Qsox1 (quiescin sulfhydryl oxidase 1)

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Gene: Qsox1 (quiescin sulfhydryl oxidase 1) Rattus norvegicus

Analyze

Symbol:

Qsox1

Name:

quiescin sulfhydryl oxidase 1

RGD ID:

68957

Description:

Exhibits FAD binding activity and flavin-linked sulfhydryl oxidase activity. Predicted to be involved in extracellular matrix assembly and negative regulation of macroautophagy. Localizes to extracellular space. Orthologous to human QSOX1 (quiescin sulfhydryl oxidase 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

FAD-dependent sulfhydryl oxidase-2; Qscn6; Qsox; quiescin Q6; quiescin Q6 sulfhydryl oxidase 1; rQSOX; rSOx; Sox-2; sulfhydryl oxidase 1

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	QSOX1 (quiescin sulfhydryl oxidase 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Qsox1 (quiescin Q6 sulfhydryl oxidase 1)	HGNC	Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Qsox1 (quiescin sulfhydryl oxidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	QSOX1 (quiescin sulfhydryl oxidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	QSOX1 (quiescin sulfhydryl oxidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Qsox1 (quiescin sulfhydryl oxidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	QSOX1 (quiescin sulfhydryl oxidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	QSOX1 (quiescin sulfhydryl oxidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Qsox1 (quiescin sulfhydryl oxidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	QSOX1 (quiescin sulfhydryl oxidase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Qsox1 (quiescin Q6 sulfhydryl oxidase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	qsox1 (quiescin Q6 sulfhydryl oxidase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	F35G2.1	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Qsox1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	F47B7.2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	Qsox2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	Qsox3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	Qsox4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	T10H10.2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	67,949,780 - 67,987,434 (-)	NCBI
Rnor_6.0 Ensembl	13	73,423,397 - 73,460,935 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	13	73,423,396 - 73,460,890 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	13	78,351,222 - 78,388,703 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	70,739,793 - 70,777,526 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	13	70,753,873 - 70,791,628 (-)	NCBI
Celera	13	67,815,702 - 67,852,956 (-)	NCBI		Celera
Cytogenetic Map	13	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

1q24 Deletion Syndrome (ISO)

substance-related disorder (ISO)

VACTERL association (ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

3,4-methylenedioxymethamphetamine (ISO)

5-fluorouracil (ISO)

acetamide (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP)

Butylbenzyl phthalate (EXP)

C60 fullerene (EXP)

calcitriol (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

chloroprene (ISO)

choline (ISO)

cisplatin (ISO)

clofibrate (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

corticosterone (EXP)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

diclofenac (ISO)

dicrotophos (ISO)

diethyl phthalate (EXP)

diethylstilbestrol (ISO)

diisobutyl phthalate (EXP)

diisononyl phthalate (EXP)

dioxygen (ISO)

endosulfan (EXP)

ethanol (ISO)

fenvalerate (EXP)

fipronil (EXP)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

gefitinib (ISO)

genistein (EXP,ISO)

hydrogen peroxide (ISO)

L-methionine (ISO)

lipopolysaccharide (ISO)

methoxyacetic acid (ISO)

naphthalene (ISO)

nickel atom (ISO)

paclitaxel (ISO)

paracetamol (ISO)

phenethyl isothiocyanate (EXP)

pirinixic acid (ISO)

progesterone (EXP)

promegestone (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

silicon dioxide (EXP)

sodium fluoride (ISO)

sulforaphane (ISO)

sunitinib (ISO)

T-2 toxin (EXP)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (EXP)

trichostatin A (ISO)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

vitamin E (ISO)

zinc atom (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

extracellular matrix assembly (ISO)

negative regulation of macroautophagy (ISO)

obsolete oxidation-reduction process (IEA)

protein folding (IBA)

protein phosphopantetheinylation (IEA)

Cellular Component

extracellular exosome (ISO)

extracellular space (IBA,IDA,ISO,ISS)

