Gene: Plg (plasminogen) Rattus norvegicus
Analyze
Symbol:
Plg
Name:
plasminogen
Description:
Exhibits endopeptidase activity and enzyme binding activity. Involved in proteolysis involved in cellular protein catabolic process. Localizes to the extracellular space; intracellular membrane-bounded organelle; and plasma membrane. Human ortholog(s) of this gene implicated in conjunctivitis and thrombophilia. Orthologous to human PLG (plasminogen); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,4-dinitrotoluene.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
Ab1-346
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PLG (plasminogen) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Plg (plasminogen) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Plg (plasminogen) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PLG (plasminogen) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PLG (plasminogen) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Plg (plasminogen) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PLG (plasminogen) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
LPA (lipoprotein(a)) HGNC
OrthoDB, OrthoMCL, Panther, Treefam
Homo sapiens (human):
LPAL2 (lipoprotein(a) like 2, pseudogene) HGNC
Panther
Alliance orthologs 3
Homo sapiens (human):
PLG (plasminogen)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Plg (plasminogen)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
plg (plasminogen)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
svh-1
Alliance
DIOPT (Ensembl Compara, PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information:
Annotation category: partial on reference assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 1 48,521,828 - 48,563,895 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 1 51,192,273 - 51,233,898 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 1 42,782,464 - 42,825,149 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 1 42,785,408 - 42,828,097 (-) NCBI Celera 1 44,117,228 - 44,159,691 (-) NCBI Celera Cytogenetic Map 1 q11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
hereditary angioedema ISO RGD:1343043 8554872 ClinVar Annotator: match by term: Hereditary angioneurotic edema ClinVar Hereditary Angioedema Types I and II ISO RGD:1343043 8554872 ClinVar Annotator: match by term: Hereditary angioneurotic edema ClinVar melanoma ISO RGD:1343043 8554872 ClinVar Annotator: match by term: Malignant melanoma ClinVar Plasminogen Deficiency, Type I ISO RGD:1343043 8554872 ClinVar Annotator: match by term: Plasminogen deficiency, type I ClinVar PMID:1427790 more ... Plasminogen Deficiency, Type I ISO RGD:1343043 8554872 ClinVar Annotator: match by term: Plasminogen deficiency, type I ClinVar PMID:10233898 more ... Plasminogen Deficiency, Type I ISO RGD:1343043 8554872 ClinVar Annotator: match by term: Plasminogen deficiency, type I ClinVar PMID:25741868 Plasminogen Deficiency, Type I ISO RGD:1343043 8554872 ClinVar Annotator: match by OMIM:217090 ClinVar Plasminogen Deficiency, Type I ISO RGD:1343043 8554872 ClinVar Annotator: match by OMIM:217090 ClinVar PMID:10233898 Plasminogen Deficiency, Type I ISO RGD:1343043 8554872 ClinVar Annotator: match by synonym: Dysplasminogenemia ClinVar PMID:9858247 Plasminogen Deficiency, Type I ISO RGD:1343043 8554872 ClinVar Annotator: match by synonym: Dysplasminogenemia ClinVar PMID:1986355 Plasminogen Deficiency, Type I ISO RGD:1343043 8554872 ClinVar Annotator: match by synonym: Dysplasminogenemia ClinVar PMID:8392398 Plasminogen Deficiency, Type I ISO RGD:1343043 8554872 ClinVar Annotator: match by OMIM:217090 ClinVar PMID:9834305 Plasminogen Deficiency, Type I ISO RGD:1343043 8554872 ClinVar Annotator: match by OMIM:217090 ClinVar PMID:9242524 Plasminogen Deficiency, Type I ISO RGD:1343043 8554872 ClinVar Annotator: match by OMIM:217090 ClinVar PMID:10233898 , PMID:9242524
Imported Annotations - CTD
