Plg (plasminogen) - Rat Genome Database

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Gene: Plg (plasminogen) Rattus norvegicus
Symbol: Plg
Name: plasminogen
RGD ID: 619893
Description: Enables endopeptidase activity and enzyme binding activity. Involved in proteolysis involved in protein catabolic process. Located in extracellular space; intracellular membrane-bounded organelle; and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; conjunctivitis; hereditary angioedema; myocardial infarction; and plasminogen deficiency type I. Orthologous to several human genes including PLG (plasminogen); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Previously known as: Ab1-346
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2148,325,186 - 48,367,643 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,325,185 - 48,367,786 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx149,016,780 - 49,059,257 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0155,002,545 - 55,044,743 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0149,092,281 - 49,134,750 (-)NCBIRnor_WKY
Rnor_6.0148,521,828 - 48,563,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,521,772 - 48,563,776 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,192,273 - 51,233,898 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,782,464 - 42,825,149 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,785,408 - 42,828,097 (-)NCBI
Celera144,117,228 - 44,159,691 (-)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-aminohexanoate  (ISO)
6-aminohexanoic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldosterone  (EXP)
amiloride  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atrazine  (EXP)
belinostat  (ISO)
benazepril  (ISO)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
caffeine  (EXP)
camostat  (EXP)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cytarabine  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diisopropyl fluorophosphate  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP)
entinostat  (ISO)
Ethyl icosapentate  (EXP)
ethylenediaminetetraacetic acid  (ISO)
folic acid  (ISO)
furan  (EXP)
genistein  (EXP)
gestodene  (ISO)
Goe 6976  (ISO)
heparin  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (EXP)
levonorgestrel  (ISO)
medroxyprogesterone acetate  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methimazole  (EXP)
morphine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nitrofen  (EXP)
nitroprusside  (EXP)
norethisterone  (ISO)
norgestimate  (ISO)
O-methyleugenol  (ISO)
omeprazole  (EXP)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
roxarsone  (ISO)
selenomethionine  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetraethyllead  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
Triptolide  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function


References - curated
# Reference Title Reference Citation
1. Congenital plasminogen deficiency caused by a Ser572 to Pro mutation. Azuma H, etal., Blood. 1993 Jul 15;82(2):475-80.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury. Gralinski LE, etal., mBio. 2013 Aug 6;4(4). pii: mBio.00271-13. doi: 10.1128/mBio.00271-13.
5. A plasminogen-like protein selectively degrades stearoyl-CoA desaturase in liver microsomes. Heinemann FS, etal., J Biol Chem 2003 Oct 31;278(44):42966-75. Epub 2003 Aug 19.
6. Characterization of plasminogen system on rat yolk sac carcinoma (L2) cells. Kanalas JJ Am J Physiol. 1995 Feb;268(2 Pt 1):C442-8.
7. Identification of the rat Heymann nephritis autoantigen (GP330) as a receptor site for plasminogen. Kanalas JJ and Makker SP, J Biol Chem 1991 Jun 15;266(17):10825-9.
8. The Chinese herbal formula Zhibai Dihuang Granule treat Yin-deficiency-heat syndrome rats by regulating the immune responses. Liu CM, etal., J Ethnopharmacol. 2018 Oct 28;225:271-278. doi: 10.1016/j.jep.2018.05.001. Epub 2018 May 2.
9. Basic mechanisms and regulation of fibrinolysis. Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
10. Imbalance of plasminogen activator inhibitor type-1 (PAI-1) and tissue plasminogen activator (t-PA) activity in patients with Noonan syndrome. Mehta P and Parker RI, J Pediatr Hematol Oncol. 2010 Oct;32(7):532-6. doi: 10.1097/MPH.0b013e3181e0d152.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Plasminogen-induced IL-1beta and TNF-alpha production in microglia is regulated by reactive oxygen species. Min KJ, etal., Biochem Biophys Res Commun 2003 Dec 26;312(4):969-74.
