Acss2 (acyl-CoA synthetase short-chain family member 2)

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Gene: Acss2 (acyl-CoA synthetase short-chain family member 2) Rattus norvegicus

Analyze

Symbol:

Acss2

Name:

acyl-CoA synthetase short-chain family member 2

RGD ID:

1305489

Description:

Enables acetate-CoA ligase activity. Involved in acetate biosynthetic process and propionate biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in orofacial cleft. Orthologous to human ACSS2 (acyl-CoA synthetase short chain family member 2); PARTICIPATES IN disulfiram pharmacodynamics pathway; fatty acid beta degradation pathway; Leigh disease pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Acas2; acetyl-Coenzyme A synthetase 2 (ADP forming); acetyl-coenzyme A synthetase, cytoplasmic; LOC311569

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	144,003,808 - 144,047,452 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	144,004,336 - 144,059,675 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	147,870,984 - 147,913,977 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	156,488,259 - 156,531,254 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	154,227,791 - 154,270,788 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	151,032,925 - 151,075,856 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	151,032,952 - 151,075,856 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	157,400,353 - 157,443,341 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	146,013,995 - 146,057,119 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	145,919,548 - 145,962,044 (+)	NCBI
Celera	3	142,729,140 - 142,772,009 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Melanoma (ISO)

genetic disease (ISO)

Inflammation (ISO)

long QT syndrome (ISO)

lymphangioleiomyomatosis (ISO)

morbid obesity (ISO)

orofacial cleft (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-alpha-phellandrene (ISO)

(-)-epigallocatechin 3-gallate (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-amino-2-deoxy-D-glucopyranose (ISO)

3,4-dichloroaniline (EXP)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrolein (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucosamine (ISO)

aldehydo-D-glucose (ISO)

aldrin (ISO)

all-trans-retinoic acid (ISO)

all-trans-retinol (EXP)

alpha-phellandrene (ISO)

alpha-pinene (ISO)

amiodarone (EXP,ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

atrazine (EXP)

avobenzone (ISO)

benzo[a]pyrene (ISO)

beta-D-glucosamine (ISO)

bezafibrate (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

bromobenzene (EXP)

caffeine (ISO)

carbon nanotube (ISO)

carnosic acid (ISO)

CGP 52608 (ISO)

chloroethene (ISO)

chloroprene (ISO)

cisplatin (ISO)

clobetasol (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) chloride (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

cyclosporin A (EXP,ISO)

D-glucose (ISO)

DDT (EXP)

dexamethasone (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP,ISO)

dimethylarsinous acid (ISO)

dioxygen (ISO)

disulfiram (ISO)

diuron (EXP)

doxorubicin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (ISO)

fenofibrate (ISO)

ferric oxide (ISO)

folic acid (ISO)

Ganoderic acid A (ISO)

gentamycin (EXP)

glafenine (EXP)

glucose (ISO)

glycidyl methacrylate (ISO)

indometacin (EXP,ISO)

inulin (ISO)

isobutanol (ISO)

ivermectin (ISO)

lipopolysaccharide (ISO)

lovastatin (ISO)

manganese(II) chloride (EXP)

methotrexate (ISO)

methylparaben (ISO)

miconazole (ISO)

N-methyl-4-phenylpyridinium (EXP)

nefazodone (EXP)

nickel atom (ISO)

nickel sulfate (ISO)

O-methyleugenol (ISO)

ochratoxin A (EXP)

oxybenzone (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

ritonavir (EXP)

rotenone (EXP,ISO)

silicon dioxide (ISO)

sodium acetate trihydrate (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sunitinib (ISO)

tamoxifen (ISO)

temozolomide (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

tetracycline (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tolcapone (EXP)

trichloroethene (EXP)

triphenyl phosphate (EXP)

Triptolide (ISO)

troglitazone (ISO)

trovafloxacin (ISO)

urethane (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

Yessotoxin (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acetate biosynthetic process (IDA)

acetyl-CoA biosynthetic process (IBA,ISO)

lipid biosynthetic process (ISO)

propionate biosynthetic process (IDA)

Cellular Component

cytoplasm (IBA,ISO)

cytosol (ISO)

membrane (IEA)

Molecular Function

acetate-CoA ligase activity (IBA,IDA,ISO)

propionate-CoA ligase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

disulfiram pharmacodynamics pathway (ISO)

fatty acid beta degradation pathway (ISO)

gluconeogenesis pathway (IEA)

glycolysis pathway (IEA)

glycolysis/gluconeogenesis pathway (IEA)

