Pmp22 (peripheral myelin protein 22) - Rat Genome Database

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Gene: Pmp22 (peripheral myelin protein 22) Rattus norvegicus
Analyze
Symbol: Pmp22
Name: peripheral myelin protein 22
RGD ID: 3359
Description: Predicted to enable cytoskeletal motor activity. Involved in several processes, including myelination; negative regulation of cell population proliferation; and negative regulation of neuron projection development. Located in bicellular tight junction and compact myelin. Is integral component of membrane. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease (multiple); Guillain-Barre syndrome; and hereditary neuropathy with liability to pressure palsies. Orthologous to human PMP22 (peripheral myelin protein 22); INTERACTS WITH (20S)-20-hydroxypregn-4-en-3-one; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Gas-3; peripheral myelin protein; PMP-22; SAG; schwann cell membrane glycoprotein; SR13 myelin protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21047,795,709 - 47,825,715 (+)NCBI
Rnor_6.0 Ensembl1049,538,588 - 49,568,583 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01049,538,588 - 49,568,583 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01049,317,000 - 49,346,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41049,305,835 - 49,335,864 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11049,319,457 - 49,349,487 (+)NCBI
Celera1047,038,544 - 47,068,443 (+)NCBICelera
Cytogenetic Map10q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-20-hydroxypregn-4-en-3-one  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aminolevulinic acid  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
casticin  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (EXP)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dieldrin  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP)
etoposide  (ISO)
fenvalerate  (EXP)
ferric ammonium citrate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
graphite  (EXP)
hemin  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
irinotecan  (EXP)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lithium chloride  (ISO)
mitomycin C  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
nickel dichloride  (EXP)
nicotinamide  (ISO)
nitroglycerin  (EXP)
ochratoxin A  (EXP)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (EXP)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sunitinib  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thyroxine  (EXP,ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
adult locomotory behavior  (ISO)
adult walking behavior  (ISO)
aggresome assembly  (ISO)
autophagy  (ISO)
axon development  (ISO)
basement membrane organization  (ISO)
bleb assembly  (ISO)
cell adhesion  (ISO)
cell death  (ISO)
cell differentiation  (IDA)
cellular lipid metabolic process  (ISO)
cellular localization  (ISO)
cellular response to heat  (ISO)
cellular response to unfolded protein  (ISO)
cholesterol metabolic process  (ISO)
fibroblast migration  (ISO)
gliogenesis  (ISO)
immune response  (ISO)
lamellipodium assembly  (ISO)
mating  (ISO)
membrane raft organization  (ISO)
motor behavior  (ISO)
multicellular organism aging  (ISO)
multicellular organism growth  (ISO)
muscle cell development  (ISO)
myelin assembly  (IBA,ISO)
myelination  (IDA,IMP,ISO)
myelination in peripheral nervous system  (ISO)
negative regulation of cell population proliferation  (IDA,IMP)
negative regulation of gene expression  (ISO)
negative regulation of neuron projection development  (IDA)
neuromuscular junction development, skeletal muscle fiber  (ISO)
neuromuscular process  (ISO)
neuronal action potential  (ISO)
neuronal action potential propagation  (ISO)
neuronal ion channel clustering  (ISO)
paranodal junction assembly  (ISO)
peripheral nervous system development  (IC,ISO)
peripheral nervous system neuron axonogenesis  (ISO)
positive regulation of gene expression  (ISO)
proteasomal protein catabolic process  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
regulation of apoptotic signaling pathway  (ISO)
regulation of gene expression  (ISO)
regulation of glial cell apoptotic process  (ISO)
regulation of inflammatory response  (ISO)
regulation of protein serine/threonine kinase activity  (ISO)
regulation of Schwann cell proliferation  (ISO)
response to bacterium  (ISO)
response to endoplasmic reticulum stress  (ISO)
Schwann cell development  (ISO)
Schwann cell differentiation  (ISO)
Schwann cell migration  (ISO)
striated muscle cell differentiation  (ISO)
transmission of nerve impulse  (ISO)
vestibular reflex  (ISO)

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:1376775   PMID:2022965   PMID:11114256   PMID:11673320   PMID:12107182   PMID:12359155   PMID:14627652   PMID:15207917   PMID:15363066   PMID:15703401   PMID:15748170   PMID:16405874  
PMID:16436605   PMID:17174099   PMID:17971504   PMID:19170179   PMID:19290556   PMID:20071523   PMID:20122990   PMID:20427655   PMID:20553714   PMID:20731761   PMID:22190549   PMID:22337502  
PMID:23012479   PMID:23468528   PMID:23847051   PMID:25014022   PMID:25150498   PMID:25429154   PMID:25453108   PMID:27583434   PMID:28108290   PMID:29315582   PMID:29771329   PMID:33883545  


Genomics

Comparative Map Data
Pmp22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21047,795,709 - 47,825,715 (+)NCBI
Rnor_6.0 Ensembl1049,538,588 - 49,568,583 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01049,538,588 - 49,568,583 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01049,317,000 - 49,346,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41049,305,835 - 49,335,864 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11049,319,457 - 49,349,487 (+)NCBI
Celera1047,038,544 - 47,068,443 (+)NCBICelera
Cytogenetic Map10q23NCBI
PMP22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1715,229,773 - 15,272,292 (-)EnsemblGRCh38hg38GRCh38
GRCh381715,229,779 - 15,265,326 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371715,133,096 - 15,168,643 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361715,073,821 - 15,109,369 (-)NCBINCBI36hg18NCBI36
Build 341715,073,821 - 15,104,818NCBI
Celera1715,157,676 - 15,193,224 (-)NCBI
Cytogenetic Map17p12NCBI
HuRef1715,027,217 - 15,062,782 (-)NCBIHuRef
CHM1_11715,141,853 - 15,177,435 (-)NCBICHM1_1
Pmp22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391163,019,808 - 63,050,373 (+)NCBIGRCm39mm39
GRCm39 Ensembl1163,019,808 - 63,050,373 (+)Ensembl
GRCm381163,128,982 - 63,159,547 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1163,128,982 - 63,159,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv371162,945,012 - 62,973,048 (+)NCBIGRCm37mm9NCBIm37
MGSCv361162,947,705 - 62,975,741 (+)NCBImm8
Celera1170,064,333 - 70,092,386 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1138.99NCBI
Pmp22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554672,423,659 - 2,457,307 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554672,422,181 - 2,456,925 (+)NCBIChiLan1.0ChiLan1.0
PMP22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11741,038,286 - 41,073,872 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1741,038,302 - 41,073,872 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01736,389,549 - 36,425,161 (+)NCBIMhudiblu_PPA_v0panPan3
PMP22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1538,806,731 - 38,839,002 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl538,807,826 - 38,838,971 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha538,951,486 - 38,983,753 (-)NCBI
ROS_Cfam_1.0538,914,812 - 38,947,091 (-)NCBI
UMICH_Zoey_3.1538,887,774 - 38,920,037 (-)NCBI
UNSW_CanFamBas_1.0538,833,093 - 38,865,352 (-)NCBI
UU_Cfam_GSD_1.0539,021,339 - 39,053,622 (-)NCBI
Pmp22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560257,777,101 - 57,810,336 (-)NCBI
SpeTri2.0NW_0049367241,747,015 - 1,780,298 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PMP22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1258,679,776 - 58,707,953 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11258,679,773 - 58,734,195 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PMP22
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11614,527,892 - 14,563,223 (-)NCBI
ChlSab1.1 Ensembl1614,527,672 - 14,563,171 (-)Ensembl
Vero_WHO_p1.0NW_0236660596,655,072 - 6,690,713 (+)NCBI
Pmp22
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248773,293,980 - 3,328,337 (-)NCBI

Position Markers
PMC64694P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21047,825,195 - 47,825,620 (+)MAPPER
Rnor_6.01049,568,064 - 49,568,488NCBIRnor6.0
Rnor_5.01049,346,476 - 49,346,900UniSTSRnor5.0
RGSC_v3.41049,335,346 - 49,335,770UniSTSRGSC3.4
Celera1047,067,925 - 47,068,349UniSTS
Cytogenetic Map10q22UniSTS
Pmp22-rs  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21047,825,363 - 47,825,567 (+)MAPPER
Rnor_6.01049,568,232 - 49,568,435NCBIRnor6.0
Rnor_5.01049,346,644 - 49,346,847UniSTSRnor5.0
RGSC_v3.41049,335,514 - 49,335,717UniSTSRGSC3.4
Celera1047,068,093 - 47,068,296UniSTS
Cytogenetic Map10q22UniSTS
RH127495  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21047,825,358 - 47,825,568 (+)MAPPER
Rnor_6.01049,568,227 - 49,568,436NCBIRnor6.0
Rnor_5.01049,346,639 - 49,346,848UniSTSRnor5.0
RGSC_v3.41049,335,509 - 49,335,718UniSTSRGSC3.4
Celera1047,068,088 - 47,068,297UniSTS
RH 3.4 Map10544.3UniSTS
Cytogenetic Map10q22UniSTS
RH94848  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21047,824,997 - 47,825,187 (+)MAPPER
Rnor_6.01049,567,866 - 49,568,055NCBIRnor6.0
Rnor_5.01049,346,278 - 49,346,467UniSTSRnor5.0
RGSC_v3.41049,335,148 - 49,335,337UniSTSRGSC3.4
Celera1047,067,727 - 47,067,916UniSTS
Cytogenetic Map10q22UniSTS
RH94849  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21047,825,216 - 47,825,364 (+)MAPPER
Rnor_6.01049,568,085 - 49,568,232NCBIRnor6.0
Rnor_5.01049,346,497 - 49,346,644UniSTSRnor5.0
RGSC_v3.41049,335,367 - 49,335,514UniSTSRGSC3.4
Celera1047,067,946 - 47,068,093UniSTS
Cytogenetic Map10q22UniSTS
RH138695  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21047,824,423 - 47,824,646 (+)MAPPER
Rnor_6.01049,567,292 - 49,567,514NCBIRnor6.0
Rnor_5.01049,345,704 - 49,345,926UniSTSRnor5.0
RGSC_v3.41049,334,574 - 49,334,796UniSTSRGSC3.4
Celera1047,067,153 - 47,067,375UniSTS
RH 3.4 Map10551.9UniSTS
Cytogenetic Map10q22UniSTS
Pmp22  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.41049,334,983 - 49,335,611UniSTSRGSC3.4
RGSC_v3.41049,334,575 - 49,334,897UniSTSRGSC3.4
Celera1047,067,562 - 47,068,190UniSTS
Celera1047,067,154 - 47,067,476UniSTS
Pmp22  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01049,346,113 - 49,346,741UniSTSRnor5.0
RGSC_v3.41049,334,983 - 49,335,611UniSTSRGSC3.4
Celera1047,067,562 - 47,068,190UniSTS
Cytogenetic Map10q22UniSTS
Pmp22  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01049,345,705 - 49,346,027UniSTSRnor5.0
RGSC_v3.41049,334,575 - 49,334,897UniSTSRGSC3.4
Celera1047,067,154 - 47,067,476UniSTS
Cytogenetic Map10q22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1076442166221621Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10587753664401490Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10622909575983805Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10642907599492409Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10752145052521450Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109841807108540162Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101263951357639513Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101263951357639513Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101263951357639513Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101482789492423564Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014827894107857673Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014827894110992275Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101537547462469074Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101646873661468736Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11712154262121542Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11712154262121542Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101824639453637634Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101940281464402814Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)1020170031102897474Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102152390683549467Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)12152390690312401Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12152390690312401Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12152390690312401Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)12152390690312401Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102152390690312401Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102170776664648311Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102290149793886300Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102386101566539843Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1023861015112626471Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1024483076107857673Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1024483076107857673Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1024483076107857673Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102723753064648311Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)1027237530101482600Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1027237530102427718Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102878928073789280Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)103002135454057745Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)103009990975099909Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)103009990975099909Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)103098380575983805Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103191939778343192Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103317903078179030Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103334319278343192Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103513942480139424Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103618592982675365Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103618592995845311Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103658437353645194Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103658437366539843Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103658456066015527Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)104051404485514044Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)104051404485514044Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1041260363106105607Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1041260363107857673Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1041260363107857673Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104318865981042642Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1043289657108540162Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104370495588704955Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104659302198939209Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104684834691848346Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104684834691848346Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104684834691848346Rat

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir29arno-miR-29a-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19170179

Predicted Target Of
Summary Value
Count of predictions:463
Count of miRNA genes:244
Interacting mature miRNAs:297
Transcripts:ENSRNOT00000041606
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 23 10 14 10 8 11 68 27 35 11 8
Low 34 31 5 31 6 8 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000041606   ⟹   ENSRNOP00000051201
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1049,541,051 - 49,568,583 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081415   ⟹   ENSRNOP00000069909
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1049,538,588 - 49,568,582 (+)Ensembl
RefSeq Acc Id: NM_017037   ⟹   NP_058733
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21047,795,709 - 47,825,714 (+)NCBI
Rnor_6.01049,538,588 - 49,568,582 (+)NCBI
Rnor_5.01049,317,000 - 49,346,995 (+)NCBI
RGSC_v3.41049,305,835 - 49,335,864 (+)RGD
Celera1047,038,544 - 47,068,443 (+)RGD
Sequence:
RefSeq Acc Id: XM_006246584   ⟹   XP_006246646
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21047,798,177 - 47,825,715 (+)NCBI
Rnor_6.01049,541,059 - 49,568,583 (+)NCBI
Rnor_5.01049,317,000 - 49,346,995 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085208   ⟹   XP_038941136
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21047,799,473 - 47,825,715 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_058733   ⟸   NM_017037
- Sequence:
RefSeq Acc Id: XP_006246646   ⟸   XM_006246584
- Peptide Label: isoform X1
- UniProtKB: P25094 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000051201   ⟸   ENSRNOT00000041606
RefSeq Acc Id: ENSRNOP00000069909   ⟸   ENSRNOT00000081415
RefSeq Acc Id: XP_038941136   ⟸   XM_039085208
- Peptide Label: isoform X1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697281
Promoter ID:EPDNEW_R7806
Type:multiple initiation site
Name:Pmp22_2
Description:peripheral myelin protein 22
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7807  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01049,538,588 - 49,538,648EPDNEW
RGD ID:13697283
Promoter ID:EPDNEW_R7807
Type:initiation region
Name:Pmp22_1
Description:peripheral myelin protein 22
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7806  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01049,541,085 - 49,541,145EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3359 AgrOrtholog
Ensembl Genes ENSRNOG00000003338 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000051201 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000069909 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000041606 UniProtKB/Swiss-Prot
  ENSRNOT00000081415 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro PMP22 UniProtKB/Swiss-Prot
  PMP22/EMP/MP20/Claudin UniProtKB/Swiss-Prot
  PMP22_EMP_MP20 UniProtKB/Swiss-Prot
KEGG Report rno:24660 UniProtKB/Swiss-Prot
NCBI Gene 24660 ENTREZGENE
PANTHER PTHR10671:SF7 UniProtKB/Swiss-Prot
Pfam PMP22_Claudin UniProtKB/Swiss-Prot
PhenoGen Pmp22 PhenoGen
PRINTS EPMEMFAMILY UniProtKB/Swiss-Prot
  PMYELIN22 UniProtKB/Swiss-Prot
PROSITE PMP22_1 UniProtKB/Swiss-Prot
  PMP22_2 UniProtKB/Swiss-Prot
UniProt P25094 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Pmp22  peripheral myelin protein 22      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Pmp22  peripheral myelin protein 22      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease defects in Pmp22 are responsible for the majority of heritable demyelinating peripheral neuropathies, including Charcot-Marie-Tooth disease 61486
gene_disease defects in Pmp22 are responsible for the majority of heritable demyelinating peripheral neuropathies, including Charcot-Marie-Tooth disease 70581
gene_disease over dosage causes Charcot-Marie-Tooth disease, decreased dosage results in neuropathy with liability to pressure palsies 61486
gene_disease over dosage causes Charcot-Marie-Tooth disease, decreased dosage results in neuropathy with liability to pressure palsies 70581
gene_disease transgenic dorsal root ganglia cultures show myelin abnormalities similar to those of human Charcot-Marie-Tooth 1A (CMT1A) neuropathy 729622
gene_expression expression highest in myolin-forming Schwann cells 61486
gene_expression expression highest in myolin-forming Schwann cells 70581
gene_expression found in lungs, intestines and epithelia 61486
gene_expression found in lungs, intestines and epithelia 70581
gene_function tetraspan glycoprotein component of intercellular junctions of epithelia 61486
gene_function tetraspan glycoprotein component of intercellular junctions of epithelia 70581