Gnb3 (G protein subunit beta 3) - Rat Genome Database

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Gene: Gnb3 (G protein subunit beta 3) Rattus norvegicus
Analyze
Symbol: Gnb3
Name: G protein subunit beta 3
RGD ID: 708344
Description: Enables spectrin binding activity. Predicted to be involved in several processes, including cell volume homeostasis; regulation of fat cell differentiation; and regulation of lipid metabolic process. Located in cell body and neuron projection. Human ortholog(s) of this gene implicated in artery disease (multiple); congenital stationary night blindness 1H; familial hyperlipidemia; mental depression; and type 2 diabetes mellitus. Orthologous to human GNB3 (G protein subunit beta 3); PARTICIPATES IN visual phototransduction pathway; chemokine mediated signaling pathway; glutamate signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aconitine; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G protein beta-subunit; G protein beta-subunit gene; guanine nucleotide binding protein (G protein), beta 3; guanine nucleotide binding protein (G protein), beta polypeptide 3; guanine nucleotide binding protein, beta 3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; guanine nucleotide-binding protein, beta-3 subunit; heterotrimeric guanine nucleotide-binding protein 2d; Hg2d; LOC60449; MGC105437; transducin beta chain 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Gnb3em1Mcwi  
Genetic Models: SS-Gnb3em1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24157,639,468 - 157,645,171 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,639,469 - 157,645,173 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,867,751 - 163,873,454 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04159,650,661 - 159,656,363 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04158,286,144 - 158,291,844 (-)NCBIRnor_WKY
Rnor_6.04157,352,558 - 157,359,237 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,352,372 - 157,358,262 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,370,234 - 224,376,918 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,957,524 - 160,963,226 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14161,202,460 - 161,208,162 (-)NCBI
Celera4146,377,383 - 146,383,085 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Photoreceptor signaling: supporting vision across a wide range of light intensities. Arshavsky VY and Burns ME, J Biol Chem. 2012 Jan 13;287(3):1620-6. Epub 2011 Nov 10.
2. Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM. Daimon M, etal., Biochem Biophys Res Commun. 2008 Sep 26;374(3):576-80. Epub 2008 Jul 24.
3. G protein beta3 subunit 825T allele is associated with depression in young, healthy subjects. Exton MS, etal., Neuroreport 2003 Mar 3;14(3):531-3.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Association of the C825T polymorphism of the G-protein beta3 subunit gene with hypertension, obesity, hyperlipidemia, insulin resistance, diabetes, diabetic complications, and diabetic therapies among Japanese. Hayakawa T, etal., Metabolism. 2007 Jan;56(1):44-8.
6. Association between a polymorphism in the G protein beta3 subunit gene (GNB3) with arterial hypertension but not with myocardial infarction. Hengstenberg C, etal., Cardiovasc Res. 2001 Mar;49(4):820-7.
7. 825T allele of the G-protein beta3 subunit gene (GNB3) is associated with impaired left ventricular diastolic filling in essential hypertension. Jacobi J, etal., J Hypertens. 1999 Oct;17(10):1457-62.
8. Immunohistochemical localization of G protein beta1, beta2, beta3, beta4, beta5, and gamma3 subunits in the adult rat brain. Liang JJ, etal., J Neurochem. 1998 Jul;71(1):345-55.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. The giant spectrin betaV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Papal S, etal., Hum Mol Genet. 2013 Sep 15;22(18):3773-88. doi: 10.1093/hmg/ddt228. Epub 2013 May 23.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. Cloning and sequencing of a rat heart cDNA encoding a G-protein beta subunit related to the human retinal beta 3 subunit. Ray K and Robishaw JD, Gene 1994 Nov 18;149(2):337-40.
14. G-protein beta3 subunit (GNB3) gene polymorphisms and cardiovascular disease: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Renner W, etal., Atherosclerosis. 2007 May;192(1):108-12. Epub 2006 Aug 14.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. Polymorphisms of genes encoding components of the sympathetic nervous system but not the renin-angiotensin system as risk factors for orthostatic hypotension. Tabara Y, etal., J Hypertens. 2002 Apr;20(4):651-6.
19. Associations of a human G protein beta3 subunit dimorphism with insulin resistance and carotid atherosclerosis. Wascher TC, etal., Stroke. 2003 Mar;34(3):605-9. Epub 2003 Feb 20.
Additional References at PubMed
PMID:12454992   PMID:12477932   PMID:15489334   PMID:19255495   PMID:23533145   PMID:25931508   PMID:29206867   PMID:29476059  