Leigh disease pathway (ISO)

primary hyperoxaluria type 2 pathway (ISO)

propanoate metabolic pathway (IEA)

pyruvate decarboxylase deficiency pathway (ISO)

pyruvate dehydrogenase E1 deficiency pathway (ISO)

pyruvate kinase deficiency of red cells pathway (ISO)

pyruvate metabolic pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Using Whole Exome Sequencing to Identify Candidate Genes With Rare Variants In Nonsyndromic Cleft Lip and Palate.	Aylward A, etal., Genet Epidemiol. 2016 Jul;40(5):432-41. doi: 10.1002/gepi.21972. Epub 2016 May 27.
2.	The subcellular distribution of short-chain fatty acyl-CoA synthetase activity in rat tissues.	Barth C, etal., Biochim Biophys Acta. 1971 Oct 5;248(1):24-33.
3.	ACSS2 gene variant associated with cleft lip and palate in two independent Hispanic populations.	Dodhia S, etal., Laryngoscope. 2017 Oct;127(10):E336-E339. doi: 10.1002/lary.26637. Epub 2017 May 23.
4.	De novo lipogenesis in adipose tissue is associated with course of morbid obesity after bariatric surgery.	Garrido-Sánchez L, etal., PLoS One. 2012;7(2):e31280. doi: 10.1371/journal.pone.0031280. Epub 2012 Feb 23.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
7.	In situ analysis of mTORC1/2 and cellular metabolism-related proteins in human Lymphangioleiomyomatosis.	Krencz I, etal., Hum Pathol. 2018 Sep;79:199-207. doi: 10.1016/j.humpath.2018.05.018. Epub 2018 Jun 6.
8.	Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth.	Lakhter AJ, etal., J Biol Chem. 2016 Oct 14;291(42):21869-21879. doi: 10.1074/jbc.M115.712166. Epub 2016 Aug 18.
9.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
10.	Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans.	Männistö VT, etal., Liver Int. 2015 Jul;35(7):1853-61. doi: 10.1111/liv.12769. Epub 2015 Jan 20.
11.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
12.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
13.	GOA pipeline	RGD automated data pipeline
14.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
15.	Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome.	Watkins PA, etal., J Lipid Res. 2007 Dec;48(12):2736-50. Epub 2007 Aug 30.

Additional References at PubMed

PMID:10843999	PMID:11150295	PMID:12477932	PMID:16790548	PMID:28003429	PMID:31505169	PMID:35902549

Genomics

Comparative Map Data

Acss2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	144,003,808 - 144,047,452 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	144,004,336 - 144,059,675 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	147,870,984 - 147,913,977 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	156,488,259 - 156,531,254 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	154,227,791 - 154,270,788 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	151,032,925 - 151,075,856 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	151,032,952 - 151,075,856 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	157,400,353 - 157,443,341 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	146,013,995 - 146,057,119 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	145,919,548 - 145,962,044 (+)	NCBI
Celera	3	142,729,140 - 142,772,009 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

ACSS2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	34,874,989 - 34,927,959 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	34,872,146 - 34,927,962 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	33,462,792 - 33,515,762 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	32,926,406 - 32,979,423 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	32,926,501 - 32,979,423	NCBI
Celera	20	30,211,860 - 30,264,862 (+)	NCBI		Celera
Cytogenetic Map	20	q11.22	NCBI
HuRef	20	30,241,182 - 30,294,089 (+)	NCBI		HuRef
CHM1_1	20	33,364,136 - 33,416,989 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	36,595,583 - 36,648,613 (+)	NCBI		T2T-CHM13v2.0

Acss2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	155,359,963 - 155,404,663 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	155,359,868 - 155,427,644 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	155,518,043 - 155,562,743 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	155,517,948 - 155,585,724 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	155,343,779 - 155,388,479 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	155,209,484 - 155,254,184 (+)	NCBI		MGSCv36	mm8
Celera	2	161,450,232 - 161,494,992 (+)	NCBI		Celera
Cytogenetic Map	2	H1	NCBI
cM Map	2	77.26	NCBI

Acss2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	26,451,598 - 26,500,546 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	26,450,899 - 26,500,336 (-)	NCBI	ChiLan1.0	ChiLan1.0

