Fzd1 (frizzled class receptor 1) - Rat Genome Database

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Gene: Fzd1 (frizzled class receptor 1) Rattus norvegicus
Analyze
Symbol: Fzd1
Name: frizzled class receptor 1
RGD ID: 61916
Description: Enables protein heterodimerization activity and protein homodimerization activity. Involved in several processes, including cellular response to vitamin D; lung alveolus development; and regulation of osteoblast differentiation. Located in plasma membrane. Orthologous to human FZD1 (frizzled class receptor 1); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; basal cell carcinoma pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Drosophila polarity gene (frizzled) homologue; Drosophila polarity gene homolog 1; ENSRNOG00000062541; frizzled family receptor 1; frizzled homolog 1; frizzled homolog 1 (Drosophila); frizzled homolog 1, (Drosophila); frizzled-1; fz-1; rFz1
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8430,265,074 - 30,269,472 (+)NCBIGRCr8
mRatBN7.2429,310,303 - 29,314,701 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl429,310,091 - 29,312,643 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl429,310,091 - 29,312,643 (+)NCBImRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx434,270,999 - 34,275,397 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0430,197,106 - 30,201,504 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0428,605,179 - 28,609,577 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0426,470,864 - 26,475,262 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl426,470,864 - 26,475,262 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0426,377,857 - 26,382,255 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4425,994,423 - 25,998,821 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1426,006,310 - 26,010,460 (+)NCBI
Celera424,743,049 - 24,747,447 (+)NCBICelera
Cytogenetic Map4q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-colchicine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
adenine  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dieldrin  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
ethosuximide  (EXP)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
hydroxyurea  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
nickel atom  (EXP,ISO)
niclosamide  (ISO)
nitrofen  (EXP)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
Ptaquiloside  (ISO)
pyrimidifen  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
astrocyte-dopaminergic neuron signaling  (IEA)
autocrine signaling  (ISO)
canonical Wnt signaling pathway  (IBA,IDA,IEA,ISO)
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation  (ISO)
cell-cell signaling  (ISO)
cellular response to growth factor stimulus  (IEP)
cellular response to peptide hormone stimulus  (IEP)
cellular response to vitamin D  (IEP)
endothelial cell differentiation  (IEA,ISO)
G protein-coupled receptor signaling pathway  (IEA)
hard palate development  (IEA,ISO)
lung alveolus development  (IEP)
membranous septum morphogenesis  (IEA,ISO)
muscular septum morphogenesis  (IEA,ISO)
negative regulation of BMP signaling pathway  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (IEA,ISO)
non-canonical Wnt signaling pathway  (IBA)
outflow tract morphogenesis  (IEA,ISO)
planar cell polarity pathway involved in neural tube closure  (IEA,ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of neuron projection development  (IDA)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of protein phosphorylation  (IEA,ISO)
regulation of mesenchymal stem cell differentiation  (ISO)
regulation of osteoblast differentiation  (IEP)
regulation of presynapse assembly  (IEA,ISO)
response to xenobiotic stimulus  (ISO)
ventricular septum morphogenesis  (ISO)
Wnt signaling pathway  (IDA)

Cellular Component
cell surface  (ISO)
plasma membrane  (IBA,IDA,IEA,TAS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Gene expression profiling in lung fibroblasts reveals new players in alveolarization. Boucherat O, etal., Physiol Genomics. 2007 Dec 19;32(1):128-41. Epub 2007 Oct 2.
2. Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues. Chan SD, etal., J Biol Chem 1992 Dec 15;267(35):25202-7.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization. Kaykas A, etal., Nat Cell Biol. 2004 Jan;6(1):52-8. Epub 2003 Dec 14.
5. Effects of parathyroid hormone on Wnt signaling pathway in bone. Kulkarni NH, etal., J Cell Biochem. 2005 Aug 15;95(6):1178-90.
6. Activation of rat frizzled-1 promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via pathways that require Galpha(q) and Galpha(o) function. Liu T, etal., J Biol Chem. 1999 Nov 19;274(47):33539-44.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Expression of Wnt genes and frizzled 1 and 2 receptors in normal breast epithelium and infiltrating breast carcinoma. Milovanovic T, etal., Int J Oncol. 2004 Nov;25(5):1337-42.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
16. A multilevel screening strategy defines a molecular fingerprint of proregenerative olfactory ensheathing cells and identifies SCARB2, a protein that improves regenerative sprouting of injured sensory spinal axons. Roet KC, etal., J Neurosci. 2013 Jul 3;33(27):11116-35. doi: 10.1523/JNEUROSCI.1002-13.2013.
17. Increased expression of secreted frizzled-related protein 4 in polycystic kidneys. Romaker D, etal., J Am Soc Nephrol. 2009 Jan;20(1):48-56. doi: 10.1681/ASN.2008040345. Epub 2008 Oct 22.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function. Varela-Nallar L, etal., Neural Dev. 2009 Nov 2;4:41.
20. Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5. Wang Z, etal., Mol Cell Biol. 2005 Jun;25(12):5022-30.
Additional References at PubMed
PMID:10395542   PMID:10557084   PMID:11433302   PMID:14627707   PMID:14739301   PMID:15143170   PMID:15809042   PMID:16936075   PMID:18521822   PMID:18929644   PMID:19188438   PMID:19388021  
PMID:19421142   PMID:19643732   PMID:20039315   PMID:20940229   PMID:21423176   PMID:21752258   PMID:28733458  


Genomics

Comparative Map Data
Fzd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8430,265,074 - 30,269,472 (+)NCBIGRCr8
mRatBN7.2429,310,303 - 29,314,701 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl429,310,091 - 29,312,643 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl429,310,091 - 29,312,643 (+)NCBImRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx434,270,999 - 34,275,397 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0430,197,106 - 30,201,504 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0428,605,179 - 28,609,577 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0426,470,864 - 26,475,262 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl426,470,864 - 26,475,262 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0426,377,857 - 26,382,255 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4425,994,423 - 25,998,821 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1426,006,310 - 26,010,460 (+)NCBI
Celera424,743,049 - 24,747,447 (+)NCBICelera
Cytogenetic Map4q13NCBI
FZD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38791,264,433 - 91,271,326 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl791,264,433 - 91,271,326 (+)EnsemblGRCh38hg38GRCh38
GRCh37790,893,748 - 90,900,641 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36790,731,719 - 90,736,068 (+)NCBINCBI36Build 36hg18NCBI36
Build 34790,538,433 - 90,542,783NCBI
Celera785,598,534 - 85,602,883 (+)NCBICelera
Cytogenetic Map7q21.13NCBI
HuRef785,501,893 - 85,506,245 (+)NCBIHuRef
CHM1_1790,823,675 - 90,828,024 (+)NCBICHM1_1
T2T-CHM13v2.0792,512,278 - 92,519,169 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2790,224,254 - 90,228,603 (+)NCBI
Fzd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3954,803,839 - 4,808,216 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl54,803,839 - 4,808,035 (-)EnsemblGRCm39 Ensembl
GRCm3854,753,839 - 4,758,216 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl54,753,839 - 4,758,035 (-)EnsemblGRCm38mm10GRCm38
MGSCv3754,753,839 - 4,758,216 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3654,759,845 - 4,763,977 (-)NCBIMGSCv36mm8
Celera54,685,028 - 4,689,405 (-)NCBICelera
Cytogenetic Map5A1NCBI
cM Map52.61NCBI
FZD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26109,152,613 - 109,162,445 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17157,420,947 - 157,429,695 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0783,269,906 - 83,277,608 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1796,805,227 - 96,876,188 (+)NCBIpanpan1.1PanPan1.1panPan2
FZD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11417,046,911 - 17,050,515 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1417,047,382 - 17,049,337 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1416,617,442 - 16,624,391 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01416,853,072 - 16,860,019 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1416,853,171 - 16,855,126 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11417,015,222 - 17,022,169 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01416,732,649 - 16,739,601 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01417,018,787 - 17,025,738 (+)NCBIUU_Cfam_GSD_1.0
Fzd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511830,465,239 - 30,469,955 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366212,900,995 - 2,902,947 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366212,899,183 - 2,903,427 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FZD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl971,349,988 - 71,352,104 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1971,346,994 - 71,356,488 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FZD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12157,695,000 - 57,702,666 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2157,699,468 - 57,701,417 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604246,532,184 - 46,537,450 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fzd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248092,021,124 - 2,025,589 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248092,021,118 - 2,025,826 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fzd1
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:883
Count of miRNA genes:316
Interacting mature miRNAs:419
Transcripts:ENSRNOT00000021979
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)42271068534430484Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat

Markers in Region
AW227548  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2429,314,063 - 29,314,209 (+)MAPPERmRatBN7.2
Rnor_6.0426,474,625 - 26,474,770NCBIRnor6.0
Rnor_5.0426,381,618 - 26,381,763UniSTSRnor5.0
RGSC_v3.4425,998,184 - 25,998,329UniSTSRGSC3.4
Celera424,746,810 - 24,746,955UniSTS
Cytogenetic Map4q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 40 10 8 11 8 55 35 33 11
Low 3 3 47 33 8 33 8 11 19 6 8
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021979   ⟹   ENSRNOP00000021979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl426,470,864 - 26,475,262 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111533   ⟹   ENSRNOP00000090878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl429,310,091 - 29,312,643 (+)Ensembl
RefSeq Acc Id: NM_021266   ⟹   NP_067089
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8430,265,074 - 30,269,472 (+)NCBI
mRatBN7.2429,310,303 - 29,314,701 (+)NCBI
Rnor_6.0426,470,864 - 26,475,262 (+)NCBI
Rnor_5.0426,377,857 - 26,382,255 (+)NCBI
RGSC_v3.4425,994,423 - 25,998,821 (+)RGD
Celera424,743,049 - 24,747,447 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_067089 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL84350 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000090878.1
GenBank Protein Q08463 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_067089   ⟸   NM_021266
- Peptide Label: precursor
- UniProtKB: Q08463 (UniProtKB/Swiss-Prot),   A6K268 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021979   ⟸   ENSRNOT00000021979
RefSeq Acc Id: ENSRNOP00000090878   ⟸   ENSRNOT00000111533
Protein Domains
FZ   G-protein coupled receptors family 2 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q08463-F1-model_v2 AlphaFold Q08463 1-641 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692840
Promoter ID:EPDNEW_R3365
Type:initiation region
Name:Fzd1_1
Description:frizzled class receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0426,470,867 - 26,470,927EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61916 AgrOrtholog
BioCyc Gene G2FUF-45785 BioCyc
Ensembl Genes ENSRNOG00000016242 Ensembl
  ENSRNOG00000062541 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000111533.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.2000.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Frizzled/SFRP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled/Smoothened_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:58868 UniProtKB/TrEMBL
NCBI Gene 58868 ENTREZGENE
PANTHER FRIZZLED-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11309 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Frizzled UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF01392 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fzd1 PhenoGen
PRINTS FRIZZLED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50038 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016242 RatGTEx
  ENSRNOG00000062541 RatGTEx
SMART FRI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF63501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC205498
UniProt A0A8I6ACQ8_RAT UniProtKB/TrEMBL
  A6K268 ENTREZGENE, UniProtKB/TrEMBL
  FZD1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Fzd1  frizzled class receptor 1  Fzd1  frizzled class receptor 1  Data merged from RGD:150342419 737654 PROVISIONAL
2022-01-06 Fzd1  frizzled class receptor 1  ENSRNOG00000062541    Symbol and/or name change 19259462 PROVISIONAL
2021-08-31 ENSRNOG00000062541        Symbol and Name status set to provisional 45752 PROVISIONAL
2014-02-06 Fzd1  frizzled class receptor 1  Fzd1  frizzled family receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Fzd1  frizzled family receptor 1  Fzd1  frizzled homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Fzd1  frizzled homolog 1 (Drosophila)      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression widely expressed 61590
gene_protein 641 amino acids 61590