Psmd10 (proteasome 26S subunit, non-ATPase 10) - Rat Genome Database

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Gene: Psmd10 (proteasome 26S subunit, non-ATPase 10) Rattus norvegicus
Analyze
Symbol: Psmd10
Name: proteasome 26S subunit, non-ATPase 10
RGD ID: 620350
Description: Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in several processes, including negative regulation of signal transduction; positive regulation of protein metabolic process; and proteasome regulatory particle assembly. Predicted to be located in cilium; cytosol; and microtubule cytoskeleton. Predicted to be part of proteasome regulatory particle, base subcomplex. Predicted to be active in cytoskeleton and nucleus. Orthologous to human PSMD10 (proteasome 26S subunit, non-ATPase 10); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; gankyrin; p28Gank; proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X109,445,291 - 109,453,605 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX109,445,291 - 109,453,605 (-)EnsemblGRCr8
mRatBN7.2X104,656,809 - 104,665,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX104,656,812 - 104,665,097 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX106,786,812 - 106,794,389 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X110,286,171 - 110,293,748 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X107,840,182 - 107,847,764 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X112,323,188 - 112,328,642 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX112,323,187 - 112,328,642 (-)Ensemblrn6Rnor6.0
Rnor_5.0352,274,008 - 52,279,025 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera343,276,201 - 43,283,816 (+)NCBICelera
RGSC_v3.1X128,864,162 - 128,864,331 (+)NCBI
Cytogenetic MapXq33NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Proteasomal interactors control activities as diverse as the cell cycle and glutaminergic neurotransmission. Rezvani K, etal., Biochem Soc Trans 2003 Apr;31(2):470-3.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Information Derived from GenBank Report RGD, Sept. 2003
Additional References at PubMed
PMID:10613832   PMID:11301474   PMID:11900540   PMID:12477932   PMID:16023600   PMID:17323924   PMID:18040287   PMID:19490896   PMID:19729910  


Genomics

Comparative Map Data
Psmd10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X109,445,291 - 109,453,605 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX109,445,291 - 109,453,605 (-)EnsemblGRCr8
mRatBN7.2X104,656,809 - 104,665,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX104,656,812 - 104,665,097 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX106,786,812 - 106,794,389 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X110,286,171 - 110,293,748 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X107,840,182 - 107,847,764 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X112,323,188 - 112,328,642 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX112,323,187 - 112,328,642 (-)Ensemblrn6Rnor6.0
Rnor_5.0352,274,008 - 52,279,025 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera343,276,201 - 43,283,816 (+)NCBICelera
RGSC_v3.1X128,864,162 - 128,864,331 (+)NCBI
Cytogenetic MapXq33NCBI
PSMD10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X108,084,207 - 108,091,542 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX108,084,207 - 108,091,549 (-)Ensemblhg38GRCh38
GRCh37X107,327,437 - 107,334,772 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X107,214,093 - 107,221,504 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34X107,133,581 - 107,140,993NCBI
CeleraX107,798,909 - 107,806,320 (-)NCBICelera
Cytogenetic MapXq22.3NCBI
HuRefX96,950,118 - 96,957,560 (-)NCBIHuRef
CHM1_1X107,238,312 - 107,245,750 (-)NCBICHM1_1
T2T-CHM13v2.0X106,521,803 - 106,529,138 (-)NCBIT2T-CHM13v2.0
Psmd10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X139,849,174 - 139,857,460 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX139,849,178 - 139,857,477 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X140,948,425 - 140,956,711 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX140,948,429 - 140,956,728 (-)Ensemblmm10GRCm38
MGSCv37X137,482,964 - 137,491,250 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X136,294,902 - 136,303,045 (-)NCBIMGSCv36mm8
CeleraX124,203,589 - 124,211,948 (-)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX61.67NCBI
Psmd10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554907,825,251 - 7,833,772 (+)Ensembl
ChiLan1.0NW_0049554907,825,202 - 7,832,347 (+)NCBIChiLan1.0ChiLan1.0
PSMD10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X107,565,318 - 107,572,651 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X107,568,922 - 107,576,255 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X97,182,090 - 97,189,523 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X107,552,180 - 107,559,616 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX107,552,186 - 107,559,616 (-)EnsemblpanPan2panpan1.1
PSMD10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X81,625,288 - 81,632,175 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX81,625,141 - 81,632,129 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX67,744,887 - 67,752,996 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X83,273,600 - 83,281,719 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX83,273,405 - 83,281,649 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X80,732,655 - 80,740,768 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X82,445,205 - 82,453,318 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X82,236,960 - 82,244,460 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Psmd10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X80,958,954 - 80,966,256 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364996,691,476 - 6,702,986 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364996,691,758 - 6,698,515 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMD10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX88,540,376 - 88,548,560 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X88,540,261 - 88,548,593 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X102,980,406 - 102,988,628 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PSMD10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X95,931,710 - 95,939,145 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX95,931,466 - 95,939,218 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606521,030,084 - 21,037,519 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psmd10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248038,407,462 - 8,420,316 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Psmd10
75 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:14
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000074133
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX105359969157758123Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X80434318125434318Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX92979612117740458Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X105468858125434318Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat

Markers in Region
RH129063  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X104,657,347 - 104,657,564 (-)MAPPERmRatBN7.2
Rnor_6.0X112,311,362 - 112,311,578NCBIRnor6.0
Rnor_5.0352,290,602 - 52,290,818UniSTSRnor5.0
RGSC_v3.4X128,790,838 - 128,791,054UniSTSRGSC3.4
Celera343,283,756 - 43,283,972UniSTS
RH 3.4 Map71125.31UniSTS
RH130489  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X104,656,950 - 104,657,132 (-)MAPPERmRatBN7.2
Rnor_6.0X112,311,794 - 112,311,975NCBIRnor6.0
Rnor_5.0352,290,205 - 52,290,386UniSTSRnor5.0
RGSC_v3.4X128,791,270 - 128,791,451UniSTSRGSC3.4
Celera343,284,188 - 43,284,369UniSTS
RH 3.4 Map71125.61UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000083150   ⟹   ENSRNOP00000071060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX109,448,775 - 109,453,605 (-)Ensembl
mRatBN7.2 EnsemblX104,660,293 - 104,665,097 (-)Ensembl
Rnor_6.0 EnsemblX112,323,187 - 112,328,642 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086698   ⟹   ENSRNOP00000071909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX109,445,291 - 109,453,605 (-)Ensembl
mRatBN7.2 EnsemblX104,656,815 - 104,665,090 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106019   ⟹   ENSRNOP00000082840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX109,445,291 - 109,453,605 (-)Ensembl
mRatBN7.2 EnsemblX104,656,812 - 104,665,096 (-)Ensembl
RefSeq Acc Id: NM_001411753   ⟹   NP_001398682
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X109,445,291 - 109,453,605 (-)NCBI
mRatBN7.2X104,656,809 - 104,665,122 (-)NCBI
RefSeq Acc Id: NM_001411754   ⟹   NP_001398683
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X109,445,291 - 109,453,605 (-)NCBI
mRatBN7.2X104,656,809 - 104,665,122 (-)NCBI
RefSeq Acc Id: NM_053925   ⟹   NP_446377
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X109,445,291 - 109,453,605 (-)NCBI
mRatBN7.2X104,656,809 - 104,665,122 (-)NCBI
Rnor_6.0X112,323,188 - 112,328,642 (-)NCBI
Rnor_5.0352,274,008 - 52,279,025 (+)NCBI
Celera343,276,201 - 43,283,816 (+)RGD
Sequence:
RefSeq Acc Id: NP_446377   ⟸   NM_053925
- Peptide Label: isoform 1
- UniProtKB: A0A8I5ZXW8 (UniProtKB/TrEMBL),   A6HLQ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071060   ⟸   ENSRNOT00000083150
Ensembl Acc Id: ENSRNOP00000071909   ⟸   ENSRNOT00000086698
Ensembl Acc Id: ENSRNOP00000082840   ⟸   ENSRNOT00000106019
RefSeq Acc Id: NP_001398683   ⟸   NM_001411754
- Peptide Label: isoform 3
- UniProtKB: B0BMV9 (UniProtKB/TrEMBL),   A6HLQ9 (UniProtKB/TrEMBL),   A0A8I5XXS7 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001398682   ⟸   NM_001411753
- Peptide Label: isoform 2
- UniProtKB: A6HLR0 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2X3-F1-model_v2 AlphaFold Q9Z2X3 1-231 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701958
Promoter ID:EPDNEW_R12482
Type:initiation region
Name:Psmd10_1
Description:proteasome 26S subunit, non-ATPase 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X112,328,671 - 112,328,731EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620350 AgrOrtholog
BioCyc Gene G2FUF-1530 BioCyc
Ensembl Genes ENSRNOG00000051669 Ensembl, ENTREZGENE
  ENSRNOG00000057649 Ensembl
Ensembl Transcript ENSRNOT00000086698 ENTREZGENE
  ENSRNOT00000106019 ENTREZGENE
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8369120 IMAGE-MGC_LOAD
InterPro Ank_repeat_dom-contain_49 UniProtKB/Swiss-Prot
  Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
KEGG Report rno:116722 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187342 IMAGE-MGC_LOAD
NCBI Gene 116722 ENTREZGENE
PANTHER CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED UniProtKB/Swiss-Prot
  PROTEASOME 26S SUBUNIT, NON-ATPASE 10 UniProtKB/Swiss-Prot
Pfam Ank UniProtKB/Swiss-Prot
  Ank_2 UniProtKB/Swiss-Prot
PhenoGen Psmd10 PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000051669 RatGTEx
  ENSRNOG00000057649 RatGTEx
SMART ANK UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot
UniProt A0A0G2JZI5_RAT UniProtKB/TrEMBL
  A0A8I5XXS7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZXW8 ENTREZGENE, UniProtKB/TrEMBL
  A6HLQ8 ENTREZGENE, UniProtKB/TrEMBL
  A6HLQ9 ENTREZGENE, UniProtKB/TrEMBL
  A6HLR0 ENTREZGENE, UniProtKB/TrEMBL
  B0BMV9 ENTREZGENE
  PSD10_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-19 Psmd10  proteasome 26S subunit, non-ATPase 10  Psmd10  proteasome (prosome, macropain) 26S subunit, non-ATPase, 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Psmd10  proteasome (prosome, macropain) 26S subunit, non-ATPase, 10      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Psmd10  proteasome (prosome, macropain) 26S subunit, non-ATPase, 10      Symbol and Name status set to provisional 70820 PROVISIONAL