Fzd1 (frizzled class receptor 1) - Rat Genome Database

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Gene: Fzd1 (frizzled class receptor 1) Mus musculus
Analyze
Symbol: Fzd1
Name: frizzled class receptor 1
RGD ID: 62209
MGI Page MGI
Description: Enables Wnt-protein binding activity. Involved in astrocyte-dopaminergic neuron signaling; negative regulation of oxidative stress-induced neuron death; and regulation of presynapse assembly. Acts upstream of or within several processes, including Wnt signaling pathway; heart morphogenesis; and negative regulation of signal transduction. Predicted to be located in cell surface and neuron projection. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and sensory organ. Orthologous to human FZD1 (frizzled class receptor 1); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; basal cell carcinoma pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW227548; frizzled homolog 1; frizzled-1; FZ-1; Fz1; mFz1
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3954,803,839 - 4,808,216 (-)NCBIGRCm39mm39
GRCm39 Ensembl54,803,839 - 4,808,035 (-)Ensembl
GRCm3854,753,839 - 4,758,216 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl54,753,839 - 4,758,035 (-)EnsemblGRCm38mm10GRCm38
MGSCv3754,753,839 - 4,758,216 (-)NCBIGRCm37mm9NCBIm37
MGSCv3654,759,845 - 4,763,977 (-)NCBImm8
Celera54,685,028 - 4,689,405 (-)NCBICelera
Cytogenetic Map5A1NCBI
cM Map52.61NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-colchicine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
adenine  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
antimycin A  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
camptothecin  (ISO)
carbon nanotube  (EXP)
chlorpyrifos  (ISO)
choline  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
disodium selenite  (EXP)
dorsomorphin  (ISO)
ethanol  (EXP)
ethosuximide  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
flutamide  (ISO)
folic acid  (EXP)
furan  (ISO)
genistein  (ISO)
hydroxyurea  (ISO)
indometacin  (ISO)
L-methionine  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
nitrofen  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorononanoic acid  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
Ptaquiloside  (EXP)
pyrimidifen  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
triclosan  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
astrocyte-dopaminergic neuron signaling  (IMP)
autocrine signaling  (ISO)
canonical Wnt signaling pathway  (IBA,IGI,IMP,ISO)
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation  (ISO)
canonical Wnt signaling pathway involved in osteoblast differentiation  (ISO)
cell surface receptor signaling pathway  (IEA)
cell-cell signaling  (IDA,ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to vitamin D  (ISO)
epithelial cell differentiation  (IDA,IGI)
G protein-coupled receptor signaling pathway  (IEA)
hard palate development  (IGI)
lung alveolus development  (ISO)
membranous septum morphogenesis  (IGI)
muscular septum morphogenesis  (IGI)
negative regulation of BMP signaling pathway  (IDA)
negative regulation of canonical Wnt signaling pathway  (IDA)
negative regulation of oxidative stress-induced neuron death  (IMP)
negative regulation of transcription, DNA-templated  (IMP)
non-canonical Wnt signaling pathway  (IBA)
outflow tract morphogenesis  (IGI)
planar cell polarity pathway involved in neural tube closure  (IGI)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of protein phosphorylation  (IMP)
positive regulation of transcription, DNA-templated  (ISO)
regulation of osteoblast differentiation  (ISO)
regulation of presynapse assembly  (IDA,IMP)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)
ventricular septum morphogenesis  (IGI)
Wnt signaling pathway  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:9362463   PMID:10349636   PMID:10559494   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11334716   PMID:11500834   PMID:11861511   PMID:12067714   PMID:12466851  
PMID:12477932   PMID:12812787   PMID:12923052   PMID:14627707   PMID:14662765   PMID:14681479   PMID:15143170   PMID:15226823   PMID:15245425   PMID:15342465   PMID:15809042   PMID:16141072  
PMID:16141073   PMID:16378759   PMID:16602821   PMID:16936075   PMID:16978288   PMID:17064353   PMID:17145500   PMID:17150988   PMID:17257418   PMID:17475678   PMID:17496152   PMID:17532316  
PMID:17576136   PMID:17582687   PMID:17804636   PMID:18351662   PMID:18351675   PMID:18364260   PMID:18635608   PMID:18800919   PMID:19515997   PMID:19562671   PMID:19883499   PMID:20171206  
PMID:20189955   PMID:20667980   PMID:20940229   PMID:21041481   PMID:21246654   PMID:21267068   PMID:21382550   PMID:21623369   PMID:21731673   PMID:21752258   PMID:21862448   PMID:21873635  
PMID:22235033   PMID:22954793   PMID:23095888   PMID:23553522   PMID:24151333   PMID:24475942   PMID:24727668   PMID:24860427   PMID:24952961   PMID:24997765   PMID:25329657   PMID:25727890  
PMID:25805134   PMID:26443994   PMID:26883626   PMID:26979619   PMID:26980182   PMID:27510977   PMID:27913639   PMID:28813421   PMID:30485816   PMID:30978219   PMID:31452509   PMID:32253237  
PMID:33141892  


