Ggh (gamma-glutamyl hydrolase) - Rat Genome Database

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Gene: Ggh (gamma-glutamyl hydrolase) Rattus norvegicus
Analyze
Symbol: Ggh
Name: gamma-glutamyl hydrolase
RGD ID: 2682
Description: Enables gamma-glutamyl-peptidase activity. Involved in several processes, including poly-gamma-glutamate metabolic process; response to ethanol; and response to insulin. Located in cytosol and extracellular space. Orthologous to human GGH (gamma-glutamyl hydrolase); PARTICIPATES IN folate cycle metabolic pathway; folate metabolic pathway; hereditary folate malabsorption pathway; INTERACTS WITH 3H-1,2-dithiole-3-thione; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: conjugase; gamma-Glu-X carboxypeptidase; gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); gamma-glutamyl hydrolase-like; GH; LOC102549738; MGC105496
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2533,529,880 - 33,552,790 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl533,529,880 - 33,552,787 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx535,643,220 - 35,666,193 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0537,235,432 - 37,258,403 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0537,174,941 - 37,197,912 (+)NCBIRnor_WKY
Rnor_6.0534,040,258 - 34,063,369 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl534,040,258 - 34,063,361 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0538,693,591 - 38,716,702 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4534,670,883 - 34,693,791 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1534,671,061 - 34,693,969 (+)NCBI
Celera532,605,342 - 32,628,233 (+)NCBICelera
Cytogenetic Map5q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7-Hydroxymethotrexate  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
diuron  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
folic acid  (EXP,ISO)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
omeprazole  (EXP)
paracetamol  (EXP,ISO)
pemetrexed  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
platinum  (ISO)
platinum(0)  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
Soman  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetrahydropalmatine  (ISO)
thioacetamide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IDA)
extracellular space  (IDA,ISO)
lysosome  (IEA)
melanosome  (IEA)
vacuole  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The effect of dietary zinc depletion and repletion on rats: Zn concentration in various tissues and activity of pancreatic gamma-glutamyl hydrolase (EC 3.4.22.12) as indices of Zn status. Canton MC and Cremin FM, Br J Nutr. 1990 Jul;64(1):201-9.
2. Insulin-dependent suppression in glutamyl hydrolase activity and elevated cellular methotrexate polyglutamates. Galivan J and Rhee MS, Biochem Pharmacol. 1995 Nov 9;50(10):1659-63.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Effect of chronic ethanol consumption on the cellular and subcellular distribution of gamma-glutamyltransferase in rat liver. Halsall S and Peters TJ, Enzyme. 1984;31(4):221-8.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Subcellular fractionation of liver organelles from phenobarbital-treated rats by counter-current partition and sucrose gradient centrifugation. Morris WB, etal., Biochem Pharmacol. 1986 Jul 1;35(13):2187-91.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Gamma-glutamyl hydrolase and drug resistance. Schneider E and Ryan TJ, Clin Chim Acta. 2006 Dec;374(1-2):25-32. Epub 2006 Jun 10.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16. The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells. Wang Y, etal., Biochim Biophys Acta 1993 Aug 7;1164(3):227-35.
17. Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase. Yao R, etal., J Biol Chem 1996 Apr 12;271(15):8525-8.
Additional References at PubMed
PMID:11005824   PMID:12477932   PMID:15489334   PMID:19056867   PMID:21630459   PMID:23376485   PMID:23533145   PMID:24006456   PMID:25645918   PMID:26432773  


