Gpc3 (glypican 3) - Rat Genome Database

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Gene: Gpc3 (glypican 3) Rattus norvegicus
Symbol: Gpc3
Name: glypican 3
RGD ID: 2725
Description: Predicted to enable peptidyl-dipeptidase inhibitor activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway and positive regulation of Wnt signaling pathway, planar cell polarity pathway. Located in plasma membrane. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Simpson-Golabi-Behmel syndrome type 1 and nephroblastoma. Orthologous to human GPC3 (glypican 3); PARTICIPATES IN glypican signaling pathway; Hedgehog signaling pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: defective in Simpson-Golabi-Behmel overgrowth syndrome; glypican-3; intestinal protein OCI-5; MGC93606; OCI-5; proteoglycan GPC3
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2X131,868,983 - 132,236,837 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX131,868,990 - 132,236,798 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX134,029,733 - 134,399,032 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X137,611,682 - 137,980,983 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X135,180,258 - 135,549,530 (-)NCBIRnor_WKY
Rnor_6.0X139,579,268 - 139,947,093 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX139,579,268 - 139,916,883 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X139,625,383 - 139,993,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X139,192,115 - 139,560,649 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X139,264,617 - 139,634,082 (-)NCBI
CeleraX130,783,069 - 131,149,772 (-)NCBICelera
Cytogenetic MapXq36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-acetamidofluorene  (EXP)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
fenvalerate  (EXP)
fulvestrant  (ISO)
furan  (EXP)
gemcitabine  (ISO)
glycerol 2-phosphate  (ISO)
glycidol  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indole-3-methanol  (EXP)
L-ascorbic acid  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
raloxifene  (EXP)
SB 431542  (ISO)
scopolamine  (EXP)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
thymoquinone  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
topotecan  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
anterior/posterior axis specification  (IEA,ISO)
biological_process  (ND)
body morphogenesis  (IEA,ISO)
bone mineralization  (IEA,ISO)
branching involved in ureteric bud morphogenesis  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cell migration  (IBA)
cell migration involved in gastrulation  (ISS)
cell proliferation involved in kidney development  (ISO,ISS)
cell proliferation involved in metanephros development  (IEA,ISO)
coronary vasculature development  (IEA,ISO,ISS)
embryonic hindlimb morphogenesis  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
kidney development  (ISO)
lung development  (IEA,ISO)
mesenchymal cell proliferation involved in ureteric bud development  (IEA,ISO)
mesonephric duct morphogenesis  (IEA,ISO,ISS)
negative regulation of canonical Wnt signaling pathway  (IDA,IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of growth  (IEA,ISO)
negative regulation of peptidase activity  (IEA)
negative regulation of smoothened signaling pathway  (IEA,ISO,ISS)
osteoclast differentiation  (IEA,ISO)
positive regulation of BMP signaling pathway  (IEA,ISO)
positive regulation of canonical Wnt signaling pathway  (IBA,ISO,ISS)
positive regulation of endocytosis  (IEA,ISO,ISS)
positive regulation of glucose import  (IEA,ISO)
positive regulation of protein catabolic process  (IEA,ISO,ISS)
positive regulation of smoothened signaling pathway  (IEA,ISO)
positive regulation of Wnt signaling pathway, planar cell polarity pathway  (IDA,IEA,IGI,ISO)
regulation of canonical Wnt signaling pathway  (ISO)
regulation of growth  (ISO)
regulation of non-canonical Wnt signaling pathway  (ISO)
regulation of protein localization to membrane  (IBA)
response to bacterium  (IEA,ISO)
smoothened signaling pathway  (IEA,ISO)
Wnt signaling pathway, planar cell polarity pathway  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome. Cano-Gauci DF, etal., J Cell Biol. 1999 Jul 12;146(1):255-64. doi: 10.1083/jcb.146.1.255.
2. Immunohistochemical expression of glypican-3 in pediatric tumors: an analysis of 414 cases. Chan ES, etal., Pediatr Dev Pathol. 2013 Jul-Aug;16(4):272-7. doi: 10.2350/12-06-1216-OA.1. Epub 2013 Mar 26.
3. [Expression of glypican-3, hepatocyte antigen, alpha-fetoprotein, CD34 and CD10 in hepatocellular carcinoma: a clinicopathologic analysis of 375 cases]. Du JL, etal., Zhonghua Bing Li Xue Za Zhi. 2012 May;41(5):309-13. doi: 10.3760/cma.j.issn.0529-5807.2012.05.006.
4. Identification of a new membrane-bound heparan sulphate proteoglycan. Filmus J, etal., Biochem J. 1995 Oct 15;311 ( Pt 2):561-5.
5. Isolation of a cDNA corresponding to a developmentally regulated transcript in rat intestine. Filmus J, etal., Mol Cell Biol 1988 Oct;8(10):4243-9.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development. Ng A, etal., Dev Biol. 2009 Nov 1;335(1):208-15. doi: 10.1016/j.ydbio.2009.08.029. Epub 2009 Sep 4.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
13. Expression of glypican 3 in placental site trophoblastic tumor. Ou-Yang RJ, etal., Diagn Pathol. 2010 Sep 25;5:64. doi: 10.1186/1746-1596-5-64.
14. Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome. Pilia G, etal., Nat Genet 1996 Mar;12(3):241-7.
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Comprehensive gene review and curation RGD comprehensive gene curation
20. Glypican-3 expression is correlated with poor prognosis in hepatocellular carcinoma. Shirakawa H, etal., Cancer Sci. 2009 Aug;100(8):1403-7. doi: 10.1111/j.1349-7006.2009.01206.x. Epub 2009 May 4.
21. The loss of glypican-3 induces alterations in Wnt signaling. Song HH, etal., J Biol Chem. 2005 Jan 21;280(3):2116-25. Epub 2004 Nov 10.
22. [Value of detection of serum glypican-3 level in diagnosis and therapeutic effect evaluation of primary hepatocellular carcinoma]. Wang YY, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2017 Aug 20;37(8):1060-1065. doi: 10.3969/j.issn.1673-4254.2017.08.10.
23. K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney. Watanabe K, etal., J Cell Biol 1995 Sep;130(5):1207-18.
24. Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response. Williams EH, etal., Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5869-74. Epub 2010 Mar 15.
25. Detection of α-fetoprotein and glypican-3 mRNAs in the peripheral blood of hepatocellular carcinoma patients by using multiple FQ-RT-PCR. Yan D, etal., J Clin Lab Anal. 2011;25(2):113-7. doi: 10.1002/jcla.20443.
26. Values of circulating GPC-3 mRNA and alpha-fetoprotein in detecting patients with hepatocellular carcinoma. Yao M, etal., Hepatobiliary Pancreat Dis Int. 2013 Apr;12(2):171-9. doi: 10.1016/s1499-3872(13)60028-4.
27. Evaluation of antiglypican-3 therapy as a promising target for amelioration of hepatic tissue damage in hepatocellular carcinoma. Zaghloul RA, etal., Eur J Pharmacol. 2015 Jan 5;746:353-62. doi: 10.1016/j.ejphar.2014.11.008. Epub 2014 Nov 18.
Additional References at PubMed
PMID:9853964   PMID:10964473   PMID:11180950   PMID:11846487   PMID:12477932   PMID:14610063   PMID:15489334   PMID:15925496   PMID:15936336   PMID:17117158   PMID:17549790   PMID:18343214  
PMID:18477453   PMID:19574424   PMID:19590577   PMID:21669573   PMID:23012479   PMID:23376485   PMID:24496449   PMID:25931508  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2X131,868,983 - 132,236,837 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX131,868,990 - 132,236,798 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX134,029,733 - 134,399,032 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X137,611,682 - 137,980,983 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X135,180,258 - 135,549,530 (-)NCBIRnor_WKY
Rnor_6.0X139,579,268 - 139,947,093 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX139,579,268 - 139,916,883 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X139,625,383 - 139,993,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X139,192,115 - 139,560,649 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X139,264,617 - 139,634,082 (-)NCBI
CeleraX130,783,069 - 131,149,772 (-)NCBICelera
Cytogenetic MapXq36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X133,535,745 - 133,985,594 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX133,535,745 - 133,987,100 (-)EnsemblGRCh38hg38GRCh38
GRCh37X132,669,773 - 133,119,621 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X132,497,439 - 132,947,332 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X132,395,297 - 132,845,186NCBI
CeleraX133,056,670 - 133,506,461 (-)NCBICelera
Cytogenetic MapXq26.2NCBI
HuRefX122,070,349 - 122,518,471 (-)NCBIHuRef
CHM1_1X132,581,479 - 133,031,377 (-)NCBICHM1_1
T2T-CHM13v2.0X131,860,879 - 132,310,724 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39X51,361,303 - 51,702,851 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX51,361,303 - 51,702,827 (-)EnsemblGRCm39 Ensembl
GRCm38X52,272,426 - 52,613,974 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX52,272,426 - 52,613,950 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X49,625,603 - 49,967,151 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X48,517,053 - 48,858,548 (-)NCBIMGSCv36mm8
CeleraX39,684,455 - 40,028,880 (-)NCBICelera
Cytogenetic MapXA5NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955473969,800 - 1,431,483 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955473969,627 - 1,431,706 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1X132,966,213 - 133,421,264 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X122,677,072 - 123,131,511 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X132,979,890 - 133,432,266 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX132,979,612 - 133,432,441 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1X104,313,426 - 104,751,215 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX104,313,591 - 104,751,756 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX90,423,525 - 90,861,387 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X106,172,656 - 106,610,807 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX106,172,666 - 106,610,973 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X103,586,071 - 104,023,982 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X105,451,609 - 105,889,924 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X105,234,374 - 105,675,118 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2X102,497,623 - 102,897,321 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366911,059,994 - 1,459,740 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366911,060,013 - 1,459,736 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 EnsemblX109,536,504 - 109,973,607 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X109,536,495 - 109,973,605 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X125,676,131 - 126,059,402 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1X108,688,706 - 109,143,653 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606546,279,325 - 46,740,727 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462479713,230,932 - 13,678,742 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479713,234,741 - 13,678,542 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Gpc3
886 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:220
Count of miRNA genes:146
Interacting mature miRNAs:158
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X132,237,528 - 132,237,746 (+)MAPPERmRatBN7.2
Rnor_6.0X139,948,240 - 139,948,457NCBIRnor6.0
Rnor_5.0X139,994,475 - 139,994,692UniSTSRnor5.0
RGSC_v3.4X139,561,395 - 139,561,612UniSTSRGSC3.4
CeleraX131,150,518 - 131,150,733UniSTS
Cytogenetic MapXq36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2325,194,287 - 25,194,478 (+)MAPPERmRatBN7.2
mRatBN7.2X131,869,048 - 131,869,238 (+)MAPPERmRatBN7.2
Rnor_6.0X139,579,331 - 139,579,520NCBIRnor6.0
Rnor_6.0325,813,337 - 25,813,526NCBIRnor6.0
Rnor_5.0331,021,019 - 31,021,208UniSTSRnor5.0
Rnor_5.0X139,625,446 - 139,625,635UniSTSRnor5.0
RGSC_v3.4X139,192,178 - 139,192,367UniSTSRGSC3.4
RGSC_v3.4321,381,930 - 21,382,119UniSTSRGSC3.4
Celera323,577,159 - 23,577,348UniSTS
CeleraX130,783,132 - 130,783,321UniSTS
RH 3.4 Map51174.5UniSTS
Cytogenetic MapXq36UniSTS
Cytogenetic Map3q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X132,027,685 - 132,027,760 (+)MAPPERmRatBN7.2
Rnor_6.0X139,737,092 - 139,737,166NCBIRnor6.0
Rnor_5.0X139,783,307 - 139,783,381UniSTSRnor5.0
RGSC_v3.4X139,351,933 - 139,352,007UniSTSRGSC3.4
CeleraX130,942,471 - 130,942,545UniSTS
Cytogenetic MapXq36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X132,233,292 - 132,233,467 (+)MAPPERmRatBN7.2
Rnor_6.0X139,943,605 - 139,943,779NCBIRnor6.0
Rnor_5.0X139,989,840 - 139,990,014UniSTSRnor5.0
RGSC_v3.4X139,557,161 - 139,557,335UniSTSRGSC3.4
CeleraX131,146,283 - 131,146,457UniSTS
Cytogenetic MapXq36UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2 1
Medium 34 35 24 5 24 4 4 56 33 32 11 4
Low 3 9 21 16 14 16 4 7 18 6 4
Below cutoff 1 1 1 2


Reference Sequences
RefSeq Acc Id: ENSRNOT00000090442   ⟹   ENSRNOP00000075712
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX131,868,990 - 132,236,798 (-)Ensembl
Rnor_6.0 EnsemblX139,579,268 - 139,916,883 (-)Ensembl
RefSeq Acc Id: NM_012774   ⟹   NP_036906
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X131,868,986 - 132,236,783 (-)NCBI
Rnor_6.0X139,579,268 - 139,947,093 (-)NCBI
Rnor_5.0X139,625,383 - 139,993,328 (-)NCBI
RGSC_v3.4X139,192,115 - 139,560,649 (-)RGD
CeleraX130,783,069 - 131,149,772 (-)RGD
RefSeq Acc Id: XM_039099498   ⟹   XP_038955426
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X131,868,983 - 132,236,837 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_036906   ⟸   NM_012774
- Peptide Label: precursor
- UniProtKB: A0A0G2KBA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075712   ⟸   ENSRNOT00000090442
RefSeq Acc Id: XP_038955426   ⟸   XM_039099498
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13265-F1-model_v2 AlphaFold P13265 1-597 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2725 AgrOrtholog
BioCyc Gene G2FUF-1030 BioCyc
Ensembl Genes ENSRNOG00000060179 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000075712 ENTREZGENE
  ENSRNOP00000075712.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090442 ENTREZGENE
  ENSRNOT00000090442.2 UniProtKB/TrEMBL
InterPro Glypican UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glypican_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25236 UniProtKB/Swiss-Prot
PANTHER PTHR10822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10822:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glypican UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gpc3 PhenoGen
UniProt Secondary Q5U326 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gpc3  Glypican 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in fetal rat intestine between E15 and E19, undetectable after weaning 728561