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Gene: Pck1 (phosphoenolpyruvate carboxykinase 1) Rattus norvegicus
Symbol: Pck1
Name: phosphoenolpyruvate carboxykinase 1
Description: Exhibits several functions, including manganese ion binding activity; nucleoside diphosphate kinase activity; and purine ribonucleoside binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to hexose stimulus; and cellular response to organonitrogen compound. Localizes to cytoplasm. Used to study type 2 diabetes mellitus. Biomarker of non-alcoholic steatohepatitis. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human PCK1 (phosphoenolpyruvate carboxykinase 1); PARTICIPATES IN gluconeogenesis pathway; glycolysis/gluconeogenesis pathway; forkhead class A signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-schisandrin B; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: GTP; MGC93820; PCK; Pepck; PEPCK-C; Phosphoenolpyruvate carboxykinase; phosphoenolpyruvate carboxykinase (GTP); phosphoenolpyruvate carboxykinase 1 (soluble); phosphoenolpyruvate carboxykinase 1, cytosolic; phosphoenolpyruvate carboxykinase, cytosolic; phosphoenolpyruvate carboxykinase, cytosolic (GTP); phosphoenolpyruvate carboxykinase, cytosolic [GTP]; phosphoenolpyruvate carboxylase; RATPEPCK
Homo sapiens (human) : PCK1 (phosphoenolpyruvate carboxykinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Pck1 (phosphoenolpyruvate carboxykinase 1, cytosolic)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pck1 (phosphoenolpyruvate carboxykinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PCK1 (phosphoenolpyruvate carboxykinase 1)
Canis lupus familiaris (dog) : PCK1 (phosphoenolpyruvate carboxykinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pck1 (phosphoenolpyruvate carboxykinase 1)
Sus scrofa (pig) : PCK1 (phosphoenolpyruvate carboxykinase 1)
Chlorocebus sabaeus (African green monkey) : PCK1 (phosphoenolpyruvate carboxykinase 1)
Heterocephalus glaber (naked mole-rat) : Pck1 (phosphoenolpyruvate carboxykinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03171,213,936 - 171,219,885 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3171,213,936 - 171,219,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03177,278,783 - 177,284,732 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43164,012,410 - 164,018,359 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13163,918,445 - 163,924,394 (+)NCBI
Celera3161,118,524 - 161,124,473 (+)NCBICelera
Cytogenetic Map3q42NCBI
RH 3.4 Map31498.6RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pck1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3267
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.