Myt1 (myelin transcription factor 1) - Rat Genome Database

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Gene: Myt1 (myelin transcription factor 1) Rattus norvegicus
Analyze
Symbol: Myt1
Name: myelin transcription factor 1
RGD ID: 1304899
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including diaphragm development; regulation of gene expression; and regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human MYT1 (myelin transcription factor 1); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC362291
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23168,890,466 - 168,950,341 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,886,089 - 168,950,341 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3173,296,066 - 173,326,848 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03182,255,163 - 182,285,949 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03178,920,491 - 178,951,261 (+)NCBIRnor_WKY
Rnor_6.03177,281,365 - 177,341,550 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3177,310,753 - 177,341,547 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,989,537 - 181,049,955 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,954,769 - 170,985,583 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13170,827,281 - 170,891,617 (+)NCBI
Celera3163,640,239 - 163,671,029 (-)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9373037   PMID:17442045   PMID:17928203   PMID:26071990   PMID:28303373  


Genomics

Comparative Map Data
Myt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23168,890,466 - 168,950,341 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,886,089 - 168,950,341 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3173,296,066 - 173,326,848 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03182,255,163 - 182,285,949 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03178,920,491 - 178,951,261 (+)NCBIRnor_WKY
Rnor_6.03177,281,365 - 177,341,550 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3177,310,753 - 177,341,547 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,989,537 - 181,049,955 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,954,769 - 170,985,583 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13170,827,281 - 170,891,617 (+)NCBI
Celera3163,640,239 - 163,671,029 (-)NCBICelera
Cytogenetic Map3q43NCBI
MYT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382064,164,452 - 64,242,253 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2064,102,394 - 64,242,253 (+)EnsemblGRCh38hg38GRCh38
GRCh372062,795,805 - 62,873,606 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362062,266,271 - 62,344,050 (+)NCBINCBI36Build 36hg18NCBI36
Build 342062,266,270 - 62,344,048NCBI
Celera2059,480,507 - 59,558,438 (+)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2059,521,605 - 59,598,530 (+)NCBIHuRef
CHM1_12062,696,840 - 62,774,541 (+)NCBICHM1_1
T2T-CHM13v2.02065,983,955 - 66,063,029 (+)NCBIT2T-CHM13v2.0
Myt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392181,405,099 - 181,469,579 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2181,405,125 - 181,469,590 (+)EnsemblGRCm39 Ensembl
GRCm382181,763,332 - 181,827,775 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2181,763,332 - 181,827,797 (+)EnsemblGRCm38mm10GRCm38
MGSCv372181,498,037 - 181,562,480 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362181,696,448 - 181,757,174 (+)NCBIMGSCv36mm8
Celera2185,838,883 - 185,903,600 (+)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.77NCBI
Myt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495552847,800 - 112,114 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495552848,198 - 108,293 (-)NCBIChiLan1.0ChiLan1.0
MYT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12062,081,231 - 62,153,741 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2062,108,924 - 62,151,936 (+)Ensemblpanpan1.1panPan2
MYT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12447,574,201 - 47,639,962 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2447,574,255 - 47,638,315 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2446,711,804 - 46,773,586 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02448,717,427 - 48,779,220 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2448,713,529 - 48,779,222 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12447,562,006 - 47,623,774 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02447,686,311 - 47,748,092 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02448,425,706 - 48,487,543 (+)NCBIUU_Cfam_GSD_1.0
Myt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640195,852,513 - 195,914,291 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651411,308,071 - 11,368,801 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493651411,305,929 - 11,367,935 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1762,979,350 - 63,014,696 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11762,955,052 - 63,020,652 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MYT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1259,574 - 96,113 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl261,371 - 96,583 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605047,439,664 - 47,531,211 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474129,775,504 - 29,837,606 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474129,779,177 - 29,837,606 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Myt1
108 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:592
Count of miRNA genes:269
Interacting mature miRNAs:358
Transcripts:ENSRNOT00000031448
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat

Markers in Region
D3Mco37  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03177,313,106 - 177,313,308NCBIRnor6.0
Rnor_5.03181,021,494 - 181,021,696UniSTSRnor5.0
RGSC_v3.43170,957,122 - 170,957,324UniSTSRGSC3.4
Celera3163,668,458 - 163,668,676UniSTS
Cytogenetic Map3q43UniSTS
RH10656  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23168,950,085 - 168,950,262 (+)MAPPERmRatBN7.2
Rnor_6.03177,341,292 - 177,341,468NCBIRnor6.0
Rnor_5.03181,049,697 - 181,049,873UniSTSRnor5.0
RGSC_v3.43170,985,328 - 170,985,504UniSTSRGSC3.4
Celera3163,640,318 - 163,640,494UniSTS
Cytogenetic Map3q43UniSTS
UniSTS:258472  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23168,919,017 - 168,919,123 (+)MAPPERmRatBN7.2
Rnor_6.03177,310,220 - 177,310,325NCBIRnor6.0
Rnor_5.03181,018,608 - 181,018,713UniSTSRnor5.0
RGSC_v3.43170,954,236 - 170,954,341UniSTSRGSC3.4
Celera3163,671,457 - 163,671,562UniSTS
Cytogenetic Map3q43UniSTS
PMC304100P8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23168,948,746 - 168,948,946 (+)MAPPERmRatBN7.2
Rnor_6.03177,339,953 - 177,340,152NCBIRnor6.0
Rnor_5.03181,048,358 - 181,048,557UniSTSRnor5.0
RGSC_v3.43170,983,989 - 170,984,188UniSTSRGSC3.4
Celera3163,641,634 - 163,641,833UniSTS
Cytogenetic Map3q43UniSTS
UniSTS:546878  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23168,923,779 - 168,924,893 (+)MAPPERmRatBN7.2
Rnor_6.03177,314,974 - 177,316,087NCBIRnor6.0
Rnor_5.03181,023,362 - 181,024,475UniSTSRnor5.0
Celera3163,665,679 - 163,666,792UniSTS
Cytogenetic Map3q43UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 63
Low 3 10 2 2 11 11
Below cutoff 9 11 7 11 7 1 1 6 23 9 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000031448   ⟹   ENSRNOP00000032420
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,919,551 - 168,950,341 (+)Ensembl
Rnor_6.0 Ensembl3177,310,753 - 177,341,547 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094940   ⟹   ENSRNOP00000080274
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,912,803 - 168,950,341 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096392   ⟹   ENSRNOP00000078394
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,912,803 - 168,950,341 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102710   ⟹   ENSRNOP00000087460
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,886,089 - 168,950,341 (+)Ensembl
RefSeq Acc Id: NM_001108615   ⟹   NP_001102085
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,919,551 - 168,950,341 (+)NCBI
Rnor_6.03177,310,753 - 177,341,547 (+)NCBI
Rnor_5.03180,989,537 - 181,049,955 (+)NCBI
RGSC_v3.43170,954,769 - 170,985,583 (+)RGD
Celera3163,640,239 - 163,671,029 (-)RGD
Sequence:
RefSeq Acc Id: XM_039105570   ⟹   XP_038961498
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,890,466 - 168,942,791 (+)NCBI
RefSeq Acc Id: XM_039105571   ⟹   XP_038961499
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,890,467 - 168,937,261 (+)NCBI
RefSeq Acc Id: XM_039105572   ⟹   XP_038961500
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,890,467 - 168,937,260 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001102085 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961498 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961499 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961500 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL88668 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001102085   ⟸   NM_001108615
- UniProtKB: D3ZYT5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000032420   ⟸   ENSRNOT00000031448
RefSeq Acc Id: XP_038961498   ⟸   XM_039105570
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961499   ⟸   XM_039105571
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038961500   ⟸   XM_039105572
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000087460   ⟸   ENSRNOT00000102710
RefSeq Acc Id: ENSRNOP00000080274   ⟸   ENSRNOT00000094940
RefSeq Acc Id: ENSRNOP00000078394   ⟸   ENSRNOT00000096392
Protein Domains
MYT1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZYT5-F1-model_v2 AlphaFold D3ZYT5 1-922 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304899 AgrOrtholog
BioCyc Gene G2FUF-46259 BioCyc
Ensembl Genes ENSRNOG00000017346 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000032420 ENTREZGENE
  ENSRNOP00000032420.4 UniProtKB/TrEMBL
  ENSRNOP00000078394.1 UniProtKB/TrEMBL
  ENSRNOP00000080274.1 UniProtKB/TrEMBL
  ENSRNOP00000087460.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031448 ENTREZGENE
  ENSRNOT00000031448.5 UniProtKB/TrEMBL
  ENSRNOT00000094940.1 UniProtKB/TrEMBL
  ENSRNOT00000096392.1 UniProtKB/TrEMBL
  ENSRNOT00000102710.1 UniProtKB/TrEMBL
InterPro Myelin_TF UniProtKB/TrEMBL
  Znf_C2HC UniProtKB/TrEMBL
  Znf_C2HC_sf UniProtKB/TrEMBL
KEGG Report rno:362291 UniProtKB/TrEMBL
NCBI Gene 362291 ENTREZGENE
Pfam MYT1 UniProtKB/TrEMBL
  zf-C2HC UniProtKB/TrEMBL
PhenoGen Myt1 PhenoGen
PROSITE ZF_CCHHC UniProtKB/TrEMBL
Superfamily-SCOP SSF103637 UniProtKB/TrEMBL
UniProt A0A8I5ZKR6_RAT UniProtKB/TrEMBL
  A0A8I5ZQB6_RAT UniProtKB/TrEMBL
  A0A8I6GF57_RAT UniProtKB/TrEMBL
  D3ZYT5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Myt1  myelin transcription factor 1   Myt1_predicted  myelin transcription factor 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Myt1_predicted  myelin transcription factor 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED