Acss2 (acyl-CoA synthetase short-chain family member 2) - Rat Genome Database

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Gene: Acss2 (acyl-CoA synthetase short-chain family member 2) Rattus norvegicus
Analyze
Symbol: Acss2
Name: acyl-CoA synthetase short-chain family member 2
RGD ID: 1305489
Description: Enables acetate-CoA ligase activity. Involved in acetate biosynthetic process and propionate biosynthetic process. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in orofacial cleft. Orthologous to human ACSS2 (acyl-CoA synthetase short chain family member 2); PARTICIPATES IN disulfiram pharmacodynamics pathway; fatty acid beta degradation pathway; Leigh disease pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Acas2; acetyl-Coenzyme A synthetase 2 (ADP forming); acetyl-coenzyme A synthetase, cytoplasmic; LOC311569
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,464,124 - 164,507,607 (+)NCBIGRCr8
mRatBN7.23144,003,808 - 144,047,452 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3144,004,336 - 144,059,675 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3147,870,984 - 147,913,977 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,488,259 - 156,531,254 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,227,791 - 154,270,788 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03151,032,925 - 151,075,856 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3151,032,952 - 151,075,856 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03157,400,353 - 157,443,341 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43146,013,995 - 146,057,119 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13145,919,548 - 145,962,044 (+)NCBI
Celera3142,729,140 - 142,772,009 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,4-dichloroaniline  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
alpha-phellandrene  (ISO)
alpha-pinene  (ISO)
amiodarone  (EXP,ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chloroethene  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
DDT  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
ferric oxide  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
FR900359  (ISO)
Ganoderic acid A  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
glycidyl methacrylate  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
manganese(II) chloride  (EXP)
methotrexate  (ISO)
methylparaben  (ISO)
miconazole  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
oxybenzone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
ritonavir  (EXP)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
sodium acetate trihydrate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
Yessotoxin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (ISO)
membrane  (IEA)
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Using Whole Exome Sequencing to Identify Candidate Genes With Rare Variants In Nonsyndromic Cleft Lip and Palate. Aylward A, etal., Genet Epidemiol. 2016 Jul;40(5):432-41. doi: 10.1002/gepi.21972. Epub 2016 May 27.
2. The subcellular distribution of short-chain fatty acyl-CoA synthetase activity in rat tissues. Barth C, etal., Biochim Biophys Acta. 1971 Oct 5;248(1):24-33.
3. ACSS2 gene variant associated with cleft lip and palate in two independent Hispanic populations. Dodhia S, etal., Laryngoscope. 2017 Oct;127(10):E336-E339. doi: 10.1002/lary.26637. Epub 2017 May 23.
4. De novo lipogenesis in adipose tissue is associated with course of morbid obesity after bariatric surgery. Garrido-Sánchez L, etal., PLoS One. 2012;7(2):e31280. doi: 10.1371/journal.pone.0031280. Epub 2012 Feb 23.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. In situ analysis of mTORC1/2 and cellular metabolism-related proteins in human Lymphangioleiomyomatosis. Krencz I, etal., Hum Pathol. 2018 Sep;79:199-207. doi: 10.1016/j.humpath.2018.05.018. Epub 2018 Jun 6.
8. Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth. Lakhter AJ, etal., J Biol Chem. 2016 Oct 14;291(42):21869-21879. doi: 10.1074/jbc.M115.712166. Epub 2016 Aug 18.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans. Männistö VT, etal., Liver Int. 2015 Jul;35(7):1853-61. doi: 10.1111/liv.12769. Epub 2015 Jan 20.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, etal., J Lipid Res. 2007 Dec;48(12):2736-50. Epub 2007 Aug 30.