Genomics

Comparative Map Data
Fzd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3954,803,839 - 4,808,216 (-)NCBIGRCm39mm39
GRCm39 Ensembl54,803,839 - 4,808,035 (-)Ensembl
GRCm3854,753,839 - 4,758,216 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl54,753,839 - 4,758,035 (-)EnsemblGRCm38mm10GRCm38
MGSCv3754,753,839 - 4,758,216 (-)NCBIGRCm37mm9NCBIm37
MGSCv3654,759,845 - 4,763,977 (-)NCBImm8
Celera54,685,028 - 4,689,405 (-)NCBICelera
Cytogenetic Map5A1NCBI
cM Map52.61NCBI
FZD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl791,264,433 - 91,271,326 (+)EnsemblGRCh38hg38GRCh38
GRCh38791,264,433 - 91,271,326 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37790,893,748 - 90,900,641 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36790,731,719 - 90,736,068 (+)NCBINCBI36hg18NCBI36
Build 34790,538,433 - 90,542,783NCBI
Celera785,598,534 - 85,602,883 (+)NCBI
Cytogenetic Map7q21.13NCBI
HuRef785,501,893 - 85,506,245 (+)NCBIHuRef
CHM1_1790,823,675 - 90,828,024 (+)NCBICHM1_1
CRA_TCAGchr7v2790,224,254 - 90,228,603 (+)NCBI
Fzd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2429,310,303 - 29,314,701 (+)NCBImRatBN7.2
Rnor_6.0426,470,864 - 26,475,262 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl426,470,864 - 26,475,262 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0426,377,857 - 26,382,255 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4425,994,423 - 25,998,821 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1426,006,310 - 26,010,460 (+)NCBI
Celera424,743,049 - 24,747,447 (+)NCBICelera
Cytogenetic Map4q13NCBI
FZD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1796,805,227 - 96,876,188 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0783,269,906 - 83,277,608 (+)NCBIMhudiblu_PPA_v0panPan3
FZD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11417,046,911 - 17,050,515 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1417,047,382 - 17,049,337 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1416,617,442 - 16,624,391 (+)NCBI
ROS_Cfam_1.01416,853,072 - 16,860,019 (+)NCBI
UMICH_Zoey_3.11417,015,222 - 17,022,169 (+)NCBI
UNSW_CanFamBas_1.01416,732,649 - 16,739,601 (+)NCBI
UU_Cfam_GSD_1.01417,018,787 - 17,025,738 (+)NCBI
Fzd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511830,465,239 - 30,469,955 (+)NCBI
SpeTri2.0NW_0049366212,899,183 - 2,903,427 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FZD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl971,349,988 - 71,352,104 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1971,346,994 - 71,356,488 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FZD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12157,695,000 - 57,702,666 (-)NCBI
ChlSab1.1 Ensembl2157,699,468 - 57,701,417 (-)Ensembl
Vero_WHO_p1.0NW_02366604246,532,184 - 46,537,450 (+)NCBI
Fzd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248092,021,118 - 2,025,826 (-)NCBI

Position Markers
AW227548  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3854,754,096 - 4,754,241UniSTSGRCm38
MGSCv3754,754,096 - 4,754,241UniSTSGRCm37
Celera54,685,285 - 4,685,430UniSTS
Cytogenetic Map5A1UniSTS
cM Map55.0UniSTS
Whitehead/MRC_RH576.18UniSTS
Fzd1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3854,756,864 - 4,757,525UniSTSGRCm38
MGSCv3754,756,864 - 4,757,525UniSTSGRCm37
Celera54,688,053 - 4,688,714UniSTS
Cytogenetic Map5A1UniSTS
cM Map55.0UniSTS
cM Map55.0UniSTS
Fzd2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811102,606,115 - 102,606,190UniSTSGRCm38
GRCm3854,755,927 - 4,756,003UniSTSGRCm38
MGSCv3711102,467,014 - 102,467,354UniSTSGRCm37
MGSCv3711102,466,845 - 102,467,501UniSTSGRCm37
MGSCv3711102,466,749 - 102,466,920UniSTSGRCm37
Celera11114,316,304 - 114,316,379UniSTS
Celera54,687,116 - 4,687,192UniSTS
Cytogenetic Map5A1UniSTS
Cytogenetic Map11E1UniSTS
cM Map11 UniSTS
REN110715  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3854,757,290 - 4,757,534UniSTSGRCm38
MGSCv3754,757,290 - 4,757,534UniSTSGRCm37
Celera54,688,479 - 4,688,723UniSTS
Cytogenetic Map5A1UniSTS
cM Map55.0UniSTS
Fzd1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3854,754,728 - 4,754,963UniSTSGRCm38
MGSCv3754,754,728 - 4,754,963UniSTSGRCm37
Celera54,685,917 - 4,686,152UniSTS
Cytogenetic Map5A1UniSTS
Fzd1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3854,754,798 - 4,754,928UniSTSGRCm38
MGSCv3754,754,798 - 4,754,928UniSTSGRCm37
Celera54,685,987 - 4,686,117UniSTS
Cytogenetic Map5A1UniSTS
Fzd1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5A1UniSTS
cM Map55.0UniSTS
Fzd1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3854,756,474 - 4,756,636UniSTSGRCm38
MGSCv3754,756,474 - 4,756,636UniSTSGRCm37
Celera54,687,663 - 4,687,825UniSTS
Cytogenetic Map5A1UniSTS
Fzd1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5A1UniSTS
Fzd1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3854,755,983 - 4,756,075UniSTSGRCm38
GRCm3811102,606,042 - 102,606,134UniSTSGRCm38
MGSCv3711102,467,356 - 102,467,448UniSTSGRCm37
MGSCv3754,755,983 - 4,756,075UniSTSGRCm37
Celera11114,316,231 - 114,316,323UniSTS
Celera54,687,172 - 4,687,264UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map5A1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141234Pbwg14_mpostnatal body weight growth 14 (mouse)Not determined5121223552Mouse
1301468Eye1_meye weight 1 (mouse)Not determined5121879650Mouse
10412081Bwq13_mbody weight QTL 13 (mouse)Not determined5123556323Mouse
12904958Gmmq8_mgastrocnemius muscle mass QTL 8 (mouse)5129371157Mouse
10401122Pgia41_mproteoglycan induced arthritis 41 (mouse)Not determined561814634618282Mouse
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5329982537299825Mouse
13442491Mecth1_mmechanosensation threshold 1 (mouse)5446800019630000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:796
Count of miRNA genes:473
Interacting mature miRNAs:573
Transcripts:ENSMUST00000054294
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000054294   ⟹   ENSMUSP00000058629
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl54,803,839 - 4,808,035 (-)Ensembl
GRCm38.p6 Ensembl54,753,839 - 4,758,035 (-)Ensembl
RefSeq Acc Id: NM_021457   ⟹   NP_067432
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3954,803,839 - 4,808,216 (-)NCBI
GRCm3854,753,839 - 4,758,216 (-)ENTREZGENE
MGSCv3754,753,839 - 4,758,216 (-)RGD
Celera54,685,028 - 4,689,405 (-)RGD
cM Map5 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_067432   ⟸   NM_021457
- Peptide Label: precursor
- UniProtKB: O70421 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000058629   ⟸   ENSMUST00000054294
Protein Domains
FZ

Promoters
RGD ID:6837547
Promoter ID:MM_KWN:41286
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_021457
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3654,755,011 - 4,759,102 (-)MPROMDB
RGD ID:6885924
Promoter ID:EPDNEW_M6412
Type:initiation region
Name:Fzd1_1
Description:Mus musculus frizzled class receptor 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3854,757,986 - 4,758,046EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1196625 AgrOrtholog
Ensembl Genes ENSMUSG00000044674 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000058629 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000054294 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.2000.10 UniProtKB/Swiss-Prot
InterPro Frizzled/SFRP UniProtKB/Swiss-Prot
  Frizzled/Smoothened_TM UniProtKB/Swiss-Prot
  Frizzled_dom UniProtKB/Swiss-Prot
  Frizzled_dom_sf UniProtKB/Swiss-Prot
  FZD1/2 UniProtKB/Swiss-Prot
  GPCR_2-like UniProtKB/Swiss-Prot
KEGG Report mmu:14362 UniProtKB/Swiss-Prot
MGD MGI:1196625 ENTREZGENE
NCBI Gene 14362 ENTREZGENE
PANTHER PTHR11309 UniProtKB/Swiss-Prot
  PTHR11309:SF34 UniProtKB/Swiss-Prot
Pfam Frizzled UniProtKB/Swiss-Prot
  PF01392 UniProtKB/Swiss-Prot
PhenoGen Fzd1 PhenoGen
PRINTS FRIZZLED UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot
  PS50038 UniProtKB/Swiss-Prot
SMART FRI UniProtKB/Swiss-Prot
  Frizzled UniProtKB/Swiss-Prot
Superfamily-SCOP SSF63501 UniProtKB/Swiss-Prot
UniProt FZD1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O08974 UniProtKB/Swiss-Prot
  Q7TS82 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-22 Fzd1  frizzled class receptor 1    frizzled homolog 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED