Plg (plasminogen) - Rat Genome Database

Name: Plg
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Plg (plasminogen) Rattus norvegicus

Analyze

Symbol:

Plg

Name:

plasminogen

RGD ID:

619893

Description:

Exhibits endopeptidase activity and enzyme binding activity. Involved in proteolysis involved in cellular protein catabolic process. Localizes to extracellular space; intracellular membrane-bounded organelle; and plasma membrane. Human ortholog(s) of this gene implicated in COVID-19; conjunctivitis; myocardial infarction; plasminogen deficiency type I; and thrombophilia. Orthologous to several human genes including PLG (plasminogen); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

Ab1-346

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PLG (plasminogen)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Plg (plasminogen)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Plg (plasminogen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100982214 (plasminogen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PLG (plasminogen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Plg (plasminogen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PLG (plasminogen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	PLG (plasminogen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Plg (plasminogen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	LPA (lipoprotein(a))	HGNC	Panther, Treefam
Homo sapiens (human):	PLGLB2 (plasminogen like B2)	HGNC	EggNOG
Alliance orthologs ³
Homo sapiens (human):	PLG (plasminogen)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	LPA (lipoprotein(a))	Alliance	DIOPT (OrthoFinder\|PANTHER\|TreeFam)
Mus musculus (house mouse):	Plg (plasminogen)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	plg (plasminogen)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	1	48,521,828 - 48,563,895 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	48,521,772 - 48,563,776 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	51,192,273 - 51,233,898 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	42,782,464 - 42,825,149 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	42,785,408 - 42,828,097 (-)	NCBI
Celera	1	44,117,228 - 44,159,691 (-)	NCBI		Celera
Cytogenetic Map	1	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (ISO)

Chemical and Drug Induced Liver Injury (ISO)

conjunctivitis (ISO)

COVID-19 (ISO)

cystic fibrosis (ISO)

Experimental Liver Cirrhosis (ISO)

hemorrhagic disease (ISO)

hereditary angioedema (ISO)

Hereditary Angioedema Types I and II (ISO)

hypertension (ISO)

leukocyte disease (ISO)

membranous glomerulonephritis (TAS)

Noonan syndrome (ISO)

osteonecrosis (ISO)

otitis media (ISO)

plasminogen deficiency type I (ISO)

severe acute respiratory syndrome (ISO)

thrombocytopenia (ISO)

thrombophilia (ISO)

Venous Thrombosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-alpha-tocopherol (ISO)

(+)-schisandrin B (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3-chloropropane-1,2-diol (EXP)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-aminohexanoate (ISO)

6-aminohexanoic acid (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

aldosterone (EXP)

amiloride (ISO)

amiodarone (EXP)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

aspartame (ISO)

atrazine (EXP)

belinostat (ISO)

benazepril (ISO)

benzbromarone (EXP)

benzene (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

cadmium dichloride (EXP)

caffeine (EXP)

camostat (EXP)

carbon nanotube (ISO)

choline (ISO)

cisplatin (EXP,ISO)

clofibrate (EXP,ISO)

cobalt dichloride (EXP)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

cylindrospermopsin (ISO)

cytarabine (ISO)

dexamethasone (EXP)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

diisopropyl fluorophosphate (ISO)

dioxygen (ISO)

doxorubicin (EXP)

entinostat (ISO)

Ethyl icosapentate (EXP)

ethylenediaminetetraacetic acid (ISO)

folic acid (ISO)

furan (EXP)

genistein (EXP)

gestodene (ISO)

Goe 6976 (ISO)

heparin (ISO)

L-ascorbic acid (ISO)

L-ethionine (EXP)

L-methionine (ISO)

Lasiocarpine (ISO)

lead diacetate (EXP)

levonorgestrel (ISO)

medroxyprogesterone acetate (ISO)

methapyrilene (ISO)

methimazole (EXP)

morphine (ISO)

N-Nitrosopyrrolidine (ISO)

nefazodone (EXP)

nickel atom (ISO)

nickel dichloride (EXP)

nitroprusside (EXP)

norethisterone (ISO)

norgestimate (ISO)

O-methyleugenol (ISO)

omeprazole (EXP)

paracetamol (ISO)

perfluorononanoic acid (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (EXP,ISO)

potassium dichromate (ISO)

roxarsone (ISO)

selenomethionine (ISO)

sodium arsenite (EXP,ISO)

sodium dichromate (EXP)

sodium fluoride (ISO)

tamoxifen (ISO)

tetrachloromethane (EXP,ISO)

tetracycline (ISO)

tetraethyllead (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

triclosan (ISO)

Triptolide (EXP)

urethane (ISO)

valproic acid (ISO)

vitamin E (ISO)

vorinostat (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological process involved in interaction with symbiont (ISO)

blood coagulation (IEA,ISO)

extracellular matrix disassembly (ISO)

fibrinolysis (IEA,ISO)

labyrinthine layer blood vessel development (ISO)

mononuclear cell migration (ISO)

muscle cell cellular homeostasis (ISO)

myoblast differentiation (ISO)

negative regulation of cell-substrate adhesion (ISO)

negative regulation of fibrinolysis (ISO)

positive regulation of blood vessel endothelial cell migration (ISO)

positive regulation of fibrinolysis (ISO)

proteolysis (IEA,ISO)

proteolysis involved in cellular protein catabolic process (IDA)

tissue regeneration (ISO)

tissue remodeling (IEA)

trans-synaptic signaling by BDNF, modulating synaptic transmission (ISO)

trophoblast giant cell differentiation (ISO)