Genomics

Comparative Map Data
Ggh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2533,529,880 - 33,552,790 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl533,529,880 - 33,552,787 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx535,643,220 - 35,666,193 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0537,235,432 - 37,258,403 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0537,174,941 - 37,197,912 (+)NCBIRnor_WKY
Rnor_6.0534,040,258 - 34,063,369 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl534,040,258 - 34,063,361 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0538,693,591 - 38,716,702 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4534,670,883 - 34,693,791 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1534,671,061 - 34,693,969 (+)NCBI
Celera532,605,342 - 32,628,233 (+)NCBICelera
Cytogenetic Map5q13NCBI
GGH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38863,015,079 - 63,038,806 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl863,014,881 - 63,039,407 (-)EnsemblGRCh38hg38GRCh38
GRCh37863,927,638 - 63,951,365 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36864,090,192 - 64,113,940 (-)NCBINCBI36Build 36hg18NCBI36
Build 34864,090,194 - 64,113,940NCBI
Celera859,917,838 - 59,941,813 (-)NCBICelera
Cytogenetic Map8q12.3NCBI
HuRef859,415,504 - 59,439,479 (-)NCBIHuRef
CHM1_1863,980,633 - 64,004,623 (-)NCBICHM1_1
T2T-CHM13v2.0863,439,652 - 63,463,378 (-)NCBIT2T-CHM13v2.0
Ggh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39420,041,963 - 20,066,111 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl420,042,052 - 20,066,750 (+)EnsemblGRCm39 Ensembl
GRCm38420,041,997 - 20,066,111 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl420,042,052 - 20,066,750 (+)EnsemblGRCm38mm10GRCm38
MGSCv37419,969,199 - 19,993,258 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36420,164,971 - 20,188,858 (+)NCBIMGSCv36mm8
Celera419,800,007 - 19,824,562 (+)NCBICelera
Cytogenetic Map4A3NCBI
Ggh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544415,900,485 - 15,931,338 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544415,901,225 - 15,930,358 (+)NCBIChiLan1.0ChiLan1.0
GGH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1861,222,194 - 61,246,096 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl861,222,194 - 61,246,252 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0859,547,821 - 59,571,523 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GGH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12913,143,881 - 13,165,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2913,134,232 - 13,165,028 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2913,471,573 - 13,492,163 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02913,246,558 - 13,267,739 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2913,245,957 - 13,267,728 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12913,258,091 - 13,279,415 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02913,375,202 - 13,396,822 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02913,641,119 - 13,662,465 (-)NCBIUU_Cfam_GSD_1.0
Ggh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530364,282,077 - 64,299,958 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649610,485,504 - 10,505,842 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493649610,485,528 - 10,505,506 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GGH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl470,996,755 - 71,021,838 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1470,996,730 - 71,020,513 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2477,279,213 - 77,303,313 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GGH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1858,908,524 - 58,932,885 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl858,908,417 - 58,932,685 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603982,649,447 - 82,674,608 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ggh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474428,752,909 - 28,785,661 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474428,752,785 - 28,786,293 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ggh
86 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:180
Count of miRNA genes:136
Interacting mature miRNAs:155
Transcripts:ENSRNOT00000009758
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
1549901Neudeg2Neurodegradation QTL 240nervous system integrity trait (VT:0010566)mononuclear cell count (CMO:0002119)52483871044045280Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 32 42 31 18 31 74 35 34 11
Low 1 11 15 10 1 10 8 11 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009758   ⟹   ENSRNOP00000009758
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl533,529,880 - 33,552,787 (+)Ensembl
Rnor_6.0 Ensembl534,040,258 - 34,063,361 (+)Ensembl
RefSeq Acc Id: NM_012960   ⟹   NP_037092
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2533,529,880 - 33,552,790 (+)NCBI
Rnor_6.0534,040,258 - 34,063,369 (+)NCBI
Rnor_5.0538,693,591 - 38,716,702 (+)NCBI
RGSC_v3.4534,670,883 - 34,693,791 (+)RGD
Celera532,605,342 - 32,628,233 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037092 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52506 (Get FASTA)   NCBI Sequence Viewer  
  AAH87602 (Get FASTA)   NCBI Sequence Viewer  
  EDL98506 (Get FASTA)   NCBI Sequence Viewer  
  Q62867 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037092   ⟸   NM_012960
- Peptide Label: precursor
- UniProtKB: Q62867 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009758   ⟸   ENSRNOT00000009758
Protein Domains
Gamma-glutamyl hydrolase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62867-F1-model_v2 AlphaFold Q62867 1-317 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693592
Promoter ID:EPDNEW_R4117
Type:initiation region
Name:Ggh_2
Description:gamma-glutamyl hydrolase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4118  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0534,040,260 - 34,040,320EPDNEW
RGD ID:13693593
Promoter ID:EPDNEW_R4118
Type:initiation region
Name:Ggh_1
Description:gamma-glutamyl hydrolase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4117  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0534,040,362 - 34,040,422EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2682 AgrOrtholog
BioCyc Gene G2FUF-41832 BioCyc
BioCyc Pathway PWY-2161B [glutamate removal from folates] BioCyc
Ensembl Genes ENSRNOG00000007351 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000009758 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009758 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.880 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7312627 IMAGE-MGC_LOAD
InterPro Class_I_gatase-like UniProtKB/Swiss-Prot
  Pept_C26_g-glut_hydrolase UniProtKB/Swiss-Prot
  Peptidase_C26 UniProtKB/Swiss-Prot
KEGG Report rno:25455 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105496 IMAGE-MGC_LOAD
NCBI Gene 25455 ENTREZGENE
PANTHER PTHR11315 UniProtKB/Swiss-Prot
Pfam Peptidase_C26 UniProtKB/Swiss-Prot
PharmGKB GGH RGD
PhenoGen Ggh PhenoGen
PROSITE PEPTIDASE_C26_GGH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52317 UniProtKB/Swiss-Prot
TIGR TC234330
UniProt GGH_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ggh  gamma-glutamyl hydrolase  LOC102549738  gamma-glutamyl hydrolase-like  Data Merged 737654 PROVISIONAL
2016-01-27 Ggh  gamma-glutamyl hydrolase  Ggh  gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102549738  gamma-glutamyl hydrolase-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-03-09 Ggh  gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)  Ggh  gamma-glutamyl hydrolase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ggh  gamma-glutamyl hydrolase      Name updated 70584 APPROVED