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Gene: Pck1 (phosphoenolpyruvate carboxykinase 1) Rattus norvegicus
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Symbol: Pck1
Name: phosphoenolpyruvate carboxykinase 1
Description: Exhibits several functions, including manganese ion binding activity; nucleoside diphosphate kinase activity; and purine ribonucleoside binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to hexose stimulus; and cellular response to organonitrogen compound. Localizes to the cytoplasm. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human PCK1 (phosphoenolpyruvate carboxykinase 1); PARTICIPATES IN gluconeogenesis pathway; glycolysis/gluconeogenesis pathway; forkhead class A signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (-)-epigallocatechin 3-gallate; (20S)-ginsenoside Rg3.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: GTP; MGC93820; PCK; Pepck; PEPCK-C; Phosphoenolpyruvate carboxykinase; phosphoenolpyruvate carboxykinase (GTP); phosphoenolpyruvate carboxykinase 1 (soluble); phosphoenolpyruvate carboxykinase 1, cytosolic; phosphoenolpyruvate carboxykinase, cytosolic; phosphoenolpyruvate carboxykinase, cytosolic (GTP); phosphoenolpyruvate carboxykinase, cytosolic [GTP]; phosphoenolpyruvate carboxylase; RATPEPCK
Orthologs:
Homo sapiens (human) : PCK1 (phosphoenolpyruvate carboxykinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Pck1 (phosphoenolpyruvate carboxykinase 1, cytosolic)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pck1 (phosphoenolpyruvate carboxykinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PCK1 (phosphoenolpyruvate carboxykinase 1)
Canis lupus familiaris (dog) : PCK1 (phosphoenolpyruvate carboxykinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pck1 (phosphoenolpyruvate carboxykinase 1)
Sus scrofa (pig) : PCK1 (phosphoenolpyruvate carboxykinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03171,213,936 - 171,219,885 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03177,278,783 - 177,284,732 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43164,012,410 - 164,018,359 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13163,918,445 - 163,924,394 (+)NCBI
Celera3161,118,524 - 161,124,473 (+)NCBICelera
Cytogenetic Map3q42NCBI
RH 3.4 Map31498.6RGD
JBrowse: View Region in Genome Browser (JBrowse)
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Genomics

Candidate Gene Status
Comparative Map Data
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QTLs in Region (Rnor_6.0)
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Sequence

Nucleotide Sequences
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Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pck1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3267
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.