CYP2C8 (cytochrome P450 family 2 subfamily C member 8) - Rat Genome Database

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Gene: CYP2C8 (cytochrome P450 family 2 subfamily C member 8) Homo sapiens
Analyze
Symbol: CYP2C8
Name: cytochrome P450 family 2 subfamily C member 8
RGD ID: 1606589
HGNC Page HGNC
Description: Enables caffeine oxidase activity and monooxygenase activity. Involved in several processes, including cellular hormone metabolic process; icosanoid metabolic process; and lipid hydroxylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Implicated in end stage renal disease and renal hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CPC8; CYP2C8DM; CYPIIC8; cytochrome P450 2C8; cytochrome P450 form 1; cytochrome P450 IIC2; cytochrome P450 MP-12; cytochrome P450 MP-20; cytochrome P450, family 2, subfamily C, polypeptide 8; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8; flavoprotein-linked monooxygenase; microsomal monooxygenase; MP-12/MP-20; P450 form 1; s-mephenytoin 4-hydroxylase; xenobiotic monooxygenase
RGD Orthologs
Mouse
Rat
Bonobo
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: CYP2C56P   CYP2C58P   CYP2C60P   CYP2C61P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1095,036,772 - 95,069,497 (-)EnsemblGRCh38hg38GRCh38
GRCh381095,036,772 - 95,069,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371096,796,529 - 96,829,254 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361096,786,519 - 96,819,244 (-)NCBINCBI36hg18NCBI36
Celera1090,537,664 - 90,570,382 (-)NCBI
Cytogenetic Map10q23.33NCBI
HuRef1090,423,094 - 90,455,810 (-)NCBIHuRef
CHM1_11097,078,287 - 97,111,019 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (ISO)
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-naphthoquinone  (EXP)
1-naphthol  (EXP)
14,15-EET  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
3-methylcholanthrene  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (EXP)
4-hydroxynon-2-enal  (ISO)
4-isopropylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-methoxyindole  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (EXP)
6-hydroxypaclitaxel  (EXP)
6-propyl-2-thiouracil  (ISO)
aconitine  (EXP)
acrylamide  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
all-trans-4-hydroxyretinoic acid  (EXP)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
almotriptan  (EXP)
aminophenazone  (EXP)
amiodarone  (EXP)
amodiaquine  (EXP)
amoxicillin  (EXP)
arachidonic acid  (EXP)
Aroclor 1254  (EXP,ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-hexachlorocyclohexane  (ISO)
bezafibrate  (EXP)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromfenac  (EXP)
Bufuralol  (EXP)
buprenorphine  (EXP)
buta-1,3-diene  (ISO)
butyric acid  (EXP)
calciol  (ISO)
camptothecin  (EXP)
Candesartan cilexetil  (EXP)
captan  (ISO)
carbamazepine  (EXP)
carbamazepine-10,11-epoxide  (EXP)
carfentanil  (EXP)
cerivastatin  (EXP)
chenodeoxycholic acid  (EXP)
chloroquine  (EXP)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cinitapride  (EXP)
ciprofibrate  (ISO)
clofibric acid  (EXP)
Clofop  (EXP)
clopidogrel  (EXP)
clotrimazole  (EXP)
clozapine  (EXP)
Clozapine N-oxide  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
cumene hydroperoxide  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (EXP,ISO)
cypermethrin  (EXP,ISO)
cyproconazole  (ISO)
daidzein  (ISO)
dapsone  (EXP)
Desethylchloroquine  (EXP)
dexamethasone  (EXP)
dextran sulfate  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dihydroergotamine  (ISO)
Dihydrotanshinone I  (EXP)
diosmetin  (EXP)
domperidone  (EXP)