acute kidney failure ISO RGD:1343043 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28885000 Chemical and Drug Induced Liver Injury ISO RGD:1343043 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22507835 Drug-Related Side Effects and Adverse Reactions ISO RGD:1343043 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28885000 Experimental Liver Cirrhosis ISO RGD:1343043 11554173 CTD Direct Evidence: therapeutic CTD PMID:14716496 hypertension ISO RGD:1343043 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:6383834 leukocyte disease ISO RGD:1343043 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30213540 Venous Thrombosis ISO RGD:1343043 11554173 CTD Direct Evidence: therapeutic CTD PMID:7215189 Imported Annotations - OMIM
Plasminogen Deficiency, Type I ISO RGD:1343043 7240710 OMIM
(+)-alpha-tocopherol multiple interactions ISO RGD:1343043 6480464 alpha-Tocopherol inhibits the reaction [Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]], alpha-Tocopherol inhibits the reaction [Humic Substances results in decreased activity of PLG protein] CTD PMID:11419606 (+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PLG mRNA] CTD PMID:31150632 13-BETA-ETHYL-17-ALPHA-ETHYNYL-17-BETA-HYDROXYGON-4-EN-3-ONE multiple interactions ISO RGD:1343043 6480464 [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of PLG protein CTD PMID:12618251 , PMID:15157790 17alpha-ethynylestradiol multiple interactions ISO RGD:1343043 6480464 [Ethinyl Estradiol binds to Norethindrone] which results in increased expression of PLG protein more ... CTD PMID:11720199 more ... 17alpha-ethynylestradiol increases expression ISO RGD:1343043 6480464 Ethinyl Estradiol results in increased expression of PLG protein CTD PMID:17374706 17beta-estradiol decreases expression ISO RGD:1343043 6480464 Estradiol results in decreased expression of PLG mRNA CTD PMID:20106945 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of PLG mRNA CTD PMID:20838740 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1343043 6480464 Tetrachlorodibenzodioxin results in decreased expression of PLG mRNA CTD PMID:20106945 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of PLG mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of PLG mRNA CTD PMID:21346803 3,3',4,4',5-pentachlorobiphenyl affects expression ISO RGD:1343043 6480464 3 more ... CTD PMID:21703328 3-chloropropane-1,2-diol increases expression EXP 6480464 alpha-Chlorohydrin results in increased expression of PLG protein CTD PMID:26072098 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expression EXP 6480464 Omeprazole affects the expression of PLG mRNA CTD PMID:19483382 6-aminohexanoate multiple interactions ISO RGD:1550861 6480464 Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK1 protein], Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK3 protein] CTD PMID:17482686 6-aminohexanoic acid multiple interactions ISO RGD:1550861 6480464 Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK1 protein], Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK3 protein] CTD PMID:17482686 6-propyl-2-thiouracil affects expression EXP 6480464 Propylthiouracil affects the expression of PLG mRNA CTD PMID:19483382 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of PLG mRNA CTD PMID:22504374 aflatoxin B1 affects expression ISO RGD:1343043 6480464 Aflatoxin B1 affects the expression of PLG protein CTD PMID:20106945 aflatoxin B1 decreases expression ISO RGD:1343043 6480464 Aflatoxin B1 results in decreased expression of PLG mRNA CTD PMID:27153756 aflatoxin B1 decreases methylation ISO RGD:1343043 6480464 Aflatoxin B1 results in decreased methylation of PLG gene CTD PMID:27153756 aflatoxin B1 decreases expression ISO RGD:1550861 6480464 Aflatoxin B1 results in decreased expression of PLG mRNA CTD PMID:19770486 amiloride multiple interactions ISO RGD:1343043 6480464 Amiloride inhibits the reaction [PLAU protein results in increased degradation of PLG protein] CTD PMID:14644129 amiodarone affects expression EXP 6480464 Amiodarone affects the expression of PLG mRNA CTD PMID:19483382 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PLG mRNA CTD PMID:16483693 arsane multiple interactions ISO RGD:1343043 6480464 alpha-Tocopherol inhibits the reaction [Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]] more ... CTD PMID:11419606 arsenic atom multiple interactions ISO RGD:1343043 6480464 alpha-Tocopherol inhibits the reaction [Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]] more ... CTD PMID:11419606 arsenic(3+) multiple interactions ISO RGD:1343043 6480464 alpha-Tocopherol inhibits the reaction [Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]] more ... CTD PMID:11419606 atrazine affects methylation EXP 6480464 Atrazine affects the methylation of PLG gene CTD PMID:28931070 belinostat decreases expression ISO RGD:1343043 6480464 belinostat results in decreased expression of PLG mRNA CTD PMID:27188386 benazepril increases activity ISO RGD:1550861 6480464 benazepril results in increased activity of PLG protein CTD PMID:15339989 benazepril multiple interactions ISO RGD:1550861 6480464 FR 173657 inhibits the reaction [benazepril results in increased activity of PLG protein] CTD PMID:15339989 benzbromarone affects expression EXP 6480464 Benzbromarone affects the expression of PLG mRNA CTD PMID:19483382 benzene increases secretion ISO RGD:1343043 6480464 Benzene results in increased secretion of PLG protein CTD PMID:30213540 benzo[a]pyrene decreases expression ISO RGD:1343043 6480464 Benzo(a)pyrene results in decreased expression of PLG mRNA CTD PMID:20106945 benzo[a]pyrene increases expression ISO RGD:1550861 6480464 Benzo(a)pyrene results in increased expression of PLG mRNA CTD PMID:22610609 benzo[a]pyrene decreases expression ISO RGD:1550861 6480464 Benzo(a)pyrene results in decreased expression of PLG mRNA CTD PMID:19770486 benzo[e]pyrene increases methylation ISO RGD:1343043 6480464 benzo(e)pyrene results in increased methylation of PLG intron CTD PMID:30157460 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:1343043 6480464 Diethylhexyl Phthalate results in decreased expression of PLG mRNA CTD PMID:31163220 bisphenol A increases expression ISO RGD:1550861 6480464 bisphenol A results in increased expression of PLG mRNA CTD PMID:22687993 , PMID:30245210 bisphenol A affects methylation ISO RGD:1550861 6480464 bisphenol A affects the methylation of PLG promoter CTD PMID:27334623 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of PLG gene CTD PMID:28505145 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of PLG mRNA CTD PMID:25181051 buta-1,3-diene decreases expression ISO RGD:1550861 6480464 1, 3-butadiene results in decreased expression of PLG mRNA CTD PMID:29038090 cadmium dichloride affects expression EXP 6480464 Cadmium Chloride affects the expression of PLG mRNA CTD PMID:22110744 caffeine decreases expression EXP 6480464 Caffeine results in decreased expression of PLG mRNA CTD PMID:25868845 carbon nanotube increases expression ISO RGD:1550861 6480464 Nanotubes, Carbon analog results in increased expression of PLG mRNA CTD PMID:25554681 choline multiple interactions ISO RGD:1550861 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PLG mRNA CTD PMID:20938992 cisplatin increases secretion EXP 6480464 Cisplatin results in increased secretion of PLG protein CTD PMID:28885000 clofibrate affects expression EXP 6480464 Clofibrate affects the expression of PLG mRNA CTD PMID:19483382 clofibrate decreases expression EXP 6480464 Clofibrate results in decreased expression of PLG mRNA CTD PMID:12851107 clofibrate multiple interactions ISO RGD:1550861 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of PLG mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PLG mRNA] CTD PMID:17585979 clofibrate decreases expression ISO RGD:1550861 6480464 Clofibrate results in decreased expression of PLG mRNA CTD PMID:17585979 clofibrate affects expression ISO RGD:1343043 6480464 Clofibrate affects the