Gene: Atxn1 (ataxin 1) Rattus norvegicus
Analyze
Symbol:
Atxn1
Name:
ataxin 1
Description:
Predicted to have several functions, including identical protein binding activity; protein C-terminus binding activity; and single-stranded RNA binding activity. Predicted to be involved in several processes, including learning or memory; nervous system development; and regulation of transcription by RNA polymerase II. Predicted to localize to the cytosol; nucleus; and protein-containing complex. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 1. Orthologous to human ATXN1 (ataxin 1); INTERACTS WITH aflatoxin B1; ammonium chloride; atrazine.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
ataxin-1; RNSCA1; Sca1; spinocerebellar ataxia 1; spinocerebellar ataxia 1 homolog (human); Spinocerebellar ataxia type 1; spinocerebellar ataxia type 1 protein homolog
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ATXN1 (ataxin 1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Atxn1 (ataxin 1) HGNC
Treefam, EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Atxn1 (ataxin 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ATXN1 (ataxin 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ATXN1 (ataxin 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Atxn1 (ataxin 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ATXN1 (ataxin 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
ATXN1 (ataxin 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Atxn1 (ataxin 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Atxn1 (ataxin 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
ATXN1 (ataxin 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
atxn1b (ataxin 1b)
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, TreeFam)
Danio rerio (zebrafish):
atxn1a (ataxin 1a)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
Atx-1
Alliance
DIOPT (Ensembl Compara, OrthoInspector, PANTHER)
Caenorhabditis elegans (roundworm):
K04F10.1
Alliance
DIOPT (Ensembl Compara, OrthoInspector, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information:
Annotation category: partial on reference assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 17 19,160,986 - 19,533,814 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 17 19,249,952 - 19,533,814 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 17 21,544,083 - 21,559,271 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 Rnor_5.0 17 21,184,036 - 21,473,347 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 17 24,719,383 - 25,138,270 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 3 103,267,365 - 103,268,238 (+) NCBI Celera 17 18,442,710 - 18,844,739 (+) NCBI Celera Cytogenetic Map 17 p14 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - CTD
atrial fibrillation ISO RGD:1344585 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29892015 , PMID:30061737 neurodegenerative disease ISO RGD:1344585 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28182653 retinal disease ISO RGD:1344585 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28182653 Spinocerebellar Ataxias ISO RGD:1344585 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:11719269 more ...
Imported Annotations - OMIM
spinocerebellar ataxia type 1 ISO RGD:1344585 7240710 OMIM
(-)-demecolcine increases expression ISO RGD:1344585 6480464 Demecolcine results in increased expression of ATXN1 mRNA CTD PMID:23649840 (S)-colchicine decreases expression ISO RGD:1344585 6480464 Colchicine results in decreased expression of ATXN1 mRNA CTD PMID:24211769 1,1-dichloroethene decreases expression ISO RGD:11258 6480464 vinylidene chloride results in decreased expression of ATXN1 mRNA CTD PMID:26682919 17beta-estradiol multiple interactions ISO RGD:1344585 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ATXN1 mRNA more ... CTD PMID:19619570 more ... 