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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:protriptyline
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Accession:CHEBI:8597 term browser browse the term
Definition:An organic tricyclic compound that has formula C19H21N.
Synonyms:exact_synonym: 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine
 related_synonym: 3-(5H-dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine;   5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene;   7-(3-methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene;   Formula=C19H21N;   InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3;   InChIKey=BWPIARFWQZKAIA-UHFFFAOYSA-N;   N-methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine;   N-methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine;   SMILES=CNCCCC1c2ccccc2C=Cc2ccccc12;   amimetilina
 xref: Beilstein:2217411;   CAS:438-60-8;   DrugBank:DB00344;   Drug_Central:2320;   KEGG:C07408;   KEGG:D08447;   LINCS:LSM-2936
 xref_mesh: MESH:D011530
 xref: PMID:10456691;   PMID:18191158;   PMID:1864117;   PMID:26096164;   PMID:27252039;   PMID:27790936;   PMID:28468029;   PMID:31643633;   PMID:32060505;   PMID:33422534;   PMID:4026507;   PMID:8325058;   PMID:8367615;   PMID:9277026;   Wikipedia:Protriptyline


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protriptyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Protriptyline results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression ISO Protriptyline results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Ereg epiregulin increases expression ISO Protriptyline results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Il24 interleukin 24 increases expression ISO Protriptyline results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Protriptyline results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Protriptyline results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Protriptyline results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 decreases expression ISO Protriptyline results in decreased expression of SLC6A2 protein CTD PMID:18923402 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Protriptyline results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Protriptyline results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
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Path 1
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  CHEBI ontology 19932
    role 19904
      application 19741
        pharmaceutical 19579
          drug 19579
            central nervous system drug 16785
              psychotropic drug 15559
                antidepressant 3760
                  protriptyline 10
                    protriptyline hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    main group molecular entity 19876
                      s-block molecular entity 19705
                        hydrogen molecular entity 19686
                          hydrides 19179
                            organic hydride 18717
                              organic fundamental parent 18717
                                hydrocarbon 18457
                                  cyclic hydrocarbon 17244
                                    arene 17225
                                      polycyclic arene 17050
                                        ortho-fused polycyclic arene 9848
                                          dibenzannulene 197
                                            dibenzo[a,d][7]annulene 197
                                              protriptyline 10
                                                protriptyline hydrochloride 0
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