expression of PLG protein CTD PMID:131008 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of PLG mRNA CTD PMID:24386269 copper atom affects binding ISO RGD:1343043 6480464 PLG protein binds to Copper CTD PMID:23896426 copper(0) affects binding ISO RGD:1343043 6480464 PLG protein binds to Copper CTD PMID:23896426 copper(2+) affects binding ISO RGD:1343043 6480464 PLG protein binds to Copper CTD PMID:23896426 copper(II) sulfate decreases expression ISO RGD:1343043 6480464 Copper Sulfate results in decreased expression of PLG mRNA CTD PMID:19549813 cyclosporin A decreases expression ISO RGD:1343043 6480464 Cyclosporine results in decreased expression of PLG mRNA CTD PMID:20106945 cylindrospermopsin decreases expression ISO RGD:1550861 6480464 cylindrospermopsin results in decreased expression of PLG mRNA CTD PMID:20936652 cytarabine affects localization ISO RGD:1343043 6480464 Cytarabine affects the localization of PLG protein CTD PMID:12165291 dexamethasone affects expression EXP 6480464 Dexamethasone affects the expression of PLG protein CTD PMID:10485340 dextran sulfate multiple interactions ISO RGD:1550861 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of PLG mRNA CTD PMID:29950665 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of PLG mRNA CTD PMID:21266533 diisopropyl fluorophosphate multiple interactions ISO RGD:1550861 6480464 Isoflurophate inhibits the reaction [PLG protein results in increased phosphorylation of MAPK1 protein], Isoflurophate inhibits the reaction [PLG protein results in increased phosphorylation of MAPK3 protein] CTD PMID:17482686 dioxygen multiple interactions ISO RGD:1550861 6480464 Oxygen deficiency promotes the reaction [PLAU protein results in increased activity of PLG protein] CTD PMID:12485432 doxorubicin increases secretion EXP 6480464 Doxorubicin results in increased secretion of PLG protein CTD PMID:28885000 entinostat decreases expression ISO RGD:1343043 6480464 entinostat results in decreased expression of PLG mRNA CTD PMID:27188386 Ethyl icosapentate increases expression EXP 6480464 eicosapentaenoic acid ethyl ester results in increased expression of PLG protein CTD PMID:14614217 ethylenediaminetetraacetic acid multiple interactions ISO RGD:1550861 6480464 Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG mRNA], Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG protein] CTD PMID:21615740 folic acid multiple interactions ISO RGD:1550861 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PLG mRNA CTD PMID:20938992 furan decreases expression EXP 6480464 furan results in decreased expression of PLG mRNA CTD PMID:26194646 genistein increases expression EXP 6480464 Genistein results in increased expression of PLG mRNA CTD PMID:20838740 gestodene multiple interactions ISO RGD:1343043 6480464 [Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PLG protein, [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PLG protein CTD PMID:11720199 , PMID:12618251 Goe 6976 multiple interactions ISO RGD:1550861 6480464 Go 6976 inhibits the reaction [Zinc results in increased expression of PLG mRNA], Go 6976 inhibits the reaction [Zinc results in increased expression of PLG protein] CTD PMID:21615740 heparin multiple interactions ISO RGD:1550861 6480464 Heparin inhibits the reaction [PLG protein affects the degradation of CCL11 protein] CTD PMID:17384413 L-ascorbic acid multiple interactions ISO RGD:1343043 6480464 Ascorbic Acid inhibits the reaction [Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]], Ascorbic Acid inhibits the reaction [Humic Substances results in decreased activity of PLG protein] CTD PMID:11419606 L-ethionine affects expression EXP 6480464 Ethionine affects the expression of PLG mRNA CTD PMID:19483382 L-methionine multiple interactions ISO RGD:1550861 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PLG mRNA CTD PMID:20938992 lead diacetate affects activity EXP 6480464 lead acetate affects the activity of PLG protein modified form CTD PMID:2143947 levonorgestrel multiple interactions ISO RGD:1343043 6480464 [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of PLG protein CTD PMID:12618251 , PMID:15157790 medroxyprogesterone acetate increases expression ISO RGD:1343043 6480464 Medroxyprogesterone Acetate results in increased expression of PLG CTD PMID:1828463 methapyrilene increases methylation ISO RGD:1343043 6480464 Methapyrilene results in increased methylation of PLG intron CTD PMID:30157460 methimazole increases expression EXP 6480464 Methimazole results in increased expression of PLG mRNA CTD PMID:22504374 morphine affects response to substance ISO RGD:1550861 6480464 PLG protein affects the susceptibility to Morphine CTD PMID:16619846 nefazodone decreases expression EXP 6480464 nefazodone results in decreased expression of PLG mRNA CTD PMID:24136188 nickel atom affects binding ISO RGD:1343043 6480464 PLG protein binds to Nickel CTD PMID:23896426 nickel atom decreases expression ISO RGD:1550861 6480464 Nickel analog results in decreased expression of PLG protein alternative form CTD PMID:25144474 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of PLG mRNA CTD PMID:22546817 nitroprusside decreases response to substance EXP 6480464 PLG protein results in decreased susceptibility to Nitroprusside CTD PMID:9710261 norethisterone multiple interactions ISO RGD:1343043 6480464 [Ethinyl Estradiol binds to Norethindrone] which results in increased expression of PLG protein CTD PMID:14561536 norgestimate multiple interactions ISO RGD:1343043 6480464 [Ethinyl Estradiol co-treated with norgestimate] results in increased expression of PLG protein CTD PMID:12618251 omeprazole affects expression EXP 6480464 Omeprazole affects the expression of PLG mRNA CTD PMID:19483382 paracetamol multiple interactions ISO RGD:1550861 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of PLG mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PLG mRNA] CTD PMID:17585979 paracetamol decreases response to substance ISO RGD:1550861 6480464 PLG gene mutant form results in decreased susceptibility to Acetaminophen CTD PMID:22507835 paracetamol decreases expression ISO RGD:1343043 6480464 Acetaminophen results in decreased expression of PLG mRNA CTD PMID:21420995 , PMID:29067470 perfluorooctanoic acid decreases expression ISO RGD:1343043 6480464 perfluorooctanoic acid results in decreased expression of PLG mRNA CTD PMID:25868421 pirinixic acid multiple interactions ISO RGD:1550861 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PLG mRNA, [pirinixic acid co-treated with PPARA] results in decreased expression of PLG mRNA CTD PMID:19710929 , PMID:20813756 pirinixic acid affects expression EXP 6480464 pirinixic acid affects the expression of PLG mRNA CTD PMID:19483382 pirinixic acid decreases expression ISO RGD:1550861 6480464 pirinixic acid results in decreased expression of PLG mRNA CTD PMID:20813756 potassium dichromate affects expression ISO RGD:1550861 6480464 Potassium Dichromate affects the expression of PLG mRNA CTD PMID:23608068 roxarsone decreases expression ISO RGD:1343043 6480464 Roxarsone results in decreased expression of PLG mRNA CTD PMID:18414637 selenomethionine affects expression ISO RGD:1343043 6480464 Selenomethionine affects the expression of PLG mRNA CTD PMID:17222674 sodium arsenite affects expression ISO RGD:1550861 6480464 sodium arsenite affects the expression of PLG mRNA CTD PMID:17450228 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of PLG protein CTD PMID:29459688 sodium arsenite decreases expression ISO RGD:1343043 6480464 sodium arsenite results in decreased expression of PLG mRNA CTD PMID:29301061 sodium dichromate affects expression EXP 6480464 sodium bichromate affects the expression of PLG mRNA CTD PMID:22110744 sodium fluoride increases expression ISO RGD:1550861 6480464 Sodium Fluoride results in increased expression of PLG protein CTD PMID:28918527 tamoxifen increases expression ISO RGD:1343043 6480464 Tamoxifen results in increased expression of PLG protein CTD PMID:8200368 tetrachloromethane multiple interactions ISO RGD:1550861 6480464 PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of AMY2A5 mRNA] more ... CTD PMID:14716496 more ... tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of PLG mRNA CTD PMID:30723492 , PMID:31150632 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PLG mRNA] CTD PMID:31150632 tetrachloromethane affects expression EXP 6480464 Carbon Tetrachloride affects the expression of PLG mRNA CTD PMID:12734012 tetrachloromethane affects response to substance ISO RGD:1550861 6480464 PLG protein affects the susceptibility to Carbon Tetrachloride CTD PMID:16006527 tetracycline increases expression ISO RGD:1550861 6480464 Tetracycline results in increased expression of PLG mRNA CTD PMID:16917069 tetraethyllead affects activity EXP 6480464 Tetraethyl Lead affects the activity of PLG protein modified form CTD PMID:2143947 thioacetamide affects expression EXP 6480464 Thioacetamide affects the expression of PLG mRNA CTD PMID:19483382 titanium dioxide multiple interactions ISO RGD:1550861 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of PLG mRNA CTD PMID:29950665 triclosan multiple interactions ISO RGD:1343043 6480464 Triclosan inhibits the reaction [TNF protein results in increased metabolism of PLG protein] CTD PMID:19874453 urethane decreases expression ISO RGD:1343043 6480464 Urethane results in decreased expression of PLG mRNA CTD PMID:28818685 valproic acid decreases expression ISO RGD:1343043 6480464 Valproic Acid results in decreased expression of PLG mRNA CTD PMID:29154799 valproic acid decreases methylation ISO RGD:1343043 6480464 Valproic Acid results in decreased methylation of PLG gene CTD PMID:29154799 vitamin E multiple interactions ISO RGD:1343043 6480464 alpha-Tocopherol inhibits the reaction [Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]], alpha-Tocopherol inhibits the reaction [Humic Substances results in decreased activity of PLG protein] CTD PMID:11419606 vorinostat decreases expression ISO RGD:1343043 6480464 vorinostat results in decreased expression of PLG mRNA CTD PMID:27188386 zinc atom multiple interactions ISO RGD:1550861 6480464 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Zinc results in increased expression of PLG mRNA] more ... CTD PMID:21615740 zinc atom affects binding ISO RGD:1343043 6480464 PLG protein binds to Zinc CTD PMID:23896426 zinc atom increases expression ISO RGD:1550861 6480464 Zinc results in increased expression of PLG mRNA, Zinc results in increased expression of PLG protein CTD PMID:21615740 zinc(0) multiple interactions ISO RGD:1550861 6480464 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Zinc results in increased expression of PLG mRNA] more ... CTD PMID:21615740 zinc(0) increases expression ISO RGD:1550861 6480464 Zinc results in increased expression of PLG mRNA, Zinc results in increased expression of PLG protein CTD PMID:21615740 zinc(0) affects binding ISO RGD:1343043 6480464 PLG protein binds to Zinc CTD PMID:23896426
Biological Process blood coagulation IEA UniRule:UR000169772 1600115 GO_REF:0000104 UniProt GO_REF:0000104 blood coagulation ISO RGD:1343043 1624291 (PMID:1986355) RGD PMID:1986355 blood coagulation IEA UniProtKB:P00747 , ensembl:ENSP000003089381600115 GO_REF:0000107 Ensembl GO_REF:0000107 extracellular matrix disassembly IEA UniProtKB:P00747 , ensembl:ENSP000003089381600115 GO_REF:0000107 Ensembl GO_REF:0000107 extracellular matrix disassembly ISO RGD:1343043 1624291 (PMID:14699093) RGD PMID:14699093 fibrinolysis IEA UniRule:UR000169772 1600115 GO_REF:0000104 UniProt GO_REF:0000104 fibrinolysis ISO RGD:1343043 1624291 (PMID:14688145), (PMID:17307854), (PMID:22025510) RGD PMID:14688145 more ... fibrinolysis IEA UniProtKB:P00747 , ensembl:ENSP000003089381600115 GO_REF:0000107 Ensembl GO_REF:0000107 interaction with symbiont ISO RGD:1343043 1624291 (PMID:12818429) RGD