ACSS2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	20	40,602,540 - 40,653,837 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	31,205,104 - 31,256,263 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	32,329,706 - 32,381,274 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	32,329,721 - 32,380,526 (+)	Ensembl	panpan1.1		panPan2

ACSS2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	23,928,800 - 23,973,383 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	23,928,838 - 23,972,651 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	23,575,057 - 23,619,550 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	24,620,738 - 24,665,236 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	24,620,678 - 24,668,479 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	23,908,064 - 23,952,517 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	24,003,357 - 24,047,830 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	24,442,065 - 24,486,750 (+)	NCBI		UU_Cfam_GSD_1.0

Acss2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	172,906,912 - 172,955,145 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936561	5,795,077 - 5,842,676 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936561	5,794,685 - 5,842,619 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ACSS2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	38,260,147 - 38,315,757 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	38,260,152 - 38,315,764 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	43,455,051 - 43,510,660 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ACSS2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	39,181,446 - 39,230,164 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	39,181,468 - 39,229,444 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	87,582,705 - 87,633,586 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Acss2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624842	4,471,360 - 4,522,849 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624842	4,470,551 - 4,523,174 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Acss2
175 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	107
Count of miRNA genes:	75
Interacting mature miRNAs:	96
Transcripts:	ENSRNOT00000064013
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141074471	169034231	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	130193298	161695983	Rat
5686842	Rf59	Renal function QTL 59			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	3	140069424	146976080	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	131635904	169034231	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	124122556	169034231	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
8552952	Pigfal13	Plasma insulin-like growth factor 1 level QTL 13			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	138799500	169034231	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	121056165	157309487	Rat
1300173	Rf11	Renal function QTL 11	3.38		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	121056165	145956249	Rat
1331726	Bp208	Blood pressure QTL 208	3.129		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141339013	162184794	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	130656562	169034231	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	130656562	169034231	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
1598877	Bp285	Blood pressure QTL 285	1.5	0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	120538241	165538241	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	118839124	163839124	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
61335	Bp20	Blood pressure QTL 20	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141339236	155617360	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
2298477	Eau4	Experimental allergic uveoretinitis QTL 4		0.0011	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	3	137398739	169034231	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	127162703	168026850	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	122438700	167438700	Rat

Markers in Region

D3Got111

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	144,006,941 - 144,007,067 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	151,035,348 - 151,035,473	NCBI	Rnor6.0
Rnor_5.0	3	157,402,817 - 157,402,942	UniSTS	Rnor5.0
RGSC_v3.4	3	146,016,390 - 146,016,515	RGD	RGSC3.4
RGSC_v3.4	3	146,016,391 - 146,016,516	UniSTS	RGSC3.4
RGSC_v3.1	3	145,922,012 - 145,922,137	RGD
Celera	3	142,731,536 - 142,731,661	UniSTS
RH 3.4 Map	3	1301.8	UniSTS
RH 3.4 Map	3	1301.8	RGD
RH 2.0 Map	3	871.5	RGD
Cytogenetic Map	3	q42	UniSTS

RH129720

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	144,047,206 - 144,047,387 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	151,075,611 - 151,075,791	NCBI	Rnor6.0
Rnor_5.0	3	157,443,096 - 157,443,276	UniSTS	Rnor5.0
RGSC_v3.4	3	146,056,874 - 146,057,054	UniSTS	RGSC3.4
Celera	3	142,771,764 - 142,771,944	UniSTS
RH 3.4 Map	3	1304.8	UniSTS
Cytogenetic Map	3	q42	UniSTS

AU046887

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	144,024,138 - 144,024,340 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	151,052,544 - 151,052,745	NCBI	Rnor6.0
Rnor_5.0	3	157,420,066 - 157,420,267	UniSTS	Rnor5.0
RGSC_v3.4	3	146,033,807 - 146,034,008	UniSTS	RGSC3.4
Celera	3	142,748,699 - 142,748,900	UniSTS
Cytogenetic Map	3	q42	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	29	42	27	19	27	8	11	72	31	32	11	8
Low		14	15	14		14			2	4	9
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107793	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006235321	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105075	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105076	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105077	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC123188	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC161963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217492	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000064013 ⟹ ENSRNOP00000059987

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	144,004,336 - 144,047,452 (+)	Ensembl
Rnor_6.0 Ensembl	3	151,032,952 - 151,075,856 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000098802 ⟹ ENSRNOP00000090034

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	144,004,543 - 144,059,675 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000107324 ⟹ ENSRNOP00000090627

