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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:8597 term browser browse the term
Definition:An organic tricyclic compound that has formula C19H21N.
Synonyms:exact_synonym: 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine
 related_synonym: 3-(5H-dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine;   5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene;   7-(3-methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene;   Formula=C19H21N;   InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3;   InChIKey=BWPIARFWQZKAIA-UHFFFAOYSA-N;   N-methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine;   N-methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine;   SMILES=CNCCCC1c2ccccc2C=Cc2ccccc12;   amimetilina
 xref: Beilstein:2217411;   CAS:438-60-8;   DrugBank:DB00344;   Drug_Central:2320;   KEGG:C07408;   KEGG:D08447;   LINCS:LSM-2936
 xref_mesh: MESH:D011530
 xref: Wikipedia:Protriptyline

show annotations for term's descendants           Sort by:
protriptyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Protriptyline results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Slc6a2 solute carrier family 6 member 2 decreases expression ISO Protriptyline results in decreased expression of SLC6A2 protein CTD PMID:18923402 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            central nervous system drug 16428
              psychotropic drug 15049
                antidepressant 3122
                  protriptyline 2
                    protriptyline hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            organic hydride 18248
                              organic fundamental parent 18248
                                hydrocarbon 17968
                                  cyclic hydrocarbon 17062
                                    arene 17058
                                      polycyclic arene 16879
                                        ortho-fused polycyclic arene 9641
                                          dibenzannulene 185
                                            dibenzo[a,d][7]annulene 185
                                              protriptyline 2
                                                protriptyline hydrochloride 0
paths to the root


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