PMID:12818429 interaction with symbiont via secreted substance IEA UniProtKB:P00747 , ensembl:ENSP000003089381600115 GO_REF:0000107 Ensembl GO_REF:0000107 interaction with symbiont via secreted substance ISO RGD:14106484 1624291 (PMID:14688145) RGD PMID:14688145 interaction with symbiont via secreted substance ISO RGD:1343043 1624291 (PMID:19270100), (PMID:22025510), (PMID:22087329) RGD PMID:19270100 more ... labyrinthine layer blood vessel development ISO RGD:1550861 1624291 MGI:MGI:1857291 (MGI:MGI:2668370 , PMID:12900459) RGD MGI:MGI:2668370 , PMID:12900459 labyrinthine layer blood vessel development IEA UniProtKB:P20918 , ensembl:ENSMUSP000000145781600115 GO_REF:0000107 Ensembl GO_REF:0000107 mononuclear cell migration ISO RGD:1550861 1624291 (MGI:MGI:3847621, PMID:17690254) RGD MGI:MGI:3847621 , PMID:17690254 mononuclear cell migration IEA UniProtKB:P20918 , ensembl:ENSMUSP000000145781600115 GO_REF:0000107 Ensembl GO_REF:0000107 muscle cell cellular homeostasis ISO RGD:1550861 1624291 MGI:MGI:2158761 (MGI:MGI:2178512 , PMID:11929773) RGD MGI:MGI:2178512 , PMID:11929773 muscle cell cellular homeostasis IEA UniProtKB:P20918 , ensembl:ENSMUSP000000145781600115 GO_REF:0000107 Ensembl GO_REF:0000107 myoblast differentiation ISO RGD:1550861 1624291 (MGI:MGI:2178512, PMID:11929773) RGD MGI:MGI:2178512 , PMID:11929773 myoblast differentiation IEA UniProtKB:P20918 , ensembl:ENSMUSP000000145781600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of cell-substrate adhesion IEA UniProtKB:P00747 , ensembl:ENSP000003089381600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of cell-substrate adhesion ISO RGD:1343043 1624291 (PMID:14699093) RGD PMID:14699093 negative regulation of fibrinolysis IEA UniProtKB:P00747 , ensembl:ENSP000003089381600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of fibrinolysis ISO RGD:1343043 1624291 (PMID:14726399) RGD PMID:14726399 positive regulation of blood vessel endothelial cell migration ISO RGD:1343043 1624291 UniProtKB:P62328 (PMID:21106936) RGD PMID:21106936 positive regulation of fibrinolysis IEA UniProtKB:P00747 , ensembl:ENSP000003089381600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of fibrinolysis ISO RGD:1343043 1624291 (PMID:26667841), (PMID:6438154) RGD PMID:26667841 , PMID:6438154 proteolysis ISO RGD:1343043 1624291 (PMID:18070902), (PMID:19270100), (PMID:9603964) RGD PMID:18070902 more ... proteolysis IEA UniProtKB-KW:KW-0645 1600115 GO_REF:0000038 UniProt GO_REF:0000038 proteolysis involved in cellular protein catabolic process IDA 1299253 ; 2301095 RGD tissue regeneration ISO RGD:1550861 1624291 MGI:MGI:2158761 (MGI:MGI:2178512 , PMID:11929773) RGD MGI:MGI:2178512 , PMID:11929773 tissue regeneration IEA UniProtKB:P20918 , ensembl:ENSMUSP000000145781600115 GO_REF:0000107 Ensembl GO_REF:0000107 tissue remodeling IEA UniRule:UR000169772 1600115 GO_REF:0000104 UniProt GO_REF:0000104 tissue remodeling IEA UniProtKB-KW:KW-0797 1600115 GO_REF:0000037 UniProt GO_REF:0000037 trans-synaptic signaling by BDNF, modulating synaptic transmission IEA UniProtKB:P20918 , ensembl:ENSMUSP000000145781600115 GO_REF:0000107 Ensembl GO_REF:0000107 trans-synaptic signaling by BDNF, modulating synaptic transmission ISO RGD:1550861 1624291 (MGI:MGI:3615067, PMID:15486301) RGD MGI:MGI:3615067 , PMID:15486301 trophoblast giant cell differentiation ISO RGD:1550861 1624291 MGI:MGI:1857291 (MGI:MGI:2668370 , PMID:12900459) RGD MGI:MGI:2668370 , PMID:12900459 trophoblast giant cell differentiation IEA UniProtKB:P20918 , ensembl:ENSMUSP000000145781600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component cell IEA GO:0046716 1600115 GO_REF:0000108 GOC GO_REF:0000108 cell surface ISO RGD:1343043 1624291 (PMID:14699093) RGD PMID:14699093 extracellular region IEA UniProtKB-SubCell:SL-0243 1600115 GO_REF:0000040 UniProt GO_REF:0000040 extracellular space IDA 12792993 PMID:7964722 CAFA extracellular space ISO RGD:1343043 1624291 (PMID:14688145), (PMID:17307854), (PMID:6216475), (PMID:6980881) RGD