Qsox1 (quiescin sulfhydryl oxidase 1) - Rat Genome Database

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Gene: Qsox1 (quiescin sulfhydryl oxidase 1) Rattus norvegicus
Analyze
Symbol: Qsox1
Name: quiescin sulfhydryl oxidase 1
RGD ID: 68957
Description: Enables FAD binding activity and flavin-dependent sulfhydryl oxidase activity. Predicted to be involved in extracellular matrix assembly; negative regulation of macroautophagy; and protein folding. Located in extracellular space. Orthologous to human QSOX1 (quiescin sulfhydryl oxidase 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FAD-dependent sulfhydryl oxidase-2; Qscn6; Qsox; quiescin Q6; quiescin Q6 sulfhydryl oxidase 1; rQSOX; rSOx; Sox-2; sulfhydryl oxidase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81370,500,060 - 70,537,711 (-)NCBIGRCr8
mRatBN7.21367,949,780 - 67,987,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1367,949,780 - 67,987,459 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1370,529,544 - 70,566,399 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01371,844,987 - 71,881,834 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01369,106,470 - 69,143,317 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01373,423,396 - 73,460,890 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1373,423,397 - 73,460,935 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01378,351,222 - 78,388,703 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41370,739,793 - 70,777,526 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11370,753,873 - 70,791,628 (-)NCBI
Celera1367,815,702 - 67,852,956 (-)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
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Evidence
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Reference
Notes
Source
Original Reference(s)
Qsox1Rat1q24 Deletion Syndrome  ISOQSOX1 (Homo sapiens)8554872ClinVar Annotator: match by term: 1q24q25 microdeletion syndromeClinVarPMID:21548129 more ...
Qsox1Ratautosomal recessive chronic granulomatous disease 2  ISOQSOX1 (Homo sapiens)8554872ClinVar Annotator: match by term: Granulomatous disease more ...ClinVarPMID:28492532
Qsox1Ratgastrointestinal stromal tumor  ISOQSOX1 (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
Qsox1Ratparathyroid carcinoma  ISOQSOX1 (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
Object Symbol
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Original Reference(s)
Qsox1Ratsubstance-related disorder  ISOQSOX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20098672
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Original Reference(s)
Qsox1RatVACTERL association  ISSQsox1 (Mus musculus)13592920OMIM:192350 more ...MouseDO 

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Original Reference(s)
Qsox1Rat(1->4)-beta-D-glucan multiple interactionsISOQsox1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of QSOX1 mRNACTDPMID:36331819
Qsox1Rat17beta-estradiol increases expressionISOQsox1 (Mus musculus)6480464Estradiol results in increased expression of QSOX1 mRNACTDPMID:15289156 and PMID:39298647
Qsox1Rat17beta-estradiol increases expressionISOQSOX1 (Homo sapiens)6480464Estradiol results in increased expression of QSOX1 mRNACTDPMID:23019147 and PMID:31614463
Qsox1Rat2,2',4,4',5,5'-hexachlorobiphenyl affects expressionISOQSOX1 (Homo sapiens)64804642 more ...CTDPMID:20638727
Qsox1Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionEXP 64804642 more ...CTDPMID:31826744
Qsox1Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOQSOX1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Qsox1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOQsox1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased methylation of QSOX1 geneCTDPMID:21212295
Qsox1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of QSOX1 mRNACTDPMID:32109520 and PMID:33387578
Qsox1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOQsox1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of QSOX1 mRNACTDPMID:21570461
Qsox1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOQSOX1 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of QSOX1 mRNACTDPMID:20106945 and PMID:21632981
Qsox1Rat2,4,6-tribromophenol increases expressionISOQSOX1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Qsox1Rat2-hydroxypropanoic acid decreases expressionISOQSOX1 (Homo sapiens)6480464Lactic Acid results in decreased expression of QSOX1 mRNACTDPMID:30851411
Qsox1Rat3,3',5,5'-tetrabromobisphenol A increases expressionISOQSOX1 (Homo sapiens)6480464tetrabromobisphenol A results in increased expression of QSOX1 proteinCTDPMID:31675489
Qsox1Rat3,4-methylenedioxymethamphetamine increases expressionISOQsox1 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of QSOX1 mRNACTDPMID:20188158 and PMID:26251327
Qsox1Rat4,4'-sulfonyldiphenol increases expressionISOQsox1 (Mus musculus)6480464bisphenol S results in increased expression of QSOX1 mRNACTDPMID:39298647
Qsox1Rat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of QSOX1 mRNACTDPMID:36041667
Qsox1Rat4,4'-sulfonyldiphenol affects methylationISOQsox1 (Mus musculus)6480464bisphenol S affects the methylation of QSOX1 geneCTDPMID:31683443
Qsox1Rat4,4'-sulfonyldiphenol increases methylationISOQsox1 (Mus musculus)6480464bisphenol S results in increased methylation of QSOX1 exonCTDPMID:33297965
Qsox1Rat5-fluorouracil multiple interactionsISOQSOX1 (Homo sapiens)6480464TP53 protein affects the reaction [Fluorouracil results in decreased expression of QSOX1 mRNA]CTDPMID:15016801
Qsox1Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of QSOX1 mRNACTDPMID:30047161

1 to 20 of 149 rows

Biological Process

  
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Original Reference(s)
Qsox1Ratextracellular matrix assembly involved_inISOQSOX1 (Homo sapiens)1624291 PMID:23867277RGDPMID:23867277
Qsox1Ratextracellular matrix assembly involved_inIEAUniProtKB:O00391 and ensembl:ENSP000003565741600115GO_REF:0000107EnsemblGO_REF:0000107
Qsox1Ratnegative regulation of macroautophagy involved_inISOQSOX1 (Homo sapiens)1624291 PMID:24475161RGDPMID:24475161
Qsox1Ratnegative regulation of macroautophagy involved_inIEAUniProtKB:O00391 and ensembl:ENSP000003565741600115GO_REF:0000107EnsemblGO_REF:0000107
Qsox1Ratprotein folding involved_inIBAFB:FBgn0033814 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Cellular Component
1 to 20 of 20 rows

  
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Original Reference(s)
Qsox1Ratextracellular exosome located_inISOQSOX1 (Homo sapiens)1624291 PMID:21082674RGDPMID:21082674
Qsox1Ratextracellular exosome located_inIEAUniProtKB:O00391 and ensembl:ENSP000003565741600115GO_REF:0000107EnsemblGO_REF:0000107
Qsox1Ratextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Qsox1Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Qsox1Ratextracellular space is_active_inIBAFB:FBgn0033814 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Qsox1Ratextracellular space located_inIEAUniProtKB:O00391 and ensembl:ENSP000003565741600115GO_REF:0000107EnsemblGO_REF:0000107
Qsox1Ratextracellular space located_inISOQSOX1 (Homo sapiens)1624291 PMID:10708601RGDPMID:10708601
Qsox1Ratextracellular space located_inIDA 67932PMID:11278790UniProt 
Qsox1Ratextracellular space located_inISSUniProtKB:O003911600115GO_REF:0000024UniProtGO_REF:0000024
Qsox1RatGolgi apparatus located_inISOQSOX1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Qsox1RatGolgi apparatus located_inIEAUniProtKB:O00391 and ensembl:ENSP000003565741600115GO_REF:0000107EnsemblGO_REF:0000107
Qsox1RatGolgi apparatus located_inIEAUniProtKB-KW:KW-03331600115GO_REF:0000043UniProtGO_REF:0000043
Qsox1RatGolgi membrane is_active_inIBAPANTHER:PTN000528008 and UniProtKB:O003911600115GO_REF:0000033GO_CentralGO_REF:0000033
Qsox1RatGolgi membrane located_inIEAUniProtKB-SubCell:SL-01341600115GO_REF:0000044UniProtGO_REF:0000044
Qsox1RatGolgi membrane located_inIEAUniProtKB:O00391 and ensembl:ENSP000003565741600115GO_REF:0000107EnsemblGO_REF:0000107
Qsox1RatGolgi membrane located_inISOQSOX1 (Homo sapiens)1624291 PMID:17331072 and PMID:29757379RGDPMID:17331072 and PMID:29757379
Qsox1RatGolgi membrane located_inISSUniProtKB:O003911600115GO_REF:0000024UniProtGO_REF:0000024
Qsox1Ratintracellular membrane-bounded organelle located_inISOQSOX1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Qsox1Ratintracellular membrane-bounded organelle located_inIEAUniProtKB:O00391 and ensembl:ENSP000003565741600115GO_REF:0000107EnsemblGO_REF:0000107
Qsox1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
1 to 17 of 17 rows

