor] results in increased expression of MAL mRNA CTD PMID:21782745 genistein affects expression ISO RGD:735676 6480464 Genistein affects the expression of MAL mRNA CTD PMID:26865667 glycidol decreases expression EXP 6480464 glycidol results in decreased expression of MAL mRNA CTD PMID:24395379 graphite affects expression EXP 6480464 Graphite affects the expression of MAL mRNA CTD PMID:29933104 ibuprofen increases expression ISO RGD:735676 6480464 Ibuprofen results in increased expression of MAL mRNA CTD PMID:17070997 irinotecan increases expression ISO RGD:735676 6480464 Irinotecan metabolite results in increased expression of MAL mRNA, Irinotecan results in increased expression of MAL mRNA CTD PMID:15956246 ketamine increases expression EXP 6480464 Ketamine results in increased expression of MAL mRNA CTD PMID:20080153 L-methionine multiple interactions ISO RGD:10882 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of MAL more ... CTD PMID:20938992 methoxychlor multiple interactions EXP 6480464 [Genistein co-treated with Methoxychlor] results in increased expression of MAL mRNA CTD PMID:21782745 methoxychlor increases expression EXP 6480464 Methoxychlor results in increased expression of MAL mRNA CTD PMID:21782745 N-methyl-4-phenylpyridinium increases expression ISO RGD:735676 6480464 1-Methyl-4-phenylpyridinium results in increased expression of MAL mRNA CTD PMID:24810058 nickel atom increases expression ISO RGD:10882 6480464 Nickel results in increased expression of MAL mRNA CTD PMID:12540486 nickel atom increases expression ISO RGD:735676 6480464 Nickel results in increased expression of MAL mRNA CTD PMID:24768652 olanzapine decreases expression ISO RGD:10882 6480464 olanzapine results in decreased expression of MAL mRNA CTD PMID:18797397 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of MAL mRNA CTD PMID:25729387 ozone multiple interactions ISO RGD:10882 6480464 [NOTCH3 gene mutant form affects the susceptibility to Ozone] which results in increased expression of MAL mRNA, TTPA protein affects the reaction [Ozone results in increased expression of MAL mRNA] CTD PMID:19555225 , PMID:25658374 ozone increases expression ISO RGD:10882 6480464 Ozone results in increased expression of MAL mRNA CTD PMID:25658374 ozone multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in increased expression of MAL mRNA CTD PMID:18636392 paracetamol multiple interactions ISO RGD:10882 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of MAL mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MAL mRNA] CTD PMID:17585979 paracetamol multiple interactions ISO RGD:735676 6480464 [Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of MAL mRNA CTD PMID:17093179 pentanal increases expression ISO RGD:735676 6480464 pentanal results in increased expression of MAL mRNA CTD PMID:26079696 perfluorobutyric acid increases expression EXP 6480464 perfluorobutyric acid analog results in increased expression of MAL mRNA CTD PMID:21878386 phencyclidine decreases expression ISO RGD:10882 6480464 Phencyclidine results in decreased expression of MAL mRNA CTD PMID:17266109 phenobarbital multiple interactions ISO RGD:10882 6480464 NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MAL mRNA] CTD PMID:19482888 phenobarbital increases expression ISO RGD:10882 6480464 Phenobarbital results in increased expression of MAL mRNA CTD PMID:19482888 progesterone decreases expression ISO RGD:10882 6480464 Progesterone results in decreased expression of MAL mRNA CTD PMID:22238285 propanal increases expression ISO RGD:735676 6480464 propionaldehyde results in increased expression of MAL mRNA CTD PMID:26079696 rofecoxib increases expression ISO RGD:735676 6480464 rofecoxib results in increased expression of MAL mRNA CTD PMID:17070997 sodium dichromate decreases expression ISO RGD:10882 6480464 sodium bichromate results in decreased expression of MAL mRNA CTD PMID:22155349 sulindac sulfide decreases expression ISO RGD:735676 6480464 sulindac sulfide results in decreased expression of MAL mRNA CTD PMID:16184548 tert-butyl hydroperoxide decreases expression ISO RGD:735676 6480464 tert-Butylhydroperoxide results in decreased expression of MAL mRNA CTD PMID:15336504 tetracycline increases expression ISO RGD:10882 6480464 Tetracycline results in increased expression of MAL mRNA CTD PMID:16917069 titanium dioxide