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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:protriptyline
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Accession:CHEBI:8597 term browser browse the term
Definition:An organic tricyclic compound that has formula C19H21N.
Synonyms:exact_synonym: 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine
 related_synonym: 3-(5H-dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine;   5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene;   7-(3-methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene;   Formula=C19H21N;   InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3;   InChIKey=BWPIARFWQZKAIA-UHFFFAOYSA-N;   N-methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine;   N-methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine;   SMILES=CNCCCC1c2ccccc2C=Cc2ccccc12;   amimetilina
 xref: Beilstein:2217411;   CAS:438-60-8;   DrugBank:DB00344;   Drug_Central:2320;   KEGG:C07408;   KEGG:D08447;   LINCS:LSM-2936
 xref_mesh: MESH:D011530
 xref: Wikipedia:Protriptyline



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protriptyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Protriptyline results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression ISO Protriptyline results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Ereg epiregulin increases expression ISO Protriptyline results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Il24 interleukin 24 increases expression ISO Protriptyline results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Protriptyline results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Protriptyline results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Protriptyline results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Slc6a2 solute carrier family 6 member 2 decreases expression ISO Protriptyline results in decreased expression of SLC6A2 protein CTD PMID:18923402 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Protriptyline results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Protriptyline results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19757
      application 19467
        pharmaceutical 19315
          drug 19315
            central nervous system drug 16520
              psychotropic drug 15171
                antidepressant 3652
                  protriptyline 10
                    protriptyline hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    main group molecular entity 19704
                      s-block molecular entity 19489
                        hydrogen molecular entity 19484
                          hydrides 18841
                            organic hydride 18350
                              organic fundamental parent 18350
                                hydrocarbon 18061
                                  cyclic hydrocarbon 17074
                                    arene 17070
                                      polycyclic arene 16889
                                        ortho-fused polycyclic arene 9664
                                          dibenzannulene 198
                                            dibenzo[a,d][7]annulene 198
                                              protriptyline 10
                                                protriptyline hydrochloride 0
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