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	144,004,336 - 144,047,442 (+)	Ensembl

RefSeq Acc Id:

NM_001107793 ⟹ NP_001101263

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	144,004,543 - 144,047,452 (+)	NCBI
Rnor_6.0	3	151,032,952 - 151,075,856 (+)	NCBI
Rnor_5.0	3	157,400,353 - 157,443,341 (+)	NCBI
RGSC_v3.4	3	146,013,995 - 146,057,119 (+)	RGD
Celera	3	142,729,140 - 142,772,009 (+)	RGD

Sequence:

show sequence

GTTTTCCCCGCCCCGGCACCCGCAGCGACCGCAACGGCGGCCAAGGTGCTCAGAACTTGACGTG
ATGGGGCTTCCCGAGGAGCGGCGCAAGAGCGGCAGCGGGAGCCGGGCTCGCGAGGAGACCGGCG
CCGAGGGCCGGGTGCGGGGTTGGTCCCCGCCGCCGGAGGTCAGACGCTCGGCGCACGTCCCCTC
TCTGCAGCGCTACCGCGAGCTGCACCGGCGTTCTGTGGAGGAGCCACGGGAGTTTTGGGGAAAC
ATTGCCAAGGAATTTTACTGGAAAACCCCATGCCCTGGCCCATTCCTCCAGTACAACTTTGATG
TGACTAAAGGGAAAATATTCACTGAGTGGATGAAAGGAGCAACCACAAACATCTGCTACAATGT
GCTGGATAGAAATGTCCATGAGAAAAAACTTGGCGACAAAGTTGCTTTTTACTGGGAGGGCAAT
GAGCCAGGGGAGACCACCAAGATCACATACCGTGAACTCCTGGTCCAGGTGTGTCAGTTCAGCA
ATGTTCTCCGTAAACAGGGTGTTCAGAAGGGTGACCGAGTGGCCATCTACATGCCTATGATCTT
GGAGCTTGTGGTGGCTATGCTGGCATGTGCTCGCCTTGGAGCTTTGCACTCCATTGTGTTTGCA
GGCTTCTCTGCAGAGTCTCTCTGTGAACGGATCTTGGATTCCAGCTGCTGCCTGCTCATTACTA
CAGATGCCTTCTACAGGGGGGAAAAACTTGTGAACCTGAAGGAGCTGGCTGATGAGTCCTTGGA
GAAGTGCCGAGAGAAGGGTTTCCCAGTGAGATGCTGCATTGTGGTCAAACATCTGGGGCGGGCA
GAGCTGGGCATGAATGACTCCCCCAGCCAGTCCCCACCCGTTAAGAGGCCATGTCCAGATGTCC
AGATCTCCTGGAATGAAGGGGTTGACTTGTGGTGGCATGAACTCATGCAGCAGGCAGGAGATGA
GTTTGAGCCTGAGTGGTGTGATGCCGAGGACCCTCTCTTCATCTTGTATACCAGTGGCTCCACA
GGCAAACCCAAGGGTGTGGTGCACACAGTTGGAGGCTACATGCTCTATGTGGCTACAACTTTCA
AGTATGTGTTTGATTTCCATCCGGAGGATGTATTCTGGTGCACAGCAGACATTGGCTGGATCAC
TGGTCATTCCTATGTCACCTATGGGCCGCTGGCGAATGGTGCCACCAGTGTTTTGTTTGAGGGG