dopamine  (ISO)
endosulfan  (ISO)
erythromycin A  (ISO)
etoposide  (ISO)
felodipine  (EXP)
fenitrothion  (EXP)
fenofibrate  (EXP)
fenvalerate  (EXP)
fipronil  (EXP,ISO)
fluconazole  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (ISO)
gallocatechin  (ISO)
gemfibrozil  (EXP)
genistein  (ISO)
glutathione  (EXP)
glyoxal  (EXP)
griseofulvin  (ISO)
Heptachlor epoxide  (ISO)
Hypaconitine  (EXP)
ibuprofen  (EXP)
ifosfamide  (EXP)
irbesartan  (EXP)
isoniazide  (EXP)
isoproturon  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP,ISO)
L-methionine  (ISO)
lansoprazole  (EXP)
Licochalcone A  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
Loratadine  (EXP)
lovastatin  (EXP)
medroxyprogesterone  (EXP)
MeIQx  (EXP)
mephenytoin  (ISO)
mercury dichloride  (ISO)
methoxsalen  (ISO)
methoxychlor  (EXP,ISO)
methyltestosterone  (EXP)
midazolam  (ISO)
mometasone furoate  (EXP)
monosodium L-glutamate  (ISO)
montelukast  (EXP)
mycophenolic acid  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-desmethylclozapine  (EXP)
N-nitrosodiethylamine  (ISO)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
naphthalene  (EXP)
Neferine  (EXP)
Nicardipine  (EXP)
nifedipine  (EXP,ISO)
Nonylphenol  (ISO)
nortriptyline  (EXP)
O-methyleugenol  (EXP)
obeticholic acid  (EXP)
okadaic acid  (ISO)
ortho-Aminoazotoluene  (ISO)
oxybutynin  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
parathion  (EXP)
pazopanib  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phencyclidine  (EXP)
Phenelzine  (EXP)
phenobarbital  (EXP,ISO)
phenytoin  (ISO)
pimecrolimus  (EXP)
pioglitazone  (EXP)
piperacillin  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probenecid  (EXP)
prochloraz  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
quercetin  (EXP,ISO)
quinidine  (ISO)
raloxifene  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
ritonavir  (EXP)
Salmeterol xinafoate  (EXP)
Salvianolic acid A  (EXP)
Salvianolic acid C  (EXP)
satraplatin  (EXP)
Senkirkine  (EXP)
silibinin  (EXP)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sorafenib  (EXP)
spironolactone  (EXP)
Sporidesmin  (EXP)
Sudan I  (EXP)
sulfadiazine  (EXP)
sulfasalazine  (ISO)
sulfinpyrazone  (EXP)
tamoxifen  (EXP,ISO)
Tanshinone I  (EXP)
testosterone  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (ISO)
tetrahydrocurcumin  (ISO)
thiacloprid  (ISO)
Thiocoraline  (EXP)
thiophanate-methyl  (ISO)
thyroxine  (EXP)
ticlopidine  (EXP)
titanium dioxide  (ISO)
tolbutamide  (EXP)
torasemide  (EXP)
trans-cinnamic acid  (EXP)
tranylcypromine  (EXP)
triadimefon  (ISO)
triflumuron  (EXP)
trimethoprim  (EXP)
Triptolide  (ISO)
troglitazone  (EXP,ISO)
tryptamines  (EXP)
valproic acid  (EXP)
vanoxerine dihydrochloride  (EXP)
verapamil  (EXP,ISO)
vincristine  (EXP)
vitamin E  (ISO)
warfarin  (ISO)
zafirlukast  (EXP)
ziram  (ISO)
zopiclone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylsalicylic acid pharmacodynamics pathway  (EXP)
antipyrine drug pathway  (EXP)
arachidonic acid metabolic pathway  (EXP,IEA)
caffeine pharmacokinetics pathway  (EXP)
carbamazepine pharmacokinetics pathway  (EXP)
celecoxib pharmacodynamics pathway  (EXP)
cyclophosphamide pharmacodynamics pathway  (EXP)
cyclophosphamide pharmacokinetics pathway  (EXP)
diclofenac pharmacodynamics pathway  (EXP)
diflunisal pharmacodynamics pathway  (EXP)
etodolac pharmacodynamics pathway  (EXP)
fenoprofen pharmacodynamics pathway  (EXP)
flurbiprofen pharmacodynamics pathway  (EXP)
ibuprofen pharmacodynamics pathway  (EXP)
ibuprofen pharmacokinetics pathway  (EXP)
ifosfamide pharmacodynamics pathway  (EXP)
