Dpep1 (dipeptidase 1) - Rat Genome Database

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Gene: Dpep1 (dipeptidase 1) Rattus norvegicus
Analyze
Symbol: Dpep1
Name: dipeptidase 1
RGD ID: 620324
Description: Predicted to enable several functions, including GPI anchor binding activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; and metallodipeptidase activity. Predicted to be involved in several processes, including GPI anchor release; cellular response to nitric oxide; and peptide catabolic process. Predicted to be located in several cellular components, including apical part of cell; endoplasmic reticulum membrane; and nucleoplasm. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hepatoblastoma. Orthologous to human DPEP1 (dipeptidase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: beta-lactamase; dipeptidase 1 (renal); microsomal dipeptidase; renal dipeptidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21951,209,831 - 51,237,004 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1951,219,660 - 51,235,257 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1958,014,788 - 58,029,351 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01958,694,560 - 58,709,533 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01960,913,384 - 60,927,951 (+)NCBIRnor_WKY
Rnor_6.01955,973,447 - 55,998,830 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,982,740 - 55,998,208 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01966,678,990 - 66,706,989 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41953,503,467 - 53,518,440 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11953,508,370 - 53,523,966 (+)NCBI
Celera1950,455,220 - 50,470,193 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP)
ammonium chloride  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
cadmium atom  (EXP)
carbon nanotube  (ISO)
choline  (ISO)
cilastatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
indole-3-methanol  (EXP)
isoprenaline  (ISO)
L-methionine  (ISO)
manganese(II) chloride  (EXP)
metformin  (ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nitrofen  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP)
paraquat  (EXP)
perfluorooctanoic acid  (ISO)
progesterone  (EXP)
propanal  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Primary structure of rat renal dipeptidase and expression of its mRNA in rat tissues and COS-1 cells. Adachi H, etal., Biochim Biophys Acta 1992 Oct 20;1132(3):311-4.
2. DPEP1 is a direct target of miR-193a-5p and promotes hepatoblastoma progression by PI3K/Akt/mTOR pathway. Cui X, etal., Cell Death Dis. 2019 Sep 20;10(10):701. doi: 10.1038/s41419-019-1943-0.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:6334084   PMID:8045301   PMID:8737157   PMID:8823187   PMID:9560193   PMID:11139399   PMID:11487543   PMID:11988094   PMID:12144777   PMID:12738806   PMID:15865404   PMID:17615681  
PMID:19056867   PMID:19879002   PMID:20031578   PMID:20435919   PMID:20824289   PMID:23376485   PMID:23533145   PMID:31442408  


Genomics

Comparative Map Data
Dpep1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21951,209,831 - 51,237,004 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1951,219,660 - 51,235,257 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1958,014,788 - 58,029,351 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01958,694,560 - 58,709,533 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01960,913,384 - 60,927,951 (+)NCBIRnor_WKY
Rnor_6.01955,973,447 - 55,998,830 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,982,740 - 55,998,208 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01966,678,990 - 66,706,989 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41953,503,467 - 53,518,440 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11953,508,370 - 53,523,966 (+)NCBI
Celera1950,455,220 - 50,470,193 (+)NCBICelera
Cytogenetic Map19q12NCBI
DPEP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381689,613,308 - 89,641,540 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1689,613,308 - 89,638,456 (+)EnsemblGRCh38hg38GRCh38
GRCh371689,679,716 - 89,707,948 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361688,214,501 - 88,232,338 (+)NCBINCBI36Build 36hg18NCBI36
Build 341688,214,500 - 88,232,338NCBI
Celera1674,743,127 - 74,769,330 (+)NCBICelera
Cytogenetic Map16q24.3NCBI
HuRef1675,374,386 - 75,400,655 (+)NCBIHuRef
CHM1_11691,091,422 - 91,116,106 (+)NCBICHM1_1
T2T-CHM13v2.01695,694,848 - 95,725,329 (+)NCBIT2T-CHM13v2.0
Dpep1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398123,912,974 - 123,928,551 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8123,912,981 - 123,928,551 (+)EnsemblGRCm39 Ensembl
GRCm388123,186,235 - 123,201,812 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8123,186,242 - 123,201,812 (+)EnsemblGRCm38mm10GRCm38
MGSCv378125,710,135 - 125,725,712 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368126,072,332 - 126,087,314 (+)NCBIMGSCv36mm8
Celera8127,417,731 - 127,433,354 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map872.08NCBI
Dpep1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555413,204,055 - 3,215,565 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555413,204,421 - 3,215,514 (+)NCBIChiLan1.0ChiLan1.0
DPEP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11689,971,984 - 89,997,978 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1689,975,105 - 89,997,978 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01670,365,900 - 70,392,377 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
DPEP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1563,909,034 - 63,923,309 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl563,909,042 - 63,923,492 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha563,921,890 - 63,936,207 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0564,136,884 - 64,151,198 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl564,136,892 - 64,151,287 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1564,156,932 - 64,171,234 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0563,994,537 - 64,008,843 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0564,401,112 - 64,415,426 (-)NCBIUU_Cfam_GSD_1.0
Dpep1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934924,625,555 - 24,643,322 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936641379,083 - 391,918 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936641379,112 - 384,711 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DPEP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6361,197 - 376,616 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16361,187 - 385,757 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26488,005 - 503,439 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103233484
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1574,963,509 - 74,987,469 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl574,977,290 - 74,987,546 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023669841183 - 2,804 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dpep1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624746310,248 - 315,654 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624746310,361 - 321,053 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dpep1
223 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:77
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000021397
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194997648153225766Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 1 1 5 21 20 11
Low 26 32 17 14 17 8 11 6 12 19 8
Below cutoff 10 14 14 14 22 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021397   ⟹   ENSRNOP00000021397
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1951,219,660 - 51,235,257 (+)Ensembl
Rnor_6.0 Ensembl1955,982,740 - 55,998,208 (+)Ensembl
RefSeq Acc Id: NM_053591   ⟹   NP_446043
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21951,219,637 - 51,234,612 (+)NCBI
Rnor_6.01955,983,210 - 55,998,183 (+)NCBI
Rnor_5.01966,678,990 - 66,706,989 (+)NCBI
RGSC_v3.41953,503,467 - 53,518,440 (+)RGD
Celera1950,455,220 - 50,470,193 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255783   ⟹   XP_006255845
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21951,209,831 - 51,237,004 (+)NCBI
Rnor_6.01955,973,447 - 55,998,830 (+)NCBI
Rnor_5.01966,678,990 - 66,706,989 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098053   ⟹   XP_038953981
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21951,209,960 - 51,237,004 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_446043   ⟸   NM_053591
- Peptide Label: precursor
- UniProtKB: Q6IN35 (UniProtKB/Swiss-Prot),   P31430 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006255845   ⟸   XM_006255783
- Peptide Label: isoform X1
- UniProtKB: Q6IN35 (UniProtKB/Swiss-Prot),   P31430 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021397   ⟸   ENSRNOT00000021397
RefSeq Acc Id: XP_038953981   ⟸   XM_039098053
- Peptide Label: isoform X1
- UniProtKB: Q6IN35 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31430-F1-model_v2 AlphaFold P31430 1-410 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701217
Promoter ID:EPDNEW_R11741
Type:single initiation site
Name:Dpep1_2
Description:dipeptidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11742  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01955,982,719 - 55,982,779EPDNEW
RGD ID:13701218
Promoter ID:EPDNEW_R11742
Type:initiation region
Name:Dpep1_1
Description:dipeptidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11741  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01955,983,198 - 55,983,258EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620324 AgrOrtholog
BioCyc Gene G2FUF-5340 BioCyc
Ensembl Genes ENSRNOG00000015880 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000021397 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021397 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7100683 IMAGE-MGC_LOAD
InterPro Dipep_AS UniProtKB/Swiss-Prot
  Dpep1 UniProtKB/Swiss-Prot
  Metal_Hydrolase UniProtKB/Swiss-Prot
  Pept_M19 UniProtKB/Swiss-Prot
KEGG Report rno:94199 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91569 IMAGE-MGC_LOAD
NCBI Gene 94199 ENTREZGENE
PANTHER PTHR10443 UniProtKB/Swiss-Prot
  PTHR10443:SF38 UniProtKB/Swiss-Prot
Pfam Peptidase_M19 UniProtKB/Swiss-Prot
PhenoGen Dpep1 PhenoGen
PROSITE RENAL_DIPEPTIDASE_1 UniProtKB/Swiss-Prot
  RENAL_DIPEPTIDASE_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51556 UniProtKB/Swiss-Prot
UniProt DPEP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6IN35 ENTREZGENE
UniProt Secondary Q6IN35 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-16 Dpep1  dipeptidase 1  Dpep1  dipeptidase 1 (renal)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Dpep1  dipeptidase 1 (renal)    dipeptidase 1  Name updated 1299863 APPROVED
2002-08-07 Dpep1  dipeptidase 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression is decreased 1.8 fold in SHR compared with WKY rats 1357414
gene_expression expressed in lung and kidney and small intestine 728405