1,2-dimethylhydrazine increases expression ISO RGD:1621606 6480464 1, 2-Dimethylhydrazine results in increased expression of MEG3 mRNA CTD PMID:22206623 1,2-dimethylhydrazine multiple interactions ISO RGD:1621606 6480464 Folic Acid inhibits the reaction [1, 2-Dimethylhydrazine results in increased expression of MEG3 mRNA] CTD PMID:22206623 1,4-dioxane decreases expression ISO RGD:1621606 6480464 1, 4-dioxane results in decreased expression of MEG3 mRNA CTD PMID:33693819 17alpha-ethynylestradiol multiple interactions ISO RGD:1621606 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MEG3 mRNA CTD PMID:17942748 17beta-estradiol increases expression ISO RGD:1621606 6480464 Estradiol results in increased expression of MEG3 mRNA CTD PMID:19484750 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO RGD:1351308 6480464 2 more ... CTD PMID:19095052 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1621606 6480464 Tetrachlorodibenzodioxin results in increased expression of MEG3 mRNA CTD PMID:33812962 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1621606 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MEG3 mRNA more ... CTD PMID:16891777 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1621606 6480464 Tetrachlorodibenzodioxin results in decreased expression of MEG3 mRNA CTD PMID:16891777 2-acetamidofluorene decreases expression ISO RGD:1621606 6480464 2-Acetylaminofluorene results in decreased expression of MEG3 mRNA CTD PMID:17317680 2-acetamidofluorene multiple interactions ISO RGD:1621606 6480464 TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of MEG3 mRNA] CTD PMID:17317680 3,4-methylenedioxymethamphetamine increases expression ISO RGD:1621606 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of MEG3 mRNA CTD PMID:20188158 , PMID:26251327 4,4'-sulfonyldiphenol decreases expression ISO RGD:1621606 6480464 bis(4-hydroxyphenyl)sulfone results in decreased expression of MEG3 mRNA CTD PMID:30951980 4,4'-sulfonyldiphenol affects methylation ISO RGD:1621606 6480464 bis(4-hydroxyphenyl)sulfone affects the methylation of MEG3 gene, bis(4-hydroxyphenyl)sulfone affects the methylation of MEG3 promoter CTD PMID:31683443 , PMID:33297965 4-hydroxyphenyl retinamide decreases expression ISO RGD:1621606 6480464 Fenretinide results in decreased expression of MEG3 mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine multiple interactions ISO RGD:1351308 6480464 Decitabine inhibits the reaction [Cadmium Chloride results in decreased expression of MEG3 mRNA], Decitabine inhibits the reaction [tobacco tar results in decreased expression of MEG3 mRNA] CTD PMID:19559774 , PMID:34520792 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of MEG3 mRNA CTD PMID:22504374 aflatoxin B1 increases methylation ISO RGD:1351308 6480464 Aflatoxin B1 results in increased methylation of MEG3 gene CTD PMID:27153756 Aflatoxin B2 alpha increases methylation ISO RGD:1351308 6480464 aflatoxin B2 results in increased methylation of MEG3 intron CTD PMID:30157460 all-trans-retinoic acid decreases methylation ISO RGD:1621606 6480464 Tretinoin results in decreased methylation of MEG3 promoter CTD PMID:33493612 all-trans-retinoic acid increases expression ISO RGD:1621606 6480464 Tretinoin results in increased expression of MEG3 mRNA CTD PMID:33493612 all-trans-retinoic acid multiple interactions ISO RGD:1621606 6480464 [bisphenol A co-treated with Tretinoin] results in increased expression of MEG3 mRNA, Tretinoin promotes the reaction [SMAD2 protein binds to MEG3 mRNA] CTD PMID:30951980 , PMID:33493612 arsane multiple interactions ISO RGD:1351308 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of MEG3 mRNA CTD PMID:32525701 arsane affects expression ISO RGD:1351308 6480464 Arsenic affects the expression of MEG3 mRNA CTD PMID:26772154 arsane affects methylation ISO RGD:1351308 6480464 Arsenic affects the methylation of MEG3 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1351308 6480464 Arsenic affects the methylation of MEG3 gene CTD PMID:25304211 arsenic atom multiple interactions ISO RGD:1351308 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of MEG3 mRNA CTD PMID:32525701 arsenic atom affects expression ISO RGD:1351308 6480464 Arsenic affects the expression of MEG3 mRNA CTD PMID:26772154 arsenous acid increases expression ISO RGD:1351308 6480464 Arsenic Trioxide results in increased expression of MEG3 mRNA CTD PMID:31003765 arsenous acid multiple interactions ISO RGD:1351308 6480464 MEG3 protein affects the reaction [Arsenic Trioxide results in decreased expression of CDH2 protein] more ... CTD PMID:31003765 benzo[a]pyrene affects methylation ISO RGD:1351308 6480464 Benzo(a)pyrene affects the methylation of MEG3 promoter CTD PMID:27901495 benzo[a]pyrene decreases methylation ISO RGD:1621606 6480464 Benzo(a)pyrene results in decreased methylation of MEG3 exon, Benzo(a)pyrene results in decreased methylation of MEG3 intron CTD PMID:27901495 benzo[a]pyrene diol epoxide I increases expression ISO RGD:1351308 6480464 7 more ... CTD PMID:20382639 benzo[b]fluoranthene increases expression ISO RGD:1621606 6480464 benzo(b)fluoranthene results in increased expression of MEG3 mRNA CTD PMID:26377693 benzo[e]pyrene increases methylation ISO RGD:1351308 6480464 benzo(e)pyrene results in increased methylation of MEG3 intron CTD PMID:30157460 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:1621606 6480464 PPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of MEG3 mRNA] CTD PMID:19850644 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:1621606 6480464 Diethylhexyl Phthalate results in decreased expression of MEG3 mRNA CTD PMID:19850644 bisphenol A decreases expression ISO RGD:1621606 6480464 bisphenol A results in decreased expression of MEG3 mRNA CTD PMID:26063408 , PMID:30951980 bisphenol A increases expression ISO RGD:1621606 6480464 bisphenol A results in increased expression of MEG3 mRNA CTD PMID:29165653 , PMID:34585602 bisphenol A multiple interactions ISO RGD:1621606 6480464 [bisphenol A co-treated with Tretinoin] results in increased expression of MEG3 mRNA CTD PMID:30951980 bisphenol A multiple interactions ISO RGD:1351308 6480464 [bisphenol A co-treated with Fulvestrant] results in decreased methylation of MEG3 gene CTD PMID:31601247 bisphenol A decreases methylation ISO RGD:1621606 6480464 bisphenol A results in decreased methylation of MEG3 promoter CTD PMID:27312807 bisphenol F multiple interactions ISO RGD:1621606 6480464 [bisphenol F co-treated with LIF protein] results in increased expression of MEG3 mRNA CTD PMID:30951980 bisphenol F decreases expression ISO RGD:1621606 6480464 bisphenol F results in decreased expression of MEG3 mRNA CTD PMID:30951980 butanal increases expression ISO RGD:1351308 6480464 butyraldehyde results in increased expression of MEG3 mRNA CTD PMID:26079696 cadmium atom increases methylation ISO RGD:1351308 6480464 Cadmium results in increased methylation of MEG3 gene CTD PMID:31528362 cadmium dichloride multiple interactions ISO RGD:1351308 6480464 Decitabine inhibits the reaction [Cadmium Chloride results in decreased expression of MEG3 mRNA] more ... CTD PMID:34520792 cadmium dichloride decreases expression ISO RGD:1351308 6480464 Cadmium Chloride results in decreased expression of MEG3 mRNA CTD PMID:34520792 cadmium dichloride decreases response to substance ISO RGD:1351308 6480464 MEG3 mRNA results in decreased susceptibility to Cadmium Chloride CTD PMID:34520792 calcitriol decreases expression ISO RGD:1351308 6480464 Calcitriol results in decreased expression of MEG3 mRNA CTD PMID:26485663 carbon nanotube decreases expression ISO RGD:1621606 6480464 Nanotubes, Carbon results in decreased expression of MEG3 mRNA CTD PMID:25620056 carmustine affects response to substance ISO RGD:1351308 6480464 MEG3 mRNA affects the susceptibility to Carmustine CTD PMID:16365179 cerium trichloride increases expression ISO RGD:1621606 6480464 cerous chloride results in increased expression of MEG3 mRNA CTD PMID:23573234 CGP 52608 multiple interactions ISO RGD:1351308 6480464 CGP 52608 promotes the reaction [RORA protein binds to MEG3 gene] CTD PMID:28238834 chlordecone decreases expression ISO RGD:1621606 6480464 Chlordecone results in decreased expression of MEG3 mRNA CTD PMID:33711761 chloroprene decreases expression ISO RGD:1621606 6480464 Chloroprene results in decreased expression of MEG3 mRNA CTD PMID:23125180 choline multiple interactions ISO RGD:1621606 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MEG3 mRNA CTD PMID:20938992 chrysene increases expression ISO RGD:1621606 6480464 chrysene results in increased expression of MEG3 mRNA CTD PMID:26377693 ciguatoxin CTX1B affects expression ISO RGD:1621606 6480464 Ciguatoxins affects the expression of MEG3 mRNA CTD PMID:18353800 cisplatin increases expression ISO RGD:1351308 6480464 Cisplatin results in increased expression of MEG3 mRNA CTD PMID:27392435 cobalt atom increases expression ISO RGD:1621606 6480464 Cobalt results in increased expression of MEG3 mRNA CTD PMID:34468815 cobalt dichloride increases expression ISO RGD:1351308 6480464 cobaltous chloride results in increased expression of MEG3 mRNA CTD PMID:33175458 DDE decreases methylation EXP 6480464 Dichlorodiphenyl Dichloroethylene results in decreased methylation of MEG3 gene CTD PMID:30153481 DDE multiple interactions EXP 6480464 [Dichlorodiphenyl Dichloroethylene results in decreased methylation of MEG3 gene] which results in increased expression of MEG3 mRNA CTD PMID:30153481 DDE increases expression EXP 6480464 Dichlorodiphenyl Dichloroethylene results in increased expression of MEG3 mRNA CTD PMID:30153481 DDT increases expression ISO RGD:1351308 6480464 DDT results in increased expression of MEG3 mRNA CTD PMID:25014179 Deoxyschizandrin multiple interactions ISO RGD:1351308 6480464 MEG3 protein affects the reaction [schizandrin A results in decreased expression of BCL2 protein] more ... CTD PMID:32057180 Deoxyschizandrin increases expression ISO RGD:1351308 6480464 schizandrin A results in increased expression of MEG3 mRNA CTD PMID:32057180 diarsenic trioxide increases expression ISO RGD:1351308 6480464 Arsenic Trioxide results in increased expression of MEG3 mRNA CTD PMID:31003765 diarsenic trioxide multiple interactions ISO RGD:1351308 6480464 MEG3 protein affects the reaction [Arsenic Trioxide results in decreased expression of CDH2 protein] more ... CTD PMID:31003765 dichloroacetic acid decreases expression ISO RGD:1621606 6480464 Dichloroacetic Acid results in decreased expression of MEG3 mRNA CTD PMID:28962523 dorsomorphin multiple interactions ISO RGD:1351308 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin decreases expression ISO RGD:1351308 6480464 Doxorubicin results in decreased expression of MEG3 mRNA CTD PMID:29803840 ethanol affects splicing ISO RGD:1621606 6480464 Ethanol affects the splicing of MEG3 mRNA CTD PMID:30319688 fipronil multiple interactions ISO RGD:1351308 6480464 [fipronil co-treated with DEET] results in decreased expression of MEG3 mRNA CTD PMID:28991164 fipronil decreases expression ISO RGD:1351308 6480464 fipronil results in decreased expression of MEG3 mRNA CTD PMID:28991164 folic acid multiple interactions ISO RGD:1621606 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MEG3 mRNA more ... CTD PMID:20938992 , PMID:22206623 folic acid decreases expression ISO RGD:1621606 6480464 Folic Acid results in decreased expression of MEG3 mRNA CTD PMID:25629700 folic acid decreases expression ISO RGD:1351308 6480464 Folic Acid results in decreased expression of MEG3 mRNA CTD PMID:21867686 fulvestrant multiple interactions ISO RGD:1351308 6480464 [bisphenol A co-treated with Fulvestrant] results in decreased methylation of MEG3 gene CTD PMID:31601247 graphene oxide increases expression ISO RGD:1621606 6480464 graphene oxide analog results in increased expression of MEG3 mRNA CTD PMID:33227293 L-methionine multiple interactions ISO RGD:1621606 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MEG3 mRNA CTD PMID:20938992 lead(0) increases methylation ISO RGD:1351308 6480464 Lead results in increased methylation of MEG3 gene CTD PMID:28123784 lead(2+) increases methylation ISO RGD:1351308 6480464 Lead results in increased methylation of MEG3 gene CTD PMID:28123784 methapyrilene increases methylation ISO RGD:1351308 6480464 Methapyrilene results in increased methylation of MEG3 intron CTD PMID:30157460 methimazole increases expression EXP 6480464 Methimazole results in increased expression of MEG3 mRNA CTD PMID:22504374 methoxychlor decreases methylation ISO RGD:1621606 6480464 Methoxychlor results in decreased methylation of MEG3 gene CTD PMID:21062904 methylisothiazolinone increases expression ISO RGD:1351308 6480464 2-methyl-4-isothiazolin-3-one results in increased expression of MEG3 mRNA CTD PMID:31629900 methylmercury chloride increases expression ISO RGD:1351308 6480464 methylmercuric chloride results in increased expression of MEG3 mRNA CTD PMID:34089799 methylmercury chloride affects expression ISO RGD:1351308 6480464 methylmercuric chloride affects the expression of MEG3 mRNA CTD PMID:34089799 N,N-diethyl-m-toluamide multiple interactions ISO RGD:1351308 6480464 [fipronil co-treated with DEET] results in decreased expression of MEG3 mRNA CTD PMID:28991164 N-methyl-4-phenylpyridinium increases expression ISO RGD:1351308 6480464 1-Methyl-4-phenylpyridinium results in increased expression of MEG3 mRNA CTD PMID:24810058 paracetamol affects expression ISO RGD:1621606 6480464 Acetaminophen affects the expression of MEG3 mRNA CTD PMID:17562736 pentanal increases expression ISO RGD:1351308 6480464 pentanal results in increased expression of MEG3 mRNA CTD PMID:26079696 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:1351308 6480464 perfluorooctane sulfonic acid results in decreased expression of MEG3 mRNA CTD PMID:27153767 phenobarbital multiple interactions ISO RGD:1621606 6480464 CTNNB1 protein affects the reaction [Phenobarbital results in increased expression of MEG3 mRNA] more ... CTD PMID:19482888 , PMID:23091169 phenobarbital increases expression ISO RGD:1351308 6480464 Phenobarbital results in increased expression of MEG3 mRNA CTD PMID:28541575 phenobarbital increases expression ISO RGD:1621606 6480464 Phenobarbital results in increased expression of MEG3 mRNA CTD PMID:19270015 more ... pirinixic acid multiple interactions ISO RGD:1621606 6480464 PPARA protein promotes the reaction [pirinixic acid results in decreased expression of MEG3 mRNA] CTD PMID:20059764 pirinixic acid decreases expression ISO RGD:1621606 6480464 pirinixic acid results in decreased expression of MEG3 mRNA CTD PMID:20059764 , PMID:23811191 propanal increases expression ISO RGD:1351308 6480464 propionaldehyde results in increased expression of MEG3 mRNA CTD PMID:26079696 S-adenosyl-L-methioninate multiple interactions ISO RGD:1351308 6480464 S-Adenosylmethionine inhibits the reaction [Arsenicals results in increased expression of MEG3 mRNA] CTD PMID:33033900 S-adenosyl-L-methionine multiple interactions ISO RGD:1351308 6480464 S-Adenosylmethionine inhibits the reaction [Arsenicals results in increased expression of MEG3 mRNA] CTD PMID:33033900 SB 431542 multiple interactions ISO RGD:1351308 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 sodium arsenate multiple interactions ISO RGD:1351308 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of MEG3 mRNA CTD PMID:32525701 tebuconazole decreases expression ISO RGD:1351308 6480464 tebuconazole results in decreased expression of MEG3 mRNA CTD PMID:30458266 temozolomide affects response to substance ISO RGD:1351308 6480464 MEG3 mRNA affects the susceptibility to Temozolomide CTD PMID:16365179 tetrachloromethane affects expression ISO RGD:1621606 6480464 Carbon Tetrachloride affects the expression of MEG3 mRNA CTD PMID:17484886 tetraphene affects expression ISO RGD:1621606 6480464 benz(a)anthracene affects the expression of MEG3 mRNA CTD PMID:26377693 titanium dioxide affects expression ISO RGD:1621606 6480464 titanium dioxide affects the expression of MEG3 mRNA CTD PMID:23557971 titanium dioxide decreases expression ISO RGD:1621606 6480464 titanium dioxide results in decreased expression of GTL2 mRNA CTD PMID:27760801 tremolite asbestos increases expression ISO RGD:1621606 6480464 tremolite results in increased expression of MEG3 mRNA CTD PMID:29279043 trichloroethene decreases expression ISO RGD:1621606 6480464 Trichloroethylene results in decreased expression of MEG3 mRNA CTD PMID:25549359 trichostatin A multiple interactions ISO RGD:1351308 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MEG3 mRNA CTD PMID:27188386 trichostatin A decreases expression ISO RGD:1351308 6480464 trichostatin A results in decreased expression of MEG3 mRNA CTD PMID:24935251 , PMID:26272509 valproic acid decreases expression ISO RGD:1351308 6480464 Valproic Acid results in decreased expression of MEG3 mRNA CTD PMID:23179753 more ... valproic acid multiple interactions ISO RGD:1351308 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MEG3 mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:1351308 6480464 Valproic Acid results in increased expression of MEG3 mRNA CTD PMID:29154799 vinclozolin decreases methylation ISO RGD:1621606 6480464 vinclozolin results in decreased methylation of MEG3 gene CTD PMID:19887539 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of MEG3 mRNA CTD PMID:20566332