Golgi apparatus (ISO)

Golgi membrane (ISO,ISS)

integral component of Golgi membrane (IBA,ISO,ISS)

intercellular bridge (IEA,ISO)

intracellular membrane-bounded organelle (ISO)

Molecular Function

FAD binding (IDA,ISO)

flavin-linked sulfhydryl oxidase activity (IBA,IDA,ISO,ISS)

protein disulfide isomerase activity (IBA,ISO,ISS)

References

References - curated


1.	Benayoun B, etal., J Biol Chem 2001 Apr 27;276(17):13830-7.
2.	Gat Y, etal., Protein Sci. 2014 Aug;23(8):1102-12. doi: 10.1002/pro.2496. Epub 2014 Jun 18.
3.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	GOA data from the GO Consortium
5.	Mairet-Coello G, etal., Neuroreport 2002 Nov 15;13(16):2049-51.
6.	MGD data from the GO Consortium
7.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:10708601	PMID:12354420	PMID:16502470	PMID:16806532	PMID:17331072	PMID:17927979	PMID:18393449	PMID:20211621	PMID:21082674	PMID:23376485	PMID:23533145
PMID:23867277	PMID:24006456	PMID:24475161	PMID:25766108	PMID:29757379

Genomics

Comparative Map Data

Qsox1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	67,949,780 - 67,987,434 (-)	NCBI
Rnor_6.0 Ensembl	13	73,423,397 - 73,460,935 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	13	73,423,396 - 73,460,890 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	13	78,351,222 - 78,388,703 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	70,739,793 - 70,777,526 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	13	70,753,873 - 70,791,628 (-)	NCBI
Celera	13	67,815,702 - 67,852,956 (-)	NCBI		Celera
Cytogenetic Map	13	q21	NCBI

QSOX1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	1	180,154,869 - 180,204,030 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	1	180,154,869 - 180,204,030 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	1	180,124,004 - 180,173,165 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	178,390,591 - 178,433,792 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	1	176,855,624 - 176,898,826	NCBI
Celera	1	153,231,536 - 153,274,744 (+)	NCBI
Cytogenetic Map	1	q25.2	NCBI
HuRef	1	151,355,443 - 151,398,518 (+)	NCBI		HuRef
CHM1_1	1	181,547,697 - 181,590,889 (+)	NCBI		CHM1_1

Qsox1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	155,653,901 - 155,688,645 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	1	155,651,775 - 155,688,635 (-)	Ensembl
GRCm38	1	155,778,155 - 155,812,899 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	155,776,029 - 155,812,889 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	157,625,285 - 157,660,029 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	1	157,540,373 - 157,575,117 (-)	NCBI			mm8
Celera	1	158,211,715 - 158,246,555 (-)	NCBI		Celera
Cytogenetic Map	1	G3	NCBI

Qsox1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955406	19,363,938 - 19,402,134 (+)	NCBI	ChiLan1.0	ChiLan1.0

QSOX1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	159,289,932 - 159,358,675 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	159,313,245 - 159,358,672 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	155,641,793 - 155,687,231 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

QSOX1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	7	13,718,799 - 13,754,114 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	7	13,718,799 - 13,754,115 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Qsox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936481	8,975,818 - 9,013,684 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

QSOX1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	121,779,796 - 121,837,437 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	121,779,072 - 121,822,829 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	133,595,396 - 133,638,610 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

QSOX1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	49,180,365 - 49,223,814 (-)	NCBI
ChlSab1.1 Ensembl	25	49,181,365 - 49,223,741 (-)	Ensembl

Qsox1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624771	449,761 - 490,372 (+)	NCBI