Cellular Component

cell surface (ISO)

extracellular region (IEA)

extracellular space (IDA,ISO)

extrinsic component of external side of plasma membrane (ISO)

extrinsic component of plasma membrane (ISO)

glutamatergic synapse (ISO)

integral component of membrane (IEA)

intracellular membrane-bounded organelle (IDA)

plasma membrane (IDA)

Schaffer collateral - CA1 synapse (ISO)

Molecular Function

apolipoprotein binding (ISO)

chaperone binding (ISO)

endopeptidase activity (IDA,ISO)

enzyme binding (IPI,ISO)

kinase binding (ISO)

protein antigen binding (ISO)

protein binding (ISO)

protein domain specific binding (ISO)

serine-type endopeptidase activity (IBA,IEA,ISO)

signaling receptor binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acenocoumarol pharmacodynamics pathway (ISO)

alteplase pharmacodynamics pathway (ISO)

aminocaproic acid pharmacodynamics pathway (ISO)

anistreplase pharmacodynamics pathway (ISO)

aprotinin pharmacodynamics pathway (ISO)

argatroban pharmacodynamics pathway (ISO)

bivalirudin pharmacodynamics pathway (ISO)

coagulation cascade pathway (IEA)

complement system pathway (IEA)

dicoumarol pharmacodynamics pathway (ISO)

enoxaparin pharmacodynamics pathway (ISO)

fibrinolysis pathway (ISO)

fondaparinux pharmacodynamics pathway (ISO)

heparin pharmacodynamics pathway (ISO)

influenza A pathway (IEA)

phenindione pharmacodynamics pathway (ISO)

reteplase pharmacodynamics pathway (ISO)

Staphylococcus aureus infection pathway (IEA)

syndecan signaling pathway (ISO)

tranexamic acid pharmacodynamics pathway (ISO)

warfarin pharmacodynamics pathway (ISO)

References

References - curated


1.	Azuma H, etal., Blood. 1993 Jul 15;82(2):475-80.
2.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	GOA data from the GO Consortium
4.	Gralinski LE, etal., mBio. 2013 Aug 6;4(4). pii: mBio.00271-13. doi: 10.1128/mBio.00271-13.
5.	Heinemann FS, etal., J Biol Chem 2003 Oct 31;278(44):42966-75. Epub 2003 Aug 19.
6.	Kanalas JJ Am J Physiol. 1995 Feb;268(2 Pt 1):C442-8.
7.	Kanalas JJ and Makker SP, J Biol Chem 1991 Jun 15;266(17):10825-9.
8.	Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
9.	Mehta P and Parker RI, J Pediatr Hematol Oncol. 2010 Oct;32(7):532-6. doi: 10.1097/MPH.0b013e3181e0d152.
10.	MGD data from the GO Consortium
11.	Min KJ, etal., Biochem Biophys Res Commun 2003 Dec 26;312(4):969-74.
12.	Nakajima K, etal., J Neurochem. 1994 Dec;63(6):2048-57.
13.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
14.	Nezi L, etal., Biol Chem 2002 Jan;383(1):167-76.
15.	Okumura N, etal., J Biol Chem. 2009 Jun 12;284(24):16553-61. doi: 10.1074/jbc.M109.011452. Epub 2009 Apr 22.
16.	OMIM Disease Annotation Pipeline
17.	Pipeline to import KEGG annotations from KEGG into RGD
18.	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19.	Pipeline to import SMPDB annotations from SMPDB into RGD
20.	RGD automated data pipeline
21.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22.	RGD automated import pipeline for gene-chemical interactions
23.	Schuster V, etal., Blood. 1997 Aug 1;90(3):958-66.
24.	Sun W, etal., Int Orthop. 2006 Jun;30(3):143-6. doi: 10.1007/s00264-005-0067-6. Epub 2006 Mar 18.
25.	Sun W, etal., Zhonghua Yi Xue Za Zhi. 2006 Feb 21;86(7):442-5.
26.	Wu Y, etal., QJM. 2020 Apr 10. pii: 5818885. doi: 10.1093/qjmed/hcaa121.

Additional References at PubMed

PMID:1986355	PMID:6216475	PMID:6438154	PMID:6980881	PMID:9603964	PMID:9786936	PMID:11929773	PMID:12477932	PMID:12666133	PMID:12818429	PMID:12867553	PMID:12900459
PMID:14688145	PMID:14699093	PMID:14726399	PMID:15486301	PMID:16480936	PMID:16502470	PMID:17307854	PMID:17574586	PMID:17587687	PMID:17663741	PMID:17690254	PMID:17849409
PMID:17892475	PMID:17940541	PMID:17964283	PMID:18070902	PMID:18971211	PMID:18981180	PMID:19199708	PMID:19270100	PMID:19433310	PMID:19574304	PMID:19932587	PMID:20028034
PMID:20727989	PMID:21106936	PMID:22025510	PMID:22087329	PMID:22516433	PMID:22619171	PMID:23376485	PMID:23533145	PMID:24196407	PMID:25931508	PMID:26667841	PMID:29767556

Genomics

Comparative Map Data

Plg
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	1	48,521,828 - 48,563,895 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	48,521,772 - 48,563,776 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	51,192,273 - 51,233,898 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	42,782,464 - 42,825,149 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	42,785,408 - 42,828,097 (-)	NCBI
Celera	1	44,117,228 - 44,159,691 (-)	NCBI		Celera
Cytogenetic Map	1	q11	NCBI