17beta-estradiol decreases expression ISO RGD:1344585 6480464 Estradiol results in decreased expression of ATXN1 mRNA CTD PMID:24758408 17beta-estradiol increases expression ISO RGD:1344585 6480464 Estradiol results in increased expression of ATXN1 mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1344585 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ATXN1 mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:11258 6480464 Tetrachlorodibenzodioxin affects the expression of ATXN1 mRNA CTD PMID:21570461 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:11258 6480464 Tetrachlorodibenzodioxin results in increased expression of ATXN1 mRNA CTD PMID:19933214 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:11258 6480464 [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of ATXN1 mRNA, Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ATXN1 gene] CTD PMID:20819909 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1344585 6480464 Tetrachlorodibenzodioxin results in increased expression of ATXN1 mRNA CTD PMID:19619570 more ... aflatoxin B1 affects expression ISO RGD:1344585 6480464 Aflatoxin B1 affects the expression of ATXN1 protein CTD PMID:20106945 aflatoxin B1 affects methylation ISO RGD:1344585 6480464 Aflatoxin B1 affects the methylation of ATXN1 intron CTD PMID:30157460 aflatoxin B1 decreases methylation ISO RGD:1344585 6480464 Aflatoxin B1 results in decreased methylation of ATXN1 gene CTD PMID:27153756 aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of ATXN1 mRNA CTD PMID:23630614 aflatoxin B1 decreases expression ISO RGD:1344585 6480464 Aflatoxin B1 results in decreased expression of ATXN1 mRNA CTD PMID:21641981 , PMID:22100608 all-trans-retinoic acid increases expression ISO RGD:1344585 6480464 Tretinoin results in increased expression of ATXN1 mRNA CTD PMID:21934132 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of ATXN1 mRNA CTD PMID:16483693 arsane affects expression ISO RGD:1344585 6480464 Arsenic affects the expression of ATXN1 mRNA CTD PMID:18414638 arsane affects methylation ISO RGD:1344585 6480464 Arsenic affects the methylation of ATXN1 gene CTD PMID:25304211 arsenic atom affects expression ISO RGD:1344585 6480464 Arsenic affects the expression of ATXN1 mRNA CTD PMID:18414638 arsenic atom affects methylation ISO RGD:1344585 6480464 Arsenic affects the methylation of ATXN1 gene CTD PMID:25304211 atrazine affects methylation EXP 6480464 Atrazine affects the methylation of ATXN1 gene CTD PMID:28931070 benzo[a]pyrene decreases expression ISO RGD:11258 6480464 Benzo(a)pyrene results in decreased expression of ATXN1 mRNA CTD PMID:19770486 benzo[a]pyrene affects methylation ISO RGD:1344585 6480464 Benzo(a)pyrene affects the methylation of ATXN1 intron CTD PMID:30157460 benzo[a]pyrene decreases expression ISO RGD:1344585 6480464 Benzo(a)pyrene results in decreased expression of ATXN1 mRNA CTD PMID:20064835 more ... benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1344585 6480464 7 more ... CTD PMID:19150397 , PMID:20382639 bis(2-ethylhexyl) phthalate increases expression ISO RGD:1344585 6480464 Diethylhexyl Phthalate results in increased expression of ATXN1 mRNA CTD PMID:31163220 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of ATXN1 mRNA CTD PMID:25181051 , PMID:30816183 bisphenol A increases expression ISO RGD:1344585 6480464 bisphenol A results in increased expression of ATXN1 mRNA CTD PMID:29275510 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of ATXN1 mRNA CTD PMID:29097150 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of ATXN1 gene CTD PMID:28505145 butanal decreases expression ISO RGD:1344585 6480464 butyraldehyde results in decreased expression of ATXN1 mRNA CTD PMID:26079696 cadmium dichloride decreases methylation EXP 6480464 Cadmium Chloride results in decreased methylation of ATXN1 promoter CTD PMID:22457795 cadmium dichloride increases expression ISO RGD:1344585 6480464 Cadmium Chloride results in increased expression of ATXN1 mRNA CTD PMID:26472689 carbamazepine affects expression ISO RGD:1344585 6480464 Carbamazepine affects the expression of ATXN1 mRNA CTD PMID:25979313 carbon nanotube decreases expression ISO RGD:11258 6480464 Nanotubes, Carbon