13. Plasminogen binds specifically to alpha-enolase on rat neuronal plasma membrane. Nakajima K, etal., J Neurochem. 1994 Dec;63(6):2048-57.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. The role of proteases in fibronectin matrix remodeling in thyroid epithelial cell monolayer cultures. Nezi L, etal., Biol Chem 2002 Jan;383(1):167-76.
16. A novel function of thrombin-activatable fibrinolysis inhibitor during rat liver regeneration and in growth-promoted hepatocytes in primary culture. Okumura N, etal., J Biol Chem. 2009 Jun 12;284(24):16553-61. doi: 10.1074/jbc.M109.011452. Epub 2009 Apr 22.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis. Schuster V, etal., Blood. 1997 Aug 1;90(3):958-66.
25. Changes in coagulation and fibrinolysis of post-SARS osteonecrosis in a Chinese population. Sun W, etal., Int Orthop. 2006 Jun;30(3):143-6. doi: 10.1007/s00264-005-0067-6. Epub 2006 Mar 18.
26. [Hematological changes and related gene mutation of post-severe acute respiratory syndrome patients with osteonecrosis]. Sun W, etal., Zhonghua Yi Xue Za Zhi. 2006 Feb 21;86(7):442-5.
27. Plasminogen improves lung lesions and hypoxemia in patients with COVID-19. Wu Y, etal., QJM. 2020 Apr 10. pii: 5818885. doi: 10.1093/qjmed/hcaa121.
Additional References at PubMed
PMID:1986355   PMID:6216475   PMID:6438154   PMID:6980881   PMID:9603964   PMID:9786936   PMID:11929773   PMID:12477932   PMID:12666133   PMID:12818429   PMID:12867553   PMID:12900459  
PMID:14688145   PMID:14699093   PMID:14726399   PMID:15486301   PMID:16480936   PMID:16502470   PMID:17307854   PMID:17574586   PMID:17587687   PMID:17663741   PMID:17690254   PMID:17849409  
PMID:17892475   PMID:17940541   PMID:17964283   PMID:18070902   PMID:18971211   PMID:18981180   PMID:19199708   PMID:19270100   PMID:19433310   PMID:19574304   PMID:19932587   PMID:20028034  
PMID:20727989   PMID:21106936   PMID:22025510   PMID:22087329   PMID:22516433   PMID:22619171   PMID:23376485   PMID:23533145   PMID:24196407   PMID:25931508   PMID:26667841   PMID:29767556  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2148,325,186 - 48,367,643 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,325,185 - 48,367,786 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx149,016,780 - 49,059,257 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0155,002,545 - 55,044,743 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0149,092,281 - 49,134,750 (-)NCBIRnor_WKY
Rnor_6.0148,521,828 - 48,563,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,521,772 - 48,563,776 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,192,273 - 51,233,898 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,782,464 - 42,825,149 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,785,408 - 42,828,097 (-)NCBI
Celera144,117,228 - 44,159,691 (-)NCBICelera
Cytogenetic Map1q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh386160,702,193 - 160,754,097 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl6160,702,238 - 160,754,097 (+)EnsemblGRCh38hg38GRCh38
GRCh376161,123,225 - 161,175,129 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366161,043,273 - 161,094,328 (+)NCBINCBI36Build 36hg18NCBI36
Build 346161,093,693 - 161,144,749NCBI
Celera6161,842,077 - 161,894,063 (+)NCBICelera
Cytogenetic Map6q26NCBI
HuRef6158,568,041 - 158,620,052 (+)NCBIHuRef
CHM1_16161,385,876 - 161,437,750 (+)NCBICHM1_1
T2T-CHM13v2.06162,049,910 - 162,101,977 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391712,597,496 - 12,638,271 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1712,597,495 - 12,638,272 (+)EnsemblGRCm39 Ensembl
GRCm381712,378,609 - 12,419,384 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,378,608 - 12,419,385 (+)EnsemblGRCm38mm10GRCm38
MGSCv371712,571,475 - 12,612,250 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,221,966 - 12,262,743 (+)NCBIMGSCv36mm8