ifosfamide pharmacokinetics pathway  (EXP)
indometacin pharmacodynamics pathway  (EXP)
indometacin pharmacodynamics pathway  (EXP)
ketoprofen pharmacodynamics pathway  (EXP)
ketorolac pharmacodynamics pathway  (EXP)
leukotriene C4 synthase deficiency pathway  (EXP)
linoleic acid metabolic pathway  (IEA)
lornoxicam pharmacodynamics pathway  (EXP)
losartan pharmacokinetics pathway  (IDA)
magnesium salicylate pharmacodynamics pathway  (EXP)
mefenamic acid pharmacodynamics pathway  (EXP)
meloxicam pharmacodynamics pathway  (EXP)
methadone pharmacodynamics pathway  (EXP)
methadone pharmacokinetics pathway  (EXP)
mycophenolic acid pharmacokinetics pathway  (EXP)
nabumetone pharmacodynamics pathway  (EXP)
naproxen pharmacodynamics pathway  (EXP)
paracetamol drug pathway  (EXP)
piroxicam pharmacodynamics pathway  (EXP)
repaglinide pharmacokinetics pathway  (TAS)
retinol metabolic pathway  (IEA)
rosiglitazone pharmacokinetics pathway  (EXP)
salicylic acid pharmacodynamics pathway  (EXP)
sodium salicylate pharmacodynamics pathway  (EXP)
sorafenib pharmacokinetics pathway  (EXP)
statin pharmacokinetics pathway  (TAS)
sulindac pharmacodynamics pathway  (EXP)
tamoxifen pharmacokinetics pathway  (IDA)
tenoxicam pharmacodynamics pathway  (EXP)
tiaprofenic acid pharmacodynamics pathway  (EXP)
tolmetin pharmacodynamics pathway  (EXP)
valdecoxib pharmacodynamics pathway  (EXP)
warfarin pharmacokinetics pathway  (TAS)

References

Additional References at PubMed
PMID:1707679   PMID:2009263   PMID:2216732   PMID:2729895   PMID:3196692   PMID:3500169   PMID:3697070   PMID:7574697   PMID:7704034   PMID:7841444   PMID:8530044   PMID:8870687  
PMID:9586955   PMID:9797707   PMID:9842986   PMID:9890157   PMID:10487415   PMID:10704292   PMID:10768437   PMID:10874126   PMID:11093772   PMID:11668219   PMID:12429347   PMID:12435384  
PMID:12477932   PMID:12756196   PMID:12756206   PMID:12865317   PMID:12920163   PMID:12936704   PMID:14534525   PMID:14559847   PMID:14646690   PMID:14676196   PMID:15028279   PMID:15039299  
PMID:15074466   PMID:15128046   PMID:15289789   PMID:15319333   PMID:15469410   PMID:15469873   PMID:15606441   PMID:15716363   PMID:15766564   PMID:15785959   PMID:15864120   PMID:15901749  
PMID:15933212   PMID:15961978   PMID:16025294   PMID:16141797   PMID:16164496   PMID:16202848   PMID:16253141   PMID:16299241   PMID:16359408   PMID:16372821   PMID:16385451   PMID:16390351  
PMID:16475901   PMID:16538176   PMID:16646575   PMID:16856883   PMID:16957870   PMID:17048007   PMID:17175891   PMID:17178266   PMID:17224914   PMID:17241877   PMID:17373732   PMID:17429317  
PMID:17558302   PMID:17627038   PMID:17635176   PMID:17670841   PMID:17701008   PMID:17913794   PMID:17923851   PMID:17925548   PMID:17975119   PMID:18216720   PMID:18303964   PMID:18413310  
PMID:18496133   PMID:18548238   PMID:18574320   PMID:18594024   PMID:18619574   PMID:18694831   PMID:18779360   PMID:18992346   PMID:19023099   PMID:19064572   PMID:19074885   PMID:19129086  
PMID:19143748   PMID:19290787   PMID:19339270   PMID:19343046   PMID:19381162   PMID:19415824   PMID:19460752   PMID:19470925   PMID:19480553   PMID:19504558   PMID:19651758   PMID:19706858  
PMID:19761371   PMID:19773535   PMID:19833260   PMID:19913121   PMID:19935798   PMID:19954515   PMID:20013305   PMID:20031551   PMID:20136364   PMID:20173083   PMID:20190184   PMID:20212519  
PMID:20214592   PMID:20368717   PMID:20375710   PMID:20379614   PMID:20389299   PMID:20436375   PMID:20437850   PMID:20523106   PMID:20529763   PMID:20602612   PMID:20602615   PMID:20628086  
PMID:20665013   PMID:20808793   PMID:20848147   PMID:20857895   PMID:20890775   PMID:20970553   PMID:21047199   PMID:21054465   PMID:21059750   PMID:21081644   PMID:21163940   PMID:21173785  
PMID:21214863   PMID:21245287   PMID:21270106   PMID:21375401   PMID:21685474   PMID:21697463   PMID:21697548   PMID:21778352   PMID:21791871   PMID:21798861   PMID:21838784   PMID:21873635  
PMID:21977947   PMID:22027337   PMID:22028317   PMID:22028915   PMID:22242967   PMID:22313047   PMID:22339777   PMID:22491019   PMID:22527101   PMID:22542470   PMID:22625877   PMID:22723340  
PMID:23118231   PMID:23171856   PMID:23307233   PMID:23336573   PMID:23413280   PMID:23426382   PMID:23755828   PMID:24057671   PMID:24088129   PMID:24288737   PMID:24430292   PMID:24458713  
PMID:24623479   PMID:24706167   PMID:24816252   PMID:24988984   PMID:25017038   PMID:25160618   PMID:25388680   PMID:25406731   PMID:25560582   PMID:25814554   PMID:25839935   PMID:25947240  
PMID:26115084   PMID:26122864   PMID:26161459   PMID:26252103   PMID:26404779   PMID:26427316   PMID:26489615   PMID:26507668   PMID:26845356   PMID:27087514   PMID:27260150   PMID:27287205  
PMID:27417579   PMID:27736846   PMID:27803446   PMID:28513222   PMID:28653847   PMID:28686288   PMID:28687336   PMID:28990182   PMID:29022765   PMID:29908721   PMID:30520341   PMID:30562214  
PMID:30630815   PMID:30709838   PMID:31540428   PMID:31849280   PMID:32366712   PMID:32814053   PMID:33775687  


Genomics

Comparative Map Data
CYP2C8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1095,036,772 - 95,069,497 (-)EnsemblGRCh38hg38GRCh38
GRCh381095,036,772 - 95,069,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371096,796,529 - 96,829,254 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361096,786,519 - 96,819,244 (-)NCBINCBI36hg18NCBI36
Celera1090,537,664 - 90,570,382 (-)NCBI
Cytogenetic Map10q23.33NCBI
HuRef1090,423,094 - 90,455,810 (-)NCBIHuRef
CHM1_11097,078,287 - 97,111,019 (-)NCBICHM1_1
Cyp2c29
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391939,275,488 - 39,319,157 (+)NCBIGRCm39mm39
GRCm39 Ensembl1939,257,849 - 39,319,157 (+)Ensembl
GRCm381939,287,044 - 39,330,713 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1939,269,405 - 39,330,713 (+)EnsemblGRCm38mm10GRCm38
MGSCv371939,361,575 - 39,405,203 (+)NCBIGRCm37mm9NCBIm37
MGSCv361939,340,415 - 39,384,007 (+)NCBImm8
Celera1940,092,921 - 40,136,495 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1933.91NCBI
Cyp2c79
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01147,236,480 - 147,307,988 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01153,536,125 - 153,596,401 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41244,400,004 - 244,493,624 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11244,496,473 - 244,590,218 (-)NCBI
Celera1234,163,008 - 234,227,113 (+)NCBICelera
Cytogenetic Map1q53NCBI
CYP2C8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11095,153,512 - 95,186,716 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1095,157,661 - 95,186,620 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01091,646,387 - 91,679,998 (-)NCBIMhudiblu_PPA_v0panPan3
CYP2C8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1988,154,131 - 88,183,915 (-)NCBI
ChlSab1.1 Ensembl988,154,134 - 88,183,458 (-)Ensembl
Vero_WHO_p1.0NW_02366604848,950,143 - 48,979,388 (-)NCBI

Position Markers
RH79997  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371096,796,601 - 96,796,765UniSTSGRCh37
Build 361096,786,591 - 96,786,755RGDNCBI36
Celera1090,537,736 - 90,537,900RGD
Cytogenetic Map10q23.33UniSTS