results in decreased expression of ATXN1 mRNA CTD PMID:25554681 chloroacetaldehyde decreases expression ISO RGD:1344585 6480464 chloroacetaldehyde results in decreased expression of ATXN1 mRNA CTD PMID:25596134 chromium(6+) affects expression ISO RGD:11258 6480464 chromium hexavalent ion affects the expression of ATXN1 mRNA CTD PMID:28472532 cidofovir anhydrous decreases expression ISO RGD:1344585 6480464 Cidofovir results in decreased expression of ATXN1 mRNA CTD PMID:25596134 cisplatin decreases expression ISO RGD:1344585 6480464 Cisplatin results in decreased expression of ATXN1 mRNA CTD PMID:24211769 more ... cisplatin multiple interactions ISO RGD:1344585 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of ATXN1 mRNA CTD PMID:27392435 clodronic acid decreases expression ISO RGD:1344585 6480464 Clodronic Acid results in decreased expression of ATXN1 mRNA CTD PMID:25596134 cocaine affects expression EXP 6480464 Cocaine affects the expression of ATXN1 mRNA CTD PMID:20187946 copper(II) sulfate increases expression ISO RGD:1344585 6480464 Copper Sulfate results in increased expression of ATXN1 mRNA CTD PMID:19549813 coumestrol multiple interactions ISO RGD:1344585 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ATXN1 mRNA CTD PMID:19167446 cyclosporin A increases expression ISO RGD:1344585 6480464 Cyclosporine results in increased expression of ATXN1 mRNA CTD PMID:25562108 , PMID:27989131 daunorubicin decreases expression EXP 6480464 Daunorubicin results in decreased expression of ATXN1 mRNA CTD PMID:27090888 dioxygen increases expression ISO RGD:1344585 6480464 Oxygen deficiency results in increased expression of ATXN1 mRNA CTD PMID:25596134 dorsomorphin multiple interactions ISO RGD:1344585 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 elemental selenium decreases expression ISO RGD:1344585 6480464 Selenium results in decreased expression of ATXN1 mRNA CTD PMID:19244175 Enterolactone multiple interactions ISO RGD:1344585 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ATXN1 mRNA CTD PMID:19167446 ethanol multiple interactions ISO RGD:1344585 6480464 [Ethanol co-treated with Folic Acid] results in increased expression of ATXN1 mRNA CTD PMID:23378141 ethanol affects splicing ISO RGD:11258 6480464 Ethanol affects the splicing of ATXN1 mRNA CTD PMID:30319688 ethyl methanesulfonate decreases expression ISO RGD:1344585 6480464 Ethyl Methanesulfonate results in decreased expression of ATXN1 mRNA CTD PMID:23649840 , PMID:24211769 etoposide decreases expression ISO RGD:1344585 6480464 Etoposide results in decreased expression of ATXN1 mRNA CTD PMID:24211769 folic acid multiple interactions ISO RGD:1344585 6480464 [Ethanol co-treated with Folic Acid] results in increased expression of ATXN1 mRNA CTD PMID:23378141 fonofos increases methylation ISO RGD:1344585 6480464 Fonofos results in increased methylation of ATXN1 promoter CTD PMID:22847954 glyphosate increases expression EXP 6480464 glyphosate results in increased expression of ATXN1 mRNA CTD PMID:26302742 hydrogen peroxide multiple interactions ISO RGD:1344585 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of ATXN1 protein mutant form], Buthionine Sulfoximine promotes the reaction [Hydrogen Peroxide affects the localization of ATXN1 protein mutant form] CTD PMID:12893416 hydrogen peroxide increases expression ISO RGD:1344585 6480464 Hydrogen Peroxide results in increased expression of ATXN1 mRNA CTD PMID:18951874 hydrogen peroxide affects localization ISO RGD:1344585 6480464 Hydrogen Peroxide affects the localization of ATXN1 protein mutant form CTD PMID:12893416 hydroxyurea decreases expression ISO RGD:1344585 6480464 Hydroxyurea results in decreased expression of ATXN1 mRNA CTD PMID:24211769 ibuprofen increases expression ISO RGD:1344585 6480464 Ibuprofen results in increased expression of ATXN1 mRNA CTD PMID:25596134 ifosfamide decreases expression ISO RGD:1344585 6480464 Ifosfamide results in decreased expression of ATXN1 mRNA CTD PMID:25596134 lead diacetate decreases expression EXP 6480464 lead acetate results in decreased expression of ATXN1 mRNA CTD PMID:11578147 lead(0) affects expression ISO RGD:1344585 6480464 Lead affects the expression of ATXN1 mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:1344585 6480464 Lead affects the expression of ATXN1 mRNA CTD PMID:28903495 methotrexate increases expression ISO RGD:1344585 6480464 Methotrexate results in increased expression of ATXN1 mRNA CTD PMID:24449571 methyl methanesulfonate decreases expression ISO RGD:1344585 6480464 Methyl Methanesulfonate results in decreased expression of ATXN1 mRNA CTD PMID:23649840 , PMID:24211769 methylmercury chloride decreases expression ISO RGD:1344585 6480464 methylmercuric chloride results in decreased expression of ATXN1 mRNA CTD PMID:28001369 mitomycin C decreases expression ISO RGD:1344585 6480464 Mitomycin results in decreased expression of ATXN1 mRNA CTD PMID:24211769 N-acetyl-L-cysteine affects localization ISO RGD:1344585 6480464 Acetylcysteine affects the localization of ATXN1 protein mutant form CTD PMID:12893416 N-acetyl-L-cysteine multiple interactions ISO RGD:1344585 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of ATXN1 protein mutant form], Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide affects the localization of ATXN1 protein mutant form] CTD PMID:12893416 nickel sulfate increases expression ISO RGD:1344585 6480464 nickel sulfate results in increased expression of ATXN1 mRNA CTD PMID:22714537 paracetamol decreases expression ISO RGD:1344585 6480464 Acetaminophen results in decreased expression of ATXN1 mRNA CTD PMID:21420995 paraquat affects expression EXP 6480464 Paraquat affects the expression of ATXN1 mRNA CTD PMID:15206577 parathion increases methylation ISO RGD:1344585 6480464 Parathion results in increased methylation of ATXN1 promoter CTD PMID:22847954 pentanal decreases expression ISO RGD:1344585 6480464 pentanal results in decreased expression of ATXN1 mRNA CTD PMID:26079696 phenobarbital decreases expression ISO RGD:11258 6480464 Phenobarbital results in decreased expression of ATXN1 mRNA CTD PMID:23091169 phenylmercury acetate increases expression ISO RGD:1344585 6480464 Phenylmercuric Acetate results in increased expression of ATXN1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1344585 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATXN1 mRNA CTD PMID:27188386 potassium chromate decreases expression ISO RGD:1344585 6480464 potassium chromate(VI) results in decreased expression of ATXN1 mRNA CTD PMID:22714537 propiconazole decreases expression ISO RGD:11258 6480464 propiconazole results in decreased expression of ATXN1 mRNA CTD PMID:21278054 S-butyl-DL-homocysteine (S,R)-sulfoximine affects localization ISO RGD:1344585 6480464 Buthionine Sulfoximine affects the localization of ATXN1 protein mutant form CTD PMID:12893416 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO RGD:1344585 6480464 Buthionine Sulfoximine promotes the reaction [Hydrogen Peroxide affects the localization of ATXN1 protein mutant form], Buthionine Sulfoximine promotes the reaction [tert-Butylhydroperoxide affects the localization of ATXN1 protein mutant form] CTD PMID:12893416 SB 431542 multiple interactions ISO RGD:1344585 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 selenium atom decreases expression ISO RGD:1344585 6480464 Selenium results in decreased expression of ATXN1 mRNA CTD PMID:19244175 silicon dioxide decreases expression ISO RGD:1344585 6480464 Silicon Dioxide analog results in decreased expression of ATXN1 mRNA CTD PMID:25895662 sodium arsenate decreases expression ISO RGD:11258 6480464 sodium arsenate results in decreased expression of ATXN1 mRNA CTD PMID:21795629 sodium fluoride increases expression ISO RGD:11258 6480464 Sodium Fluoride results in increased expression of ATXN1 mRNA CTD PMID:27862939 succimer multiple interactions ISO RGD:11258 6480464 [Succimer binds to Magnetite Nanoparticles] which results in increased expression of ATXN1 mRNA CTD PMID:21641980 