Additional References at PubMed
PMID:10843999   PMID:11150295   PMID:12477932   PMID:16790548   PMID:28003429   PMID:31505169   PMID:35902549  


Genomics

Comparative Map Data
Acss2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,464,124 - 164,507,607 (+)NCBIGRCr8
mRatBN7.23144,003,808 - 144,047,452 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3144,004,336 - 144,059,675 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3147,870,984 - 147,913,977 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,488,259 - 156,531,254 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,227,791 - 154,270,788 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03151,032,925 - 151,075,856 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3151,032,952 - 151,075,856 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03157,400,353 - 157,443,341 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43146,013,995 - 146,057,119 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13145,919,548 - 145,962,044 (+)NCBI
Celera3142,729,140 - 142,772,009 (+)NCBICelera
Cytogenetic Map3q42NCBI
ACSS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382034,874,989 - 34,927,959 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2034,872,146 - 34,927,962 (+)EnsemblGRCh38hg38GRCh38
GRCh372033,462,792 - 33,515,762 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362032,926,406 - 32,979,423 (+)NCBINCBI36Build 36hg18NCBI36
Build 342032,926,501 - 32,979,423NCBI
Celera2030,211,860 - 30,264,862 (+)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2030,241,182 - 30,294,089 (+)NCBIHuRef
CHM1_12033,364,136 - 33,416,989 (+)NCBICHM1_1
T2T-CHM13v2.02036,595,583 - 36,648,613 (+)NCBIT2T-CHM13v2.0
Acss2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392155,359,963 - 155,404,663 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2155,359,868 - 155,427,644 (+)EnsemblGRCm39 Ensembl
GRCm382155,518,043 - 155,562,743 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2155,517,948 - 155,585,724 (+)EnsemblGRCm38mm10GRCm38
MGSCv372155,343,779 - 155,388,479 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362155,209,484 - 155,254,184 (+)NCBIMGSCv36mm8
Celera2161,450,232 - 161,494,992 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map277.26NCBI
Acss2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542226,451,598 - 26,500,546 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542226,450,899 - 26,500,336 (-)NCBIChiLan1.0ChiLan1.0
ACSS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22140,609,437 - 40,660,734 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12040,602,540 - 40,653,837 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02031,205,104 - 31,256,263 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12032,329,706 - 32,381,274 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2032,329,721 - 32,380,526 (+)Ensemblpanpan1.1panPan2
ACSS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12423,928,800 - 23,973,383 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2423,928,838 - 23,972,651 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2423,575,057 - 23,619,550 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02424,620,738 - 24,665,236 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2424,620,678 - 24,668,479 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12423,908,064 - 23,952,517 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02424,003,357 - 24,047,830 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02424,442,065 - 24,486,750 (+)NCBIUU_Cfam_GSD_1.0
Acss2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640172,906,912 - 172,955,145 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365615,795,077 - 5,842,676 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365615,794,685 - 5,842,619 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACSS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1738,260,147 - 38,315,757 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11738,260,152 - 38,315,764 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21743,455,051 - 43,510,660 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACSS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1239,181,446 - 39,230,164 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl239,181,468 - 39,229,444 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605087,582,705 - 87,633,586 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acss2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248424,471,360 - 4,522,849 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248424,470,551 - 4,523,174 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acss2
175 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:107
Count of miRNA genes:75
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000064013
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat

Markers in Region
D3Got111  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23144,006,941 - 144,007,067 (+)MAPPERmRatBN7.2
Rnor_6.03151,035,348 - 151,035,473NCBIRnor6.0
Rnor_5.03157,402,817 - 157,402,942UniSTSRnor5.0
RGSC_v3.43146,016,390 - 146,016,515RGDRGSC3.4
RGSC_v3.43146,016,391 - 146,016,516UniSTSRGSC3.4
RGSC_v3.13145,922,012 - 145,922,137RGD
Celera3142,731,536 - 142,731,661UniSTS