Celera1712,409,327 - 12,450,146 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.5NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495543920,317,552 - 20,366,475 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543920,317,814 - 20,366,724 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.16163,674,142 - 163,722,630 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6163,673,464 - 163,736,777 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06158,662,192 - 158,713,413 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1149,497,229 - 49,535,260 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,497,229 - 49,535,260 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha150,340,229 - 50,378,262 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,682,496 - 49,720,525 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,682,496 - 49,720,525 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,564,853 - 49,602,878 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0149,436,580 - 49,474,619 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0150,051,672 - 50,089,725 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404946144,523,021 - 144,556,568 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,775,243 - 11,805,651 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493648911,775,243 - 11,808,482 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl17,061,192 - 7,110,555 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,062,399 - 7,109,521 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.218,740,127 - 8,787,546 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11388,266,054 - 88,321,596 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1388,268,198 - 88,322,644 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604060,598,947 - 60,654,431 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248552,360,229 - 2,402,079 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248552,362,793 - 2,401,519 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Plg
198 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:37
Interacting mature miRNAs:37
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,326,542 - 48,326,723 (+)MAPPERmRatBN7.2
Rnor_6.0148,523,187 - 48,523,365NCBIRnor6.0
Rnor_5.0151,232,363 - 51,232,541UniSTSRnor5.0
RGSC_v3.4142,783,820 - 42,783,999RGDRGSC3.4
RGSC_v3.4142,783,821 - 42,783,999UniSTSRGSC3.4
RGSC_v3.1142,786,766 - 42,786,944RGD
RH 3.4 Map1571.4UniSTS
RH 3.4 Map1571.4RGD
RH 2.0 Map1287.6RGD
Cytogenetic Map1q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,362,654 - 48,362,895 (+)MAPPERmRatBN7.2
Rnor_6.0148,559,338 - 48,559,576NCBIRnor6.0
Rnor_5.0151,196,456 - 51,196,694UniSTSRnor5.0
RGSC_v3.4142,820,197 - 42,820,436RGDRGSC3.4
RGSC_v3.4142,820,198 - 42,820,436UniSTSRGSC3.4
RGSC_v3.1142,823,142 - 42,823,381RGD
Celera144,154,461 - 44,154,703UniSTS
RH 2.0 Map1302.6RGD
Cytogenetic Map1q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,325,244 - 48,325,436 (+)MAPPERmRatBN7.2
Rnor_6.0148,521,889 - 48,522,080NCBIRnor6.0
Rnor_5.0151,233,648 - 51,233,839UniSTSRnor5.0
RGSC_v3.4142,782,523 - 42,782,714UniSTSRGSC3.4
Celera144,117,287 - 44,117,478UniSTS
RH 3.4 Map1571.4UniSTS
Cytogenetic Map1q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,368,930 - 48,369,114 (+)MAPPERmRatBN7.2
Rnor_6.0148,565,047 - 48,565,230NCBIRnor6.0
Rnor_5.0151,190,802 - 51,190,985UniSTSRnor5.0
RGSC_v3.4142,826,437 - 42,826,620UniSTSRGSC3.4
Celera144,160,979 - 44,161,162UniSTS
RH 3.4 Map1585.3UniSTS
Cytogenetic Map1q11UniSTS
Cytogenetic Map3q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23112,509,632 - 112,509,834 (+)MAPPERmRatBN7.2
mRatBN7.2148,368,897 - 48,369,099 (-)MAPPERmRatBN7.2
mRatBN7.2148,368,897 - 48,369,099 (+)MAPPERmRatBN7.2
mRatBN7.23112,509,632 - 112,509,834 (-)MAPPERmRatBN7.2
Rnor_6.03117,525,088 - 117,525,289NCBIRnor6.0
Rnor_6.0148,565,014 - 48,565,215NCBIRnor6.0
Rnor_5.0151,190,817 - 51,191,018UniSTSRnor5.0
Rnor_5.03124,048,806 - 124,049,007UniSTSRnor5.0
RGSC_v3.43112,562,078 - 112,562,279UniSTSRGSC3.4
RGSC_v3.4142,826,404 - 42,826,605UniSTSRGSC3.4
Celera144,160,946 - 44,161,147UniSTS
Celera3111,366,080 - 111,366,281UniSTS
Cytogenetic Map1q11UniSTS
Cytogenetic Map3q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,325,210 - 48,325,453 (+)MAPPERmRatBN7.2
Rnor_6.0148,521,855 - 48,522,097NCBIRnor6.0
Rnor_5.0151,233,631 - 51,233,873UniSTSRnor5.0
RGSC_v3.4142,782,489 - 42,782,731UniSTSRGSC3.4
Celera144,117,253 - 44,117,495UniSTS
Cytogenetic Map1q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,325,213 - 48,325,575 (+)MAPPERmRatBN7.2
Rnor_6.0148,521,858 - 48,522,219NCBIRnor6.0
Rnor_5.0151,233,509 - 51,233,870UniSTSRnor5.0
RGSC_v3.4142,782,492 - 42,782,853UniSTSRGSC3.4
Celera144,117,256 - 44,117,617UniSTS
Cytogenetic Map1q11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 25 25 25
Medium 1 18 16 16 2 1
Low 32 14 15 6 6 13 13 32 9 6
Below cutoff 2 11 4 2 5 61 19 7 1 2


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023368   ⟹   ENSRNOP00000023370
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl148,325,185 - 48,367,786 (-)Ensembl
Rnor_6.0 Ensembl148,521,772 - 48,563,776 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080352   ⟹   ENSRNOP00000073928
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl148,331,107 - 48,362,479 (-)Ensembl
Rnor_6.0 Ensembl148,527,786 - 48,559,162 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099285   ⟹   ENSRNOP00000083556
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl148,325,185 - 48,363,732 (-)Ensembl
RefSeq Acc Id: NM_053491   ⟹   NP_445943
Rat AssemblyChrPosition (strand)Source
mRatBN7.2148,325,186 - 48,367,643 (-)NCBI
Rnor_6.0148,521,830 - 48,563,759 (-)NCBI
Rnor_5.0151,192,273 - 51,233,898 (+)NCBI
RGSC_v3.4142,782,464 - 42,825,149 (-)RGD
Celera144,117,228 - 44,159,691 (-)RGD
Reference Sequences
RefSeq Acc Id: NP_445943   ⟸   NM_053491
- Peptide Label: precursor
- UniProtKB: Q9R0W3 (UniProtKB/Swiss-Prot),   Q01177 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073928   ⟸   ENSRNOT00000080352
RefSeq Acc Id: ENSRNOP00000023370   ⟸   ENSRNOT00000023368
RefSeq Acc Id: ENSRNOP00000083556   ⟸   ENSRNOT00000099285
Protein Domains
Apple   Kringle   PAN   Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q01177-F1-model_v2 AlphaFold Q01177 1-812 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13689620
Promoter ID:EPDNEW_R145
Type:initiation region
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0148,563,778 - 48,563,838EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619893 AgrOrtholog
BioCyc Gene G2FUF-61564 BioCyc
Ensembl Genes ENSRNOG00000017223 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023370 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000073928.2 UniProtKB/TrEMBL
  ENSRNOP00000083556.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023368 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000080352.2 UniProtKB/TrEMBL
  ENSRNOT00000099285.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pan_app UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_S1A_plasmin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:85253 UniProtKB/Swiss-Prot
Pfam Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plg PhenoGen
PIRSF Plasmin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PAN_AP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K6S8_RAT UniProtKB/TrEMBL
UniProt Secondary Q5BKB6 UniProtKB/Swiss-Prot
  Q9R0W3 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Plg  plasminogen      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Plg  plasminogen      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds to the Heymann nephritis autoantigen (gp330), and thus may be associated with the rat model of human idiopathic glomerulonephropathy 1299252