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Gene: Abat (4-aminobutyrate aminotransferase) Rattus norvegicus
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Symbol: Abat
Name: 4-aminobutyrate aminotransferase
Description: Exhibits 4-aminobutyrate transaminase activity. Involved in several processes, including gamma-aminobutyric acid biosynthetic process; positive regulation of inhibitory postsynaptic potential; and regulation of secretion. Localizes to the mitochondrial matrix and neuron projection. Used to study several diseases, including Huntington's disease; epilepsy (multiple); heroin dependence; ischemia; and mental depression. Human ortholog(s) of this gene implicated in Alzheimer's disease; GABA aminotransferase deficiency; and Huntington's disease. Orthologous to human ABAT (4-aminobutyrate aminotransferase); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 1-bromopropane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: (S)-3-amino-2-methylpropionate transaminase; 4-aminobutyrate aminotransferase, mitochondrial; beta-AlaAT; GABA aminotransferase; GABA transaminase; GABA-AT; GABA-T; Gabat; gamma-amino-N-butyrate transaminase; L-AIBAT; MGC93392
Orthologs:
Homo sapiens (human) : ABAT (4-aminobutyrate aminotransferase)  HGNC  Alliance
Mus musculus (house mouse) : Abat (4-aminobutyrate aminotransferase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Abat (4-aminobutyrate aminotransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : ABAT (4-aminobutyrate aminotransferase)
Canis lupus familiaris (dog) : ABAT (4-aminobutyrate aminotransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Abat (4-aminobutyrate aminotransferase)
Sus scrofa (pig) : ABAT (4-aminobutyrate aminotransferase)
more info ...
Allele / Splice: AbatTn(sb-T2/Bart3)2.163Mcwi  
Genetic Models: F344-AbatTn(sb-T2/Bart3)2.163Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0107,093,406 - 7,200,439 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl107,093,405 - 7,200,499 (-)Ensembl
Rnor_5.0105,894,187 - 6,002,068 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4107,040,725 - 7,137,154 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1107,040,724 - 7,137,154 (-)NCBI
Celera105,995,207 - 6,088,218 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Abat
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620948
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.