PLG
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	6	160,702,238 - 160,753,315 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p13 Ensembl	6	160,702,238 - 160,754,097 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	6	160,702,193 - 160,754,097 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	6	161,123,225 - 161,175,086 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	161,043,273 - 161,094,328 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	6	161,093,693 - 161,144,749	NCBI
Celera	6	161,842,077 - 161,894,063 (+)	NCBI
Cytogenetic Map	6	q26	NCBI
HuRef	6	158,568,041 - 158,620,052 (+)	NCBI		HuRef
CHM1_1	6	161,385,876 - 161,437,750 (+)	NCBI		CHM1_1

Plg
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	12,597,496 - 12,638,271 (+)	NCBI	GRCm39		mm39
GRCm38	17	12,378,609 - 12,419,384 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	12,378,608 - 12,419,385 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	12,571,475 - 12,612,250 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	17	12,221,966 - 12,262,743 (+)	NCBI			mm8
Celera	17	12,409,327 - 12,450,146 (+)	NCBI		Celera
Cytogenetic Map	17	A1	NCBI
cM Map	17	8.5	NCBI

Plg
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955439	20,317,552 - 20,366,475 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955439	20,317,814 - 20,366,724 (+)	NCBI	ChiLan1.0	ChiLan1.0

LOC100982214
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	6	163,674,142 - 163,722,630 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	163,673,464 - 163,736,777 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	6	158,662,192 - 158,713,413 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

PLG
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	1	49,497,229 - 49,535,260 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	1	49,497,229 - 49,535,260 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Plg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936489	11,775,243 - 11,808,482 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PLG
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	7,061,191 - 7,110,555 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	7,062,399 - 7,109,521 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	8,740,127 - 8,787,546 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PLG
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	88,266,054 - 88,321,596 (+)	NCBI
ChlSab1.1 Ensembl	13	88,268,198 - 88,322,644 (+)	Ensembl

Plg
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624855	2,362,793 - 2,401,519 (+)	NCBI

Position Markers

D1Got60

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	1	48,523,187 - 48,523,365	NCBI	Rnor6.0
Rnor_5.0	1	51,232,363 - 51,232,541	UniSTS	Rnor5.0
RGSC_v3.4	1	42,783,820 - 42,783,999	RGD	RGSC3.4
RGSC_v3.4	1	42,783,821 - 42,783,999	UniSTS	RGSC3.4
RGSC_v3.1	1	42,786,766 - 42,786,944	RGD
Cytogenetic Map	1	q11	UniSTS
RH 3.4 Map	1	571.4	RGD
RH 3.4 Map	1	571.4	UniSTS
RH 2.0 Map	1	287.6	RGD

D1Got55

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	1	48,559,338 - 48,559,576	NCBI	Rnor6.0
Rnor_5.0	1	51,196,456 - 51,196,694	UniSTS	Rnor5.0
RGSC_v3.4	1	42,820,197 - 42,820,436	RGD	RGSC3.4
RGSC_v3.4	1	42,820,198 - 42,820,436	UniSTS	RGSC3.4
RGSC_v3.1	1	42,823,142 - 42,823,381	RGD
Celera	1	44,154,461 - 44,154,703	UniSTS
Cytogenetic Map	1	q11	UniSTS
RH 2.0 Map	1	302.6	RGD

RH131691

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	1	48,521,889 - 48,522,080	NCBI	Rnor6.0
Rnor_5.0	1	51,233,648 - 51,233,839	UniSTS	Rnor5.0
RGSC_v3.4	1	42,782,523 - 42,782,714	UniSTS	RGSC3.4
Celera	1	44,117,287 - 44,117,478	UniSTS
Cytogenetic Map	1	q11	UniSTS
RH 3.4 Map	1	571.4	UniSTS

RH128566

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	1	48,565,047 - 48,565,230	NCBI	Rnor6.0
Rnor_5.0	1	51,190,802 - 51,190,985	UniSTS	Rnor5.0
RGSC_v3.4	1	42,826,437 - 42,826,620	UniSTS	RGSC3.4
Celera	1	44,160,979 - 44,161,162	UniSTS
Cytogenetic Map	1	q11	UniSTS
Cytogenetic Map	3	q36	UniSTS
RH 3.4 Map	1	585.3	UniSTS

D1Bda1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	3	117,525,088 - 117,525,289	NCBI	Rnor6.0
Rnor_6.0	1	48,565,014 - 48,565,215	NCBI	Rnor6.0
Rnor_5.0	3	124,048,806 - 124,049,007	UniSTS	Rnor5.0
Rnor_5.0	1	51,190,817 - 51,191,018	UniSTS	Rnor5.0
RGSC_v3.4	3	112,562,078 - 112,562,279	UniSTS	RGSC3.4
RGSC_v3.4	1	42,826,404 - 42,826,605	UniSTS	RGSC3.4
Celera	3	111,366,080 - 111,366,281	UniSTS
Celera	1	44,160,946 - 44,161,147	UniSTS
Cytogenetic Map	1	q11	UniSTS
Cytogenetic Map	3	q36	UniSTS

Plg

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	1	48,521,855 - 48,522,097	NCBI	Rnor6.0
Rnor_5.0	1	51,233,631 - 51,233,873	UniSTS	Rnor5.0
RGSC_v3.4	1	42,782,489 - 42,782,731	UniSTS	RGSC3.4
Celera	1	44,117,253 - 44,117,495	UniSTS
Cytogenetic Map	1	q11	UniSTS

UniSTS:498273

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	1	48,521,858 - 48,522,219	NCBI	Rnor6.0
Rnor_5.0	1	51,233,509 - 51,233,870	UniSTS	Rnor5.0
RGSC_v3.4	1	42,782,492 - 42,782,853	UniSTS	RGSC3.4
Celera	1	44,117,256 - 44,117,617	UniSTS
Cytogenetic Map	1	q11	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738020	Pia8	Pristane induced arthritis QTL 8	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	1	64407321	Rat
1554320	Bmd1	Bone mineral density QTL 1	12.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	254393	86904217	Rat
7421626	Bp360	Blood pressure QTL 360		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	4578693	49578693	Rat
631688	Hcas2	Hepatocarcinoma susceptibility QTL 2	3	0.0001	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	5655769	122614963	Rat
4889451	Eae29	Experimental allergic encephalomyelitis QTL 29	5.51		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	1	5655772	85706974	Rat
1300167	Hrtrt2	Heart rate QTL 2	4.35		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	11314489	75844121	Rat
2313062	Bmd73	Bone mineral density QTL 73	3.9	0.0001	tibia mineral mass (VT:1000283)	cortical volumetric bone mineral density (CMO:0001730)	1	11314489	83657083	Rat
2313065	Bss67	Bone structure and strength QTL 67	3.1	0.0001	tibia area (VT:1000281)	tibia total energy absorbed before break (CMO:0001736)	1	11314489	83657083	Rat
2313069	Bss68	Bone structure and strength QTL 68	2.9	0.0001	tibia size trait (VT:0100001)	tibia total energy absorbed before break (CMO:0001736)	1	11314489	83657083	Rat
2313075	Bss66	Bone structure and strength QTL 66	3.4	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	11314489	83657083	Rat
2313077	Bss69	Bone structure and strength QTL 69	3.5	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	11314489	83657083	Rat
2313092	Bmd72	Bone mineral density QTL 72	2.5	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	11314489	83657083	Rat
2313097	Bss70	Bone structure and strength QTL 70	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	11314489	83657083	Rat
631508	Sald1	Serum aldosterone level QTL 1	3.7		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	1	12493439	57493439	Rat
2302038	Pia31	Pristane induced arthritis QTL 31	5.5	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	1	13629251	58629251	Rat
5684998	Bss101	Bone structure and strength QTL 101	3.6		tibia strength trait (VT:1000284)	tibia ultimate force (CMO:0001734)	1	16143143	49547474	Rat
5684999	Bss102	Bone structure and strength QTL 102	5.5	0.00000072	tibia strength trait (VT:1000284)	tibia stiffness (CMO:0001735)	1	16143143	49547474	Rat
634353	Rends2	Renal damage susceptibility QTL 2		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	1	20341560	58000154	Rat
724520	Bp145	Blood pressure QTL 145	2.1	0.0024	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	21079305	66079305	Rat
631494	Bp95	Blood pressure QTL 95	40	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	21300822	49454378	Rat
1357397	Bw41	Body weight QTL 41	4.19	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	1	23406428	49547474	Rat
1357401	Bw43	Body weight QTL 43	3.75		body mass (VT:0001259)	body weight (CMO:0000012)	1	23406428	49547474	Rat
1357400	Bw62	Body weight QTL62	4.05		inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	1	23406428	68406428	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	23406428	108057505	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	24297799	78748000	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	25951907	130917265	Rat
1331785	Rf27	Renal function QTL 27	4.643		urine sodium amount (VT:0006274)	urine sodium level (CMO:0000129)	1	31489454	79689689	Rat
1354643	Foco2	Food consumption QTL 2	7.17	0.0001	eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	1	34449112	79449112	Rat
1354599	Bw29	Body weight QTL 29	3.46	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	1	34449112	79449112	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34993530	173445086	Rat
1300172	Bp172	Blood pressure QTL 172	3.56		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	35377508	94364229	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	35377692	217372257	Rat
9589820	Insglur3	Insulin/glucose ratio QTL 3	10.75	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	1	35854167	80854167	Rat
8552900	Pigfal1	Plasma insulin-like growth factor 1 level QTL 1	7.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	35854167	80854167	Rat
8552948	Pigfal11	Plasma insulin-like growth factor 1 level QTL 11	4.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	35854167	80854167	Rat
1331732	Srn4	Serum renin concentration QTL 4	4.467		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	1	36033165	79689689	Rat
1331792	Rf29	Renal function QTL 29	4.589		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	1	36033165	79689689	Rat
2302059	Pia36	Pristane induced arthritis QTL 36	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	41907249	86907249	Rat
2313051	Bss57	Bone structure and strength QTL 57	3.7	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	43579208	126240667	Rat
2313059	Bss55	Bone structure and strength QTL 55	3.2	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	1	43579208	126240667	Rat
2313072	Bss53	Bone structure and strength QTL 53	4.3	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	43579208	126240667	Rat
2313078	Bss54	Bone structure and strength QTL 54	3.5	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	1	43579208	126240667	Rat
2313094	Bss58	Bone structure and strength QTL 58	3.7	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	43579208	126240667	Rat
2313098	Bmd70	Bone mineral density QTL 70	3.6	0.0001	tibia mineral mass (VT:1000283)	cortical volumetric bone mineral density (CMO:0001730)	1	43579208	126240667	Rat
2313099	Bss56	Bone structure and strength QTL 56	2.4	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	1	43579208	126240667	Rat
1331778	Rf28	Renal function QTL 28	4.66		urine potassium amount (VT:0010539)	urine potassium excretion rate (CMO:0000761)	1	46113461	79689689	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	37
Count of miRNA genes:	37
Interacting mature miRNAs:	37
Transcripts:	ENSRNOT00000023368
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High			25	25		25
Medium	1		18	16		16					2	1
Low		32	14		15		6	6	13	13	32	9	6
Below cutoff	2	11			4		2	5	61	19	7	1	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053491	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017589803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AABR07001509	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AABR07001510	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AABR07001511	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AABR07001512	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01002940	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01002941	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01002942	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01002943	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ242649	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY325159	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC091135	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474059	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ209864	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210878	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218248	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218353	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218358	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M62832	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000023368 ⟹ ENSRNOP00000023370

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	1	48,521,772 - 48,563,776 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000080352 ⟹ ENSRNOP00000073928

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	1	48,527,786 - 48,559,162 (-)	Ensembl

RefSeq Acc Id:

NM_053491 ⟹ NP_445943

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	48,521,830 - 48,563,759 (-)	NCBI
Rnor_5.0	1	51,192,273 - 51,233,898 (+)	NCBI
RGSC_v3.4	1	42,782,464 - 42,825,149 (-)	RGD
Celera	1	44,117,228 - 44,159,691 (-)	RGD

Sequence:

show sequence

GGACACAGTTGTCCAGGTGCTGTTGGCCAGTCCCAACATGGACCATAAGGAAATAATCCTTCTG
TTTCTCTTGTTTCTGAAACCAGGACAAGGGGACTCACTGGATGGCTATGTAAGCACACAGGGGG
CTTCACTGCATAGCCTCACCAAGAAGCAGCTAGCGGCAGGAAGCATAGCAGACTGTTTGGCCAA
ATGTGAAGGGGAAACAGACTTCATCTGCAGGTCATTCCAGTACCACAGCAAAGAGCAGCAGTGC
GTGATCATGGCCGAGAACAGCAAGACTTCCTCCATCATCCGGATGAGAGATGTCATCTTATTCG
AAAAGAGAGTGTATCTGTCAGAGTGTAAGACTGGCATCGGCAAGGGCTACAGAGGAACCATGTC
CAAGACAAAGACTGGTGTTACCTGTCAAAAGTGGAGTGACACGTCCCCCCACGTACCCAAATAC
TCCCCCAGCACACACCCCAGCGAGGGACTAGAGGAGAACTACTGTAGGAACCCAGACAATGATG
AACAAGGGCCCTGGTGCTACACAACAGACCCGGACCAGAGATATGAGTACTGCAACATCCCCGA
ATGCGAAGAGGAATGCATGTACTGCAGTGGAGAAAAGTACGAGGGCAAAATCTCCAAGACCATG
TCTGGACTCGACTGCCAGTCCTGGGATTCTCAGAGCCCACATGCTCACGGATACATCCCTGCCA
AATTTCCAAGCAAGAACTTGAAGATGAATTACTGTCGCAACCCTGACGGGGAGCCGCGGCCCTG
GTGCTTCACCACAGACCCCAACAAACGCTGGGAATACTGTGACATCCCCCGCTGCACAACACCC
CCACCCCCACCGGGCCCAACCTACCAATGTCTGAAGGGGAGAGGTGAAAATTACCGAGGGACCG
TGTCTGTCACTGCGTCTGGGAAAACCTGTCAGCGCTGGAGTGAGCAAACACCTCATAGGCACAA
CAGGACGCCAGAAAACTTCCCCTGCAAAAATCTGGAAGAGAACTACTGCCGGAACCCAGATGGA
GAAACTGCTCCCTGGTGCTATACCACTGACAGCCAGCTGAGGTGGGAGTACTGTGAGATTCCGT
CCTGCGGGTCCTCGGTATCACCAGACCAGTCAGATTCCTCAGTTCTTCCGGAGCAAACACCTGT
GGTCCAGGAGTGCTACCAGGGCAATGGAAAGAGCTATCGGGGCACATCGTCCACTACCAACACA
GGGAAGAAGTGCCAGTCCTGGGTATCTATGACTCCACATAGTCACTCGAAGACCCCAGCGAACT
TCCCAGATGCTGGCTTGGAGATGAACTACTGCAGGAACCCAGATAATGACCAGAGGGGCCCTTG
GTGCTTCACCACTGACCCGAGCGTCAGGTGGGAATACTGCAACCTGAAGCGGTGCTCGGAGACA
GGAGGGGGTGTTGCGGAATCAGCCATAGTCCCCCAAGTTCCCAGTGCGCCAGGCACCTCTGAGA
CAGACTGCATGTATGGGAATGGCAAAGAATATCGGGGCAAAACGGCCGTCACTGCAGCTGGAAC
CCCCTGCCAGGAATGGGCTGCCCAGGAGCCCCACAGTCACAGAATCTTCACCCCACAGACAAAC
CCACGGGCAGGTCTGGAAAAGAATTACTGCCGAAACCCGGATGGGGATGTCAATGGGCCCTGGT
GCTATACAATGAACCCCAGAAAACTTTACGACTATTGTAACATTCCCCTTTGTGCATCATTATC
GTCCTTTGAATGTGGGAAGCCTCAGGTGGAGCCGAAGAAATGCCCTGGGAGGGTGGTGGGTGGC
TGTGTGGCCAACCCTCACTCCTGGCCCTGGCAAATCAGCCTTAGAACAAGATTTTCTGGACAGC
ACTTCTGTGGCGGTACTTTAATATCCCCAGAGTGGGTGCTGACTGCCGCTCACTGCTTGGAGAA
ATCTTCGAGACCTGAATTCTACAAGGTTATCCTGGGAGCACACGAAGAACGAATCCTTGGGTCA
GATGTTCAGCAAATAGCAGTAACCAAACTGGTCTTGGAACCCAACGACGCTGACATTGCCCTGC
TGAAGCTAAGCCGCCCAGCCACCATCACAGATAATGTCATCCCAGCTTGTCTGCCATCTCCAAA
TTATGTGGTTGCCGACCGGACACTGTGTTACATCACCGGCTGGGGAGAAACGAAAGGGACTCCA
GGTGCCGGCCGTCTCAAGGAGGCCCAGCTGCCCGTGATCGAGAACAAGGTGTGCAACCGCGCTG
AGTATCTAAACAACAGAGTCAAATCCACCGAGCTCTGTGCCGGGCATCTGGCTGGTGGCATCGA
CAGTTGCCAGGGCGACAGTGGAGGACCTCTGGTTTGCTTCGAGAAGGACAAGTATATTTTACAA
GGAGTCACTTCTTGGGGTCTTGGCTGTGCTCGCCCCAATAAGCCTGGTGTCTATGTTCGTGTTT
CCCGGTACGTTAATTGGATTGAAAGGGAGATGAGGAATGACTAATTGGGTGGGAGGCAGAACAA
AACTACTAAATATGGGGAGGGGATTAGGGCGCTTGAAAAAAAACCTGACAGCAATCAAACCAAA
GACACTACACTGGACCACTACTTCCTGTCACCCCTCAGCTCCTCCCTCTTTTTGTATTATTGTG
GGTAAAATTTTCCTGTCCCTGGACTTCTGGATTTTGTGACAATAGACCATCACTTCTGTGACCT
TTGTTGAAAATAAACTCGATACTTACTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_017589803 ⟹ XP_017445292

