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Gene: Pck1 (phosphoenolpyruvate carboxykinase 1, cytosolic) Mus musculus
Symbol: Pck1
Name: phosphoenolpyruvate carboxykinase 1, cytosolic
RGD ID: 11062
Description: Exhibits phosphoenolpyruvate carboxykinase (GTP) activity. Involved in several processes, including carboxylic acid metabolic process; cellular response to potassium ion starvation; and gluconeogenesis. Localizes to cytosol. Is expressed in several structures, including alimentary system; brown fat; liver; and urinary system. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human PCK1 (phosphoenolpyruvate carboxykinase 1); PARTICIPATES IN forkhead class A signaling pathway; fructose-1,6-bisphosphatase deficiency pathway; gluconeogenesis pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1,1-dichloroethene; 1,2-dichloroethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI265463; Pck-; Pck-1; PEP; PEPCK; PEPCK-C; phosphoenolpyruvate carboxykinase, cytosolic; phosphoenolpyruvate carboxykinase, cytosolic [GTP]; phosphoenolpyruvate carboxylase; serine-protein kinase PCK1
Homo sapiens (human) : PCK1 (phosphoenolpyruvate carboxykinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pck1 (phosphoenolpyruvate carboxykinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pck1 (phosphoenolpyruvate carboxykinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PCK1 (phosphoenolpyruvate carboxykinase 1)
Canis lupus familiaris (dog) : PCK1 (phosphoenolpyruvate carboxykinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pck1 (phosphoenolpyruvate carboxykinase 1)
Sus scrofa (pig) : PCK1 (phosphoenolpyruvate carboxykinase 1)
Chlorocebus sabaeus (African green monkey) : PCK1 (phosphoenolpyruvate carboxykinase 1)
Heterocephalus glaber (naked mole-rat) : Pck1 (phosphoenolpyruvate carboxykinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392172,994,866 - 173,001,067 (+)NCBI
GRCm382173,153,073 - 173,159,274 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2173,153,048 - 173,159,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv372172,978,574 - 172,984,755 (+)NCBIGRCm37mm9NCBIm37
MGSCv362172,796,012 - 172,802,193 (+)NCBImm8
Celera2179,118,257 - 179,124,444 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map295.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pck1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11062
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.