Gfer (growth factor, augmenter of liver regeneration) - Rat Genome Database

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Gene: Gfer (growth factor, augmenter of liver regeneration) Rattus norvegicus
Analyze
Symbol: Gfer
Name: growth factor, augmenter of liver regeneration
RGD ID: 61845
Description: Enables flavin-dependent sulfhydryl oxidase activity. Involved in several processes, including cellular response to actinomycin D; liver regeneration; and negative regulation of natural killer cell mediated cytotoxicity. Located in extracellular space. Used to study acute kidney failure. Biomarker of acute kidney failure; cryptorchidism; and ureteral obstruction. Human ortholog(s) of this gene implicated in kidney failure and renal fibrosis. Orthologous to human GFER (growth factor, augmenter of liver regeneration); PARTICIPATES IN intermembrane space assembly pathway of mitochondrial protein import; mitochondrial iron-sulfur cluster export pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ALR; augmenter of liver regeneration; FAD-linked sulfhydryl oxidase ALR; FAD-linked sulfhydryl oxidase ALR-like; growth factor erv1 (S. cerevisiae)-like (augmenter of liver regeneration); growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration); growth factor, erv1 -like; growth factor, erv1 homolog; growth factor, erv1 homolog (S. cerevisiae); growth factor, erv1-like (augmenter of liver regeneration); LOC100912596; translation initiation factor IF-2-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,223,023 - 14,225,736 (-)NCBIGRCr8
mRatBN7.21013,718,489 - 13,721,782 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,718,489 - 13,720,869 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,465,172 - 18,467,528 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,954,025 - 17,956,381 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,453,227 - 13,455,583 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,059,347 - 14,061,703 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,059,347 - 14,061,703 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,876,328 - 13,878,685 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,946,311 - 13,948,665 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,946,310 - 13,948,665 (-)NCBI
Celera1013,398,231 - 13,400,587 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Augmenter of liver regeneration ameliorates renal fibrosis in rats with obstructive nephropathy. Chen GT, etal., Biosci Rep. 2014 Sep 5;34(5). pii: BSR20140038. doi: 10.1042/BSR20140038.
2. [Expression of augmenter of liver regeneration in cryptorchidism spermatogenic cells and its implication]. Chen X, etal., Zhonghua Nan Ke Xue. 2007 Aug;13(8):700-5.
3. The in vivo effect of hepatotrophic factors augmenter of liver regeneration, hepatocyte growth factor, and insulin-like growth factor-II on liver natural killer cell functions. Francavilla A, etal., Hepatology. 1997 Feb;25(2):411-5.
4. Transient GFER knockdown in vivo impairs liver regeneration after partial hepatectomy. Francavilla A, etal., Int J Biochem Cell Biol. 2014 Aug;53:343-51. doi: 10.1016/j.biocel.2014.05.029. Epub 2014 May 28.
5. A fresh look at augmenter of liver regeneration in rats. Gandhi CR, etal., Hepatology. 1999 May;29(5):1435-45.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Cloning and sequence analysis of the rat augmenter of liver regeneration (ALR) gene: expression of biologically active recombinant ALR and demonstration of tissue distribution. Hagiya M, etal., Proc Natl Acad Sci U S A 1994 Aug 16;91(17):8142-6.
9. Cloning and sequence analysis of the rat augmenter of liver regeneration (ALR) gene: expression of biologically active recombinant ALR and demonstration of tissue distribution. Hagiya M, etal., Proc Natl Acad Sci U S A 1995 Mar 28;92(7):3076.
10. Augmenter of liver regeneration may be a candidate for prognosis of HBV related acute-on-chronic liver failure as a regenerative marker. Hongbo S, etal., Hepatogastroenterology. 2012 Sep;59(118):1933-8. doi: 10.5754/hge11679.
11. Correlation between augmenter of liver regeneration and IFN-gamma expression in graft after rat orthotopic liver transplantation. Liang S, etal., J Surg Res. 2012 Dec;178(2):968-73. doi: 10.1016/j.jss.2012.06.032. Epub 2012 Jul 5.
12. Augmenter of liver regeneration protects kidneys from ischaemia/reperfusion injury in rats. Liao XH, etal., Nephrol Dial Transplant. 2010 Sep;25(9):2921-9. doi: 10.1093/ndt/gfq151. Epub 2010 Mar 23.
13. Expression of augmenter of liver regeneration in rats with gentamicin-induced acute renal failure and its protective effect on kidney. Liao XH, etal., Ren Fail. 2009;31(10):946-55. doi: 10.3109/08860220903216154.
14. Mammalian augmenter of liver regeneration protein is a sulfhydryl oxidase. Lisowsky T, etal., Dig Liver Dis. 2001 Mar;33(2):173-80.
15. Augmentor of liver regeneration ameliorates renal tubular epithelial cell injury after rat liver transplantation. Long FW, etal., Transplant Proc. 2008 Oct;40(8):2696-9. doi: 10.1016/j.transproceed.2008.08.015.
16. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N and Rouault TA, Biochim Biophys Acta. 2015 Jun;1853(6):1493-512. doi: 10.1016/j.bbamcr.2014.09.009. Epub 2014 Sep 19.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. The MIA pathway: a key regulator of mitochondrial oxidative protein folding and biogenesis. Mordas A and Tokatlidis K, Acc Chem Res. 2015 Aug 18;48(8):2191-9. doi: 10.1021/acs.accounts.5b00150. Epub 2015 Jul 27.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Augmenter of liver regeneration (ALR) gene therapy attenuates CCl(4)-induced liver injury and fibrosis in rats. Song M, etal., Biochem Biophys Res Commun. 2011 Nov 11;415(1):152-6. doi: 10.1016/j.bbrc.2011.10.039. Epub 2011 Oct 18.
25. Overexpression of aldehyde reductase protects PC12 cells from the cytotoxicity of methylglyoxal or 3-deoxyglucosone. Suzuki K, etal., J Biochem. 1998 Feb;123(2):353-7.
26. Augmenter of liver regeneration: an important intracellular survival factor for hepatocytes. Thirunavukkarasu C, etal., J Hepatol. 2008 Apr;48(4):578-88. doi: 10.1016/j.jhep.2007.12.010. Epub 2008 Jan 28.
27. Augmenter of liver regeneration (ALR) is a novel biomarker of hepatocellular stress/inflammation: in vitro, in vivo and in silico studies. Vodovotz Y, etal., Mol Med. 2013 Jan 22;18:1421-9. doi: 10.2119/molmed.2012.00183.
28. Augmenter of liver regeneration promotes hepatocyte proliferation induced by Kupffer cells. Wang CP, etal., World J Gastroenterol. 2006 Aug 14;12(30):4859-65.
29. Augmenter of liver regeneration improves therapeutic effect of hepatocyte homotransplantation in acute liver failure rats. Wang N, etal., Int Immunopharmacol. 2013 Feb;15(2):325-32. doi: 10.1016/j.intimp.2013.01.002. Epub 2013 Jan 19.
30. Effect of naked eukaryotic expression plasmid encoding rat augmenter of liver regeneration on acute hepatic injury and hepatic failure in rats. Zhang LM, etal., World J Gastroenterol. 2005 Jun 28;11(24):3680-5.
Additional References at PubMed
PMID:12717032   PMID:14651853   PMID:16937489   PMID:18614015   PMID:19629817   PMID:19859909   PMID:22224850   PMID:23676665   PMID:33878312  


Genomics

Comparative Map Data
Gfer
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,223,023 - 14,225,736 (-)NCBIGRCr8
mRatBN7.21013,718,489 - 13,721,782 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,718,489 - 13,720,869 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,465,172 - 18,467,528 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,954,025 - 17,956,381 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,453,227 - 13,455,583 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,059,347 - 14,061,703 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,059,347 - 14,061,703 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,876,328 - 13,878,685 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,946,311 - 13,948,665 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,946,310 - 13,948,665 (-)NCBI
Celera1013,398,231 - 13,400,587 (-)NCBICelera
Cytogenetic Map10q12NCBI
GFER
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38161,984,193 - 1,987,749 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl161,984,193 - 1,987,749 (+)EnsemblGRCh38hg38GRCh38
GRCh37162,034,194 - 2,037,750 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,974,151 - 1,977,751 (+)NCBINCBI36Build 36hg18NCBI36
Build 34161,974,150 - 1,977,749NCBI
Celera162,246,329 - 2,249,928 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef161,958,203 - 1,961,803 (+)NCBIHuRef
CHM1_1162,034,076 - 2,037,676 (+)NCBICHM1_1
T2T-CHM13v2.0162,004,138 - 2,007,694 (+)NCBIT2T-CHM13v2.0
Gfer
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,912,164 - 24,915,065 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,912,161 - 24,915,503 (-)EnsemblGRCm39 Ensembl
GRCm381724,693,190 - 24,696,156 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,693,187 - 24,696,156 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,830,136 - 24,833,101 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,420,790 - 24,423,748 (-)NCBIMGSCv36mm8
Celera1725,216,107 - 25,219,071 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.48NCBI
Gfer
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,281,419 - 15,283,266 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544215,280,753 - 15,283,405 (-)NCBIChiLan1.0ChiLan1.0
GFER
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,359,690 - 2,363,217 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,141,337 - 6,144,864 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v016716,640 - 720,196 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,073,064 - 2,076,592 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,073,064 - 2,076,592 (+)Ensemblpanpan1.1panPan2
GFER