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	48,521,828 - 48,563,895 (-)	NCBI

Sequence:

show sequence

TTTTGTAAGCTCCCTGTTCGAGGTAATGTTTGCTCCTTCTGTGTATGGTGGCAGGGGGCCCAGA
CAATGATTAACCTCATCAGACTACCTTGCTTGCGGATGCCTTTGCTCCCCTTTAAGTCAACACC
TGGGACTGGGACACAGTTGTCCAGGTGCTGTTGGCCAGTCCCAACATGGACCATAAGGAAATAA
TCCTTCTGTTTCTCTTGTTTCTGAAACCAGGACAAGGGGACTCACTGGATGGCTATGTAAGCAC
ACAGGGGGCTTCACTGCATAGCCTCACCAAGAAGCAGCTAGCGGCAGGAAGCATAGCAGACTGT
TTGGCCAAATGTGAAGGGGAAACAGACTTCATCTGCAGGTCATTCCAGTACCACAGCAAAGAGC
AGCAGTGCGTGATCATGGCCGAGAACAGCAAGACTTCCTCCATCATCCGGATGAGAGATGTCAT
CTTATTCGAAAAGAGAGTGTATCTGTCAGAGTGTAAGACTGGCATCGGCAAGGGCTACAGAGGA
ACCATGTCCAAGACAAAGACTGGTGTTACCTGTCAAAAGTGGAGTGACACGTCCCCCCACGTAC
CCAAATACTCCCCCAGCACACACCCCAGCGAGGGACTAGAGGAGAACTACTGTAGGAACCCAGA
CAATGATGAACAAGGGCCCTGGTGCTACACAACAGACCCGGACCAGAGATATGAGTACTGCAAC
ATCCCCGAATGCGAAGAGGAATGCATGTACTGCAGTGGAGAAAAGTACGAGGGCAAAATCTCCA
AGACCATGTCTGGACTCGACTGCCAGTCCTGGGATTCTCAGAGCCCACATGCTCACGGATACAT
CCCTGCCAAATTTCCAAGCAAGAACTTGAAGATGAATTACTGTCGCAACCCTGACGGGGAGCCG
CGGCCCTGGTGCTTCACCACAGACCCCAACAAACGCTGGGAATACTGTGACATCCCCCGCTGCA
CTATTGTGGTTGTCATTATTGTCATCATCGTCATCATCATCTTCATCTTCATCATCTTCATCTT
CATCATCATCATCTTCATCATCATGATGCCACTACCACTTAAGGGGAGCAGTCTGGGGAGAGGT
GAAAATTACCGAGGGACCGTGTCTGTCACTGCGTCTGGGAAAACCTGTCAGCGCTGGAGTGAGC
AAACACCTCATAGGCACAACAGGACGCCAGAAAACTTCCCCTGCAAAAATCTGGAAGAGAACTA
CTGCCGGAACCCAGATGGAGAAACTGCTCCCTGGTGCTATACCACTGACAGCCAGCTGAGGTGG
GAGTACTGTGAGATTCCGTCCTGCGGGTCCTCGGTATCACCAGACCAGTCAGATTCCTCAGTTC
TTCCGGAGCAAACACCTGTGGTCCAGGAGTGCTACCAGGGCAATGGAAAGAGCTATCGGGGCAC
ATCGTCCACTACCAACACAGGGAAGAAGTGCCAGTCCTGGGTATCTATGACTCCACATAGTCAC
TCGAAGACCCCAGCGAACTTCCCAGATGCTTACCAGAACCTCCTCATACAGCACTGGCGACCAA
GTGTTTACTACATGAGCCTGTGGGAGACATTTCTGATTCACACCCACAACCAGAAGTACAGCGT
ATTTCAACTGAAAGAAAGCAGTGGCTTGGAGATGAACTACTGCAGGAACCCAGATAATGACCAG
AGGGGCCCTTGGTGCTTCACCACTGACCCGAGCGTCAGGTGGGAATACTGCAACCTGAAGCGGT
GCTCGGAGACAGGAGGGGGTGTTGCGGAATCAGCCATAGTCCCCCAAGTTCCCAGTGCGCCAGG
CACCTCTGAGACAGACTGCATGTATGGGAATGGCAAAGAATATCGGGGCAAAACGGCCGTCACT
GCAGCTGGAACCCCCTGCCAGGAATGGGCTGCCCAGGAGCCCCACAGTCACAGAATCTTCACCC
CACAGACAAACCCACGGGCAGGTCTGGAAAAGAATTACTGCCGAAACCCGGATGGGGATGTCAA
TGGGCCCTGGTGCTATACAATGAACCCCAGAAAACTTTACGACTATTGTAACATTCCCCTTTGT
GCATCATTATCGTCCTTTGAATGTGGGAAGCCTCAGGTGGAGCCGAAGAAATGCCCTGGGAGGG
TGGTGGGTGGCTGTGTGGCCAACCCTCACTCCTGGCCCTGGCAAATCAGCCTTAGAACAAGATT
TTCTGGACAGCACTTCTGTGGCGGTACTTTAATATCCCCAGAGTGGGTGCTGACTGCCGCTCAC
TGCTTGGAGAAATCTTCGAGACCTGAATTCTACAAGGTTATCCTGGGAGCACACGAAGAACGAA
TCCTTGGGTCAGATGTTCAGCAAATAGCAGTAACCAAACTGGTCTTGGAACCCAACGACGCTGA
CATTGCCCTGCTGAAGCTAAGCCGCCCAGCCACCATCACAGATAATGTCATCCCAGCTTGTCTG
CCATCTCCAAATTATGTGGTTGCCGACCGGACACTGTGTTACATCACCGGCTGGGGAGAAACGA
AAGGGACTCCAGGTGCCGGCCGTCTCAAGGAGGCCCAGCTGCCCGTGATCGAGAACAAGGTGTG
CAACCGCGCTGAGTATCTAAACAACAGAGTCAAATCCACCGAGCTCTGTGCCGGGCATCTGGCT
GGTGGCATCGACAGTTGCCAGGGCGACAGTGGAGGACCTCTGGTTTGCTTCGAGAAGGACAAGT
ATATTTTACAAGGAGTCACTTCTTGGGGTCTTGGCTGTGCTCGCCCCAATAAGCCTGGTGTCTA
TGTTCGTGTTTCCCGGTACGTTAATTGGATTGAAAGGGAGATGAGGAATGACTAATTGGGTGGG
AGGCAGAACAAAACTACTAAATATGGGGAGGGGATTAGGGCGCTTGAAAAAAAACCTGACAGCA
ATCAAACCAAAGACACTACACTGGACCACTACTTCCTGTCACCCCTCAGCTCCTCCCTCTTTTT
GTATTATTGTGGGTAAAATTTTCCTGTCCCTGGACTTCTGGATTTTGTGACAATAGACCATCAC
TTCTGTGACCTTTGTTGAAAATAAACTCGATACTTACTTTGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_445943	(Get FASTA)	NCBI Sequence Viewer
	XP_017445292	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41884	(Get FASTA)	NCBI Sequence Viewer
	AAH91135	(Get FASTA)	NCBI Sequence Viewer
	AAP92560	(Get FASTA)	NCBI Sequence Viewer
	CAB46014	(Get FASTA)	NCBI Sequence Viewer
	EDL83065	(Get FASTA)	NCBI Sequence Viewer
	EDL83066	(Get FASTA)	NCBI Sequence Viewer
	EDL83067	(Get FASTA)	NCBI Sequence Viewer
	EDL83068	(Get FASTA)	NCBI Sequence Viewer
	EDL83069	(Get FASTA)	NCBI Sequence Viewer
	EDL83070	(Get FASTA)	NCBI Sequence Viewer
	EDL83071	(Get FASTA)	NCBI Sequence Viewer
	EDL83072	(Get FASTA)	NCBI Sequence Viewer
	EDL83073	(Get FASTA)	NCBI Sequence Viewer
	EDL83074	(Get FASTA)	NCBI Sequence Viewer
	Q01177	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_445943 ⟸ NM_053491
- Peptide Label:	precursor
- UniProtKB:	Q01177 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MDHKEIILLFLLFLKPGQGDSLDGYVSTQGASLHSLTKKQLAAGSIADCLAKCEGETDFICRSF QYHSKEQQCVIMAENSKTSSIIRMRDVILFEKRVYLSECKTGIGKGYRGTMSKTKTGVTCQKWS DTSPHVPKYSPSTHPSEGLEENYCRNPDNDEQGPWCYTTDPDQRYEYCNIPECEEECMYCSGEK YEGKISKTMSGLDCQSWDSQSPHAHGYIPAKFPSKNLKMNYCRNPDGEPRPWCFTTDPNKRWEY CDIPRCTTPPPPPGPTYQCLKGRGENYRGTVSVTASGKTCQRWSEQTPHRHNRTPENFPCKNLE ENYCRNPDGETAPWCYTTDSQLRWEYCEIPSCGSSVSPDQSDSSVLPEQTPVVQECYQGNGKSY RGTSSTTNTGKKCQSWVSMTPHSHSKTPANFPDAGLEMNYCRNPDNDQRGPWCFTTDPSVRWEY CNLKRCSETGGGVAESAIVPQVPSAPGTSETDCMYGNGKEYRGKTAVTAAGTPCQEWAAQEPHS HRIFTPQTNPRAGLEKNYCRNPDGDVNGPWCYTMNPRKLYDYCNIPLCASLSSFECGKPQVEPK KCPGRVVGGCVANPHSWPWQISLRTRFSGQHFCGGTLISPEWVLTAAHCLEKSSRPEFYKVILG AHEERILGSDVQQIAVTKLVLEPNDADIALLKLSRPATITDNVIPACLPSPNYVVADRTLCYIT GWGETKGTPGAGRLKEAQLPVIENKVCNRAEYLNNRVKSTELCAGHLAGGIDSCQGDSGGPLVC FEKDKYILQGVTSWGLGCARPNKPGVYVRVSRYVNWIEREMRND hide sequence

