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Gene: Pah (phenylalanine hydroxylase) Rattus norvegicus
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Symbol: Pah
Name: phenylalanine hydroxylase
Description: Exhibits several functions, including iron ion binding activity; phenylalanine 4-monooxygenase activity; and protein homodimerization activity. Involved in cellular amino acid metabolic process; protein hydroxylation; and tetrahydrobiopterin metabolic process. Human ortholog(s) of this gene implicated in intellectual disability and phenylketonuria. Orthologous to human PAH (phenylalanine hydroxylase); PARTICIPATES IN phenylketonuria pathway; tyrosinemia type II pathway; tyrosinemia type III pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: phe-4-monooxygenase; phenylalanine-4-hydroxylase
Orthologs:
Homo sapiens (human) : PAH (phenylalanine hydroxylase)  HGNC  Alliance
Mus musculus (house mouse) : Pah (phenylalanine hydroxylase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pah (phenylalanine hydroxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : PAH (phenylalanine hydroxylase)
Canis lupus familiaris (dog) : PAH (phenylalanine hydroxylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pah (phenylalanine hydroxylase)
Sus scrofa (pig) : PAH (phenylalanine hydroxylase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0728,066,639 - 28,129,772 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0728,180,707 - 28,245,428 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4724,175,898 - 24,243,592 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1724,196,183 - 24,263,859 (+)NCBI
Celera719,108,301 - 19,168,259 (+)NCBICelera
Cytogenetic Map7q13NCBI
RH 3.4 Map7119.56RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pah
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3248
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.