ATCCCCACATACCCAGATGAAGGCCGCTTGTGGAGCATTGTGGACAAATACAAGGTGACCAAGT
TCTACACGGCACCAACAGCAATCCGGATGCTCATGAAGTTTGGAGATGATCCTGTCACCAAGCA
TAGCCGGGCATCCTTGCAGGTGCTGGGCACAGTAGGTGAACCCATCAACCCTGAAGCCTGGCTA
TGGTACCATCGGGTAGTAGGTTCCCAGCGTTGCCCCATTGTAGACACCTTCTGGCAAACAGAAA
CAGGTGGCCATATGCTGACCCCTCTCCCTGGTGCCACACCCATGAAACCAGGTTCTGCTTCTTT
CCCGTTCTTTGGTGTTGCGCCTGCAATCCTGAACGAGTCGGGGGAAGAACTGGAAGGGGAAGCT
GAAGGTTATCTGGTGTTCAAGCAGCCCTGGCCAGGGATCATGCGCACAGTTTATGGGAACCACA
CACGTTTCGAGACCACCTACTTTAAGAAGTTCCCTGGCTACTACGTGACTGGAGATGGCTGCCG
ACGGGATCAGGACGGCTATTACTGGATCACTGGCAGGATTGATGACATGCTCAATGTGTCTGGA
CATCTTCTGAGTACAGCAGAGGTGGAATCAGCACTTGTGGAACATGAGGCTGTTGCAGAGGCAG
CTGTGGTGGGCCACCCTCATCCTGTGAAGGGTGAATGCCTCTACTGCTTTGTTACCTTGTGTGA
CGGCCATACCTTCAGCCCCACCCTCACTGAGGAACTCAAGAAGCAGATTAGAGAAAAGATTGGC
CCCATTGCCACACCAGACTACATCCAGAATGCACCCGGCTTGCCTAAAACACGCTCAGGAAAAA
TCATGAGGAGAGTACTCCGGAAGATTGCTCAGAATGACCACGACCTGGGGGATACCTCTACAGT
GGCTGACCCATCTGTCATCAACCATCTCTTCAGTCACCGCTGCCTGACCACACAGTGAACAAGA
CTCTTATCCAGGATTTCCCTGTGCTTGGCTCTCCAAATTTCTGCCCATCTATCCTGTCCCTCAC
CCAAGAGTACCAAGGGCCAGTGCTAGTTGACATTTAGGTTGAAACTAGGGAGACAGTTACTTAG
ACTGCCAGGTCGAAGGGAACAGGGCTCAGGTCAACCATGCACTGATACTCTCCTAGGCTACAGA
GATCTCCAAGCCCAGAACAGAGACTTGAACACCATGTCCTTAACCAGAGTTAGCTATGCAGAGT
GTAAGTGAGGGCCTACCTAGAAGCAGGCGGCACCTCTAATCCTTTTTCAGCTTTCTCAGAAAGC
ACCAGTTCTTACCTTGGGCCTGCACTAGCCTTTATAAGTGACAGTTAGCAAGTCTATGAATAAT
TATTTTTTAAAATACTTTGTTGTCTCTGTTCTGAGTCTGAATTCCTTGTCAAATGATAGCAGTG
TCTGTTCATTTGCTCAAGAGACTAGGCAAGTGGCTTCAGTCTCCAGAGGACTTCCATATCATCT
GCTTCGTTGAAAGATTAAGATATGCTGGTCCTAGAACCAAGGGAGTTAACATTCCTAGTCTGCA
CCAGGAACAGAACCCTGCCCATGAGAGGCACTTGTAGGCGAAACTCTCTTTTCTTGTACTTTTT
GTGCTAAAGACCCACTGTTGTAGGAATAAAGTTTATGAACTCAAGAACATA

hide sequence

RefSeq Acc Id:

XM_006235321 ⟹ XP_006235383

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	144,004,215 - 144,047,450 (+)	NCBI
Rnor_6.0	3	151,032,925 - 151,075,854 (+)	NCBI
Rnor_5.0	3	157,400,353 - 157,443,341 (+)	NCBI

Sequence:

show sequence

CCGAGGCCCCGCCTCTAGGGTCGACCTGTTTTCCCCGCCCCGGCACCCGCAGCGACCGCAACGG
CGGCCAAGGTGCTCAGAACTTGACGTGATGGGGCTTCCCGAGGAGCGGCGCAAGAGCGGCAGCG
GGAGCCGGGCTCGCGAGGAGACCGGCGCCGAGGGCCGGGTGCGGGGTTGGTCCCCGCCGCCGGA
GGTCAGACGCTCGGCGCACGTCCCCTCTCTGCAGCGCTACCGCGAGCTGCACCGGCGTTCTGTG
GAGGAGCCACGGGAGTTTTGGGGAAACATTGCCAAGGAATTTTACTGGAAAACCCCATGCCCTG
GCCCATTCCTCCAGTACAACTTTGATGTGACTAAAGGGAAAATATTCACTGAGTGGATGAAAGG
AGCAACCACAAACATCTGCTACAATGTGCTGGATAGAAATGTCCATGAGAAAAAACTTGGCGAC
AAAGTTGCTTTTTACTGGGAGGGCAATGAGCCAGGGGAGACCACCAAGATCACATACCGTGAAC
TCCTGGTCCAGGTGTGTCAGTTCAGCAATGTTCTCCGTAAACAGGGTGTTCAGAAGGGTGACCG
AGTGGCCATCTACATGCCTATGATCTTGGAGCTTGTGGTGGCTATGCTGGCATGTGCTCGCCTT
GGAGCTTTGCACTCCATTGTGTTTGCAGGCTTCTCTGCAGAGTCTCTCTGTGAACGGATCTTGG
ATTCCAGCTGCTGCCTGCTCATTACTACAGATGCCTTCTACAGGGGGGAAAAACTTGTGAACCT
GAAGGAGCTGGCTGATGAGTCCTTGGAGAAGTGCCGAGAGAAGGGTTTCCCAGTGAGATGCTGC
ATTGTGGTCAAACATCTGGGGCGGGCAGAGCTGGGCATGAATGACTCCCCCAGCCAGTCCCCAC
CCGTTAAGAGGCCATGTCCAGATGTCCAGGGTAAGCTGAAAGAGAAATCCAAGTGCATCCGACC
CCAGATCTCCTGGAATGAAGGGGTTGACTTGTGGTGGCATGAACTCATGCAGCAGGCAGGAGAT
GAGTTTGAGCCTGAGTGGTGTGATGCCGAGGACCCTCTCTTCATCTTGTATACCAGTGGCTCCA
CAGGCAAACCCAAGGGTGTGGTGCACACAGTTGGAGGCTACATGCTCTATGTGGCTACAACTTT
CAAGTATGTGTTTGATTTCCATCCGGAGGATGTATTCTGGTGCACAGCAGACATTGGCTGGATC
ACTGGTCATTCCTATGTCACCTATGGGCCGCTGGCGAATGGTGCCACCAGTGTTTTGTTTGAGG
GGATCCCCACATACCCAGATGAAGGCCGCTTGTGGAGCATTGTGGACAAATACAAGGTGACCAA
GTTCTACACGGCACCAACAGCAATCCGGATGCTCATGAAGTTTGGAGATGATCCTGTCACCAAG
CATAGCCGGGCATCCTTGCAGGTGCTGGGCACAGTAGGTGAACCCATCAACCCTGAAGCCTGGC
TATGGTACCATCGGGTAGTAGGTTCCCAGCGTTGCCCCATTGTAGACACCTTCTGGCAAACAGA
AACAGGTGGCCATATGCTGACCCCTCTCCCTGGTGCCACACCCATGAAACCAGGTTCTGCTTCT
TTCCCGTTCTTTGGTGTTGCGCCTGCAATCCTGAACGAGTCGGGGGAAGAACTGGAAGGGGAAG
CTGAAGGTTATCTGGTGTTCAAGCAGCCCTGGCCAGGGATCATGCGCACAGTTTATGGGAACCA
CACACGTTTCGAGACCACCTACTTTAAGAAGTTCCCTGGCTACTACGTGACTGGAGATGGCTGC
CGACGGGATCAGGACGGCTATTACTGGATCACTGGCAGGATTGATGACATGCTCAATGTGTCTG
GACATCTTCTGAGTACAGCAGAGGTGGAATCAGCACTTGTGGAACATGAGGCTGTTGCAGAGGC
AGCTGTGGTGGGCCACCCTCATCCTGTGAAGGGTGAATGCCTCTACTGCTTTGTTACCTTGTGT
GACGGCCATACCTTCAGCCCCACCCTCACTGAGGAACTCAAGAAGCAGATTAGAGAAAAGATTG
GCCCCATTGCCACACCAGACTACATCCAGAATGCACCCGGCTTGCCTAAAACACGCTCAGGAAA
AATCATGAGGAGAGTACTCCGGAAGATTGCTCAGAATGACCACGACCTGGGGGATACCTCTACA
GTGGCTGACCCATCTGTCATCAACCATCTCTTCAGTCACCGCTGCCTGACCACACAGTGAACAA
GACTCTTATCCAGGATTTCCCTGTGCTTGGCTCTCCAAATTTCTGCCCATCTATCCTGTCCCTC
ACCCAAGAGTACCAAGGGCCAGTGCTAGTTGACATTTAGGTTGAAACTAGGGAGACAGTTACTT
AGACTGCCAGGTCGAAGGGAACAGGGCTCAGGTCAACCATGCACTGATACTCTCCTAGGCTACA
GAGATCTCCAAGCCCAGAACAGAGACTTGAACACCATGTCCTTAACCAGAGTTAGCTATGCAGA
GTGTAAGTGAGGGCCTACCTAGAAGCAGGCGGCACCTCTAATCCTTTTTCAGCTTTCTCAGAAA
GCACCAGTTCTTACCTTGGGCCTGCACTAGCCTTTATAAGTGACAGTTAGCAAGTCTATGAATA
ATTATTTTTTAAAATACTTTGTTGTCTCTGTTCTGAGTCTGAATTCCTTGTCAAATGATAGCAG
TGTCTGTTCATTTGCTCAAGAGACTAGGCAAGTGGCTTCAGTCTCCAGAGGACTTCCATATCAT
CTGCTTCGTTGAAAGATTAAGATATGCTGGTCCTAGAACCAAGGGAGTTAACATTCCTAGTCTG
CACCAGGAACAGAACCCTGCCCATGAGAGGCACTTGTAGGCGAAACTCTCTTTTCTTGTACTTT
TTGTGCTAAAGACCCACTGTTGTAGGAATAAAGTTTATGAACTCAAGAACA