  
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Original Reference(s)
Qsox1RatFAD binding enablesIDA 14397567PMID:24888638UniProt 
Qsox1RatFAD binding enablesIEAUniProtKB:O00391 and ensembl:ENSP000003565741600115GO_REF:0000107EnsemblGO_REF:0000107
Qsox1RatFAD binding enablesISOQSOX1 (Homo sapiens)1624291 PMID:20211621RGDPMID:20211621
Qsox1Ratflavin-dependent sulfhydryl oxidase activity enablesIDA 67932PMID:11278790UniProt 
Qsox1Ratflavin-dependent sulfhydryl oxidase activity enablesIBAPANTHER:PTN000528008 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Qsox1Ratflavin-dependent sulfhydryl oxidase activity enablesIEAUniProtKB:O00391 and ensembl:ENSP000003565741600115GO_REF:0000107EnsemblGO_REF:0000107
Qsox1Ratflavin-dependent sulfhydryl oxidase activity enablesIEAInterPro:IPR0397981600115GO_REF:0000002InterProGO_REF:0000002
Qsox1Ratflavin-dependent sulfhydryl oxidase activity enablesISOQSOX1 (Homo sapiens)1624291 PMID:17331072 and PMID:18393449RGDPMID:17331072 and PMID:18393449
Qsox1Ratflavin-dependent sulfhydryl oxidase activity enablesISSUniProtKB:O003911600115GO_REF:0000024UniProtGO_REF:0000024
Qsox1Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Qsox1Ratprotein disulfide isomerase activity enablesISSUniProtKB:O003911600115GO_REF:0000024UniProtGO_REF:0000024
Qsox1Ratprotein disulfide isomerase activity enablesIEAUniProtKB:O00391 and ensembl:ENSP000003565741600115GO_REF:0000107EnsemblGO_REF:0000107
Qsox1Ratprotein disulfide isomerase activity enablesIBAPANTHER:PTN000528008 and UniProtKB:O003911600115GO_REF:0000033GO_CentralGO_REF:0000033
Qsox1Ratprotein disulfide isomerase activity enablesISOQSOX1 (Homo sapiens)1624291 PMID:17331072 and PMID:18393449RGDPMID:17331072 and PMID:18393449
Qsox1Ratthiol oxidase activity enablesIEARHEA:173571600115GO_REF:0000116RHEAGO_REF:0000116
Qsox1Ratthiol oxidase activity enablesIEAInterPro:IPR017905 and InterPro:IPR0367741600115GO_REF:0000002InterProGO_REF:0000002
Qsox1Ratthiol oxidase activity enablesIEAEC:1.8.3.21600115GO_REF:0000003UniProtGO_REF:0000003
1 to 17 of 17 rows


#
Reference Title
Reference Citation
1. Rat seminal vesicle fad-dependent sulfhydryl oxidase. biochemical characterization and molecular cloning of a member of the new sulfhydryl oxidase/quiescin q6 gene family. Benayoun B, etal., J Biol Chem 2001 Apr 27;276(17):13830-7.
2. Enzyme structure captures four cysteines aligned for disulfide relay. Gat Y, etal., Protein Sci. 2014 Aug;23(8):1102-12. doi: 10.1002/pro.2496. Epub 2014 Jun 18.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Expression of SOx-2, a member of the FAD-dependent sulfhydryl oxidase/quiescin Q6 gene family, in rat brain. Mairet-Coello G, etal., Neuroreport 2002 Nov 15;13(16):2049-51.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:8889548   PMID:10708601   PMID:12354420   PMID:16502470   PMID:16806532   PMID:17331072   PMID:17927979   PMID:18393449   PMID:20211621   PMID:21082674   PMID:23376485   PMID:23533145  
PMID:23867277   PMID:24006456   PMID:24475161   PMID:25766108   PMID:29757379  



Qsox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81370,500,060 - 70,537,711 (-)NCBIGRCr8
mRatBN7.21367,949,780 - 67,987,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1367,949,780 - 67,987,459 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1370,529,544 - 70,566,399 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01371,844,987 - 71,881,834 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01369,106,470 - 69,143,317 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01373,423,396 - 73,460,890 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1373,423,397 - 73,460,935 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01378,351,222 - 78,388,703 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41370,739,793 - 70,777,526 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11370,753,873 - 70,791,628 (-)NCBI
Celera1367,815,702 - 67,852,956 (-)NCBICelera
Cytogenetic Map13q21NCBI
QSOX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381180,154,869 - 180,204,030 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1180,154,869 - 180,204,030 (+)EnsemblGRCh38hg38GRCh38
GRCh371180,124,004 - 180,173,165 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361178,390,591 - 178,433,792 (+)NCBINCBI36Build 36hg18NCBI36
Build 341176,855,624 - 176,898,826NCBI
Celera1153,231,536 - 153,274,744 (+)NCBICelera
Cytogenetic Map1q25.2NCBI
HuRef1151,355,443 - 151,398,518 (+)NCBIHuRef
CHM1_11181,547,697 - 181,590,889 (+)NCBICHM1_1
T2T-CHM13v2.01179,510,604 - 179,559,769 (+)NCBIT2T-CHM13v2.0
Qsox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391155,653,901 - 155,688,645 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1155,651,775 - 155,688,635 (-)EnsemblGRCm39 Ensembl
GRCm381155,778,155 - 155,812,899 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1155,776,029 - 155,812,889 (-)EnsemblGRCm38mm10GRCm38
MGSCv371157,625,285 - 157,660,029 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361157,540,373 - 157,575,117 (-)NCBIMGSCv36mm8
Celera1158,211,715 - 158,246,555 (-)NCBICelera
Cytogenetic Map1G3NCBI
cM Map167.64NCBI
Qsox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540619,363,938 - 19,402,134 (+)NCBIChiLan1.0ChiLan1.0
QSOX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2169,563,559 - 69,606,794 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1169,221,823 - 69,265,043 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01155,641,793 - 155,687,231 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11159,289,932 - 159,358,675 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1159,313,245 - 159,358,672 (+)Ensemblpanpan1.1panPan2
QSOX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1713,718,799 - 13,754,115 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl713,718,799 - 13,754,114 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha713,297,965 - 13,333,390 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0713,446,573 - 13,482,007 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl713,446,567 - 13,482,619 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1713,357,448 - 13,392,875 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0713,463,885 - 13,499,332 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0713,588,279 - 13,623,755 (+)NCBIUU_Cfam_GSD_1.0
Qsox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934491,129,070 - 91,166,948 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364818,975,790 - 9,013,723 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364818,975,818 - 9,013,684 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
QSOX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9121,779,792 - 121,822,825 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19121,779,072 - 121,822,829 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29133,595,396 - 133,638,610 (+)NCBISscrofa10.2Sscrofa10.2susScr3
QSOX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12549,180,365 - 49,223,814 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2549,181,365 - 49,223,741 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605550,571,837 - 50,617,458 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Qsox1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624771449,992 - 489,693 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624771449,761 - 490,372 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Qsox1
260 total Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
13 78352374 78352375 C T snv DOB/Oda (KyushuU) View more Information

Predicted Target Of
Summary Value
Count of predictions:299
Count of miRNA genes:140
Interacting mature miRNAs:163
Transcripts:ENSRNOT00000005052, ENSRNOT00000068044
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 32 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
2303028Bp329Blood pressure QTL 329arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135849787273485113Rat

