Npy5r (neuropeptide Y receptor Y5) - Rat Genome Database

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Gene: Npy5r (neuropeptide Y receptor Y5) Rattus norvegicus
Analyze
Symbol: Npy5r
Name: neuropeptide Y receptor Y5
RGD ID: 3199
Description: Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Involved in several processes, including generation of ovulation cycle rhythm; negative regulation of GABAergic synaptic transmission; and regulation of acute inflammatory response. Predicted to be located in membrane. Predicted to be active in several cellular components, including GABA-ergic synapse; neuron projection; and presynapse. Used to study childhood absence epilepsy; hyperinsulinism; and visual epilepsy. Biomarker of coronary restenosis; obesity; and prolactinoma. Human ortholog(s) of this gene implicated in lipid metabolism disorder and obesity. Orthologous to human NPY5R (neuropeptide Y receptor Y5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitriptyline.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: neuropeptide Y receptor type 5; neuropeptide Y5 receptor; NPY-Y5 receptor; NPY5-R; NPYR5; NPYY5-R; Y5 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Niddm38 Arunc1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21623,055,427 - 23,063,384 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1623,055,427 - 23,063,382 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1626,418,641 - 26,426,581 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01629,853,331 - 29,861,273 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01625,784,247 - 25,792,193 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01624,796,685 - 24,805,730 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1624,797,124 - 24,805,079 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01624,680,437 - 24,688,657 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41624,765,175 - 24,773,132 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11624,765,172 - 24,773,128 (+)NCBI
Celera1623,179,732 - 23,187,687 (+)NCBICelera
RH 3.4 Map16280.0RGD
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. NPY modulates epinephrine-induced leukocytosis via Y-1 and Y-5 receptor activation in vivo: sympathetic co-transmission during leukocyte mobilization. Bedoui S, etal., J Neuroimmunol 2002 Nov;132(1-2):25-33.
3. Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans. Coletta DK, etal., Obesity (Silver Spring). 2007 Apr;15(4):809-15.
4. Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPY Y1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26). Dimitrijevic M, etal., J Neuroimmunol. 2002 Aug;129(1-2):35-42.
5. The anti-inflammatory effect of neuropeptide Y (NPY) in rats is dependent on dipeptidyl peptidase 4 (DP4) activity and age. Dimitrijevic M, etal., Peptides. 2008 Dec;29(12):2179-87. doi: 10.1016/j.peptides.2008.08.017. Epub 2008 Sep 3.
6. BODIPY-conjugated neuropeptide Y ligands: new fluorescent tools to tag Y1, Y2, Y4 and Y5 receptor subtypes. Dumont Y, etal., Br J Pharmacol. 2005 Dec;146(8):1069-81.
7. Neuropeptide Y1 and Y5 receptors mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis. Fekete C, etal., Endocrinology 2002 Dec;143(12):4513-9.
8. Selective activation of central NPY Y1 vs. Y5 receptor elicits hyperinsulinemia via distinct mechanisms. Gao J, etal., Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E706-11. Epub 2004 Jun 8.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Lipolysis and apoptosis of adipocytes induced by neuropeptide Y-Y5 receptor antisense oligodeoxynucleotides in obese rats. Gong HX, etal., Acta Pharmacol Sin. 2003 Jun;24(6):569-75.
12. Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. Hu Y, etal., J Biol Chem 1996 Oct 18;271(42):26315-9.
13. Neuropeptide y and neuropeptide y y5 receptor interaction restores impaired growth potential of aging bone marrow stromal cells. Igura K, etal., Rejuvenation Res. 2011 Aug;14(4):393-403. doi: 10.1089/rej.2010.1129. Epub 2011 May 19.
14. Novel polymorphisms in the neuropeptide-Y Y5 receptor associated with obesity in Pima Indians. Jenkinson CP, etal., Int J Obes Relat Metab Disord. 2000 May;24(5):580-4.
15. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
16. Neuropeptide Y-induced acceleration of postangioplasty occlusion of rat carotid artery. Li L, etal., Arterioscler Thromb Vasc Biol. 2003 Jul 1;23(7):1204-10. Epub 2003 Apr 10.
17. Of mice and men: neuropeptide Y and its receptors are associated with atherosclerotic lesion burden and vulnerability. Li L, etal., J Cardiovasc Transl Res. 2011 Jun;4(3):351-62. doi: 10.1007/s12265-011-9271-5. Epub 2011 Apr 6.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Neuropeptide Y suppresses absence seizures in a genetic rat model primarily through effects on Y receptors. Morris MJ, etal., Eur J Neurosci. 2007 Feb;25(4):1136-43.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists. Parker EM, etal., Eur J Pharmacol 1998 May 15;349(1):97-105.
22. Upregulation of pancreatic polypeptide-sensitive neuropeptide Y (NPY) receptors in estrogen-induced hypertrophy of the anterior pituitary gland in the Fischer-344 rat. Parker MS, etal., Mol Cell Endocrinol. 2000 Jun;164(1-2):239-49.
23. Mitogenic actions of neuropeptide Y in vascular smooth muscle cells: synergetic interactions with the beta-adrenergic system. Pons J, etal., Can J Physiol Pharmacol. 2003 Feb;81(2):177-85.
24. Multiple NPY receptors Inhibit GABA(A) synaptic responses of rat medial parvocellular effector neurons in the hypothalamic paraventricular nucleus. Pronchuk N, etal., Endocrinology. 2002 Feb;143(2):535-43.
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Comprehensive gene review and curation RGD comprehensive gene curation
29. Functional interaction between neuropeptide Y receptors and modulation of calcium channels in the rat hippocampus. Silva AP, etal., Neuropharmacology. 2003 Feb;44(2):282-92.
30. Central administration of Y5 receptor antisense decreases spontaneous food intake and attenuates feeding in response to exogenous neuropeptide Y. Tang-Christensen M, etal., J Endocrinol. 1998 Nov;159(2):307-12.
31. Chronic neuropeptide Y Y5 receptor stimulation suppresses reproduction in virgin female and lactating rats. Toufexis DJ, etal., J Neuroendocrinol. 2002 Jun;14(6):492-7.
32. Difference of NPY and its receptor gene expressions between obesity and obesity-resistant rats in response to high-fat diet. Wang C, etal., Horm Metab Res. 2007 Apr;39(4):262-7.
33. Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors. Woldbye DP, etal., Nat Med. 1997 Jul;3(7):761-4.
Additional References at PubMed
PMID:8700207   PMID:9802393   PMID:10557353   PMID:10698177   PMID:12429884   PMID:12900925   PMID:15044185   PMID:15123022   PMID:15544855   PMID:15582717   PMID:16954600   PMID:17363455  
PMID:19419662   PMID:19593212   PMID:21629996   PMID:21771616   PMID:23179670   PMID:24316073   PMID:24444822   PMID:25993471   PMID:28057538  


Genomics

Comparative Map Data
Npy5r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21623,055,427 - 23,063,384 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1623,055,427 - 23,063,382 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1626,418,641 - 26,426,581 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01629,853,331 - 29,861,273 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01625,784,247 - 25,792,193 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01624,796,685 - 24,805,730 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1624,797,124 - 24,805,079 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01624,680,437 - 24,688,657 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41624,765,175 - 24,773,132 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11624,765,172 - 24,773,128 (+)NCBI
Celera1623,179,732 - 23,187,687 (+)NCBICelera
RH 3.4 Map16280.0RGD
Cytogenetic Map16p14NCBI
NPY5R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384163,343,892 - 163,352,403 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4163,343,892 - 163,351,934 (+)EnsemblGRCh38hg38GRCh38
GRCh374164,265,044 - 164,273,086 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364164,484,541 - 164,492,536 (+)NCBINCBI36Build 36hg18NCBI36
Build 344164,622,695 - 164,630,689NCBI
Celera4161,597,299 - 161,605,294 (+)NCBICelera
Cytogenetic Map4q32.2NCBI
HuRef4160,019,138 - 160,027,132 (+)NCBIHuRef
CHM1_14164,241,524 - 164,249,529 (+)NCBICHM1_1
T2T-CHM13v2.04166,691,703 - 166,700,212 (+)NCBIT2T-CHM13v2.0
Npy5r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39867,132,617 - 67,140,746 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl867,132,617 - 67,140,780 (-)EnsemblGRCm39 Ensembl
GRCm38866,679,965 - 66,688,094 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl866,679,965 - 66,688,128 (-)EnsemblGRCm38mm10GRCm38
MGSCv37869,203,864 - 69,211,993 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36869,608,956 - 69,617,083 (-)NCBIMGSCv36mm8
Celera869,234,119 - 69,242,248 (-)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map833.15NCBI
Npy5r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540341,667,632 - 41,675,619 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540341,667,632 - 41,675,619 (-)NCBIChiLan1.0ChiLan1.0
NPY5R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan14161,515,067 - 161,523,610 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04155,603,739 - 155,612,302 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14167,392,174 - 167,400,258 (+)NCBIpanpan1.1PanPan1.1panPan2
NPY5R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11559,600,212 - 59,608,576 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1559,606,902 - 59,608,273 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1559,971,335 - 59,972,706 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01560,359,613 - 60,366,872 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1560,365,210 - 60,366,581 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11559,599,312 - 59,600,683 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01559,690,026 - 59,691,397 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01560,059,226 - 60,060,597 (+)NCBIUU_Cfam_GSD_1.0
Npy5r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494316,314,341 - 16,321,819 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365552,248,699 - 2,252,637 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365552,248,699 - 2,252,637 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPY5R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl852,174,434 - 52,183,341 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1852,173,906 - 52,183,336 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2855,301,393 - 55,310,791 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NPY5R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17109,790,907 - 109,801,929 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603789,599,999 - 89,607,808 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npy5r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475813,518,951 - 13,524,840 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475813,518,722 - 13,521,292 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Npy5r
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:60
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000018976
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat

Markers in Region
RH94803  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21623,062,843 - 23,063,081 (+)MAPPERmRatBN7.2
Rnor_6.01624,804,541 - 24,804,778NCBIRnor6.0
Rnor_5.01624,687,944 - 24,688,181UniSTSRnor5.0
RGSC_v3.41624,772,592 - 24,772,829UniSTSRGSC3.4
Celera1623,187,147 - 23,187,384UniSTS
RH 3.4 Map16280.0UniSTS
Cytogenetic Map16p14UniSTS
PMC123072P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21623,062,173 - 23,062,424 (+)MAPPERmRatBN7.2
Rnor_6.01624,803,871 - 24,804,121NCBIRnor6.0
Rnor_5.01624,687,274 - 24,687,524UniSTSRnor5.0
RGSC_v3.41624,771,922 - 24,772,172UniSTSRGSC3.4
Celera1623,186,477 - 23,186,727UniSTS
Cytogenetic Map16p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

nervous system renal system reproductive system
High
Medium
Low 48 2
Below cutoff 22 5 18

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018976   ⟹   ENSRNOP00000018976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1623,055,427 - 23,063,382 (+)Ensembl
Rnor_6.0 Ensembl1624,797,124 - 24,805,079 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099301   ⟹   ENSRNOP00000089710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1623,055,996 - 23,063,271 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109751   ⟹   ENSRNOP00000086593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1623,055,614 - 23,063,271 (+)Ensembl
RefSeq Acc Id: NM_012869   ⟹   NP_037001
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21623,055,427 - 23,063,384 (+)NCBI
Rnor_6.01624,797,124 - 24,805,081 (+)NCBI
Rnor_5.01624,680,437 - 24,688,657 (+)NCBI
RGSC_v3.41624,765,175 - 24,773,132 (+)RGD
Celera1623,179,732 - 23,187,687 (+)RGD
Sequence:
RefSeq Acc Id: XM_006253014   ⟹   XP_006253076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21623,055,510 - 23,063,384 (+)NCBI
Rnor_6.01624,796,685 - 24,805,730 (+)NCBI
Rnor_5.01624,680,437 - 24,688,657 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_037001   ⟸   NM_012869
- UniProtKB: P70586 (UniProtKB/Swiss-Prot),   Q63634 (UniProtKB/Swiss-Prot),   A6KFL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253076   ⟸   XM_006253014
- Peptide Label: isoform X1
- UniProtKB: P70586 (UniProtKB/Swiss-Prot),   Q63634 (UniProtKB/Swiss-Prot),   A6KFL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018976   ⟸   ENSRNOT00000018976
RefSeq Acc Id: ENSRNOP00000086593   ⟸   ENSRNOT00000109751
RefSeq Acc Id: ENSRNOP00000089710   ⟸   ENSRNOT00000099301

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63634-F1-model_v2 AlphaFold Q63634 1-445 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3199 AgrOrtholog
BioCyc Gene G2FUF-11661 BioCyc
Ensembl Genes ENSRNOG00000014172 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000018976 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000086593 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000089710 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018976 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000099301 UniProtKB/Swiss-Prot
  ENSRNOT00000109751 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPY5_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPY_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25340 UniProtKB/Swiss-Prot
NCBI Gene 25340 ENTREZGENE
PANTHER NEUROPEPTIDE Y RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROPEPTIDE Y RECEPTOR TYPE 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Npy5r PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRPEPTIDEY5R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRPEPTIDEYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KFL9 ENTREZGENE, UniProtKB/TrEMBL
  NPY5R_RAT UniProtKB/Swiss-Prot
  P70586 ENTREZGENE
  Q63634 ENTREZGENE
UniProt Secondary P70586 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Npy5r  neuropeptide Y receptor Y5    Neuropeptide Y5 receptor  Name updated 629478 APPROVED
2002-06-10 Npy5r  Neuropeptide Y5 receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process activation involved in an increase in food consumption 628420