HuRef1090,423,166 - 90,423,330UniSTS
RH69099  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371096,796,719 - 96,796,895UniSTSGRCh37
Build 361096,786,709 - 96,786,885RGDNCBI36
Celera1090,537,854 - 90,538,030RGD
Cytogenetic Map10q23.33UniSTS
HuRef1090,423,284 - 90,423,460UniSTS
GeneMap99-GB4 RH Map10448.63UniSTS
NCBI RH Map101036.4UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR107hsa-miR-107Mirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI22723340
MIR103A1hsa-miR-103a-3pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI22723340

Predicted Target Of
Summary Value
Count of predictions:2409
Count of miRNA genes:754
Interacting mature miRNAs:845
Transcripts:ENST00000371270, ENST00000479946, ENST00000490994, ENST00000525991, ENST00000526814, ENST00000527420, ENST00000527953, ENST00000531714, ENST00000533320, ENST00000535898, ENST00000539050
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 133 133 133
Medium 158 10 426 272 40 273 1 2 182 20 295 9 4
Low 929 1052 1128 142 848 41 1897 422 2960 257 751 1304 102 796 1065
Below cutoff 1265 1817 20 67 833 9 2345 1712 519 99 327 178 66 400 1707 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_007972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001198853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001198854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001198855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH009072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL359672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY392132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY514490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD014119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M21941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M21942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X51535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000371270   ⟹   ENSP00000360317
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1095,036,772 - 95,069,497 (-)Ensembl
RefSeq Acc Id: ENST00000479946
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1095,038,959 - 95,069,497 (-)Ensembl
RefSeq Acc Id: ENST00000490994   ⟹   ENSP00000433314
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1095,036,773 - 95,069,497 (-)Ensembl
RefSeq Acc Id: ENST00000525991   ⟹   ENSP00000433842
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1095,036,984 - 95,069,497 (-)Ensembl
RefSeq Acc Id: ENST00000526814
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1095,036,778 - 95,069,486 (-)Ensembl
RefSeq Acc Id: ENST00000527420   ⟹   ENSP00000433191
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1095,036,773 - 95,069,403 (-)Ensembl
RefSeq Acc Id: ENST00000527953
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1095,036,778 - 95,069,486 (-)Ensembl
RefSeq Acc Id: ENST00000531714
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1095,037,182 - 95,039,375 (-)Ensembl
RefSeq Acc Id: ENST00000533320
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1095,036,802 - 95,069,427 (-)Ensembl
RefSeq Acc Id: ENST00000535898   ⟹   ENSP00000445062
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1095,036,772 - 95,069,497 (-)Ensembl
RefSeq Acc Id: ENST00000539050   ⟹   ENSP00000442343
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1095,036,772 - 95,069,497 (-)Ensembl
RefSeq Acc Id: ENST00000623108   ⟹   ENSP00000485110
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1095,036,772 - 95,069,497 (-)Ensembl
RefSeq Acc Id: ENST00000628935   ⟹   ENSP00000487145
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1095,040,928 - 95,067,430 (-)Ensembl