Position Markers

RH139452

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	13	73,423,415 - 73,423,557	NCBI	Rnor6.0
Rnor_5.0	13	78,351,241 - 78,351,383	UniSTS	Rnor5.0
RGSC_v3.4	13	70,739,812 - 70,739,954	UniSTS	RGSC3.4
Celera	13	67,815,721 - 67,815,863	UniSTS
RH 3.4 Map	13	344.6	UniSTS
Cytogenetic Map	13	q21	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	1	107975663	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	107975663	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	107975663	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	9016906	82995569	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	9016906	82995569	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	12193394	108478121	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	24502279	108770533	Rat
70170	Eae14	Experimental allergic encephalomyelitis QTL 14		0.0024	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	28584452	73584452	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	29076934	74076934	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	29076934	74076934	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	35301263	107975663	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	36147533	99968921	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	36147533	99968921	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	36147533	99968921	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	36147533	99968921	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	37346348	82346348	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	39372927	84372927	Rat
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	39501300	93652524	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	42310744	86833540	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	42310744	87310744	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	42508345	87508345	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	42508345	87508345	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	43575717	88575717	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	45676629	90676629	Rat
12879441	Bp396	Blood pressure QTL 396			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	51080989	96080989	Rat
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	51569248	96569248	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	51577824	90675199	Rat
1641901	Alcrsp6	Alcohol response QTL 6			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	13	57903612	102903612	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	62975663	107975663	Rat
2303028	Bp329	Blood pressure QTL 329			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	63611283	79034003	Rat
724564	Uae11	Urinary albumin excretion QTL 11	5.7		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	13	64501351	82995671	Rat
738026	Lnnr5	Liver neoplastic nodule remodeling QTL 5	3.29		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	65008245	91629354	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	66971778	111971778	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	71230858	114033958	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	71230858	114033958	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	72583716	114033958	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	299
Count of miRNA genes:	140
Interacting mature miRNAs:	163
Transcripts:	ENSRNOT00000005052, ENSRNOT00000068044
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	34	20	20		20			65	25	41	11
Low	1	9	37	21	19	21	8	11	9	10			8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_053431	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB044285	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF217799	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF285078	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY623665	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BM387067	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000243	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000005052 ⟹ ENSRNOP00000005052

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	13	73,423,397 - 73,460,912 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000068044 ⟹ ENSRNOP00000061072

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	13	73,424,027 - 73,460,935 (-)	Ensembl

RefSeq Acc Id:

NM_001109898 ⟹ NP_001103368

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	67,949,780 - 67,987,434 (-)	NCBI
Rnor_6.0	13	73,423,396 - 73,460,890 (-)	NCBI
Rnor_5.0	13	78,351,222 - 78,388,703 (-)	NCBI
RGSC_v3.4	13	70,739,793 - 70,777,526 (-)	RGD
Celera	13	67,815,702 - 67,852,956 (-)	RGD

Sequence:

show sequence

GCGAGGTGGACAGTCAAGCCGCCTAGGATGAGGAGGTGCGGCCGCCACTCGGGGCCGCCGTCGC
TGCTGCTGCTACTTCTGCTGCTCCCGCCGCTGCTGCTCTCGGTGCCCGGCGCTTACGCGGCCCG
GCTCTCGGTGCTCTACTCGTCCTCTGATCCACTGACGCTGCTGGATGCGGACACCGTGCGCCCG
GCTGTGCTGGGATCCAGTAGCGCCTGGGCGGTGGAGTTCTTCGCCTCCTGGTGTGGCCATTGCA
TCGCCTTCGCTCCGACGTGGAAGGAGCTTGCTAACGACGTGAAAGACTGGAGGCCAGCACTAAA
TCTTGCTGTCCTGGACTGTGCTGATGAGACCAATAGTGCTGTCTGCAGAGAGTTCAACATCGCC
GGCTTCCCCACTGTGAGGTTTTTTAAGGCCTTTTCCAAGAACGGTACTGGAACAGCATTGCCAG
CCGCTGGTGCTAATGTGCAGACGCTGCGTATGAGGCTCATCGATGCTCTGGAGTCCCACCGTGA
CACGTGGCCCCCAGCATGTCCACCCCTGGAGCCTGCCAAGCTGAAGGATATCAATGAATTCTTT
ACAAGAAGTAAAGCAGAGTACCTGGCCCTGATCTTTGAAAGGGAAGACTCCTATCTGGGTAGAG
AGGTAACTCTGGACCTGTCCCAGTTCCATGCTGTGGCAGTGCGCAGGGTCTTGAATTCAGAGAG
CGACGTGGTGAGCAAGTTTGCTGTCACTGACTTTCCATCTTGCTACCTGCTGCTTCGGAATGGT
TCTGTTTCCCGAGTGCCTGTGCTGGTAGAGTCCAGGCCTTTCTATACATCCTACCTGCGGGGGC
TCCCTGGACTGACCAGGGAGGCTCCCCCAACCACAGCTGCACCAGTCACTCCTGATAAGATAGC
ACCCACAGTGTGGAAGTTTGCAGACCGCTCCAAGATCTACATGGCTGACCTGGAGTCTGCACTA
CACTACATCTTGCGTGTAGAAGTGGGAAAGTTCTCAGTTCTGGAGGGACAGCGCTTGGTGGCCC
TGAAAAAGTTTGTGGCAGTATTGGCCAAGTACTTCCCTGGCCAGCCTCTGGTCCAGAACTTCTT
GCATTCCATAAACGATTGGCTTCAGAAGCAGCAGAAAAAGAAGATTCCCTATAGTTACTTCAAA
GCCGCTCTGGACAGCAGGAAGGAGAACGCTGTCCTTGCTGAGAAGGTGAACTGGATTGGTTGCC
AGGGCAGTGAGCCACATTTCCGGGGATTCCCCTGCTCCCTGTGGGTCCTCTTCCACTTCCTGAC
TGTGCAGGCACACCGATACAGTGAGGCCCACCCACAAGAACCAGCTGACGGCCAGGAGGTCCTG
CAAGCCATGCGAAGCTATGTGCAGTCCTTCTTCGGCTGCCGAGACTGTGCCAACCATTTTGAGC
AGATGGCTGCAGCATCCATGCACCAAGTGAAAAGTCCCAGTAATGCCGTTCTCTGGCTCTGGAC
GAGTCACAACAGGGTCAACGCTCGCCTCTCGGGTGCTCTGAGCGAGGACCCCCAATTCCCCAAG
GTGCAGTGGCCACCCCGTGAGCTGTGTTCTGCCTGTCACAATGAAGTCAACGGACAAGTGCCTT
TGTGGGACCTCGGTGCCACCCTCAACTTTCTCAAGGCTCACTTCTCCCCAGCAAACATCGTCAG
AGACCCTCCTGCACCTGGACCAGCATCCCGGAGGGGCACCCAGGATCCAGAAGCTTCCCCCAAC
CTGGTAATGGATACATTAAAACTGGAGACCGGGAATTCAGTGCTGGGCCATGAGCAGGCTGCTT
CTGCAGCATCCCCGGGAGCCACTGCCCTAGATGTACCAGCTGGGAAGCCTGAAGCAAGTGGTCC
CCAGGAACTAAACGCAGGCCTCAGTATGGGTGGAGCGTCACCAGGGCAGGGCCCTCCTGAGCAC
ACGGAAGAGCTTCTGAGGGATGTGCAGGAGAATGCCCAGGGGCAGCAACACTTGAGCAAGAGAG
ACACTGAAGCCTTATTGCTGCCTGAGGTGAACCACCTCCAAGGCCCTTTAGCGCCCAGGCGAGG
CGGCCACAGCCCCAAGCAGCTAGCCAGTATACTCGAAGGAGAGCCAGAGGCCCTAGCTATACAG
GGCCGACGCCAGTGGCTCCAGGTTCTGGGAGGAGGAGTTTCCTTCCTGGACATTAGCCTCTGTG
TGGGGCTCTACTCTGTGTCCTTCATGGGCTTGCTGGCCATGTATACCTACTTCCGGGCCAGGAT
GAGAACCCCCAAGGGCCATGTTAGTTACCCCACAGCCTGAACTGCCCAGCAAAGGACCGAGAAG
GAGCTGCTGTCTATGGGGTGTTTTGTTTTTTGCCCACTGGCCCCCTTGCTGCCTTTCTACCCCC
TGTCCCATTGTCTGGCTTAGGAGAGTGGGAAGTCCAAGAAAGTGAGTTGTTGCAGTGAACCCTG
GCGTCTACTGTGAGGATTCCATAGACAAAACAGAAACAGGGTGCTGGTCTGGCCTGGCCAGCAT
GGGGTAGGAGCAGCCTAATGCAGGGCTCACAGGGCTCGCAGGGCTCCGGGCTTCTGGGAGGCTC
AGCACCAAATTCTGTTTTTCAGCTTTTGTGAAGCCCTGCCCCATTCCTGCTGAAGTCTCAGTGT
CTCCTGCTTGGCCTTGGCCTTGAACTGAGGCAAACAAGTCCAGAGTTTCCAAGGTTTCTCATCC
AGAGGAGAGTATCGGGGCGGGGTGGGCAGGGGTGGACCTCCTCACGCCTTCTGAGGTTGTCCAC
TTCCCTCCCTCTCAACATGAAGAAAACCGCATCCCTTCCGGCCTTCTCTGGCCTACCCAGCTCC
AGCACCTCAGCTGTGGTGGGGTCTGGGAGCCTCAGGAAATGACTCTGGTCACCCAGGCTCACAG
TGGGGTTTCTGCTGCAAGAGTGTAGCTCGAGGTGGTGTGGTTTGGCAGGCTGGAGGGGGACAGT
TGCCGGACTGTGGGTGCAGCGCTTGCTTGGTGGTAGGGGAAAGGGGGTGGGTGATGCTGGGGTC
TGGAGTGCCTTAGTCCTGAGCTACCTGTGAGAGGGCAGACTCCTCTCTGGGCTGGATGCTTGTC
TCTTACTTTGGTCTCTAAAATCAATGCTAACTGGGGGGTGTGGAAGGTGCTAGGTTGAGAGCAG
TAAGCAGAATGTCCCTCTCTCCTGGCTGGTTCCACGGCTGGCAGGAGGGGGTGGAGAGACCGGC
TCACGTGCTTCATTCCCACCAGTTCCTACTGCTTGGGAGGGATGTGGAATAAAATTATTTTTGT
TAAGTCTCAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_053431 ⟹ NP_445883