PMID:14688145 more ... extrinsic component of external side of plasma membrane IEA UniProtKB:P00747 , ensembl:ENSP000003089381600115 GO_REF:0000107 Ensembl GO_REF:0000107 extrinsic component of external side of plasma membrane ISO RGD:1343043 1624291 (PMID:14699093) RGD PMID:14699093 extrinsic component of plasma membrane ISO RGD:1550861 1624291 (MGI:MGI:3847621, PMID:17690254) RGD MGI:MGI:3847621 , PMID:17690254 glutamatergic synapse IEA UniProtKB:P20918 , ensembl:ENSMUSP000000145781600115 GO_REF:0000107 Ensembl GO_REF:0000107 glutamatergic synapse ISO RGD:1550861 1624291 (MGI:MGI:3615067, PMID:15486301) RGD MGI:MGI:3615067 , PMID:15486301 integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000038 UniProt GO_REF:0000038 intracellular membrane-bounded organelle IDA 1299253 RGD other organism cell membrane IEA UniProtKB:P00747 , ensembl:ENSP000003089381600115 GO_REF:0000107 Ensembl GO_REF:0000107 other organism cell membrane ISO RGD:1343043 1624291 (PMID:17307854) RGD PMID:17307854 plasma membrane IDA 7243112 RGD Schaffer collateral - CA1 synapse IEA UniProtKB:P20918 , ensembl:ENSMUSP000000145781600115 GO_REF:0000107 Ensembl GO_REF:0000107 Schaffer collateral - CA1 synapse ISO RGD:1550861 1624291 (MGI:MGI:3615067, PMID:15486301) RGD MGI:MGI:3615067 , PMID:15486301 Molecular Function apolipoprotein binding IEA UniProtKB:P00747 , ensembl:ENSP000003089381600115 GO_REF:0000107 Ensembl GO_REF:0000107 apolipoprotein binding ISO RGD:1343043 1624291 UniProtKB:P02749 (PMID:16480936) RGD PMID:16480936 chaperone binding IEA UniProtKB:P00747 , ensembl:ENSP000003089381600115 GO_REF:0000107 Ensembl GO_REF:0000107 chaperone binding ISO RGD:1343043 1624291 UniProtKB:B7GT47 more ... RGD PMID:17307854 more ... endopeptidase activity IDA 1299253 ; 2301095 RGD endopeptidase activity ISO RGD:1343043 1624291 (PMID:9603964) RGD PMID:9603964 enzyme binding IPI UniProtKB:P04764 12792993 PMID:7964722 CAFA enzyme binding ISO RGD:1343043 1624291 UniProtKB:A0A0J1HQ93 more ... RGD PMID:12666133 more ... kinase binding IEA UniProtKB:P00747 , ensembl:ENSP000003089381600115 GO_REF:0000107 Ensembl GO_REF:0000107 kinase binding IEA UniProtKB:P20918 , ensembl:ENSMUSP000000145781600115 GO_REF:0000107 Ensembl GO_REF:0000107 kinase binding ISO RGD:1550861 1624291 UniProtKB:Q04LZ5 (MGI:MGI:5887190 , PMID:24196407) RGD MGI:MGI:5887190 , PMID:24196407 kinase binding ISO RGD:1343043 1624291 UniProtKB:Q04LZ5 (PMID:24196407) RGD PMID:24196407 proteasome core complex binding IEA UniProtKB:P00747 , ensembl:ENSP000003089381600115 GO_REF:0000107 Ensembl GO_REF:0000107 proteasome core complex binding ISO RGD:1343043 1624291 UniProtKB:P9WHT9 (PMID:17849409) RGD PMID:17849409 protein antigen binding IEA UniProtKB:P00747 , ensembl:ENSP000003089381600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein antigen binding ISO RGD:1343043 1624291 UniProtKB:P9WQN7 (PMID:17849409) RGD PMID:17849409 protein binding ISO RGD:1343043 1624291 UniProtKB:A0A077XEH2 more ... RGD PMID:10077593 more ... protein domain specific binding IEA UniProtKB:P00747 , ensembl:ENSP000003089381600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein domain specific binding ISO RGD:1343043 1624291 UniProtKB:P05452 , UniProtKB:P08169 (PMID:20028034), (PMID:9786936) RGD PMID:20028034 , PMID:9786936 serine-type endopeptidase activity IEA UniRule:UR000169772 1600115 GO_REF:0000104 UniProt GO_REF:0000104 serine-type endopeptidase activity IBA PANTHER:PTN001207579 more ... 13792537 PMID:21873635 GO_Central serine-type endopeptidase activity ISO RGD:1343043 1624291 (PMID:14688145), (PMID:14699093), (PMID:17307854), (PMID:18070902), (PMID:19270100), (PMID:20727989) RGD PMID:14688145 more ... signaling receptor binding ISO RGD:1343043 1624291 UniProtKB:P08169 (PMID:20028034) RGD PMID:20028034 signaling receptor binding IEA UniProtKB:P00747 , ensembl:ENSP000003089381600115 GO_REF:0000107 Ensembl GO_REF:0000107
Gene-Chemical Interaction Annotations