RefSeq Acc Id: NM_000770   ⟹   NP_000761
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381095,036,772 - 95,069,497 (-)NCBI
GRCh371096,796,529 - 96,829,255 (-)NCBI
Build 361096,786,519 - 96,819,244 (-)NCBI Archive
HuRef1090,423,094 - 90,455,810 (-)ENTREZGENE
CHM1_11097,078,287 - 97,111,019 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001198853   ⟹   NP_001185782
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381095,036,772 - 95,069,497 (-)NCBI
GRCh371096,796,529 - 96,829,255 (-)NCBI
HuRef1090,423,094 - 90,455,810 (-)ENTREZGENE
CHM1_11097,078,287 - 97,111,019 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001198854   ⟹   NP_001185783
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381095,036,772 - 95,069,497 (-)NCBI
GRCh371096,796,529 - 96,829,255 (-)NCBI
HuRef1090,423,094 - 90,455,810 (-)ENTREZGENE
CHM1_11097,078,287 - 97,111,019 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001198855   ⟹   NP_001185784
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381095,036,772 - 95,069,497 (-)NCBI
GRCh371096,796,529 - 96,829,255 (-)NCBI
HuRef1090,423,094 - 90,455,810 (-)ENTREZGENE
CHM1_11097,078,287 - 97,111,019 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_000761   ⟸   NM_000770
- Peptide Label: isoform a precursor
- UniProtKB: P10632 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001185783   ⟸   NM_001198854
- Peptide Label: isoform c
- UniProtKB: P10632 (UniProtKB/Swiss-Prot),   B7Z1F5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001185782   ⟸   NM_001198853
- Peptide Label: isoform b
- UniProtKB: P10632 (UniProtKB/Swiss-Prot),   B7Z1F5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001185784   ⟸   NM_001198855
- Peptide Label: isoform b
- UniProtKB: P10632 (UniProtKB/Swiss-Prot),   B7Z1F5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000360317   ⟸   ENST00000371270
RefSeq Acc Id: ENSP00000433314   ⟸   ENST00000490994
RefSeq Acc Id: ENSP00000485110   ⟸   ENST00000623108
RefSeq Acc Id: ENSP00000445062   ⟸   ENST00000535898
RefSeq Acc Id: ENSP00000487145   ⟸   ENST00000628935
RefSeq Acc Id: ENSP00000442343   ⟸   ENST00000539050
RefSeq Acc Id: ENSP00000433842   ⟸   ENST00000525991
RefSeq Acc Id: ENSP00000433191   ⟸   ENST00000527420

Promoters
RGD ID:7218241
Promoter ID:EPDNEW_H14867
Type:initiation region
Name:CYP2C8_1
Description:cytochrome P450 family 2 subfamily C member 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381095,069,497 - 95,069,557EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
CYP2C8*5 deletion DRUG METABOLISM, ALTERED, CYP2C8-RELATED [RCV000008922] Chr10:95067214 [GRCh38]
Chr10:96826971 [GRCh37]
Chr10:10q23.33
pathogenic
GRCh38/hg38 10q23.33-24.1(chr10:94872737-95346558)x3 copy number gain See cases [RCV000051183] Chr10:94872737..95346558 [GRCh38]
Chr10:96632494..97106315 [GRCh37]
Chr10:96622484..97096305 [NCBI36]
Chr10:10q23.33-24.1
uncertain significance
GRCh38/hg38 10q23.33-24.2(chr10:92626680-97755102)x1 copy number loss See cases [RCV000052564] Chr10:92626680..97755102 [GRCh38]
Chr10:94386437..99514859 [GRCh37]
Chr10:94376417..99504849 [NCBI36]
Chr10:10q23.33-24.2
pathogenic
GRCh38/hg38 10q23.33-24.32(chr10:93181201-101356779)x1 copy number loss See cases [RCV000052565] Chr10:93181201..101356779 [GRCh38]
Chr10:94940958..103116536 [GRCh37]
Chr10:94930948..103106526 [NCBI36]
Chr10:10q23.33-24.32
pathogenic
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3
pathogenic
NM_000770.3(CYP2C8):c.1165G>A (p.Ala389Thr) single nucleotide variant Malignant melanoma [RCV000069104] Chr10:95039023 [GRCh38]
