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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:17356
Term: 2-acetamidofluorene
Definition: The parent of the class of 2-acetamidofluorenes, being an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. It is a carcinogenic and mutagenic derivative of fluorene.
Chemical ID: MESH:D015073
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaincreases expressionEXP 6480464CTD2-Acetylaminofluorene results in increased expression of RELA proteinPMID:26364502
Relamultiple interactionsEXP 6480464CTDgeraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of RELA protein]; RELA protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1B mRNA]PMID:11020383 PMID:26364502
Relaincreases activityISORELA (Homo sapiens)6480464CTD2-Acetylaminofluorene results in increased activity of RELA proteinPMID:11960367
Relaincreases localizationISORela (Mus musculus)6480464CTD2-Acetylaminofluorene results in increased localization of RELA proteinPMID:17303067
Relamultiple interactionsISORELA (Homo sapiens)6480464CTD[RELA protein binds to NFKB1 protein] affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA]PMID:11960367
Relamultiple interactionsISORela (Mus musculus)6480464CTD2-Acetylaminofluorene inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased localization of RELA protein]PMID:14670622 PMID:17303067
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