Cdkn3 (cyclin-dependent kinase inhibitor 3) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Cdkn3 (cyclin-dependent kinase inhibitor 3) Rattus norvegicus
Analyze
Symbol: Cdkn3
Name: cyclin-dependent kinase inhibitor 3
RGD ID: 1307781
Description: Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to act upstream of or within regulation of cell cycle. Predicted to be located in cytosol and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CDKN3 (cyclin dependent kinase inhibitor 3); INTERACTS WITH (S)-colchicine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CDK2-associated dual-specificity phosphatase; kinase-associated phosphatase; LOC289993
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81522,502,299 - 22,513,725 (+)NCBIGRCr8
mRatBN7.21520,022,522 - 20,033,948 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1520,022,664 - 20,033,945 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1522,803,376 - 22,814,712 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01523,761,370 - 23,772,706 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01522,011,622 - 22,022,961 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01523,553,171 - 23,564,538 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1523,553,128 - 23,564,535 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01527,496,654 - 27,508,025 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41522,617,409 - 22,624,922 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11522,633,120 - 22,644,448 (+)NCBI
Celera1520,421,091 - 20,428,602 (+)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzophenanthridine  (ISO)
beta-D-glucosamine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boron nitride  (ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
chlordecone  (ISO)
chlorendic acid  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
coumestrol  (ISO)
cryptolepine  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
etoposide  (ISO)
fenpyroximate  (ISO)
fipronil  (EXP)
folic acid  (ISO)
furan  (EXP)
gallic acid  (ISO)
genistein  (ISO)
geraniol  (ISO)
glafenine  (EXP)
glycidol  (EXP)
heptachlor  (EXP)
irinotecan  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
lovastatin  (EXP)
lucanthone  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (EXP)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mirex  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
niclosamide  (ISO)
nimesulide  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thifluzamide  (ISO)
tioguanine  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
tungsten  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vincaleukoblastine  (EXP)
vorinostat  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (IEA,ISO)
nucleus  (IBA)
perinuclear region of cytoplasm  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. CDKN3 expression is negatively associated with pathological tumor stage and CDKN3 inhibition promotes cell survival in hepatocellular carcinoma. Dai W, etal., Mol Med Rep. 2016 Aug;14(2):1509-14. doi: 10.3892/mmr.2016.5410. Epub 2016 Jun 17.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Cyclin-dependent kinase-associated protein phosphatase is overexpressed in alcohol-related hepatocellular carcinoma and influences xenograft tumor growth. Lin WR, etal., Oncol Rep. 2013 Mar;29(3):903-10. doi: 10.3892/or.2012.2208. Epub 2012 Dec 24.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Cyclin-dependent kinase inhibitor 3 is overexpressed in hepatocellular carcinoma and promotes tumor cell proliferation. Xing C, etal., Biochem Biophys Res Commun. 2012 Mar 30;420(1):29-35. doi: 10.1016/j.bbrc.2012.02.107. Epub 2012 Feb 27.
Additional References at PubMed
PMID:8242750   PMID:10669749   PMID:12477932   PMID:12745075  


Genomics

Comparative Map Data
Cdkn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81522,502,299 - 22,513,725 (+)NCBIGRCr8
mRatBN7.21520,022,522 - 20,033,948 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1520,022,664 - 20,033,945 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1522,803,376 - 22,814,712 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01523,761,370 - 23,772,706 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01522,011,622 - 22,022,961 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01523,553,171 - 23,564,538 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1523,553,128 - 23,564,535 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01527,496,654 - 27,508,025 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41522,617,409 - 22,624,922 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11522,633,120 - 22,644,448 (+)NCBI
Celera1520,421,091 - 20,428,602 (+)NCBICelera
Cytogenetic Map15p14NCBI
CDKN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381454,397,007 - 54,420,218 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1454,396,849 - 54,420,218 (+)EnsemblGRCh38hg38GRCh38
GRCh371454,863,725 - 54,886,936 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361453,933,476 - 53,956,682 (+)NCBINCBI36Build 36hg18NCBI36
Build 341453,933,475 - 53,956,682NCBI
Celera1434,913,202 - 34,936,466 (+)NCBICelera
Cytogenetic Map14q22.2NCBI
HuRef1435,026,265 - 35,049,580 (+)NCBIHuRef
CHM1_11454,802,348 - 54,825,637 (+)NCBICHM1_1
T2T-CHM13v2.01448,602,154 - 48,625,376 (+)NCBIT2T-CHM13v2.0
Cdkn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391446,997,912 - 47,008,987 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1446,997,998 - 47,009,126 (+)EnsemblGRCm39 Ensembl
GRCm381446,760,461 - 46,771,530 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1446,760,541 - 46,771,669 (+)EnsemblGRCm38mm10GRCm38
MGSCv371447,380,216 - 47,391,200 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361445,682,418 - 45,693,546 (+)NCBIMGSCv36mm8
Celera1442,925,363 - 42,936,240 (+)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1424.28NCBI
Cdkn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554099,015,353 - 9,031,050 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554099,015,220 - 9,030,983 (-)NCBIChiLan1.0ChiLan1.0
CDKN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21555,518,975 - 55,545,881 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11454,735,482 - 54,759,956 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01434,984,819 - 35,008,807 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11453,263,518 - 53,287,119 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1453,263,584 - 53,287,113 (+)Ensemblpanpan1.1panPan2
CDKN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1830,344,991 - 30,374,410 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl830,345,082 - 30,360,563 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha830,113,573 - 30,142,985 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0830,602,027 - 30,632,721 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl830,602,109 - 30,617,597 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1830,206,074 - 30,235,518 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0830,282,425 - 30,311,885 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0830,648,188 - 30,678,870 (+)NCBIUU_Cfam_GSD_1.0
Cdkn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864074,896,356 - 74,909,986 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936697670,785 - 683,996 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936697669,154 - 684,077 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDKN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1183,792,688 - 183,809,174 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11183,792,606 - 183,809,178 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21204,290,145 - 204,304,772 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDKN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12431,554,461 - 31,578,916 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2431,554,510 - 31,579,664 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605319,789,412 - 19,812,821 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdkn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473114,838,561 - 14,852,554 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473114,838,555 - 14,853,588 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdkn3
38 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:27
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000012985
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)colorectal tumor number (CMO:0001794)15226636822711984Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15226636822711984Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat

Markers in Region
AA859789  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21520,032,225 - 20,033,856 (+)MAPPERmRatBN7.2
Rnor_6.01523,562,816 - 23,564,446NCBIRnor6.0
Rnor_5.01527,506,303 - 27,507,933UniSTSRnor5.0
RGSC_v3.41522,627,026 - 22,628,656UniSTSRGSC3.4
Celera1520,430,706 - 20,432,336UniSTS
RH 3.4 Map15189.9UniSTS
Cytogenetic Map15p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 28 34 26 15 26 1 1 51 21 37 1 1
Low 15 22 14 4 14 6 9 23 14 4 10 6
Below cutoff 1 1 1 1 1 1

Sequence


RefSeq Acc Id: ENSRNOT00000012985   ⟹   ENSRNOP00000012985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1520,022,664 - 20,033,945 (+)Ensembl
Rnor_6.0 Ensembl1523,553,128 - 23,564,535 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110557   ⟹   ENSRNOP00000096902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1520,024,498 - 20,033,945 (+)Ensembl
RefSeq Acc Id: NM_001106028   ⟹   NP_001099498
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81522,502,386 - 22,509,899 (+)NCBI
mRatBN7.21520,022,609 - 20,030,122 (+)NCBI
Rnor_6.01523,553,199 - 23,560,712 (+)NCBI
Rnor_5.01527,496,654 - 27,508,025 (+)NCBI
RGSC_v3.41522,617,409 - 22,624,922 (+)RGD
Celera1520,421,091 - 20,428,602 (+)RGD
Sequence:
RefSeq Acc Id: NM_001401040   ⟹   NP_001387969
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81522,502,398 - 22,513,725 (+)NCBI
mRatBN7.21520,022,621 - 20,033,948 (+)NCBI
RefSeq Acc Id: XM_006251792   ⟹   XP_006251854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81522,502,299 - 22,513,725 (+)NCBI
mRatBN7.21520,022,522 - 20,033,948 (+)NCBI
Rnor_6.01523,553,171 - 23,564,538 (+)NCBI
Rnor_5.01527,496,654 - 27,508,025 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063274093   ⟹   XP_063130163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81522,502,367 - 22,513,725 (+)NCBI
RefSeq Acc Id: NP_001099498   ⟸   NM_001106028
- Peptide Label: isoform 2
- UniProtKB: A6KE22 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251854   ⟸   XM_006251792
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ARV6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012985   ⟸   ENSRNOT00000012985
RefSeq Acc Id: ENSRNOP00000096902   ⟸   ENSRNOT00000110557
RefSeq Acc Id: NP_001387969   ⟸   NM_001401040
- Peptide Label: isoform 1
- UniProtKB: B2RZ50 (UniProtKB/Swiss-Prot),   A0A8I6ARV6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130163   ⟸   XM_063274093
- Peptide Label: isoform X2
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RZ50-F1-model_v2 AlphaFold B2RZ50 1-212 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699603
Promoter ID:EPDNEW_R10127
Type:initiation region
Name:Cdkn3_1
Description:cyclin-dependent kinase inhibitor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01523,553,233 - 23,553,293EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307781 AgrOrtholog
BioCyc Gene G2FUF-14173 BioCyc
Ensembl Genes ENSRNOG00000009785 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055027193 UniProtKB/Swiss-Prot
  ENSRNOG00060022990 UniProtKB/Swiss-Prot
  ENSRNOG00065031861 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012985 ENTREZGENE
  ENSRNOT00000012985.7 UniProtKB/Swiss-Prot
  ENSRNOT00000110557.1 UniProtKB/TrEMBL
  ENSRNOT00055047015 UniProtKB/Swiss-Prot
  ENSRNOT00060039845 UniProtKB/Swiss-Prot
  ENSRNOT00065054894 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8375927 IMAGE-MGC_LOAD
InterPro CDK_inhib_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CDKN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_dom UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:289993 UniProtKB/TrEMBL
MGC_CLONE MGC:189250 IMAGE-MGC_LOAD
NCBI Gene 289993 ENTREZGENE
PANTHER CYCLIN-DEPENDENT KINASE INHIBITOR 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CDKN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdkn3 PhenoGen
PIRSF CDKN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009785 RatGTEx
  ENSRNOG00055027193 RatGTEx
  ENSRNOG00060022990 RatGTEx
  ENSRNOG00065031861 RatGTEx
SMART PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ARV6 ENTREZGENE, UniProtKB/TrEMBL
  A6KE22 ENTREZGENE, UniProtKB/TrEMBL
  B2RZ50 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Cdkn3  cyclin-dependent kinase inhibitor 3   Cdkn3_predicted  cyclin-dependent kinase inhibitor 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cdkn3_predicted  cyclin-dependent kinase inhibitor 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED