Cyp2c79 (cytochrome P450, family 2, subfamily c, polypeptide 79) - Rat Genome Database

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Gene: Cyp2c79 (cytochrome P450, family 2, subfamily c, polypeptide 79) Rattus norvegicus
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Symbol: Cyp2c79
Name: cytochrome P450, family 2, subfamily c, polypeptide 79
RGD ID: 1308166
Description: Predicted to enable caffeine oxidase activity and monooxygenase activity. Predicted to be involved in several processes, including icosanoid metabolic process; lipid hydroxylation; and retinoic acid metabolic process. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Human ortholog(s) of this gene implicated in end stage renal disease and renal hypertension. Orthologous to human CYP2C8 (cytochrome P450 family 2 subfamily C member 8); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
Previously known as: Cyp2c65; cytochrome P450, family 2, subfamily c, polypeptide 65; LOC293985
RGD Orthologs
Human
Mouse
Bonobo
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Genome Annotation Status: not in current annotation release
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01147,236,480 - 147,307,988 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01153,536,125 - 153,596,401 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41244,400,004 - 244,493,624 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11244,496,473 - 244,590,218 (-)NCBI
Celera1234,163,008 - 234,227,113 (+)NCBICelera
Cytogenetic Map1q53NCBI


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-naphthoquinone  (ISO)
1-naphthol  (ISO)
14,15-EET  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3-methylcholanthrene  (ISO)
4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenol  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
4-hydroxynon-2-enal  (ISO)
4-isopropylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxyindole  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-hydroxypaclitaxel  (ISO)
6-propyl-2-thiouracil  (EXP)
aconitine  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-4-hydroxyretinoic acid  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
almotriptan  (ISO)
aminophenazone  (ISO)
amiodarone  (ISO)
amodiaquine  (ISO)
amoxicillin  (ISO)
arachidonic acid  (ISO)
Aroclor 1254  (ISO)
atrazine  (ISO)
Auriculasin  (ISO)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bezafibrate  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromfenac  (ISO)
Bufuralol  (ISO)
buprenorphine  (ISO)
buta-1,3-diene  (ISO)
butyric acid  (ISO)
calciol  (ISO)
camptothecin  (ISO)
Candesartan cilexetil  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbamazepine-10,11-epoxide  (ISO)
carfentanil  (ISO)
cerivastatin  (ISO)
chenodeoxycholic acid  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cinitapride  (ISO)
ciprofibrate  (ISO)
clofibric acid  (ISO)
Clofop  (ISO)
clopidogrel  (ISO)
clotrimazole  (ISO)
clozapine  (ISO)
Clozapine N-oxide  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
cumene hydroperoxide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
dabrafenib  (ISO)
daidzein  (ISO)
dapsone  (ISO)
deoxycholic acid  (ISO)
Desethylchloroquine  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dihydroergotamine  (ISO)
Dihydrotanshinone I  (ISO)
diosmetin  (ISO)
domperidone  (ISO)
dopamine  (ISO)
endosulfan  (ISO)
erythromycin A  (ISO)
etoposide  (ISO)
felbamate  (ISO)
felodipine  (ISO)
fenitrothion  (ISO)
fenofibrate  (ISO)
fenvalerate  (ISO)
fipronil  (ISO)
fluconazole  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP,ISO)
gallocatechin  (ISO)
gemfibrozil  (ISO)
genistein  (ISO)
glutathione  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyoxal  (ISO)
griseofulvin  (ISO)
Heptachlor epoxide  (ISO)
Hypaconitine  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
irbesartan  (ISO)
isoniazide  (ISO)
isoproturon  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
lansoprazole  (ISO)
Licochalcone A  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
loratadine  (ISO)
lovastatin  (ISO)
medroxyprogesterone  (ISO)
MeIQx  (ISO)
mephenytoin  (ISO)
mercury dichloride  (ISO)
methidathion  (ISO)
methoxsalen  (ISO)
methoxychlor  (ISO)
methyltestosterone  (ISO)
midazolam  (ISO)
mometasone furoate  (ISO)
monosodium L-glutamate  (ISO)
montelukast  (ISO)
