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Gene: Sorl1 (sortilin related receptor 1) Rattus norvegicus
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Symbol: Sorl1
Name: sortilin related receptor 1
Description: Predicted to have ADP-ribosylation factor binding activity; amyloid-beta binding activity; and low-density lipoprotein particle binding activity. Involved in cell migration and cell population proliferation. Localizes to the multivesicular body and neuronal cell body. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SORL1 (sortilin related receptor 1); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC300652; Lr11; RGD619914; similar to sortilin-related receptor, LDLR class A repeats-containing; sortilin-related receptor; sortilin-related receptor, L(DLR class) A repeats-containing; sortilin-related receptor, LDLR class A repeats-containing
Orthologs:
Homo sapiens (human) : SORL1 (sortilin related receptor 1)  HGNC  Alliance
Mus musculus (house mouse) : Sorl1 (sortilin-related receptor, LDLR class A repeats-containing)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sorl1 (sortilin related receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SORL1 (sortilin related receptor 1)
Canis lupus familiaris (dog) : SORL1 (sortilin related receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sorl1 (sortilin related receptor 1)
Sus scrofa (pig) : SORL1 (sortilin related receptor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0846,228,077 - 46,287,171 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0844,702,383 - 44,872,500 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4844,962,730 - 45,101,843 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1844,971,645 - 45,214,890 (-)NCBI
Celera841,934,828 - 42,097,222 (-)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Sorl1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619914
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.