hide sequence

RefSeq Acc Id:

XM_039105075 ⟹ XP_038961003

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	144,003,808 - 144,047,450 (+)	NCBI

RefSeq Acc Id:

XM_039105076 ⟹ XP_038961004

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	144,003,809 - 144,047,450 (+)	NCBI

RefSeq Acc Id:

XM_039105077 ⟹ XP_038961005

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	144,004,827 - 144,047,450 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101263	(Get FASTA)	NCBI Sequence Viewer
	XP_006235383	(Get FASTA)	NCBI Sequence Viewer
	XP_038961003	(Get FASTA)	NCBI Sequence Viewer
	XP_038961004	(Get FASTA)	NCBI Sequence Viewer
	XP_038961005	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI61963	(Get FASTA)	NCBI Sequence Viewer
	EDL85913	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001101263 ⟸ NM_001107793

- UniProtKB:

G3V9U0 (UniProtKB/TrEMBL), A6KI41 (UniProtKB/TrEMBL), B1WC11 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGLPEERRKSGSGSRAREETGAEGRVRGWSPPPEVRRSAHVPSLQRYRELHRRSVEEPREFWGN
IAKEFYWKTPCPGPFLQYNFDVTKGKIFTEWMKGATTNICYNVLDRNVHEKKLGDKVAFYWEGN
EPGETTKITYRELLVQVCQFSNVLRKQGVQKGDRVAIYMPMILELVVAMLACARLGALHSIVFA
GFSAESLCERILDSSCCLLITTDAFYRGEKLVNLKELADESLEKCREKGFPVRCCIVVKHLGRA
ELGMNDSPSQSPPVKRPCPDVQISWNEGVDLWWHELMQQAGDEFEPEWCDAEDPLFILYTSGST
GKPKGVVHTVGGYMLYVATTFKYVFDFHPEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEG
IPTYPDEGRLWSIVDKYKVTKFYTAPTAIRMLMKFGDDPVTKHSRASLQVLGTVGEPINPEAWL
WYHRVVGSQRCPIVDTFWQTETGGHMLTPLPGATPMKPGSASFPFFGVAPAILNESGEELEGEA
EGYLVFKQPWPGIMRTVYGNHTRFETTYFKKFPGYYVTGDGCRRDQDGYYWITGRIDDMLNVSG
HLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPTLTEELKKQIREKIG
PIATPDYIQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDTSTVADPSVINHLFSHRCLTTQ

hide sequence

RefSeq Acc Id:	XP_006235383 ⟸ XM_006235321
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6GJ11 (UniProtKB/TrEMBL), G3V9U0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGLPEERRKSGSGSRAREETGAEGRVRGWSPPPEVRRSAHVPSLQRYRELHRRSVEEPREFWGN IAKEFYWKTPCPGPFLQYNFDVTKGKIFTEWMKGATTNICYNVLDRNVHEKKLGDKVAFYWEGN EPGETTKITYRELLVQVCQFSNVLRKQGVQKGDRVAIYMPMILELVVAMLACARLGALHSIVFA GFSAESLCERILDSSCCLLITTDAFYRGEKLVNLKELADESLEKCREKGFPVRCCIVVKHLGRA ELGMNDSPSQSPPVKRPCPDVQGKLKEKSKCIRPQISWNEGVDLWWHELMQQAGDEFEPEWCDA EDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHPEDVFWCTADIGWITGHSYVTYG PLANGATSVLFEGIPTYPDEGRLWSIVDKYKVTKFYTAPTAIRMLMKFGDDPVTKHSRASLQVL GTVGEPINPEAWLWYHRVVGSQRCPIVDTFWQTETGGHMLTPLPGATPMKPGSASFPFFGVAPA ILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHTRFETTYFKKFPGYYVTGDGCRRDQDGYYW ITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPTL TEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDTSTVADPSVINH LFSHRCLTTQ hide sequence