sunitinib decreases expression ISO RGD:1344585 6480464 Sunitinib results in decreased expression of ATXN1 mRNA CTD PMID:31533062 terbufos increases methylation ISO RGD:1344585 6480464 terbufos results in increased methylation of ATXN1 promoter CTD PMID:22847954 tert-butyl hydroperoxide affects localization ISO RGD:1344585 6480464 tert-Butylhydroperoxide affects the localization of ATXN1 protein mutant form CTD PMID:12893416 tert-butyl hydroperoxide multiple interactions ISO RGD:1344585 6480464 Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide affects the localization of ATXN1 protein mutant form], Buthionine Sulfoximine promotes the reaction [tert-Butylhydroperoxide affects the localization of ATXN1 protein mutant form] CTD PMID:12893416 tert-butyl hydroperoxide decreases expression ISO RGD:1344585 6480464 tert-Butylhydroperoxide results in decreased expression of ATXN1 mRNA CTD PMID:15336504 thimerosal decreases expression ISO RGD:1344585 6480464 Thimerosal results in decreased expression of ATXN1 mRNA CTD PMID:27188386 trichostatin A increases expression ISO RGD:1344585 6480464 trichostatin A results in increased expression of ATXN1 mRNA CTD PMID:24935251 urethane increases expression ISO RGD:1344585 6480464 Urethane results in increased expression of ATXN1 mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:1344585 6480464 Valproic Acid affects the expression of ATXN1 mRNA CTD PMID:25979313 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of ATXN1 mRNA CTD PMID:29427782 valproic acid increases expression ISO RGD:1344585 6480464 Valproic Acid results in increased expression of ATXN1 mRNA CTD PMID:19101580 more ... valproic acid multiple interactions ISO RGD:1344585 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATXN1 mRNA CTD PMID:27188386 zoledronic acid increases expression ISO RGD:1344585 6480464 zoledronic acid results in increased expression of ATXN1 mRNA CTD PMID:24714768 , PMID:25596134
Biological Process adult locomotory behavior ISO RGD:11258 1624291 MGI:MGI:2181805 (MGI:MGI:1270078 , PMID:9651231) RGD MGI:MGI:1270078 , PMID:9651231 anatomical structure development IBA MGI:MGI:104783 more ... 13792537 PMID:21873635 GO_Central biological_process ND 1598407 02/2007: no relevant rat data RGD brain development ISO RGD:11258 1624291 (MGI:MGI:5888926, PMID:28288114) RGD MGI:MGI:5888926 , PMID:28288114 brain development ISS UniProtKB:P54254 1600115 GO_REF:0000024 UniProt GO_REF:0000024 excitatory postsynaptic potential ISO RGD:11258 1624291 MGI:MGI:2181805 (MGI:MGI:1270078 , PMID:9651231) RGD MGI:MGI:1270078 , PMID:9651231 learning ISO RGD:11258 1624291 (MGI:MGI:5888926, PMID:28288114) RGD MGI:MGI:5888926 , PMID:28288114 learning ISS UniProtKB:P54254 1600115 GO_REF:0000024 UniProt GO_REF:0000024 lung alveolus development ISO RGD:11258 1624291 MGI:MGI:1918972 more ... RGD MGI:MGI:5298126 , PMID:22014525 memory ISO RGD:11258 1624291 (MGI:MGI:5888926, PMID:28288114) RGD MGI:MGI:5888926 , PMID:28288114 memory ISS UniProtKB:P54254 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of insulin-like growth factor receptor signaling pathway ISO RGD:11258 1624291 MGI:MGI:2429435 (MGI:MGI:3774689 , PMID:18216249) RGD MGI:MGI:3774689 , PMID:18216249 negative regulation of phosphorylation ISO RGD:11258 1624291 MGI:MGI:2429435 (MGI:MGI:3774689 , PMID:18216249) RGD MGI:MGI:3774689 , PMID:18216249 negative regulation of transcription by RNA polymerase II ISO RGD:11258 1624291 MGI:MGI:1918972 (MGI:MGI:5298126 , PMID:22014525) RGD MGI:MGI:5298126 , PMID:22014525 negative regulation of transcription by RNA polymerase II IBA MGI:MGI:104783 , PANTHER:PTN002667591 13792537 PMID:21873635 GO_Central negative regulation of transcription, DNA-templated ISO RGD:1344585 1624291 (PMID:15016912) RGD PMID:15016912 negative regulation of transcription, DNA-templated ISS UniProtKB:P54253 1600115 GO_REF:0000024 UniProt GO_REF:0000024 nervous system development IBA MGI:MGI:104783 , PANTHER:PTN002667591 13792537 PMID:21873635 GO_Central nuclear export ISO RGD:1344585 1624291 (PMID:15615787) RGD PMID:15615787 nuclear export ISS UniProtKB:P54253 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of glial cell proliferation ISO RGD:11258 1624291 (MGI:MGI:4462742, PMID:20531390) RGD MGI:MGI:4462742 , PMID:20531390 positive regulation of transcription by RNA polymerase II ISO RGD:11258 1624291 MGI:MGI:2429435 (MGI:MGI:3774689 , PMID:18216249) RGD MGI:MGI:3774689 , PMID:18216249 regulation of transcription, DNA-templated IBA MGI:MGI:104783 more ... 13792537 PMID:21873635 GO_Central social behavior ISO RGD:11258 1624291 (MGI:MGI:5888926, PMID:28288114) RGD MGI:MGI:5888926 , PMID:28288114 social behavior ISS UniProtKB:P54254 1600115 GO_REF:0000024 UniProt GO_REF:0000024 visual learning ISO RGD:11258 1624291 MGI:MGI:2181805 more ... RGD MGI:MGI:1270078 more ... Cellular Component cellular_component ND 1598407 02/2007: no relevant rat data RGD cytoplasm ISO RGD:1344585 1624291 (PMID:7647801) RGD PMID:7647801 cytoplasm ISS UniProtKB:P54253 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cytosol IEA UniProtKB:P54253 , ensembl:ENSP000002447691600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol ISO RGD:1344585 1624291 RGD GO_REF:0000052 nuclear inclusion body ISO RGD:11258 1624291 (MGI:MGI:3522382, PMID:15615787) RGD MGI:MGI:3522382 , PMID:15615787 nuclear inclusion body ISS UniProtKB:P54253 1600115 GO_REF:0000024 UniProt GO_REF:0000024 nuclear inclusion body ISO RGD:1344585 1624291 (PMID:15615787) RGD PMID:15615787 nuclear matrix ISO RGD:1344585 1624291 (PMID:17557114), (PMID:9353120) RGD PMID:17557114 , PMID:9353120 nuclear matrix ISS UniProtKB:P54253 1600115 GO_REF:0000024 UniProt GO_REF:0000024 nucleolus IEA UniProtKB:P54253 , ensembl:ENSP000002447691600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleolus ISO RGD:1344585 1624291 RGD GO_REF:0000052 nucleoplasm ISO RGD:1344585 1624291 (PMID:12757932) RGD GO_REF:0000052, PMID:12757932 nucleoplasm ISS UniProtKB:P54253 1600115 GO_REF:0000024 UniProt GO_REF:0000024 nucleus IBA MGI:MGI:104783 more ... 13792537 PMID:21873635 GO_Central nucleus ISS UniProtKB:P54253 1600115 GO_REF:0000024 UniProt GO_REF:0000024 nucleus ISO RGD:1344585 1624291 (PMID:19208651), (PMID:7647801), (PMID:9353120) RGD PMID:19208651 more ... nucleus ISO RGD:11258 1624291 (MGI:MGI:4462742, PMID:20531390) RGD MGI:MGI:4462742 , PMID:20531390 postsynapse IEA GO:0060079 1600115 GO_REF:0000108 GOC GO_REF:0000108 protein-containing complex ISO RGD:11258 1624291 (MGI:MGI:3784682, PMID:18337722) RGD MGI:MGI:3784682 , PMID:18337722 Molecular Function chromatin binding ISO RGD:11258 1624291 (MGI:MGI:4818500, PMID:20628574) RGD MGI:MGI:4818500 , PMID:20628574 DNA binding IEA UniProtKB-KW:KW-0238 1600115 GO_REF:0000043 UniProt GO_REF:0000043 identical protein binding ISO RGD:1344585 1624291 UniProtKB:P54253 (PMID:11001934), (PMID:15893665), (PMID:16713569), (PMID:18337722), (PMID:25416956) RGD PMID:11001934 more ... molecular_function ND 1598407 02/2007: no relevant rat data RGD poly(G) binding ISO RGD:1344585 1624291 (PMID:11136710) RGD PMID:11136710 poly(G) binding ISS UniProtKB:P54253 1600115 GO_REF:0000024 UniProt GO_REF:0000024 poly(U) RNA binding ISO RGD:1344585 1624291 (PMID:11136710) RGD PMID:11136710 poly(U) RNA binding ISS UniProtKB:P54253 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein binding ISO RGD:11258 1624291 UniProtKB:P51448 more ... RGD MGI:MGI:3693029 more ... protein binding ISO RGD:1344585 1624291 UniProtKB:O15379 more ... RGD PMID:11001934 more ... protein C-terminus binding ISO RGD:1344585 1624291 UniProtKB:P38432 more ... RGD PMID:12757932 , PMID:15016912 protein C-terminus binding ISS UniProtKB:P54253 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein self-association ISO RGD:1344585 1624291 (PMID:9097953) RGD PMID:9097953 protein self-association ISS UniProtKB:P54253 1600115 GO_REF:0000024 UniProt GO_REF:0000024 RNA binding ISO RGD:11258 1624291 (MGI:MGI:3522382, PMID:15615787) RGD MGI:MGI:3522382 , PMID:15615787
Gene-Chemical Interaction Annotations