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	67,949,780 - 67,987,434 (-)	NCBI
Rnor_6.0	13	73,423,396 - 73,460,890 (-)	NCBI
Rnor_5.0	13	78,351,222 - 78,388,703 (-)	NCBI
RGSC_v3.4	13	70,739,793 - 70,777,526 (-)	RGD
Celera	13	67,815,702 - 67,852,956 (-)	RGD

Sequence:

show sequence

GCGAGGTGGACAGTCAAGCCGCCTAGGATGAGGAGGTGCGGCCGCCACTCGGGGCCGCCGTCGC
TGCTGCTGCTACTTCTGCTGCTCCCGCCGCTGCTGCTCTCGGTGCCCGGCGCTTACGCGGCCCG
GCTCTCGGTGCTCTACTCGTCCTCTGATCCACTGACGCTGCTGGATGCGGACACCGTGCGCCCG
GCTGTGCTGGGATCCAGTAGCGCCTGGGCGGTGGAGTTCTTCGCCTCCTGGTGTGGCCATTGCA
TCGCCTTCGCTCCGACGTGGAAGGAGCTTGCTAACGACGTGAAAGACTGGAGGCCAGCACTAAA
TCTTGCTGTCCTGGACTGTGCTGATGAGACCAATAGTGCTGTCTGCAGAGAGTTCAACATCGCC
GGCTTCCCCACTGTGAGGTTTTTTAAGGCCTTTTCCAAGAACGGTACTGGAACAGCATTGCCAG
CCGCTGGTGCTAATGTGCAGACGCTGCGTATGAGGCTCATCGATGCTCTGGAGTCCCACCGTGA
CACGTGGCCCCCAGCATGTCCACCCCTGGAGCCTGCCAAGCTGAAGGATATCAATGAATTCTTT
ACAAGAAGTAAAGCAGAGTACCTGGCCCTGATCTTTGAAAGGGAAGACTCCTATCTGGGTAGAG
AGGTAACTCTGGACCTGTCCCAGTTCCATGCTGTGGCAGTGCGCAGGGTCTTGAATTCAGAGAG
CGACGTGGTGAGCAAGTTTGCTGTCACTGACTTTCCATCTTGCTACCTGCTGCTTCGGAATGGT
TCTGTTTCCCGAGTGCCTGTGCTGGTAGAGTCCAGGCCTTTCTATACATCCTACCTGCGGGGGC
TCCCTGGACTGACCAGGGAGGCTCCCCCAACCACAGCTGCACCAGTCACTCCTGATAAGATAGC
ACCCACAGTGTGGAAGTTTGCAGACCGCTCCAAGATCTACATGGCTGACCTGGAGTCTGCACTA
CACTACATCTTGCGTGTAGAAGTGGGAAAGTTCTCAGTTCTGGAGGGACAGCGCTTGGTGGCCC
TGAAAAAGTTTGTGGCAGTATTGGCCAAGTACTTCCCTGGCCAGCCTCTGGTCCAGAACTTCTT
GCATTCCATAAACGATTGGCTTCAGAAGCAGCAGAAAAAGAAGATTCCCTATAGTTACTTCAAA
GCCGCTCTGGACAGCAGGAAGGAGAACGCTGTCCTTGCTGAGAAGGTGAACTGGATTGGTTGCC
AGGGCAGTGAGCCACATTTCCGGGGATTCCCCTGCTCCCTGTGGGTCCTCTTCCACTTCCTGAC
TGTGCAGGCACACCGATACAGTGAGGCCCACCCACAAGAACCAGCTGACGGCCAGGAGGTCCTG
CAAGCCATGCGAAGCTATGTGCAGTCCTTCTTCGGCTGCCGAGACTGTGCCAACCATTTTGAGC
AGATGGCTGCAGCATCCATGCACCAAGTGAAAAGTCCCAGTAATGCCGTTCTCTGGCTCTGGAC
GAGTCACAACAGGGTCAACGCTCGCCTCTCGGGTGCTCTGAGCGAGGACCCCCAATTCCCCAAG
GTGCAGTGGCCACCCCGTGAGCTGTGTTCTGCCTGTCACAATGAAGTCAACGGACAAGTGCCTT
TGTGGGACCTCGGTGCCACCCTCAACTTTCTCAAGGCTCACTTCTCCCCAGCAAACATCGTCAG
AGACCCTCCTGCACCTGGACCAGCATCCCGGAGGGGCACCCAGGATCCAGAAGCTTCCCCCAAC
CTGCTTTTGTGAAGCCCTGCCCCATTCCTGCTGAAGTCTCAGTGTCTCCTGCTTGGCCTTGGCC
TTGAACTGAGGCAAACAAGTCCAGAGTTTCCAAGGTTTCTCATCCAGAGGAGAGTATCGGGGCG
GGGTGGGCAGGGGTGGACCTCCTCACGCCTTCTGAGGTTGTCCACTTCCCTCCCTCTCAACATG
AAGAAAACCGCATCCCTTCCGGCCTTCTCTGGCCTACCCAGCTCCAGCACCTCAGCTGTGGTGG
GGTCTGGGAGCCTCAGGAAATGACTCTGGTCACCCAGGCTCACAGTGGGGTTTCTGCTGCAAGA
GTGTAGCTCGAGGTGGTGTGGTTTGGCAGGCTGGAGGGGGACAGTTGCCGGACTGTGGGTGCAG
CGCTTGCTTGGTGGTAGGGGAAAGGGGGTGGGTGATGCTGGGGTCTGGAGTGCCTTAGTCCTGA
GCTACCTGTGAGAGGGCAGACTCCTCTCTGGGCTGGATGCTTGTCTCTTACTTTGGTCTCTAAA
ATCAATGCTAACTGGGGGGTGTGGAAGGTGCTAGGTTGAGAGCAGTAAGCAGAATGTCCCTCTC
TCCTGGCTGGTTCCACGGCTGGCAGGAGGGGGTGGAGAGACCGGCTCACGTGCTTCATTCCCAC
CAGTTCCTACTGCTTGGGAGGGATGTGGAATAAAATTATTTTTGTTAAGTCTCAAAAAAAAAAA
AAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001103368	(Get FASTA)	NCBI Sequence Viewer
	NP_445883	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG53892	(Get FASTA)	NCBI Sequence Viewer
	AAM67412	(Get FASTA)	NCBI Sequence Viewer
	AAT40988	(Get FASTA)	NCBI Sequence Viewer
	BAB21937	(Get FASTA)	NCBI Sequence Viewer
	EDM09504	(Get FASTA)	NCBI Sequence Viewer
	EDM09505	(Get FASTA)	NCBI Sequence Viewer
	Q6IUU3	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_445883 ⟸ NM_053431
- Peptide Label:	isoform B precursor
- UniProtKB:	Q6IUU3 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MRRCGRHSGPPSLLLLLLLLPPLLLSVPGAYAARLSVLYSSSDPLTLLDADTVRPAVLGSSSAW AVEFFASWCGHCIAFAPTWKELANDVKDWRPALNLAVLDCADETNSAVCREFNIAGFPTVRFFK AFSKNGTGTALPAAGANVQTLRMRLIDALESHRDTWPPACPPLEPAKLKDINEFFTRSKAEYLA LIFEREDSYLGREVTLDLSQFHAVAVRRVLNSESDVVSKFAVTDFPSCYLLLRNGSVSRVPVLV ESRPFYTSYLRGLPGLTREAPPTTAAPVTPDKIAPTVWKFADRSKIYMADLESALHYILRVEVG KFSVLEGQRLVALKKFVAVLAKYFPGQPLVQNFLHSINDWLQKQQKKKIPYSYFKAALDSRKEN AVLAEKVNWIGCQGSEPHFRGFPCSLWVLFHFLTVQAHRYSEAHPQEPADGQEVLQAMRSYVQS FFGCRDCANHFEQMAAASMHQVKSPSNAVLWLWTSHNRVNARLSGALSEDPQFPKVQWPPRELC SACHNEVNGQVPLWDLGATLNFLKAHFSPANIVRDPPAPGPASRRGTQDPEASPNLLL hide sequence