RefSeq Acc Id:

ENSRNOP00000059987 ⟸ ENSRNOT00000064013

RefSeq Acc Id:	XP_038961003 ⟸ XM_039105075
- Peptide Label:	isoform X2
- UniProtKB:	B1WC11 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038961004 ⟸ XM_039105076
- Peptide Label:	isoform X3
- UniProtKB:	B1WC11 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038961005 ⟸ XM_039105077
- Peptide Label:	isoform X3
- UniProtKB:	B1WC11 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000090034 ⟸ ENSRNOT00000098802

RefSeq Acc Id:

ENSRNOP00000090627 ⟸ ENSRNOT00000107324

Protein Domains

Acetyl-coenzyme A synthetase N-terminal AMP-binding enzyme C-terminal AMP-dependent synthetase/ligase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V9U0-F1-model_v2	AlphaFold	G3V9U0	1-701	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305489	AgrOrtholog
BioCyc Gene	G2FUF-47130	BioCyc
BioCyc Pathway	PWY0-1313 [acetate conversion to acetyl-CoA]	BioCyc
	PWY66-162 [ethanol degradation IV]	BioCyc
	PWY66-21 [ethanol degradation II]	BioCyc
Ensembl Genes	ENSRNOG00000018755	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000059987	ENTREZGENE
	ENSRNOP00000059987.2	UniProtKB/TrEMBL
	ENSRNOP00000090034.1	UniProtKB/TrEMBL
	ENSRNOP00000090627	ENTREZGENE
	ENSRNOP00000090627.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000064013	ENTREZGENE
	ENSRNOT00000064013.2	UniProtKB/TrEMBL
	ENSRNOT00000098802.1	UniProtKB/TrEMBL
	ENSRNOT00000107324	ENTREZGENE
	ENSRNOT00000107324.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.300.30	UniProtKB/TrEMBL
	3.40.50.12780	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:9028172	IMAGE-MGC_LOAD
InterPro	ACAS_N	UniProtKB/TrEMBL
	AMP-bd_C_sf	UniProtKB/TrEMBL
	AMP-binding_CS	UniProtKB/TrEMBL
	AMP-dep_Synth/Lig	UniProtKB/TrEMBL
	AMP-dep_Synthh-like_sf	UniProtKB/TrEMBL
	DUF4009	UniProtKB/TrEMBL
KEGG Report	rno:311569	UniProtKB/TrEMBL
MGC_CLONE	MGC:187768	IMAGE-MGC_LOAD
NCBI Gene	311569	ENTREZGENE
PANTHER	ACETYL-COENZYME A SYNTHETASE	UniProtKB/TrEMBL
	ACETYL-COENZYME A SYNTHETASE, CYTOPLASMIC	UniProtKB/TrEMBL
Pfam	ACAS_N	UniProtKB/TrEMBL
	AMP-binding	UniProtKB/TrEMBL
	DUF4009	UniProtKB/TrEMBL
PhenoGen	Acss2	PhenoGen
PROSITE	AMP_BINDING	UniProtKB/TrEMBL
Superfamily-SCOP	Acetyl-CoA synthetase-like	UniProtKB/TrEMBL
UniProt	A0A8I6AD12_RAT	UniProtKB/TrEMBL
	A0A8I6GJ11	ENTREZGENE, UniProtKB/TrEMBL
	A6KI41	ENTREZGENE, UniProtKB/TrEMBL
	B1WC11	ENTREZGENE, UniProtKB/TrEMBL
	G3V9U0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Acss2	acyl-CoA synthetase short-chain family member 2	Acss2_predicted	acyl-CoA synthetase short-chain family member 2 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Acss2_predicted	acyl-CoA synthetase short-chain family member 2 (predicted)	Acas2_predicted	acetyl-Coenzyme A synthetase 2 (ADP forming) (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-12	Acas2_predicted	acetyl-Coenzyme A synthetase 2 (ADP forming) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)