mycophenolic acid  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-desmethylclozapine  (ISO)
N-nitrosodiethylamine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalene  (ISO)
Neferine  (ISO)
nicardipine  (ISO)
nifedipine  (ISO)
Nonylphenol  (ISO)
nortriptyline  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
ortho-Aminoazotoluene  (ISO)
oxybutynin  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
parathion  (ISO)
pazopanib  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phencyclidine  (ISO)
Phenelzine  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
pimecrolimus  (ISO)
pioglitazone  (ISO)
piperacillin  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probenecid  (ISO)
prochloraz  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinidine  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
ritonavir  (ISO)
Salmeterol xinafoate  (ISO)
Salvianolic acid A  (ISO)
Salvianolic acid C  (ISO)
satraplatin  (ISO)
Senkirkine  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sorafenib  (ISO)
spironolactone  (ISO)
sporidesmin A  (ISO)
Sudan I  (ISO)
sulfadiazine  (ISO)
sulfasalazine  (ISO)
sulfinpyrazone  (ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetrahydrocurcumin  (ISO)
thiacloprid  (ISO)
Thiocoraline  (ISO)
thiophanate-methyl  (ISO)
thyroxine  (ISO)
ticlopidine  (ISO)
titanium dioxide  (ISO)
tolbutamide  (ISO)
torasemide  (ISO)
trans-cinnamic acid  (ISO)
tranylcypromine  (ISO)
triadimefon  (ISO)
triflumuron  (ISO)
trimethoprim  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
tryptamines  (ISO)
valproic acid  (ISO)
vanoxerine dihydrochloride  (ISO)
verapamil  (ISO)
vincristine  (ISO)
warfarin  (ISO)
zafirlukast  (ISO)
ziram  (ISO)
zopiclone  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylsalicylic acid pharmacodynamics pathway  (ISO)
antipyrine drug pathway  (ISO)
arachidonic acid metabolic pathway  (ISO)
caffeine pharmacokinetics pathway  (ISO)
carbamazepine pharmacokinetics pathway  (ISO)
celecoxib pharmacodynamics pathway  (ISO)
cyclophosphamide pharmacodynamics pathway  (ISO)
cyclophosphamide pharmacokinetics pathway  (ISO)
diclofenac pharmacodynamics pathway  (ISO)
diflunisal pharmacodynamics pathway  (ISO)
etodolac pharmacodynamics pathway  (ISO)
fenoprofen pharmacodynamics pathway  (ISO)
flurbiprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacokinetics pathway  (ISO)
ifosfamide pharmacodynamics pathway  (ISO)
ifosfamide pharmacokinetics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
ketoprofen pharmacodynamics pathway  (ISO)
ketorolac pharmacodynamics pathway  (ISO)
leukotriene C4 synthase deficiency pathway  (ISO)
lornoxicam pharmacodynamics pathway  (ISO)
losartan pharmacokinetics pathway  (ISO)
magnesium salicylate pharmacodynamics pathway  (ISO)
mefenamic acid pharmacodynamics pathway  (ISO)
meloxicam pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
methadone pharmacokinetics pathway  (ISO)
mycophenolic acid pharmacokinetics pathway  (ISO)
nabumetone pharmacodynamics pathway  (ISO)
naproxen pharmacodynamics pathway  (ISO)
paracetamol drug pathway  (ISO)
piroxicam pharmacodynamics pathway  (ISO)
repaglinide pharmacokinetics pathway  (ISO)
rosiglitazone pharmacokinetics pathway  (ISO)
salicylic acid pharmacodynamics pathway  (ISO)
sodium salicylate pharmacodynamics pathway  (ISO)
sorafenib pharmacokinetics pathway  (ISO)
statin pharmacokinetics pathway  (ISO)
sulindac pharmacodynamics pathway  (ISO)
tamoxifen pharmacokinetics pathway  (ISO)
tenoxicam pharmacodynamics pathway  (ISO)
tiaprofenic acid pharmacodynamics pathway  (ISO)
tolmetin pharmacodynamics pathway  (ISO)
valdecoxib pharmacodynamics pathway  (ISO)
warfarin pharmacokinetics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. Impact of CYP3A5*3 and CYP2C8-HapC on paclitaxel/carboplatin-induced myelosuppression in patients with ovarian cancer. Green H, etal., J Pharm Sci. 2011 Oct;100(10):4205-9. doi: 10.1002/jps.22680. Epub 2011 Jun 23.
3. Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice. Lee CR, etal., FASEB J. 2010 Oct;24(10):3770-81. doi: 10.1096/fj.10-160119. Epub 2010 May 21.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease. Smith HE, etal., Pharmacogenet Genomics. 2008 Nov;18(11):943-53. doi: 10.1097/FPC.0b013e32830e1e16.
Additional References at PubMed
PMID:7574697   PMID:11093772   PMID:12865317   PMID:14559847   PMID:15766564   PMID:18619574   PMID:19651758  


Genomics

Comparative Map Data
Cyp2c79
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01147,236,480 - 147,307,988 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01153,536,125 - 153,596,401 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41244,400,004 - 244,493,624 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11244,496,473 - 244,590,218 (-)NCBI
Celera1234,163,008 - 234,227,113 (+)NCBICelera
Cytogenetic Map1q53NCBI
CYP2C8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381095,036,772 - 95,069,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1095,036,772 - 95,069,497 (-)EnsemblGRCh38hg38GRCh38
GRCh371096,796,529 - 96,829,254 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361096,786,519 - 96,819,244 (-)NCBINCBI36Build 36hg18NCBI36
Celera1090,537,664 - 90,570,382 (-)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1090,423,094 - 90,455,810 (-)NCBIHuRef
CHM1_11097,078,287 - 97,111,019 (-)NCBICHM1_1
T2T-CHM13v2.01095,915,890 - 95,948,616 (-)NCBIT2T-CHM13v2.0
Cyp2c29
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391939,275,488 - 39,319,157 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1939,257,849 - 39,319,157 (+)EnsemblGRCm39 Ensembl
GRCm381939,287,044 - 39,330,713 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1939,269,405 - 39,330,713 (+)EnsemblGRCm38mm10GRCm38
MGSCv371939,361,575 - 39,405,203 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361939,340,415 - 39,384,007 (+)NCBIMGSCv36mm8
Celera1940,092,921 - 40,136,495 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1933.91NCBI
CYP2C8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11095,153,512 - 95,186,716 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1095,157,661 - 95,186,620 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01091,646,387 - 91,679,998 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CYP2C8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1988,154,131 - 88,183,915 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl988,154,134 - 88,183,458 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604848,950,143 - 48,979,388 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:49
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000017367
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_001080345
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera1234,163,008 - 234,227,113 (+)RGD
RefSeq Acc Id: XM_006229640   ⟹   XP_006229702
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_5.01153,536,125 - 153,596,401 (-)NCBI
RefSeq Acc Id: XM_008759633   ⟹   XP_008757855
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01147,236,480 - 147,307,988 (-)NCBI
RefSeq Acc Id: XM_219933   ⟹   XP_219933
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_5.01153,536,125 - 153,596,401 (-)NCBI
RGSC_v3.41244,400,004 - 244,493,624 (-)RGD

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308166 AgrOrtholog
NCBI Gene 293985 ENTREZGENE
PharmGKB CYP2C8 RGD
PhenoGen Cyp2c79 PhenoGen


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Cyp2c79  cytochrome P450, family 2, subfamily c, polypeptide 79   Cyp2c79_predicted  cytochrome P450, family 2, subfamily c, polypeptide 79 (predicted)  'predicted' is removed 2292626 APPROVED
2007-07-06 Cyp2c79_predicted  cytochrome P450, family 2, subfamily c, polypeptide 79 (predicted)  Cyp2c65_predicted  cytochrome P450, family 2, subfamily c, polypeptide 65 (predicted)  Name updated 1299863 APPROVED
2005-01-12 Cyp2c65_predicted  cytochrome P450, family 2, subfamily c, polypeptide 65 (predicted)      Symbol and Name status set to approved 70820 APPROVED