RefSeq Acc Id:

XP_017445292 ⟸ XM_017589803

- Peptide Label:

isoform X1

- Sequence:

show sequence

MDHKEIILLFLLFLKPGQGDSLDGYVSTQGASLHSLTKKQLAAGSIADCLAKCEGETDFICRSF
QYHSKEQQCVIMAENSKTSSIIRMRDVILFEKRVYLSECKTGIGKGYRGTMSKTKTGVTCQKWS
DTSPHVPKYSPSTHPSEGLEENYCRNPDNDEQGPWCYTTDPDQRYEYCNIPECEEECMYCSGEK
YEGKISKTMSGLDCQSWDSQSPHAHGYIPAKFPSKNLKMNYCRNPDGEPRPWCFTTDPNKRWEY
CDIPRCTIVVVIIVIIVIIIFIFIIFIFIIIIFIIMMPLPLKGSSLGRGENYRGTVSVTASGKT
CQRWSEQTPHRHNRTPENFPCKNLEENYCRNPDGETAPWCYTTDSQLRWEYCEIPSCGSSVSPD
QSDSSVLPEQTPVVQECYQGNGKSYRGTSSTTNTGKKCQSWVSMTPHSHSKTPANFPDAYQNLL
IQHWRPSVYYMSLWETFLIHTHNQKYSVFQLKESSGLEMNYCRNPDNDQRGPWCFTTDPSVRWE
YCNLKRCSETGGGVAESAIVPQVPSAPGTSETDCMYGNGKEYRGKTAVTAAGTPCQEWAAQEPH
SHRIFTPQTNPRAGLEKNYCRNPDGDVNGPWCYTMNPRKLYDYCNIPLCASLSSFECGKPQVEP
KKCPGRVVGGCVANPHSWPWQISLRTRFSGQHFCGGTLISPEWVLTAAHCLEKSSRPEFYKVIL
GAHEERILGSDVQQIAVTKLVLEPNDADIALLKLSRPATITDNVIPACLPSPNYVVADRTLCYI
TGWGETKGTPGAGRLKEAQLPVIENKVCNRAEYLNNRVKSTELCAGHLAGGIDSCQGDSGGPLV
CFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRYVNWIEREMRND

hide sequence

RefSeq Acc Id:

ENSRNOP00000073928 ⟸ ENSRNOT00000080352

RefSeq Acc Id:

ENSRNOP00000023370 ⟸ ENSRNOT00000023368

Protein Domains

Kringle PAN Peptidase S1

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13689620

Promoter ID:

EPDNEW_R145

Type:

initiation region

Name:

Plg_1

Description:

plasminogen

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	48,563,778 - 48,563,838	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619893	AgrOrtholog
Ensembl Genes	ENSRNOG00000017223	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000023370	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000073928	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000023368	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000080352	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.40.20.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7369357	IMAGE-MGC_LOAD
InterPro	Kringle	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kringle-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kringle_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kringle_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pan_app	UniProtKB/Swiss-Prot
	Pept_S1A_plasmin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_S1_PA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/Swiss-Prot
	Trypsin_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/Swiss-Prot
KEGG Report	rno:85253	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:108638	IMAGE-MGC_LOAD
NCBI Gene	85253	ENTREZGENE
Pfam	Kringle	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PAN_1	UniProtKB/Swiss-Prot
	Trypsin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Plg	PhenoGen
PIRSF	Plasmin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	CHYMOTRYPSIN	UniProtKB/Swiss-Prot
PROSITE	KRINGLE_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	KRINGLE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PAN	UniProtKB/Swiss-Prot
	TRYPSIN_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/Swiss-Prot
SMART	PAN_AP	UniProtKB/Swiss-Prot
	SM00130	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tryp_SPc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF50494	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF57440	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene	Rn.20178	ENTREZGENE
UniProt	PLMN_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q7TP84_RAT	UniProtKB/TrEMBL
UniProt Secondary	Q5BKB6	UniProtKB/Swiss-Prot
	Q9R0W3	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Plg	plasminogen			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Plg	plasminogen			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_physical_interaction	binds to the Heymann nephritis autoantigen (gp330), and thus may be associated with the rat model of human idiopathic glomerulonephropathy	1299252

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)