increases expression ISO RGD:10882 6480464 titanium dioxide results in increased expression of MAL mRNA CTD PMID:27760801 topotecan increases expression EXP 6480464 Topotecan results in increased expression of MAL mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of MAL mRNA CTD PMID:25729387 Tributyltin oxide increases expression EXP 6480464 bis(tri-n-butyltin)oxide results in increased expression of MAL mRNA CTD PMID:17553608 Tungsten carbide multiple interactions ISO RGD:735676 6480464 [tungsten carbide binds to Cobalt] which results in decreased expression of MAL mRNA CTD PMID:20105288 Tungsten carbide decreases expression ISO RGD:735676 6480464 tungsten carbide results in decreased expression of MAL mRNA CTD PMID:20105288 valproic acid affects expression ISO RGD:735676 6480464 Valproic Acid affects the expression of MAL mRNA CTD PMID:25979313 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of MAL mRNA CTD PMID:23034163 zinc atom increases expression ISO RGD:735676 6480464 Zinc results in increased expression of MAL mRNA CTD PMID:15226459 zinc sulfate increases expression ISO RGD:735676 6480464 Zinc Sulfate results in increased expression of MAL mRNA CTD PMID:15226459 zinc(0) increases expression ISO RGD:735676 6480464 Zinc results in increased expression of MAL mRNA CTD PMID:15226459
Biological Process intracellular protein transport TAS 625622 RGD myelination IDA 729172 RGD myelination IBA PANTHER:PTN000512260 more ... 13792537 PMID:21873635 GO_Central myelination ISO RGD:10882 1624291 (MGI:MGI:1913197, PMID:11032882) RGD MGI:MGI:1913197 , PMID:11032882 myelination IBA MGI:MGI:892970 more ... 13792537 PMID:21873635 GO_Central positive regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO RGD:10882 1624291 (MGI:MGI:3687876, PMID:12776198) RGD MGI:MGI:3687876 , PMID:12776198 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA UniProtKB:O09198 , ensembl:ENSMUSP000000288541600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein insertion into plasma membrane IEA UniProtKB:O09198 , ensembl:ENSMUSP000000288541600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein insertion into plasma membrane ISO RGD:10882 1624291 MGI:MGI:3053860 (MGI:MGI:5521464 , PMID:22323295) RGD MGI:MGI:5521464 , PMID:22323295 protein localization to paranode region of axon IEA UniProtKB:O09198 , ensembl:ENSMUSP000000288541600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein localization to paranode region of axon ISO RGD:10882 1624291 MGI:MGI:3053860 (MGI:MGI:3053254 , PMID:15337780) RGD MGI:MGI:3053254 , PMID:15337780 Cellular Component apical plasma membrane ISO RGD:10882 1624291 (MGI:MGI:1913197, PMID:11032882) RGD MGI:MGI:1913197 , PMID:11032882 endoplasmic reticulum ISO RGD:735676 1624291 (PMID:8132541) RGD PMID:8132541 endoplasmic reticulum IEA UniProtKB:P21145 , ensembl:ENSP000003108801600115 GO_REF:0000107 Ensembl GO_REF:0000107 extrinsic component of membrane IDA 625622 RGD hinge region between urothelial plaques of apical plasma membrane IEA UniProtKB:O09198 , ensembl:ENSMUSP000000288541600115 GO_REF:0000107 Ensembl GO_REF:0000107 hinge region between urothelial plaques of apical plasma membrane ISO RGD:10882 1624291 MGI:MGI:3053860 (MGI:MGI:5521464 , PMID:22323295) RGD MGI:MGI:5521464 , PMID:22323295 integral component of membrane IBA PANTHER:PTN001103553 , UniProtKB:Q9UBR5 13792537 PMID:21873635 GO_Central membrane raft IDA 1358759 RGD membrane raft ISO RGD:10882 1624291 (MGI:MGI:5521464, PMID:22323295) RGD MGI:MGI:5521464 , PMID:22323295 membrane raft ISO RGD:735676 1624291 (PMID:12153479), (PMID:23264465) RGD PMID:12153479 , PMID:23264465 membrane raft ISO RGD:12378299 1624291 (PMID:23264465) RGD PMID:23264465 plasma membrane raft IEA UniProtKB:O09198 , ensembl:ENSMUSP000000288541600115 GO_REF:0000107 Ensembl GO_REF:0000107 plasma membrane raft ISO RGD:10882 1624291 MGI:MGI:3053860 (MGI:MGI:3053254 , PMID:15337780) RGD MGI:MGI:3053254 , PMID:15337780 Molecular Function protein binding ISO RGD:735676 1624291 UniProtKB:P26715 more ... RGD PMID:21988832 more ... structural constituent of myelin sheath IDA 625622 RGD structural constituent of myelin sheath IBA PANTHER:PTN000512260 more ... 13792537 PMID:21873635 GO_Central structural constituent of myelin sheath ISO RGD:735676 1624291 (PMID:12153479) RGD PMID:12153479
Gene-Chemical Interaction Annotations