RefSeq Acc Id:	NP_001103368 ⟸ NM_001109898
- Peptide Label:	isoform A precursor
- UniProtKB:	Q6IUU3 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MRRCGRHSGPPSLLLLLLLLPPLLLSVPGAYAARLSVLYSSSDPLTLLDADTVRPAVLGSSSAW AVEFFASWCGHCIAFAPTWKELANDVKDWRPALNLAVLDCADETNSAVCREFNIAGFPTVRFFK AFSKNGTGTALPAAGANVQTLRMRLIDALESHRDTWPPACPPLEPAKLKDINEFFTRSKAEYLA LIFEREDSYLGREVTLDLSQFHAVAVRRVLNSESDVVSKFAVTDFPSCYLLLRNGSVSRVPVLV ESRPFYTSYLRGLPGLTREAPPTTAAPVTPDKIAPTVWKFADRSKIYMADLESALHYILRVEVG KFSVLEGQRLVALKKFVAVLAKYFPGQPLVQNFLHSINDWLQKQQKKKIPYSYFKAALDSRKEN AVLAEKVNWIGCQGSEPHFRGFPCSLWVLFHFLTVQAHRYSEAHPQEPADGQEVLQAMRSYVQS FFGCRDCANHFEQMAAASMHQVKSPSNAVLWLWTSHNRVNARLSGALSEDPQFPKVQWPPRELC SACHNEVNGQVPLWDLGATLNFLKAHFSPANIVRDPPAPGPASRRGTQDPEASPNLVMDTLKLE TGNSVLGHEQAASAASPGATALDVPAGKPEASGPQELNAGLSMGGASPGQGPPEHTEELLRDVQ ENAQGQQHLSKRDTEALLLPEVNHLQGPLAPRRGGHSPKQLASILEGEPEALAIQGRRQWLQVL GGGVSFLDISLCVGLYSVSFMGLLAMYTYFRARMRTPKGHVSYPTA hide sequence

RefSeq Acc Id:

ENSRNOP00000005052 ⟸ ENSRNOT00000005052

RefSeq Acc Id:

ENSRNOP00000061072 ⟸ ENSRNOT00000068044

Protein Domains

ERV/ALR sulfhydryl oxidase Thioredoxin

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698909

Promoter ID:

EPDNEW_R9434

Type:

initiation region

Name:

Qsox1_1

Description:

quiescin sulfhydryl oxidase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	73,460,961 - 73,461,021	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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CSV

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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CSV

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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CSV

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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CSV

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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CSV

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Damaging Variants

Assembly: Rnor_5.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
13	78352374	78352375	C	T	snv	DOB/Oda (KyushuU)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:68957	AgrOrtholog
Ensembl Genes	ENSRNOG00000003649	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000005052	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000061072	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000005052	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000068044	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.120.1960	UniProtKB/Swiss-Prot
	1.20.120.310	UniProtKB/Swiss-Prot
	3.40.30.10	UniProtKB/Swiss-Prot
InterPro	ERV/ALR_sulphydryl_oxid_sf	UniProtKB/Swiss-Prot
	ERV/ALR_sulphydryl_oxidase	UniProtKB/Swiss-Prot
	QSOX_FAD-bd_dom	UniProtKB/Swiss-Prot
	QSOX_FAD-bd_sf	UniProtKB/Swiss-Prot
	QSOX_Trx1	UniProtKB/Swiss-Prot
	Sulfhydryl_oxidase	UniProtKB/Swiss-Prot
	Thioredoxin-like_sf	UniProtKB/Swiss-Prot
	Thioredoxin_domain	UniProtKB/Swiss-Prot
KEGG Report	rno:84491	UniProtKB/Swiss-Prot
NCBI Gene	84491	ENTREZGENE
PANTHER	PTHR22897	UniProtKB/Swiss-Prot
Pfam	Evr1_Alr	UniProtKB/Swiss-Prot
	FAD_SOX	UniProtKB/Swiss-Prot
	QSOX_Trx1	UniProtKB/Swiss-Prot
	Thioredoxin	UniProtKB/Swiss-Prot
PhenoGen	Qsox1	PhenoGen
PROSITE	ERV_ALR	UniProtKB/Swiss-Prot
	THIOREDOXIN_2	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52833	UniProtKB/Swiss-Prot
	SSF69000	UniProtKB/Swiss-Prot
UniProt	Q6IUU3	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q8K4M2	UniProtKB/Swiss-Prot
	Q99J80	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-02	Qsox1	quiescin sulfhydryl oxidase 1	Qsox1	quiescin Q6 sulfhydryl oxidase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-18	Qsox1	quiescin Q6 sulfhydryl oxidase 1	Qscn6	quiescin Q6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Qscn6	quiescin Q6			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	highly expressed in diencephalon and telencephalon	1299176
gene_function	converts alkyl thiols and oxygen to their dialkyl disulfides and hydrogen peroxide	67932
gene_protein	570 amino acids	67932
gene_transcript	2472 nucleotide cDNA with an open reading frame of 1710 base pairs	67932

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI