Pck1 (phosphoenolpyruvate carboxykinase 1) - Rat Genome Database

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Gene: Pck1 (phosphoenolpyruvate carboxykinase 1) Rattus norvegicus
Analyze
Symbol: Pck1
Name: phosphoenolpyruvate carboxykinase 1
RGD ID: 3267
Description: Enables several functions, including guanyl ribonucleotide binding activity; manganese ion binding activity; and nucleoside diphosphate kinase activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to hexose stimulus; and cellular response to organonitrogen compound. Located in cytoplasm. Used to study type 2 diabetes mellitus. Biomarker of non-alcoholic steatohepatitis. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human PCK1 (phosphoenolpyruvate carboxykinase 1); PARTICIPATES IN gluconeogenesis pathway; glycolysis/gluconeogenesis pathway; forkhead class A signaling pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (20S)-ginsenoside Rg3.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GTP; MGC93820; PCK; Pepck; PEPCK-C; Phosphoenolpyruvate carboxykinase; phosphoenolpyruvate carboxykinase (GTP); phosphoenolpyruvate carboxykinase 1 (soluble); phosphoenolpyruvate carboxykinase 1, cytosolic; phosphoenolpyruvate carboxykinase, cytosolic; phosphoenolpyruvate carboxykinase, cytosolic (GTP); phosphoenolpyruvate carboxykinase, cytosolic [GTP]; phosphoenolpyruvate carboxylase; RATPEPCK; serine-protein kinase PCK1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23161,930,256 - 161,936,205 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl3161,930,256 - 161,936,191 (+)Ensembl
Rnor_6.03171,213,936 - 171,219,885 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3171,213,936 - 171,219,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03177,278,783 - 177,284,732 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43164,012,410 - 164,018,359 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13163,918,445 - 163,924,394 (+)NCBI
Celera3161,118,524 - 161,124,473 (+)NCBICelera
RH 3.4 Map31498.6RGD
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(20S)-ginsenoside Rg3  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2,3,4,7,8-Hexachlorodibenzodioxin  (EXP)
1,2-dichloroethane  (ISO)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (ISO)
2-chloroethanol  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-dihydrocoumarin  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
3-phenoxybenzoic acid  (EXP)
3-phenylprop-2-enal  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
9-cis-retinoic acid  (EXP,ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
alpha-linolenic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
AM-251  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
betulin  (ISO)
bezafibrate  (ISO)
bifenthrin  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bucladesine  (EXP,ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
cefaloridine  (EXP)
chlordecone  (ISO)
chloroethene  (ISO)
choline  (ISO)
chromium atom  (ISO)
ciglitazone  (ISO)
clemizole  (ISO)
clofibrate  (EXP,ISO)
Clofop  (ISO)
clopidogrel  (ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cortisol  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (EXP)
DDT  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dimethylarsinic acid  (ISO)
Diosbulbin B  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
duvoglustat  (ISO)
endosulfan  (EXP,ISO)
ethanol  (EXP)
farnesol  (ISO)
fenofibrate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fructose  (EXP)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
ginsenoside Re  (ISO)
ginsenoside Rg2  (ISO)
glucagon  (EXP)
glucose  (ISO)
glyburide  (EXP)
GW 4064  (ISO)
GW 501516  (ISO)
GW 7647  (ISO)
hexadecanoic acid  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
imiquimod  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
irinotecan  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
iron(III) nitrilotriacetate  (EXP)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (EXP)
lovastatin  (ISO)
malathion  (EXP)
menadione  (ISO)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methimazole  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
mifepristone  (EXP,ISO)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naringin  (ISO)
nefazodone  (EXP)
nicotinic acid  (EXP,ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
oleic acid  (ISO)
ozone  (EXP)
palmitoleic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl caffeate  (EXP)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
phlorizin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
prednisolone  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
Propiverine  (EXP)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (ISO)
Rutamarin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 203580  (EXP)
SB 431542  (ISO)
selenic acid  (ISO)
silicon dioxide  (ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sucrose  (EXP)
sulconazole  (ISO)
sulforaphane  (EXP)
taurine  (ISO)
tauroursodeoxycholic acid  (EXP)
teriflunomide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
wortmannin  (EXP)
XL147  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
cellular hyperosmotic salinity response  (IEP)
cellular hypotonic salinity response  (IEP)
cellular response to cAMP  (IEP)
cellular response to dexamethasone stimulus  (IBA)
cellular response to fructose stimulus  (IEP)
cellular response to glucagon stimulus  (IEP)
cellular response to glucose stimulus  (IBA,IDA,ISO)
cellular response to hypoxia  (IEP)
cellular response to insulin stimulus  (IBA,IEP,ISO,ISS)
cellular response to interleukin-1  (IEP)
cellular response to phorbol 13-acetate 12-myristate  (IEP)
cellular response to potassium ion starvation  (ISO)
cellular response to raffinose  (IEP)
cellular response to retinoic acid  (IEP)
cellular response to tumor necrosis factor  (IEP)
gluconeogenesis  (IBA,IDA,IEA,ISO,TAS)
glucose homeostasis  (IDA)
glucose metabolic process  (IMP,ISO)
glycerol biosynthetic process from pyruvate  (IBA,IDA,ISO)
hepatocyte differentiation  (IBA)
lipid metabolic process  (ISO)
oxaloacetate metabolic process  (IDA,ISO)
peptidyl-serine phosphorylation  (ISO,ISS)
positive regulation of memory T cell differentiation  (ISO,ISS)
positive regulation of transcription from RNA polymerase II promoter in response to acidic pH  (ISO)
propionate catabolic process  (IBA)
regulation of lipid biosynthetic process  (ISO,ISS)
response to activity  (IEP)
response to bacterium  (ISO)
response to insulin  (ISO,ISS)
response to interleukin-6  (IEP)
response to lipid  (IBA,IEP)
response to lipopolysaccharide  (IEP)
response to methionine  (IEP)
response to starvation  (IBA)

Cellular Component
cytoplasm  (IDA)
cytosol  (IBA,ISO,ISS,TAS)
endoplasmic reticulum  (ISO,ISS)
mitochondrion  (IBA)

References

References - curated
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5. Cadoudal T, etal., Diabetologia. 2007 Mar;50(3):666-75. Epub 2007 Jan 23.
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10. Christ B Horm Metab Res. 2008 Jan;40(1):18-23.
11. Dong Y, etal., Diabetes Res Clin Pract. 2009 Feb;83(2):227-32. Epub 2008 Dec 13.
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26. KEGG
27. Kong SE, etal., Am J Physiol Endocrinol Metab 2002 Oct;283(4):E692-701.
28. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
29. Latorre-Muro P, etal., Mol Cell. 2018 Sep 6;71(5):718-732.e9. doi: 10.1016/j.molcel.2018.07.031.
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33. MGD data from the GO Consortium
34. Miller WH, etal., J Biol Chem. 1992 Oct 15;267(29):21220-4.
35. NCBI rat LocusLink and RefSeq merged data July 26, 2002
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37. OMIM Disease Annotation Pipeline
38. Parimi PS, etal., Pediatr Res. 2003 Feb;53(2):325-32.
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41. Pipeline to import KEGG annotations from KEGG into RGD
42. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
43. Pipeline to import SMPDB annotations from SMPDB into RGD
44. RGD automated data pipeline
45. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
46. RGD automated import pipeline for gene-chemical interactions
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Additional References at PubMed
PMID:1716357   PMID:2909519   PMID:2993287   PMID:3015903   PMID:6090458   PMID:6304730   PMID:9242918   PMID:10224131   PMID:11792850   PMID:11916968   PMID:11968005   PMID:12409311  
PMID:12788931   PMID:12947022   PMID:14744869   PMID:15147725   PMID:15489334   PMID:15604115   PMID:15733865   PMID:16126724   PMID:17158265   PMID:17211624   PMID:17678617   PMID:17903369  
PMID:17964299   PMID:18304430   PMID:18492826   PMID:18772387   PMID:19056867   PMID:19458124   PMID:19521512   PMID:19548567   PMID:19850730   PMID:20167786   PMID:20797423   PMID:21504969  
PMID:21731709   PMID:22142627   PMID:22808220   PMID:23012479   PMID:23015202   PMID:23376485   PMID:26348778   PMID:26681041   PMID:26971250   PMID:27724862   PMID:29601231   PMID:30445425  
PMID:31180589   PMID:32036699  


Genomics

Candidate Gene Status
Pck1 is a candidate Gene for QTL Eau4
Comparative Map Data
Pck1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23161,930,256 - 161,936,205 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl3161,930,256 - 161,936,191 (+)Ensembl
Rnor_6.03171,213,936 - 171,219,885 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3171,213,936 - 171,219,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03177,278,783 - 177,284,732 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43164,012,410 - 164,018,359 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13163,918,445 - 163,924,394 (+)NCBI
Celera3161,118,524 - 161,124,473 (+)NCBICelera
RH 3.4 Map31498.6RGD
Cytogenetic Map3q42NCBI
PCK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382057,561,110 - 57,568,121 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2057,561,080 - 57,568,121 (+)EnsemblGRCh38hg38GRCh38
GRCh372056,136,166 - 56,143,177 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362055,569,543 - 55,574,922 (+)NCBINCBI36hg18NCBI36
Build 342055,569,542 - 55,574,922NCBI
Celera2052,876,507 - 52,881,880 (+)NCBI
Cytogenetic Map20q13.31NCBI
HuRef2052,917,936 - 52,923,310 (+)NCBIHuRef
CHM1_12056,037,177 - 56,042,551 (+)NCBICHM1_1
Pck1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392172,994,866 - 173,001,067 (+)NCBIGRCm39mm39
GRCm39 Ensembl2172,994,841 - 173,001,066 (+)Ensembl
GRCm382173,153,073 - 173,159,274 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2173,153,048 - 173,159,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv372172,978,574 - 172,984,755 (+)NCBIGRCm37mm9NCBIm37
MGSCv362172,796,012 - 172,802,193 (+)NCBImm8
Celera2179,118,257 - 179,124,444 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map295.79NCBI
Pck1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554451,908,946 - 1,915,002 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554451,909,012 - 1,914,032 (-)NCBIChiLan1.0ChiLan1.0
PCK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12055,179,549 - 55,184,920 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2055,179,429 - 55,184,920 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02053,901,738 - 53,907,090 (+)NCBIMhudiblu_PPA_v0panPan3
PCK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12442,538,858 - 42,544,200 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2442,538,882 - 42,544,198 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2441,785,578 - 41,791,088 (+)NCBI
ROS_Cfam_1.02443,403,776 - 43,409,160 (+)NCBI
ROS_Cfam_1.0 Ensembl2443,403,838 - 43,409,160 (+)Ensembl
UMICH_Zoey_3.12442,488,683 - 42,493,998 (+)NCBI
UNSW_CanFamBas_1.02442,628,235 - 42,633,550 (+)NCBI
UU_Cfam_GSD_1.02443,286,331 - 43,291,858 (+)NCBI
Pck1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640182,939,216 - 182,945,488 (-)NCBI
SpeTri2.0NW_004936530361,872 - 367,005 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1757,930,432 - 57,938,896 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11757,930,507 - 57,936,523 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21765,094,783 - 65,100,751 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.126,550,806 - 6,556,499 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl26,549,652 - 6,556,478 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605054,608,451 - 54,614,130 (-)NCBIVero_WHO_p1.0
Pck1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474123,985,257 - 23,990,354 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D3Mgh26  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera3161,114,063 - 161,114,271UniSTS
RH 3.4 Map31497.9RGD
RH 3.4 Map31497.9UniSTS
RH 2.0 Map31013.8RGD
FHH x ACI Map3103.83RGD
Cytogenetic Map3q42UniSTS
D9Mit10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,935,792 - 161,935,942 (+)MAPPERmRatBN7.2
Rnor_6.03171,219,473 - 171,219,622NCBIRnor6.0
Rnor_5.03177,284,320 - 177,284,469UniSTSRnor5.0
RGSC_v3.43164,017,947 - 164,018,096UniSTSRGSC3.4
RGSC_v3.43164,017,946 - 164,018,096RGDRGSC3.4
RGSC_v3.13163,923,982 - 163,924,132RGD
Celera3161,124,061 - 161,124,210UniSTS
RH 3.4 Map31495.5UniSTS
RH 3.4 Map31495.5RGD
RH 2.0 Map31013.5RGD
Cytogenetic Map3q42UniSTS
D3Arb24  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,935,834 - 161,936,089 (+)MAPPERmRatBN7.2
Rnor_6.03171,219,515 - 171,219,769NCBIRnor6.0
Rnor_5.03177,284,362 - 177,284,616UniSTSRnor5.0
RGSC_v3.43164,017,988 - 164,018,243RGDRGSC3.4
RGSC_v3.43164,017,989 - 164,018,243UniSTSRGSC3.4
RGSC_v3.13163,924,024 - 163,924,279RGD
Celera3161,124,103 - 161,124,357UniSTS
RH 2.0 Map31012.8RGD
Cytogenetic Map3q42UniSTS
PMC152262P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,934,097 - 161,934,271 (+)MAPPERmRatBN7.2
Rnor_6.03171,217,778 - 171,217,951NCBIRnor6.0
Rnor_5.03177,282,625 - 177,282,798UniSTSRnor5.0
RGSC_v3.43164,016,252 - 164,016,425UniSTSRGSC3.4
Celera3161,122,366 - 161,122,539UniSTS
Cytogenetic Map3q42UniSTS
PMC86435P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,930,677 - 161,931,227 (+)MAPPERmRatBN7.2
Rnor_6.03171,214,358 - 171,214,907NCBIRnor6.0
Rnor_5.03177,279,205 - 177,279,754UniSTSRnor5.0
RGSC_v3.43164,012,832 - 164,013,381UniSTSRGSC3.4
Celera3161,118,946 - 161,119,495UniSTS
Cytogenetic Map3q42UniSTS
PMC133887P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,929,820 - 161,930,160 (+)MAPPERmRatBN7.2
Rnor_6.03171,213,501 - 171,213,840NCBIRnor6.0
Rnor_5.03177,278,348 - 177,278,687UniSTSRnor5.0
RGSC_v3.43164,011,975 - 164,012,314UniSTSRGSC3.4
Celera3161,118,089 - 161,118,428UniSTS
Cytogenetic Map3q42UniSTS
Pck1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,933,962 - 161,934,036 (+)MAPPERmRatBN7.2
Rnor_6.03171,217,643 - 171,217,716NCBIRnor6.0
Rnor_5.03177,282,490 - 177,282,563UniSTSRnor5.0
RGSC_v3.43164,016,117 - 164,016,190UniSTSRGSC3.4
Celera3161,122,231 - 161,122,304UniSTS
Cytogenetic Map3q42UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:55
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000031586
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 11 11 10 12
Medium 2 1 28 13 7 13 1 1 15 6 8 1
Low 1 15 5 4 9 4 7 8 9 4 20 2 7
Below cutoff 25 12 12 2 12 2 16 4 11 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000031586   ⟹   ENSRNOP00000030913
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3161,930,256 - 161,936,191 (+)Ensembl
Rnor_6.0 Ensembl3171,213,936 - 171,219,871 (+)Ensembl
RefSeq Acc Id: NM_198780   ⟹   NP_942075
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23161,930,256 - 161,936,205 (+)NCBI
Rnor_6.03171,213,936 - 171,219,885 (+)NCBI
Rnor_5.03177,278,783 - 177,284,732 (+)NCBI
RGSC_v3.43164,012,410 - 164,018,359 (+)RGD
Celera3161,118,524 - 161,124,473 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_942075   ⟸   NM_198780
- UniProtKB: P07379 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000030913   ⟸   ENSRNOT00000031586

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07379-F1-model_v2 AlphaFold P07379 1-622 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692711
Promoter ID:EPDNEW_R3236
Type:single initiation site
Name:Pck1_1
Description:phosphoenolpyruvate carboxykinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03171,213,936 - 171,213,996EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3267 AgrOrtholog
BioCyc Gene G2FUF-46515 BioCyc
Ensembl Genes ENSRNOG00000028616 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000030913 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000031586 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.449.10 UniProtKB/Swiss-Prot
  3.90.228.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7110760 IMAGE-MGC_LOAD
InterPro PEP_carboxykin_GTP_CS UniProtKB/Swiss-Prot
  PEP_carboxykinase_C UniProtKB/Swiss-Prot
  PEP_carboxykinase_GTP UniProtKB/Swiss-Prot
  PEP_carboxykinase_GTP_C UniProtKB/Swiss-Prot
  PEP_carboxykinase_GTP_N UniProtKB/Swiss-Prot
  PEP_carboxykinase_N UniProtKB/Swiss-Prot
KEGG Report rno:362282 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93820 IMAGE-MGC_LOAD
NCBI Gene 362282 ENTREZGENE
PANTHER PTHR11561 UniProtKB/Swiss-Prot
Pfam PEPCK_GTP UniProtKB/Swiss-Prot
  PEPCK_N UniProtKB/Swiss-Prot
PhenoGen Pck1 PhenoGen
PIRSF PEP_carboxykinase_GTP UniProtKB/Swiss-Prot
PROSITE PEPCK_GTP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF68923 UniProtKB/Swiss-Prot
UniProt P07379 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Pck1  phosphoenolpyruvate carboxykinase 1  Pck1  phosphoenolpyruvate carboxykinase 1 (soluble)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-02-26 Pck1  phosphoenolpyruvate carboxykinase 1 (soluble)  Pck1  phosphoenolpyruvate carboxykinase 1, cytosolic  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Pck1  phosphoenolpyruvate carboxykinase 1, cytosolic  Pck1  phosphoenolpyruvate carboxykinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Pck1  phosphoenolpyruvate carboxykinase 1      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Pck1  phosphoenolpyruvate carboxykinase 1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease increased expression is correlated with the growth arrest of hepatoma cells 625518
gene_expression found mainly in liver, kidney and adipocytes 625518
gene_expression expressed in intestine 625518
gene_process an immediate-early response gene for liver regeneration 625518
gene_process functions in gluconeogenesis 625518
gene_regulation regulated by thyroid hormone, prolactin, diacyl glycerol, pH and retinoic acid 625518
gene_regulation regulated by insulin, glucocorticoids, cAMP, and diet 625518