Gnb3 (G protein subunit beta 3) - Rat Genome Database

Name: Gnb3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Gnb3 (G protein subunit beta 3) Ictidomys tridecemlineatus

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Symbol:

Gnb3

Name:

G protein subunit beta 3

RGD ID:

12711567

Description:

ENCODES a protein that exhibits spectrin binding (ortholog); INVOLVED IN regulation of feeding behavior (ortholog); regulation of locomotion involved in locomotory behavior (ortholog); PARTICIPATES IN visual phototransduction pathway; ASSOCIATED WITH carotid artery disease (ortholog); congenital stationary night blindness (ortholog); congenital stationary night blindness 1H (ortholog); FOUND IN cell body (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

G protein subunit beta 3, transcript variant X1; G protein subunit beta 3, transcript variant X2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	102,302,620 - 102,309,507 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936709	970,172 - 976,863 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936709	970,169 - 977,059 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

carotid artery disease (ISO)

congenital stationary night blindness (ISO)

congenital stationary night blindness 1H (ISO)

coronary artery disease (ISO)

depressive disorder (ISO)

developmental and epileptic encephalopathy 21 (ISO)

diabetes mellitus (ISO)

essential hypertension (ISO)

familial hyperlipidemia (ISO)

genetic disease (ISO)

Hyperphosphatemic Familial Tumoral Calcinosis 1 (ISO)

hypertension (ISO)

Insulin Resistance (ISO)

Klippel-Feil syndrome 3 (ISO)

lymphoproliferative syndrome 2 (ISO)

obesity (ISO)

Orthostatic Hypotension (ISO)

peroxisome biogenesis disorder 2B (ISO)

Temtamy syndrome (ISO)

type 2 diabetes mellitus (ISO)

Weight Gain (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell volume homeostasis (IEA)

regulation of cholesterol metabolic process (IEA)

regulation of fat cell differentiation (IEA)

regulation of feeding behavior (ISO)

regulation of gene expression (IEA)

regulation of glucose metabolic process (IEA)

regulation of hormone metabolic process (IEA)

regulation of locomotion involved in locomotory behavior (ISO)

regulation of phospholipid metabolic process (IEA)

regulation of triglyceride metabolic process (IEA)

signal transduction (IEA)

Cellular Component

cell body (ISO)

dendrite (IEA)

heterotrimeric G-protein complex (IEA)

Molecular Function

GTPase binding (IEA)

protein binding (ISO)

spectrin binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

visual phototransduction pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Gnb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	102,302,620 - 102,309,507 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936709	970,172 - 976,863 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936709	970,169 - 977,059 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GNB3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	6,840,925 - 6,847,393 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	6,839,954 - 6,847,393 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	6,950,089 - 6,956,557 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	6,819,636 - 6,826,818 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	6,819,635 - 6,826,818	NCBI
Celera	12	8,566,659 - 8,573,841 (+)	NCBI		Celera
Cytogenetic Map	12	p13.31	NCBI
HuRef	12	6,803,098 - 6,810,284 (+)	NCBI		HuRef
CHM1_1	12	6,948,373 - 6,955,555 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	6,850,217 - 6,856,691 (+)	NCBI		T2T-CHM13v2.0

Gnb3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	124,811,203 - 124,817,238 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	124,811,203 - 124,817,238 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	124,834,240 - 124,840,275 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	124,834,240 - 124,840,275 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	124,784,258 - 124,790,293 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	124,799,859 - 124,805,894 (-)	NCBI		MGSCv36	mm8
Celera	6	126,510,369 - 126,516,404 (-)	NCBI		Celera
Cytogenetic Map	6	F2	NCBI
cM Map	6	59.17	NCBI

Gnb3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	159,325,741 - 159,331,443 (-)	NCBI		GRCr8
mRatBN7.2	4	157,639,468 - 157,645,171 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	157,639,469 - 157,645,173 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	163,867,751 - 163,873,454 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	159,650,661 - 159,656,363 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	158,286,144 - 158,291,844 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	157,352,558 - 157,359,237 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	157,352,372 - 157,358,262 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	224,370,234 - 224,376,918 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	160,957,524 - 160,963,226 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	161,202,460 - 161,208,162 (-)	NCBI
Celera	4	146,377,383 - 146,383,085 (-)	NCBI		Celera
Cytogenetic Map	4	q42	NCBI

Gnb3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	4,440,693 - 4,447,416 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	4,440,693 - 4,447,419 (+)	NCBI	ChiLan1.0	ChiLan1.0

GNB3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	12,403,159 - 12,410,535 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	12,399,910 - 12,407,293 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	6,971,854 - 6,979,214 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	6,883,280 - 6,890,692 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	6,883,280 - 6,890,692 (+)	Ensembl	panpan1.1		panPan2

GNB3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	38,175,928 - 38,182,473 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	38,175,931 - 38,181,763 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	8,434,984 - 8,440,816 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	38,528,834 - 38,535,384 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	38,528,834 - 38,534,666 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	38,402,886 - 38,408,718 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	38,443,911 - 38,449,741 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	7,913,716 - 7,919,548 (+)	NCBI		UU_Cfam_GSD_1.0

GNB3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	63,863,661 - 63,870,433 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	63,863,656 - 63,871,352 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	66,299,162 - 66,306,064 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GNB3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	6,873,043 - 6,880,676 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	6,874,351 - 6,880,179 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666063	1,342,884 - 1,350,505 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gnb3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624860	3,509,397 - 3,515,352 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624860	3,509,185 - 3,515,025 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005338323	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021735254	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000015588 ⟹ ENSSTOP00000013951

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936709	970,172 - 976,863 (-)	Ensembl

RefSeq Acc Id:

XM_005338323 ⟹ XP_005338380

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404945	102,302,620 - 102,309,507 (-)	NCBI
SpeTri2.0	NW_004936709	970,169 - 977,059 (-)	NCBI

Sequence:

show sequence

TCATCCCCTCCTCCCTCTCTAGGCTAGCTGTGGGGGGCCACTCCTCTCTCTAGCCCATATTCCT
GCTCCCACCCCTCCTACAGGCTGGGCCCAAGTCTCTCTAGAAGCCACACACCTTCCTCCCTCCC
TGTCCTCTCCCCCAGTCCCTGCCAGCTGATTTCATTTGCCTGAGTTGTTGGTTGTTGTCATTGG
CCCTACCCTTCCCTGTCAGTCTCCCCCCCCACACCCAGCACAGTCAGGGCCAGGCCAGGCCAGC
TTCTCTGGCAGCAGAGCGGGGCAGGTGACAGGCAGGCGTCGCAGCTGAGGGAGTGAGGAGGCGC
CTGGGAACCGGAGCTGGAAACCTGGGATAGGTCCAGCCAGAGCCCAAGAGCCGGAGCTACCCCT
CTACCTGTCCGCCATGGGGGAAATGGAGCAGCTGAGGCAGGAAGCGGAGCAGCTCAAGAAGCAG
ATTGCAGATGCCAGGAAAGCCTGTGCTGACACTACCCTGGCAGAGCTGGTGTCTGGCCTAGAGG
TGGTGGGACGAGTCCAGCTGCGGACACGGCGGACATTAAGGGGGCACCTGGCCAAGATCTATGC
CATGCACTGGGCCACTGACTCTAAGCTGCTGGTAAGTGCCTCGCAAGACGGGAAGCTGATTGTG
TGGGACACCTACACCACCAACAAGGTGCATGCCATCCCACTGCGCTCCTCCTGGGTCATGACTT
GTGCCTACGCCCCATCGGGGAACTTTGTGGCATGTGGGGGGCTGGACAACATGTGCTCCATCTA
TAGCCTCAAATCCCGTGAGGGCAATGTCAAGGTCAGCCGGGAGCTCTCTGCTCACACAGGTTAT
CTCTCCTGCTGTCGCTTCCTGGATGACAACAACATTGTGACCAGCTCAGGGGACACCACGTGTG
CTCTGTGGGATGTTGAGACGGGGCAACAGAAGACTGTGTTTGTGGGACATACGGGTGACTGTAT
GAGCCTGGCTGTGTCTCCAGACTACAAACTCTTCATTTCGGGGGCTTGTGATGCCAGCGCCAAG
CTCTGGGACGTGCGGGAGGGGACCTGCCGTCAGACTTTCACTGGCCACGAGTCTGACATCAACG
CCATCTGTTTCTTCCCCAATGGAGAGGCCATCTGCACAGGTTCAGACGATGCTTCCTGTCGCCT
CTTTGACCTGCGGGCAGACCAAGAACTGACCAACTACTCCCATGAGAGCATCATCTGTGGCATA
ACATCTGTGGCCTTCTCGCTTAGTGGCCGCCTGCTCTTCGCAGGCTATGATGACTTCAACTGCA
ATGTCTGGGATGCCTTGAAGTGTGAGCGTGTGGGCATCCTCTCTGGTCATGACAACAGGGTCAG
CTGCCTGGGGGTCACAGCTGATGGGATGGCTGTGGCCACTGGTTCCTGGGACAGCTTCCTCAAA
ATCTGGAACTGAGGCCTGTGGAAGGCCATGAAGATACTCAGCTGACCCCCGACACCTGATCTCC
TTTAGGGTCTCTCTTCTATATCCCAGGGGCCATTCCCACTAAGCTTCTTCCTCTGAGGCAATGG
GAGTATGGGAGTGTGCCTTTGGGAGGCAGTATCAGGGACAAAGAGGCAAAGAACTGCCCAATCT
CCTCCCATGGCTTCCCCTCCCTATAGTCCTTACAGCCTTTCCCTTAGGTGCAACCCTTACCCAT
TCCTTTGTAGGCCTAGAAGTTTTCCAAGGTGAAACCTCAGGCCCTAGGAGTCCTCCTCTAAGAG
CCATTACTTTTGTACACAGCCCTGTGACTATGGCTCTAACACTGATAGACTCCTGGTCCTTTTC
TCCTTCATGCTTTCTCCTTTTTCTATTTTTTGTTCCTCTCCCAAAGTACTTGTAATAAAATGTA
GAACTTGGTACCTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005338380	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000013951.2
GenBank Protein	KAG3292512	(Get FASTA)	NCBI Sequence Viewer
	KAG3292513	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005338380 ⟸ XM_005338323

- UniProtKB:

I3MQ00 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGEMEQLRQEAEQLKKQIADARKACADTTLAELVSGLEVVGRVQLRTRRTLRGHLAKIYAMHWA
TDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYSLKS
REGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDVETGQQKTVFVGHTGDCMSLAV
SPDYKLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLR
ADQELTNYSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDALKCERVGILSGHDNRVSCLGV
TADGMAVATGSWDSFLKIWN

hide sequence

Ensembl Acc Id:

ENSSTOP00000013951 ⟸ ENSSTOT00000015588

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000015586	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000015588.3	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	G-protein_beta_WD-40_rep	UniProtKB/TrEMBL
	Gprotein_B	UniProtKB/TrEMBL
	Guanine_nucleotide-bd_bsu	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_CS	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Gnb3	ENTREZGENE
PANTHER	GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)/G(S)/G(T) SUBUNIT BETA-3	UniProtKB/TrEMBL
	PTHR19850	UniProtKB/TrEMBL
Pfam	WD40	UniProtKB/TrEMBL
PIRSF	GN-bd_beta	UniProtKB/TrEMBL
PRINTS	GPROTEINB	UniProtKB/TrEMBL
	GPROTEINBRPT	UniProtKB/TrEMBL
PROSITE	WD_REPEATS_1	UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50978	UniProtKB/TrEMBL
UniProt	I3MQ00	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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