1 to 10 of 32 rows
RH139452  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21367,949,798 - 67,949,941 (+)MAPPERmRatBN7.2
Rnor_6.01373,423,415 - 73,423,557NCBIRnor6.0
Rnor_5.01378,351,241 - 78,351,383UniSTSRnor5.0
RGSC_v3.41370,739,812 - 70,739,954UniSTSRGSC3.4
Celera1367,815,721 - 67,815,863UniSTS
RH 3.4 Map13344.6UniSTS
Cytogenetic Map13q21UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000005052   ⟹   ENSRNOP00000005052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1367,949,782 - 67,987,459 (-)Ensembl
Rnor_6.0 Ensembl1373,423,397 - 73,460,912 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000068044   ⟹   ENSRNOP00000061072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1367,949,780 - 67,987,434 (-)Ensembl
Rnor_6.0 Ensembl1373,424,027 - 73,460,935 (-)Ensembl
RefSeq Acc Id: NM_001109898   ⟹   NP_001103368
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81370,500,060 - 70,537,711 (-)NCBI
mRatBN7.21367,949,780 - 67,987,434 (-)NCBI
Rnor_6.01373,423,396 - 73,460,890 (-)NCBI
Rnor_5.01378,351,222 - 78,388,703 (-)NCBI
RGSC_v3.41370,739,793 - 70,777,526 (-)RGD
Celera1367,815,702 - 67,852,956 (-)RGD
Sequence:
RefSeq Acc Id: NM_053431   ⟹   NP_445883
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81370,500,060 - 70,537,711 (-)NCBI
mRatBN7.21367,949,780 - 67,987,434 (-)NCBI
Rnor_6.01373,423,396 - 73,460,890 (-)NCBI
Rnor_5.01378,351,222 - 78,388,703 (-)NCBI
RGSC_v3.41370,739,793 - 70,777,526 (-)RGD
Celera1367,815,702 - 67,852,956 (-)RGD
Sequence:
RefSeq Acc Id: NP_445883   ⟸   NM_053431
- Peptide Label: isoform B precursor
- UniProtKB: A6ICZ3 (UniProtKB/TrEMBL),   A6ICZ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001103368   ⟸   NM_001109898
- Peptide Label: isoform A precursor
- UniProtKB: Q8K4M2 (UniProtKB/Swiss-Prot),   Q99J80 (UniProtKB/Swiss-Prot),   Q6IUU3 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005052   ⟸   ENSRNOT00000005052
Ensembl Acc Id: ENSRNOP00000061072   ⟸   ENSRNOT00000068044
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IUU3-F1-model_v2 AlphaFold Q6IUU3 1-750 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698909
Promoter ID:EPDNEW_R9434
Type:initiation region
Name:Qsox1_1
Description:quiescin sulfhydryl oxidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01373,460,961 - 73,461,021EPDNEW


1 to 39 of 39 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-17831 BioCyc
Ensembl Genes ENSRNOG00000003649 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005052 ENTREZGENE
  ENSRNOT00000005052.10 UniProtKB/Swiss-Prot
  ENSRNOT00000068044 ENTREZGENE
  ENSRNOT00000068044.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.1960 UniProtKB/Swiss-Prot
  1.20.120.310 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/Swiss-Prot
InterPro ERV/ALR_sulphydryl_oxid_sf UniProtKB/Swiss-Prot
  ERV/ALR_sulphydryl_oxidase UniProtKB/Swiss-Prot
  QSOX_FAD-bd_dom UniProtKB/Swiss-Prot
  QSOX_FAD-bd_sf UniProtKB/Swiss-Prot
  QSOX_Trx1 UniProtKB/Swiss-Prot
  Sulfhydryl_oxidase UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
  Thioredoxin_domain UniProtKB/Swiss-Prot
KEGG Report rno:84491 UniProtKB/Swiss-Prot
NCBI Gene 84491 ENTREZGENE
PANTHER PTHR22897 UniProtKB/Swiss-Prot
  SULFHYDRYL OXIDASE 1 UniProtKB/Swiss-Prot
Pfam Evr1_Alr UniProtKB/Swiss-Prot
  FAD_SOX UniProtKB/Swiss-Prot
  QSOX_Trx1 UniProtKB/Swiss-Prot
  Thioredoxin UniProtKB/Swiss-Prot
PhenoGen Qsox1 PhenoGen
PROSITE ERV_ALR UniProtKB/Swiss-Prot
  THIOREDOXIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003649 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
  SSF69000 UniProtKB/Swiss-Prot
UniProt A6ICZ2 ENTREZGENE, UniProtKB/TrEMBL
  A6ICZ3 ENTREZGENE, UniProtKB/TrEMBL
  Q6IUU3 ENTREZGENE
  Q8K4M2 ENTREZGENE
  Q99J80 ENTREZGENE
  QSOX1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q8K4M2 UniProtKB/Swiss-Prot
  Q99J80 UniProtKB/Swiss-Prot
1 to 39 of 39 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Qsox1  quiescin sulfhydryl oxidase 1  Qsox1  quiescin Q6 sulfhydryl oxidase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Qsox1  quiescin Q6 sulfhydryl oxidase 1  Qscn6  quiescin Q6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Qscn6  quiescin Q6      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_expression highly expressed in diencephalon and telencephalon 1299176
gene_function converts alkyl thiols and oxygen to their dialkyl disulfides and hydrogen peroxide 67932
gene_protein 570 amino acids 67932
gene_transcript 2472 nucleotide cDNA with an open reading frame of 1710 base pairs 67932