RH 3.4 Map31301.8UniSTS
RH 3.4 Map31301.8RGD
RH 2.0 Map3871.5RGD
Cytogenetic Map3q42UniSTS
RH129720  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23144,047,206 - 144,047,387 (+)MAPPERmRatBN7.2
Rnor_6.03151,075,611 - 151,075,791NCBIRnor6.0
Rnor_5.03157,443,096 - 157,443,276UniSTSRnor5.0
RGSC_v3.43146,056,874 - 146,057,054UniSTSRGSC3.4
Celera3142,771,764 - 142,771,944UniSTS
RH 3.4 Map31304.8UniSTS
Cytogenetic Map3q42UniSTS
AU046887  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23144,024,138 - 144,024,340 (+)MAPPERmRatBN7.2
Rnor_6.03151,052,544 - 151,052,745NCBIRnor6.0
Rnor_5.03157,420,066 - 157,420,267UniSTSRnor5.0
RGSC_v3.43146,033,807 - 146,034,008UniSTSRGSC3.4
Celera3142,748,699 - 142,748,900UniSTS
Cytogenetic Map3q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 29 42 27 19 27 8 11 72 31 32 11 8
Low 14 15 14 14 2 4 9
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000064013   ⟹   ENSRNOP00000059987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3144,004,336 - 144,047,452 (+)Ensembl
Rnor_6.0 Ensembl3151,032,952 - 151,075,856 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098802   ⟹   ENSRNOP00000090034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3144,004,543 - 144,059,675 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107324   ⟹   ENSRNOP00000090627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3144,004,336 - 144,047,442 (+)Ensembl
RefSeq Acc Id: NM_001107793   ⟹   NP_001101263
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,464,703 - 164,507,607 (+)NCBI
mRatBN7.23144,004,543 - 144,047,452 (+)NCBI
Rnor_6.03151,032,952 - 151,075,856 (+)NCBI
Rnor_5.03157,400,353 - 157,443,341 (+)NCBI
RGSC_v3.43146,013,995 - 146,057,119 (+)RGD
Celera3142,729,140 - 142,772,009 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235321   ⟹   XP_006235383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,464,635 - 164,507,600 (+)NCBI
mRatBN7.23144,004,215 - 144,047,450 (+)NCBI
Rnor_6.03151,032,925 - 151,075,854 (+)NCBI
Rnor_5.03157,400,353 - 157,443,341 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105076   ⟹   XP_038961004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,464,124 - 164,507,600 (+)NCBI
mRatBN7.23144,003,809 - 144,047,450 (+)NCBI
RefSeq Acc Id: NP_001101263   ⟸   NM_001107793
- UniProtKB: A6KI41 (UniProtKB/TrEMBL),   B1WC11 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235383   ⟸   XM_006235321
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GJ11 (UniProtKB/TrEMBL),   G3V9U0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000059987   ⟸   ENSRNOT00000064013
RefSeq Acc Id: XP_038961004   ⟸   XM_039105076
- Peptide Label: isoform X2
- UniProtKB: B1WC11 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000090034   ⟸   ENSRNOT00000098802
RefSeq Acc Id: ENSRNOP00000090627   ⟸   ENSRNOT00000107324
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9U0-F1-model_v2 AlphaFold G3V9U0 1-701 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692584
Promoter ID:EPDNEW_R3109
Type:initiation region
Name:Acss2_1
Description:acyl-CoA synthetase short-chain family member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03151,032,976 - 151,033,036EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305489 AgrOrtholog
BioCyc Gene G2FUF-47130 BioCyc
BioCyc Pathway PWY0-1313 [acetate conversion to acetyl-CoA] BioCyc
  PWY66-162 [ethanol degradation IV] BioCyc
  PWY66-21 [ethanol degradation II] BioCyc
BioCyc Pathway Image PWY0-1313 BioCyc
  PWY66-162 BioCyc
  PWY66-21 BioCyc
Ensembl Genes ENSRNOG00000018755 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064013 ENTREZGENE
  ENSRNOT00000064013.2 UniProtKB/TrEMBL
  ENSRNOT00000098802.1 UniProtKB/TrEMBL
  ENSRNOT00000107324.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.300.30 UniProtKB/TrEMBL
  3.40.50.12780 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9028172 IMAGE-MGC_LOAD
InterPro ACAS_N UniProtKB/TrEMBL
  AMP-bd_C_sf UniProtKB/TrEMBL
  AMP-binding_CS UniProtKB/TrEMBL
  AMP-dep_Synth/Lig UniProtKB/TrEMBL
  AMP-dep_Synthh-like_sf UniProtKB/TrEMBL
  DUF4009 UniProtKB/TrEMBL
KEGG Report rno:311569 UniProtKB/TrEMBL
MGC_CLONE MGC:187768 IMAGE-MGC_LOAD
NCBI Gene 311569 ENTREZGENE
PANTHER ACETYL-COENZYME A SYNTHETASE UniProtKB/TrEMBL
  ACETYL-COENZYME A SYNTHETASE, CYTOPLASMIC UniProtKB/TrEMBL
Pfam ACAS_N UniProtKB/TrEMBL
  AMP-binding UniProtKB/TrEMBL
  DUF4009 UniProtKB/TrEMBL
PhenoGen Acss2 PhenoGen
PROSITE AMP_BINDING UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018755 RatGTEx
Superfamily-SCOP Acetyl-CoA synthetase-like UniProtKB/TrEMBL
UniProt A0A8I6AD12_RAT UniProtKB/TrEMBL
  A0A8I6GJ11 ENTREZGENE, UniProtKB/TrEMBL
  A6KI41 ENTREZGENE, UniProtKB/TrEMBL
  B1WC11 ENTREZGENE, UniProtKB/TrEMBL
  G3V9U0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Acss2  acyl-CoA synthetase short-chain family member 2   Acss2_predicted  acyl-CoA synthetase short-chain family member 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Acss2_predicted  acyl-CoA synthetase short-chain family member 2 (predicted)  Acas2_predicted  acetyl-Coenzyme A synthetase 2 (ADP forming) (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Acas2_predicted  acetyl-Coenzyme A synthetase 2 (ADP forming) (predicted)      Symbol and Name status set to approved 70820 APPROVED