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,948,927 - 38,951,300 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,949,484 - 38,951,703 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,188,617 - 40,190,946 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,265,945 - 39,268,274 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,266,502 - 39,268,893 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,942,725 - 38,945,054 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,915,028 - 38,917,357 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,393,915 - 39,396,244 (-)NCBIUU_Cfam_GSD_1.0
Gfer
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,655,651 - 104,658,098 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366942,051,325 - 2,053,818 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366942,051,362 - 2,053,812 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GFER
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,981,940 - 39,984,991 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,981,938 - 39,984,451 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,197,274 - 42,199,315 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GFER
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,880,025 - 1,886,829 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl51,879,968 - 1,883,696 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606829,184,259 - 29,187,914 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gfer
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624913273,705 - 275,693 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624913273,126 - 276,353 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gfer
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:380
Count of miRNA genes:215
Interacting mature miRNAs:243
Transcripts:ENSRNOT00000017917
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000017917   ⟹   ENSRNOP00000017917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,718,489 - 13,720,869 (-)Ensembl
Rnor_6.0 Ensembl1014,059,347 - 14,061,703 (-)Ensembl
RefSeq Acc Id: NM_013222   ⟹   NP_037354
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,223,023 - 14,225,379 (-)NCBI
mRatBN7.21013,718,489 - 13,720,845 (-)NCBI
Rnor_6.01014,059,347 - 14,061,703 (-)NCBI
Rnor_5.01013,876,328 - 13,878,685 (-)NCBI
RGSC_v3.41013,946,311 - 13,948,665 (-)RGD
Celera1013,398,231 - 13,400,587 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085317   ⟹   XP_038941245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,223,023 - 14,225,736 (-)NCBI
mRatBN7.21013,719,129 - 13,721,782 (-)NCBI
Protein Sequences
Protein RefSeqs NP_037354 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941245 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF12808 (Get FASTA)   NCBI Sequence Viewer  
  BAA06399 (Get FASTA)   NCBI Sequence Viewer  
  EDM03859 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017917.3
GenBank Protein Q63042 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037354   ⟸   NM_013222
- UniProtKB: Q63042 (UniProtKB/Swiss-Prot),   A6HCV4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017917   ⟸   ENSRNOT00000017917
RefSeq Acc Id: XP_038941245   ⟸   XM_039085317
- Peptide Label: isoform X1
Protein Domains
ERV/ALR sulfhydryl oxidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KAE4-F1-model_v2 AlphaFold A0A0G2KAE4 1-148 view protein structure
AF-Q63042-F1-model_v2 AlphaFold Q63042 1-198 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697022
Promoter ID:EPDNEW_R7547
Type:multiple initiation site
Name:Gfer_1
Description:growth factor, augmenter of liver regeneration
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01014,061,653 - 14,061,713EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61845 AgrOrtholog
BioCyc Gene G2FUF-25835 BioCyc
Ensembl Genes ENSRNOG00000013370 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017917.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.310 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ALR/ERV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERV/ALR_sulphydryl_oxid_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERV/ALR_sulphydryl_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:27100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene Gfer ENTREZGENE
PANTHER ALR/ERV UniProtKB/TrEMBL
  FAD-LINKED SULFHYDRYL OXIDASE ALR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12645 UniProtKB/Swiss-Prot
Pfam Evr1_Alr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gfer PhenoGen
PROSITE ERV_ALR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013370 RatGTEx
Superfamily-SCOP FAD-dependent thiol oxidase UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6HCV4 ENTREZGENE, UniProtKB/TrEMBL
  ALR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Gfer  growth factor, augmenter of liver regeneration  LOC100912596  FAD-linked sulfhydryl oxidase ALR-like  Data merged from RGD:6486432 737654 PROVISIONAL
2012-07-05 LOC100912596  FAD-linked sulfhydryl oxidase ALR-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-10-17 Gfer  growth factor, augmenter of liver regeneration  Gfer  growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Gfer  growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)  Gfer  growth factor, erv1 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Gfer  growth factor, erv1 homolog (S. cerevisiae)    growth factor, erv1 -like   Name updated 1299863 APPROVED
2002-06-10 Gfer  growth factor, erv1 -like       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization expressed in cytosol 61605
gene_expression expressed in liver of weanling rats 61605
gene_process auguments liver cell proliferation in response to hepatectomy 61605