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Gene: CYP2C8 (cytochrome P450 family 2 subfamily C member 8) Homo sapiens
Symbol: CYP2C8
Name: cytochrome P450 family 2 subfamily C member 8
Description: Exhibits caffeine oxidase activity and monooxygenase activity. Involved in several processes, including cellular hormone metabolic process; icosanoid metabolic process; and lipid hydroxylation. Predicted to localize to the cytoplasm and intracellular membrane-bounded organelle. Implicated in end stage renal failure and renal hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CPC8; CYP2C8DM; CYPIIC8; cytochrome P450 2C8; cytochrome P450 form 1; cytochrome P450 IIC2; cytochrome P450 MP-12; cytochrome P450 MP-20; cytochrome P450, family 2, subfamily C, polypeptide 8; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8; flavoprotein-linked monooxygenase; microsomal monooxygenase; MP-12/MP-20; P450 form 1; s-mephenytoin 4-hydroxylase; xenobiotic monooxygenase
Related Pseudogenes: CYP2C56P   CYP2C58P   CYP2C60P   CYP2C61P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381095,036,772 - 95,069,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371096,796,529 - 96,829,255 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361096,786,519 - 96,819,244 (-)NCBINCBI36hg18NCBI36
Celera1090,537,664 - 90,570,382 (-)NCBI
Cytogenetic Map10q23.33NCBI
HuRef1090,423,094 - 90,455,810 (-)NCBIHuRef
CHM1_11097,078,287 - 97,111,019 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CYP2C8
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1606589
Created: 2007-04-29
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.