Chr10:96798780 [GRCh37]
Chr10:96788770 [NCBI36]
Chr10:10q23.33
not provided
NM_000770.3(CYP2C8):c.1026G>A (p.Arg342=) single nucleotide variant not provided [RCV000944491] Chr10:95043013 [GRCh38]
Chr10:96802770 [GRCh37]
Chr10:96792760 [NCBI36]
Chr10:10q23.33
likely benign|not provided
NM_000770.3(CYP2C8):c.77G>A (p.Arg26Lys) single nucleotide variant Malignant melanoma [RCV000069106] Chr10:95069326 [GRCh38]
Chr10:96829083 [GRCh37]
Chr10:96819073 [NCBI36]
Chr10:10q23.33
not provided
NM_000770.3(CYP2C8):c.*293G>C single nucleotide variant Lung cancer [RCV000109491] Chr10:95036835 [GRCh38]
Chr10:96796592 [GRCh37]
Chr10:10q23.33
uncertain significance
GRCh38/hg38 10q23.33(chr10:94298267-95267990)x1 copy number loss See cases [RCV000134773] Chr10:94298267..95267990 [GRCh38]
Chr10:96058024..97027747 [GRCh37]
Chr10:96048014..97017737 [NCBI36]
Chr10:10q23.33
uncertain significance
GRCh38/hg38 10q23.33-24.1(chr10:94401557-95444828)x3 copy number gain See cases [RCV000137970] Chr10:94401557..95444828 [GRCh38]
Chr10:96161314..97204585 [GRCh37]
Chr10:96151304..97194575 [NCBI36]
Chr10:10q23.33-24.1
uncertain significance
GRCh38/hg38 10q23.33-24.1(chr10:92643919-95471137)x1 copy number loss See cases [RCV000137919] Chr10:92643919..95471137 [GRCh38]
Chr10:94403676..97230894 [GRCh37]
Chr10:94393656..97220884 [NCBI36]
Chr10:10q23.33-24.1
pathogenic
GRCh38/hg38 10q23.33-24.1(chr10:94376979-95466604)x3 copy number gain See cases [RCV000142079] Chr10:94376979..95466604 [GRCh38]
Chr10:96136736..97226361 [GRCh37]
Chr10:96126726..97216351 [NCBI36]
Chr10:10q23.33-24.1
uncertain significance
CYP2C8*4 single nucleotide variant CYP2C8 POLYMORPHISM [RCV000656545] Chr10:95058362 [GRCh38]
Chr10:96818119 [GRCh37]
Chr10:10q23.33
benign
GRCh37/hg19 10q23.33(chr10:96796795-96805661)x3 copy number gain See cases [RCV000449302] Chr10:96796795..96805661 [GRCh37]
Chr10:10q23.33
likely benign
GRCh37/hg19 10q23.31-24.1(chr10:92667881-98970384)x1 copy number loss See cases [RCV000447362] Chr10:92667881..98970384 [GRCh37]
Chr10:10q23.31-24.1
pathogenic
GRCh37/hg19 10q23.1-25.1(chr10:85557432-105804295)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000431909] Chr10:85557432..105804295 [GRCh37]
Chr10:10q23.1-25.1
pathogenic|drug response
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
NM_000770.3(CYP2C8):c.1196A>G (p.Lys399Arg) single nucleotide variant rosiglitazone response - Metabolism/PK [RCV000660764] Chr10:95038992 [GRCh38]
Chr10:96798749 [GRCh37]
Chr10:10q23.33
drug response
NM_000770.3(CYP2C8):c.168+669A>G single nucleotide variant not specified [RCV000454447] Chr10:95068566 [GRCh38]
Chr10:96828323 [GRCh37]
Chr10:10q23.33
benign
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q23.32-26.3(chr10:93283493-135427143)x3 copy number gain See cases [RCV000510972] Chr10:93283493..135427143 [GRCh37]
Chr10:10q23.32-26.3
pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3
drug response
CYP2C8*2 single nucleotide variant CYP2C8 POLYMORPHISM [RCV000656546] Chr10:95058349 [GRCh38]
Chr10:96818106 [GRCh37]
Chr10:10q23.33
benign
GRCh37/hg19 10q23.32-24.2(chr10:93908171-101809723)x1 copy number loss See cases [RCV000512315] Chr10:93908171..101809723 [GRCh37]
Chr10:10q23.32-24.2
pathogenic
GRCh37/hg19 10q23.33-26.3(chr10:94346520-135427143)x3 copy number gain not provided [RCV000683291] Chr10:94346520..135427143 [GRCh37]
Chr10:10q23.33-26.3
pathogenic
GRCh37/hg19 10q23.33(chr10:96788561-96824975)x3 copy number gain not provided [RCV000749784] Chr10:96788561..96824975 [GRCh37]
Chr10:10q23.33
benign
GRCh37/hg19 10q23.33(chr10:96826827-96870066)x0 copy number loss not provided [RCV000749785] Chr10:96826827..96870066 [GRCh37]
Chr10:10q23.33
benign
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
NM_000770.3(CYP2C8):c.456T>A (p.Leu152=) single nucleotide variant not provided [RCV000944061] Chr10:95067233 [GRCh38]
Chr10:96826990 [GRCh37]
Chr10:10q23.33
likely benign
NM_000770.3(CYP2C8):c.541G>A (p.Val181Ile) single nucleotide variant not provided [RCV000969902] Chr10:95064901 [GRCh38]
Chr10:96824658 [GRCh37]
Chr10:10q23.33
benign
GRCh37/hg19 10q23.33-24.1(chr10:94393383-97219175) copy number loss not provided [RCV000767566] Chr10:94393383..97219175 [GRCh37]
Chr10:10q23.33-24.1
likely pathogenic
GRCh37/hg19 10q23.33-24.1(chr10:96711444-97306336)x3 copy number gain not provided [RCV000849461] Chr10:96711444..97306336 [GRCh37]
Chr10:10q23.33-24.1
uncertain significance
NM_000770.3(CYP2C8):c.1059C>T (p.His353=) single nucleotide variant not provided [RCV000955419] Chr10:95042980 [GRCh38]
Chr10:96802737 [GRCh37]
Chr10:10q23.33
benign
NM_000770.3(CYP2C8):c.1150G>A (p.Gly384Ser) single nucleotide variant not provided [RCV000908979] Chr10:95039038 [GRCh38]
Chr10:96798795 [GRCh37]
Chr10:10q23.33
likely benign
NM_000770.3(CYP2C8):c.1033A>G (p.Met345Val) single nucleotide variant not provided [RCV000994483] Chr10:95043006 [GRCh38]
Chr10:96802763 [GRCh37]
Chr10:10q23.33
uncertain significance
GRCh37/hg19 10q23.33-24.1(chr10:96140621-97222801)x3 copy number gain not provided [RCV001258459] Chr10:96140621..97222801 [GRCh37]
Chr10:10q23.33-24.1
uncertain significance
NM_000770.3(CYP2C8):c.394C>T (p.Arg132Trp) single nucleotide variant not provided [RCV001358021] Chr10:95067295 [GRCh38]
Chr10:96827052 [GRCh37]
Chr10:10q23.33
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2622 AgrOrtholog
COSMIC CYP2C8 COSMIC
Ensembl Genes ENSG00000138115 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000360317 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000433191 UniProtKB/TrEMBL
  ENSP00000433314 UniProtKB/TrEMBL
  ENSP00000433842 UniProtKB/TrEMBL
  ENSP00000445062 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000485110 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000487145 UniProtKB/TrEMBL
Ensembl Transcript ENST00000371270 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000490994 UniProtKB/TrEMBL
  ENST00000525991 UniProtKB/TrEMBL
  ENST00000527420 UniProtKB/TrEMBL
  ENST00000535898 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000623108 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000628935 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000138115 GTEx
HGNC ID HGNC:2622 ENTREZGENE
Human Proteome Map CYP2C8 Human Proteome Map
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1558 UniProtKB/Swiss-Prot
NCBI Gene 1558 ENTREZGENE
OMIM 601129 OMIM
  618018 OMIM
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CYP2C8 RGD, PharmGKB
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0D9SG51_HUMAN UniProtKB/TrEMBL
  B7Z1F5 ENTREZGENE, UniProtKB/TrEMBL
  CP2C8_HUMAN UniProtKB/Swiss-Prot
  E9PIW6_HUMAN UniProtKB/TrEMBL
  E9PLI9_HUMAN UniProtKB/TrEMBL
  G3V188_HUMAN UniProtKB/TrEMBL
  P10632 ENTREZGENE
UniProt Secondary A8K9N8 UniProtKB/Swiss-Prot
  B0AZN2 UniProtKB/Swiss-Prot
  B7Z1F6 UniProtKB/Swiss-Prot
  F5H7Q9 UniProtKB/TrEMBL
  Q5VX93 UniProtKB/Swiss-Prot
  Q8WWB1 UniProtKB/Swiss-Prot
  Q9UCZ9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-15 CYP2C8  cytochrome P450 family 2 subfamily C member 8    cytochrome P450, family 2, subfamily C, polypeptide 8  Symbol and/or name change 5135510 APPROVED