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Gene: Cxcl12 (C-X-C motif chemokine ligand 12) Rattus norvegicus
Symbol: Cxcl12
Name: C-X-C motif chemokine ligand 12
RGD ID: 3651
Description: Predicted to have CXCR chemokine receptor binding activity; chemokine activity; and integrin binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; nervous system development; and regulation of ion transport. Localizes to several cellular components, including extracellular space; nucleus; and plasma membrane. Used to study myocardial infarction. Biomarker of anti-basement membrane glomerulonephritis; brain ischemia; myocardial infarction; status epilepticus; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Orthologous to human CXCL12 (C-X-C motif chemokine ligand 12); PARTICIPATES IN hypoxia inducible factor pathway; syndecan signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: chemokine (C-X-C motif) ligand 12; chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1); SDF-1 gamma; Sdf1; Stromal cell-derived factor 1; stromal cell-derived factor-1 gamma
Homo sapiens (human) : CXCL12 (C-X-C motif chemokine ligand 12)  HGNC  Alliance
Mus musculus (house mouse) : Cxcl12 (chemokine (C-X-C motif) ligand 12)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cxcl12 (C-X-C motif chemokine ligand 12)
Pan paniscus (bonobo/pygmy chimpanzee) : CXCL12 (C-X-C motif chemokine ligand 12)
Canis lupus familiaris (dog) : CXCL12 (C-X-C motif chemokine ligand 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cxcl12 (C-X-C motif chemokine ligand 12)
Sus scrofa (pig) : CXCL12 (C-X-C motif chemokine ligand 12)
Chlorocebus sabaeus (African green monkey) : CXCL12 (C-X-C motif chemokine ligand 12)
Heterocephalus glaber (naked mole-rat) : Cxcl12 (C-X-C motif chemokine ligand 12)
more info ...
Allele / Splice: Cxcl12_v3   Cxcl12_v1   Cxcl12_v2  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04149,261,044 - 149,273,891 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4149,261,044 - 149,273,891 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04215,195,689 - 215,208,536 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44153,503,576 - 153,516,423 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14153,748,473 - 153,755,186 (+)NCBI
Celera4139,267,343 - 139,280,188 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cxcl12
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3651
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.