Genomics

Comparative Map Data
Gnb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24157,639,468 - 157,645,171 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,639,469 - 157,645,173 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,867,751 - 163,873,454 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04159,650,661 - 159,656,363 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04158,286,144 - 158,291,844 (-)NCBIRnor_WKY
Rnor_6.04157,352,558 - 157,359,237 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,352,372 - 157,358,262 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,370,234 - 224,376,918 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,957,524 - 160,963,226 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14161,202,460 - 161,208,162 (-)NCBI
Celera4146,377,383 - 146,383,085 (-)NCBICelera
Cytogenetic Map4q42NCBI
GNB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,840,925 - 6,847,393 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl126,839,954 - 6,847,393 (+)EnsemblGRCh38hg38GRCh38
GRCh37126,950,089 - 6,956,557 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,819,636 - 6,826,818 (+)NCBINCBI36Build 36hg18NCBI36
Build 34126,819,635 - 6,826,818NCBI
Celera128,566,659 - 8,573,841 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,803,098 - 6,810,284 (+)NCBIHuRef
CHM1_1126,948,373 - 6,955,555 (+)NCBICHM1_1
T2T-CHM13v2.0126,850,217 - 6,856,691 (+)NCBIT2T-CHM13v2.0
Gnb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,811,203 - 124,817,238 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,811,203 - 124,817,238 (-)EnsemblGRCm39 Ensembl
GRCm386124,834,240 - 124,840,275 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,834,240 - 124,840,275 (-)EnsemblGRCm38mm10GRCm38
MGSCv376124,784,258 - 124,790,293 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366124,799,859 - 124,805,894 (-)NCBIMGSCv36mm8
Celera6126,510,369 - 126,516,404 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
Gnb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,440,693 - 4,447,416 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,440,693 - 4,447,419 (+)NCBIChiLan1.0ChiLan1.0
GNB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1126,883,280 - 6,890,692 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,883,280 - 6,890,692 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0126,971,854 - 6,979,214 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GNB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,175,928 - 38,182,473 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,175,931 - 38,181,763 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,434,984 - 8,440,816 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,528,834 - 38,535,384 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,528,834 - 38,534,666 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,402,886 - 38,408,718 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,443,911 - 38,449,741 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,913,716 - 7,919,548 (+)NCBIUU_Cfam_GSD_1.0
Gnb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,302,620 - 102,309,507 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936709970,172 - 976,863 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936709970,169 - 977,059 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,863,661 - 63,870,433 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,863,656 - 63,871,352 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,299,162 - 66,306,064 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GNB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,873,043 - 6,880,676 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl116,874,351 - 6,880,179 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660631,342,884 - 1,350,505 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gnb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,509,397 - 3,515,352 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,509,185 - 3,515,025 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gnb3
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:198
Count of miRNA genes:127
Interacting mature miRNAs:138
Transcripts:ENSRNOT00000021481
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat

Markers in Region
RH131999  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,639,507 - 157,639,695 (+)MAPPERmRatBN7.2
Rnor_6.04157,352,598 - 157,352,785NCBIRnor6.0
Rnor_5.04224,370,274 - 224,370,461UniSTSRnor5.0
RGSC_v3.44160,957,564 - 160,957,751UniSTSRGSC3.4
Celera4146,377,423 - 146,377,610UniSTS
RH 3.4 Map41005.8UniSTS
Cytogenetic Map4q42UniSTS
RH136873  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,646,252 - 157,646,441 (+)MAPPERmRatBN7.2
Rnor_6.04157,359,342 - 157,359,530NCBIRnor6.0
Rnor_5.04224,377,018 - 224,377,206UniSTSRnor5.0
RGSC_v3.44160,964,308 - 160,964,496UniSTSRGSC3.4
Celera4146,384,167 - 146,384,355UniSTS
RH 3.4 Map41004.3UniSTS
Cytogenetic Map4q42UniSTS
MARC_10541-10542:1000149110:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,642,135 - 157,642,688 (+)MAPPERmRatBN7.2
Rnor_6.04157,355,225 - 157,355,777NCBIRnor6.0
Rnor_5.04224,372,901 - 224,373,453UniSTSRnor5.0
RGSC_v3.44160,960,191 - 160,960,743UniSTSRGSC3.4
Celera4146,380,050 - 146,380,602UniSTS
Cytogenetic Map4q42UniSTS


Genetic Models
This gene Gnb3 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 2
Low 3 20 22 6 19 6 3 5 72 25 37 11 3
Below cutoff 33 33 33 5 6 10 2 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021481   ⟹   ENSRNOP00000021480
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,639,469 - 157,645,173 (-)Ensembl
Rnor_6.0 Ensembl4157,352,559 - 157,358,262 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090898   ⟹   ENSRNOP00000069551
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4157,352,372 - 157,358,007 (-)Ensembl
RefSeq Acc Id: NM_021858   ⟹   NP_068630
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24157,639,468 - 157,645,171 (-)NCBI
Rnor_6.04157,352,558 - 157,358,260 (-)NCBI
Rnor_5.04224,370,234 - 224,376,918 (-)NCBI
RGSC_v3.44160,957,524 - 160,963,226 (-)RGD
Celera4146,377,383 - 146,383,085 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_068630   ⟸   NM_021858
- UniProtKB: P52287 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021480   ⟸   ENSRNOT00000021481
RefSeq Acc Id: ENSRNOP00000069551   ⟸   ENSRNOT00000090898

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52287-F1-model_v2 AlphaFold P52287 1-340 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693392
Promoter ID:EPDNEW_R3917
Type:single initiation site
Name:Gnb3_1
Description:G protein subunit beta 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04157,358,239 - 157,358,299EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708344 AgrOrtholog
BioCyc Gene G2FUF-43063 BioCyc
Ensembl Genes ENSRNOG00000015541 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000021480 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021481 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7193131 IMAGE-MGC_LOAD
InterPro G-protein_beta_WD-40_rep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gprotein_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanine_nucleotide-bd_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60449 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105437 IMAGE-MGC_LOAD
NCBI Gene 60449 ENTREZGENE
PANTHER PTHR19850 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GNB3 RGD
PhenoGen Gnb3 PhenoGen
PRINTS GPROTEINB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPROTEINBRPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot
SMART WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt GBB3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q45QL4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Gnb3  guanine nucleotide binding protein (G protein), beta polypeptide 3  Gnb3  guanine nucleotide binding protein (G protein), beta 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-20 Gnb3  guanine nucleotide binding protein (G protein), beta 3  Gnb3  guanine nucleotide binding protein, beta 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Gnb3  guanine nucleotide binding protein, beta 3  LOC60449  G protein beta-subunit gene  Symbol and Name updated 1299863 APPROVED