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Gene: GNB3 (G protein subunit beta 3) Homo sapiens
Symbol: GNB3
Name: G protein subunit beta 3
RGD ID: 1346162
Description: Exhibits GTPase binding activity. Involved in several processes, including cell volume homeostasis; regulation of fat cell differentiation; and regulation of lipid metabolic process. Localizes to extracellular exosome. Implicated in artery disease (multiple); congenital stationary night blindness 1H; familial hyperlipidemia; mental depression; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CSNB1H; G protein, beta-3 subunit; GTP-binding regulatory protein beta-3 chain; guanine nucleotide binding protein (G protein), beta polypeptide 3; guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; hypertension associated protein; transducin beta chain 3
Mus musculus (house mouse) : Gnb3 (guanine nucleotide binding protein (G protein), beta 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gnb3 (G protein subunit beta 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gnb3 (G protein subunit beta 3)
Pan paniscus (bonobo/pygmy chimpanzee) : GNB3 (G protein subunit beta 3)
Canis lupus familiaris (dog) : GNB3 (G protein subunit beta 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gnb3 (G protein subunit beta 3)
Sus scrofa (pig) : GNB3 (G protein subunit beta 3)
Chlorocebus sabaeus (African green monkey) : GNB3 (G protein subunit beta 3)
Heterocephalus glaber (naked mole-rat) : Gnb3 (G protein subunit beta 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl126,839,954 - 6,847,393 (+)EnsemblGRCh38hg38GRCh38
GRCh38126,840,922 - 6,847,393 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37126,949,375 - 6,956,564 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,819,636 - 6,826,818 (+)NCBINCBI36hg18NCBI36
Build 34126,819,635 - 6,826,818NCBI
Celera128,566,659 - 8,573,841 (+)NCBI
Cytogenetic Map12p13.31NCBI
HuRef126,803,098 - 6,810,284 (+)NCBIHuRef
CHM1_1126,949,016 - 6,955,557 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GNB3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346162
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.