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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3267
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pck1
Name: phosphoenolpyruvate carboxykinase 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pck1affects expressionEXP 6480464CTDresveratrol affects the expression of PCK1 proteinPMID:17346750
Pck1increases expressionEXP 6480464CTDresveratrol results in increased expression of PCK1 mRNAPMID:23209300 PMID:23824959
Pck1multiple interactionsEXP 6480464CTDresveratrol inhibits the reaction [INS1 protein results in decreased expression of PCK1 mRNA]PMID:16626303
Pck1decreases expressionISOPck1 (Mus musculus)6480464CTDresveratrol results in decreased expression of PCK1 mRNA; resveratrol results in decreased expression of PCK1 proteinPMID:19819963
Pck1multiple interactionsISOPck1 (Mus musculus)6480464CTD[Resveratrol co-treated with Imiquimod] results in increased expression of PCK1 mRNA; Resveratrol inhibits the reaction [Sodium Glutamate results in increased expression of PCK1 mRNA]; Resveratrol promotes the reaction [T0901317 results in decreased expression of PCK1 mRNA]PMID:23591747 PMID:25965695 PMID:28708105
Pck1multiple interactionsISOPCK1 (Homo sapiens)6480464CTD[Plant Extracts co-treated with Resveratrol] results in decreased expression of PCK1 mRNAPMID:23557933
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