FZD1 (frizzled class receptor 1) - Rat Genome Database

Name: FZD1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: FZD1 (frizzled class receptor 1) Canis lupus familiaris

Analyze

Symbol:

FZD1

Name:

frizzled class receptor 1

RGD ID:

12060987

Description:

ENCODES a protein that exhibits identical protein binding (ortholog); protein heterodimerization activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); cell-cell signaling (ortholog); cellular response to growth factor stimulus (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH breast carcinoma (ortholog); pleomorphic xanthoastrocytoma (ortholog); FOUND IN cell surface (inferred); membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

frizzled 1, seven transmembrane spanning receptor; frizzled family receptor 1; frizzled homolog 1; frizzled-1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FZD1 (frizzled class receptor 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Fzd1 (frizzled class receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Fzd1 (frizzled class receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FZD1 (frizzled class receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fzd1 (frizzled class receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FZD1 (frizzled class receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FZD1 (frizzled class receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fzd1 (frizzled class receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	17,046,911 - 17,050,515 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	17,047,382 - 17,049,337 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	16,617,442 - 16,624,391 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	16,853,072 - 16,860,019 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	16,853,171 - 16,855,126 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	17,015,222 - 17,022,169 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	16,732,649 - 16,739,601 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	17,018,787 - 17,025,738 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

breast carcinoma (ISO)

pleomorphic xanthoastrocytoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

astrocyte-dopaminergic neuron signaling (IEA)

autocrine signaling (IEA)

canonical Wnt signaling pathway (IEA,ISO)

cell surface receptor signaling pathway (IEA)

cell-cell signaling (IEA,ISO)

cellular response to growth factor stimulus (ISO)

cellular response to peptide hormone stimulus (ISO)

cellular response to vitamin D (ISO)

endothelial cell differentiation (IEA,ISO)

G protein-coupled receptor signaling pathway (IEA)

hard palate development (IEA,ISO)

lung alveolus development (ISO)

membranous septum morphogenesis (IEA,ISO)

muscular septum morphogenesis (IEA,ISO)

negative regulation of BMP signaling pathway (IEA,ISO)

negative regulation of canonical Wnt signaling pathway (IEA,ISO)

negative regulation of DNA-templated transcription (IEA,ISO)

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway (IEA)

obsolete planar cell polarity pathway involved in neural tube closure (IEA,ISO)

outflow tract morphogenesis (IEA,ISO)

positive regulation of DNA-binding transcription factor activity (IEA)

positive regulation of DNA-templated transcription (IEA)

positive regulation of neuron projection development (ISO)

positive regulation of osteoblast differentiation (IEA)

positive regulation of protein phosphorylation (ISO)

regulation of mesenchymal stem cell differentiation (IEA)

regulation of osteoblast differentiation (ISO)

regulation of presynapse assembly (IEA)

response to xenobiotic stimulus (IEA)

ventricular septum morphogenesis (IEA,ISO)

Wnt signaling pathway (IEA,ISO)

Cellular Component

cell surface (IEA)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

frizzled binding (IEA)

G protein-coupled receptor activity (IEA)

identical protein binding (ISO)

PDZ domain binding (IEA)

protein binding (ISO)

protein heterodimerization activity (ISO)

protein homodimerization activity (ISO)

signaling receptor binding (IEA)

transmembrane signaling receptor activity (IEA)

Wnt receptor activity (IEA)

Wnt-protein binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

Wnt signaling pathway (ISO)

Wnt signaling, canonical pathway (ISO)

References

Additional References at PubMed

PMID:19194078	PMID:30032202

Genomics

Comparative Map Data

FZD1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	17,046,911 - 17,050,515 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	17,047,382 - 17,049,337 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	16,617,442 - 16,624,391 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	16,853,072 - 16,860,019 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	16,853,171 - 16,855,126 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	17,015,222 - 17,022,169 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	16,732,649 - 16,739,601 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	17,018,787 - 17,025,738 (+)	NCBI		UU_Cfam_GSD_1.0

FZD1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	91,264,433 - 91,271,326 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	91,264,433 - 91,271,326 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	90,893,748 - 90,900,641 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	90,731,719 - 90,736,068 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	90,538,433 - 90,542,783	NCBI
Celera	7	85,598,534 - 85,602,883 (+)	NCBI		Celera
Cytogenetic Map	7	q21.13	NCBI
HuRef	7	85,501,893 - 85,506,245 (+)	NCBI		HuRef
CHM1_1	7	90,823,675 - 90,828,024 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	92,512,278 - 92,519,169 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	90,224,254 - 90,228,603 (+)	NCBI

Fzd1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	4,803,839 - 4,808,216 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	4,803,839 - 4,808,035 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	4,753,839 - 4,758,216 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	4,753,839 - 4,758,035 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	4,753,839 - 4,758,216 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	4,759,845 - 4,763,977 (-)	NCBI		MGSCv36	mm8
Celera	5	4,685,028 - 4,689,405 (-)	NCBI		Celera
Cytogenetic Map	5	A1	NCBI
cM Map	5	2.61	NCBI

Fzd1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	30,265,074 - 30,269,472 (+)	NCBI		GRCr8
mRatBN7.2	4	29,310,303 - 29,314,701 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	29,310,091 - 29,312,643 (+)	Ensembl		mRatBN7.2 Ensembl
mRatBN7.2 Ensembl	4	29,310,091 - 29,312,643 (+)	NCBI		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	34,270,999 - 34,275,397 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	30,197,106 - 30,201,504 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	28,605,179 - 28,609,577 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	26,470,864 - 26,475,262 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	26,470,864 - 26,475,262 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	26,377,857 - 26,382,255 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	25,994,423 - 25,998,821 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	26,006,310 - 26,010,460 (+)	NCBI
Celera	4	24,743,049 - 24,747,447 (+)	NCBI		Celera
Cytogenetic Map	4	q13	NCBI

FZD1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	109,152,613 - 109,162,445 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	157,420,947 - 157,429,695 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	83,269,906 - 83,277,608 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	96,805,227 - 96,876,188 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

Fzd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	30,465,239 - 30,469,955 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936621	2,900,995 - 2,902,947 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936621	2,899,183 - 2,903,427 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FZD1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	71,349,988 - 71,352,104 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	71,346,994 - 71,356,488 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

FZD1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	57,695,000 - 57,702,666 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	57,699,468 - 57,701,417 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	46,532,184 - 46,537,450 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fzd1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624809	2,021,124 - 2,025,589 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624809	2,021,118 - 2,025,826 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in FZD1
19 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium	2		8	1		1	6				10	3
Low	3	5	14	5	6	5		6	12	8		3
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_038494471	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038556765	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038620700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038686385	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_539411	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU332999	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000156	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000003022 ⟹ ENSCAFP00000002804

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	14	17,047,382 - 17,049,337 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845021501 ⟹ ENSCAFP00845016898

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	14	16,853,171 - 16,855,126 (+)	Ensembl

RefSeq Acc Id:

XM_038494471 ⟹ XP_038350399

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	14	17,015,222 - 17,022,169 (+)	NCBI

RefSeq Acc Id:

XM_038556765 ⟹ XP_038412693

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	14	17,018,787 - 17,025,738 (+)	NCBI

RefSeq Acc Id:

XM_038620700 ⟹ XP_038476628

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	14	16,732,649 - 16,739,601 (+)	NCBI

RefSeq Acc Id:

XM_038686385 ⟹ XP_038542313

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	14	16,853,072 - 16,860,019 (+)	NCBI

RefSeq Acc Id:

XM_539411 ⟹ XP_539411

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	14	17,046,911 - 17,050,515 (+)	NCBI
Dog10K_Boxer_Tasha	14	16,617,442 - 16,624,391 (+)	NCBI

Sequence:

show sequence

TGCGGGGCGCCTGGAAACCGGTCCGAGGGCGCGCGCGAGAGAGGAGAGCGAGCGAGTTGAGGGA
TTGACACAAATGGTCAGGCGGCGGCGGCGGAGAAGGAGGCGGAGGCGCAGGGGGGAGTCGAGGC
CGCTGGGCTGCGGAGAGTTGCGCGCTCCACGGGGCCGCGGCCACTAGCGCTGCGCCGCCAGCCG
GGAACCCGCAACGCCAAGGGCCGGGAAGGCGGGACGCGACCCCGGCGCGCCGGAGCCACCCGGG
CTCTCCCCGCCGCCCACGCTTCATGAATCGCAAGTTTCCGCGGCGGCGGCGGCTGCGGGACGCG
GAGCGGGAGCCGGGGCAGCGGGCGGAGCGCGGCTTGGGCTCGACGGAGGGCACCGGCGCGGAGG
AGATCTCCCCGGCCGCTGGGGGGGCCGCCGCCCGCTGCGCCACTGCCAGCCCGCGCCGAGCGGC
GCCGAGGACGGAGCCGAGAAAGTATGGCTGAAGAGGAGGCGCCTAAGAAGTCCCGGGCCGCCGG
CGGCCGCGCGAGCTGGGAACTTTGCGCTGGGGCGCTCCCGGCGGGACCCGGCGCGGAGCCGAGC
GGGGACGCGGGCAGCCGCCGCCGCCGCCGCCCGCGAGCTGACTCCGGACGCTTGGCGCGCCGGC
TGCTGCTACTGCTTTGGCTGCTGGAGGCTCCGCTGCTGCCGGGGGTCCGGGGGCAGGCGGGGGG
CCAGGGGCCGGGCCAGGGCCCCGGGCCGGGGCAGCAGCCCCCGCCGCCGGCGCCTCAGCAGCAG
CAGAGCGGGCAACAGTACAATGGCGAGAGGGGCATCTCCATCCCGGACCACGGCTACTGCCAGC
CCATCTCCATCCCGCTGTGCACGGACATCGCGTACAACCAGACCATCATGCCCAACCTTTTGGG
CCACACCAACCAGGAGGACGCGGGCCTCGAGGTGCACCAGTTCTACCCGTTGGTGAAGGTGCAG
TGTTCGGCGGAGCTCAAGTTCTTCCTGTGCTCCATGTACGCGCCCGTGTGCACCGTGCTGGAGC
AGGCGCTGCCGCCCTGCCGCTCTCTGTGCGAGCGCGCGCGCCAGGGCTGCGAGGCGCTCATGAA
CAAGTTCGGCTTCCAGTGGCCTGACACGCTCAAGTGCGAGAAGTTCCCGGTGCACGGCGCGGGC
GAGCTGTGCGTGGGCCAGAACACGTCGGACAAGGGCACCCCGACGCCCTCCTTGCTGCCGGAGT
TCTGGACCAGCAACCCTCAGCACGGCGGCGGGGGGCACCGTGGCGGCGGCTTTCCGGGGGGCGC
GGGCGCGTCGGAGCGGGGCAAGTTCTCGTGCCCGCGCGCCCTCAAGGTGCCCTCCTACCTCAAC
TACCACTTCCTGGGGGAGAAAGACTGCGGCGCGCCGTGTGAGCCGACCAAGGTGTACGGGCTCA
TGTACTTTGGGCCCGAGGAACTGCGCTTCTCGCGCACCTGGATCGGCATCTGGTCGGTGCTGTG
CTGCGCCTCCACGCTCTTCACGGTGCTCACCTACCTGGTGGACATGCGGCGCTTCAGCTACCCG
GAGCGGCCCATCATCTTCCTGTCGGGCTGCTACACGGCGGTGGCCGTGGCCTACATCGCCGGCT
TCCTGCTGGAGGACCGTGTGGTGTGTAACGACAAGTTCTCCGAGGACGGGGCGCGCACAGTGGC
GCAGGGCACCAAGAAGGAGGGCTGCACCATCCTCTTCATGATGCTCTACTTCTTTAGCATGGCC
AGCTCCATCTGGTGGGTGATTCTGTCGCTCACCTGGTTCCTGGCAGCCGGCATGAAGTGGGGTC
ACGAAGCCATCGAGGCTAACTCGCAGTATTTTCACCTGGCTGCTTGGGCCGTGCCAGCCATCAA
GACCATCACCATCCTGGCGCTGGGCCAGGTGGACGGCGACGTGCTGAGCGGGGTGTGCTTCGTG
GGGCTCAATAACGTGGACGCGCTGCGCGGCTTCGTGCTGGCGCCGCTCTTCGTGTACCTGTTCA
TCGGCACGTCCTTCCTGCTGGCCGGCTTCGTGTCCCTCTTCCGCATTCGCACCATCATGAAGCA
CGACGGCACCAAGACGGAGAAGCTGGAGAAGCTCATGGTGCGCATCGGCGTCTTCAGCGTGCTC
TACACGGTGCCAGCCACCATCGTCATCGCCTGCTACTTCTACGAGCAGGCCTTCCGGGACCAGT
GGGAGCGCAGCTGGGTGGCCCAGAGCTGCAAGAGCTATGCCATCCCCTGCCCCCACCTCCAGGC
GGGTGGAGGCGCCCCGCCCCACCCGCCCATGAGCCCAGACTTCACAGTCTTCATGATCAAGTAC
CTTATGACACTGATCGTGGGCATCACGTCAGGCTTCTGGATCTGGTCCGGCAAGACCCTCAACT
CCTGGAGGAAGTTCTATACCAGGCTTACCAACAGCAAACAGGGAGAGACCACCGTCTGAGACCC
CCGGGGGCTCAGCCCAGTCCCAGCCACCCCCAACACGCTGGCCCCGTGGAAACCTTGCCAGACC
TGGCTACTCAAGGCTTCCTCGCTAGCCCTTCGCTTTTCGCAGGCTCCTTTTCACAACGCGGCTC
CTGCAAAAGCTTCCGTCCCCGGGGGGCAAACGGACTGGAGGGCCCAACCGCCACAGGGGGGACA
GAGAGACGCCTCTCTCGTCCTCACACTCTGGTACCTGGACTGTGTGCTTTTATGATTGTAAATA
GCCTGTGTAAGATTTTTGTAAGTATATTTGTATTTAAATGACGACCGATCACGCGTTTTTCTTT
TTCTTCCTCTTCTTTTCTTTTTTTGGTTTTGTTCGAATTTTAATTATTTAGGGGCCCGTTTAAC
CATCTGAGGCTTTTCCTTCTTTCTCTTTTCAAAGTACTGCAGAGATAAAACCGGAGCTCGCGGT
GCTCCCCCTTGTTCTGGCACGCCCCTCCCTGCGGGCGGTGGGGTGCCTCTGGGCCCGGCGGCCC
AAGTCGCTCGCCTCCTCCTCTTTCTACTCCCCCCACCCCCACCTTTCCCTTCAGTGCTTGGGGT
CAGGACTCTTTAGTTACAGAGCTCCACAGAGTTTCCAAAACCGGGGGTAGGCCCCTGCCCATCC
CAGGCGTACCCTCGAGGAGCAGGAGGTCCCAGATTGTGAAGGCCTTGTCCCTCTGACTATCCGA
AACTGAATTTTTCTCTGTCGAGAACCTTACCCTTAGCTTCTAGGAGGCCCACAGATACAGGCTG
TGGCAGTCCCAGCCTCCTTCCACACCAGCTTCCAACGCCCAGGCACTCCCTCCTTCCACCTAAG
TTGCTTAGAGGTTGAGTGGGATAACCAGTGCCAAACTTTTTCAAGTCTAATTTTTGGTGGATGA
GCTCATTTCATTCTCTAGTGTCTAAAACCTGGTATGGGTTTGGCCAGCGTCATGGAAAGATGTG
GTTGCTGAGATTTGGGAAGAGGCATGAAGCTTTGTGTGGTTTGGGAGAGACTGAAGATGGGGAT
TATAAAATGTTAATTCTAATTGCATACGGATGCCTGGCAAACTGCCTATAGCACTGAGACAGCC
CACATTTCAGTTTTACCTTTCTGTAAAAAAAAAAAAAAAAAGAAAGAAACAGTAAGTCACCTGG
AAAGCTTTGTTAAGGAGTTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_038350399	(Get FASTA)	NCBI Sequence Viewer
	XP_038412693	(Get FASTA)	NCBI Sequence Viewer
	XP_038476628	(Get FASTA)	NCBI Sequence Viewer
	XP_038542313	(Get FASTA)	NCBI Sequence Viewer
	XP_539411	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ACA13166	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000002804.4
	ENSCAFP00030015613.1
	ENSCAFP00040027300.1
	ENSCAFP00845016898
	ENSCAFP00845016898.1

RefSeq Acc Id:

XP_539411 ⟸ XM_539411

- UniProtKB:

A0A8C0R260 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAEEEAPKKSRAAGGRASWELCAGALPAGPGAEPSGDAGSRRRRRPRADSGRLARRLLLLLWLL
EAPLLPGVRGQAGGQGPGQGPGPGQQPPPPAPQQQQSGQQYNGERGISIPDHGYCQPISIPLCT
DIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRS
LCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQH
GGGGHRGGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEEL
RFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVV
CNDKFSEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANS
QYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLA
GFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQ
SCKSYAIPCPHLQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTR
LTNSKQGETTV

hide sequence

Ensembl Acc Id:

ENSCAFP00000002804 ⟸ ENSCAFT00000003022

RefSeq Acc Id:

XP_038350399 ⟸ XM_038494471

RefSeq Acc Id:

XP_038476628 ⟸ XM_038620700

RefSeq Acc Id:	XP_038542313 ⟸ XM_038686385
- UniProtKB:	A0A8C0Z0A4 (UniProtKB/TrEMBL), A0A8I3NK38 (UniProtKB/TrEMBL), A0A8C0R260 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038412693 ⟸ XM_038556765
- UniProtKB:	A0A8C0R260 (UniProtKB/TrEMBL), A0A8C0Z0A4 (UniProtKB/TrEMBL), A0A8I3NK38 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845016898 ⟸ ENSCAFT00845021501

Protein Domains

FZ G-protein coupled receptors family 2 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000001906	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030009671	UniProtKB/TrEMBL
	ENSCAFG00040017012	UniProtKB/TrEMBL
	ENSCAFG00845012103	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000003022.4	UniProtKB/TrEMBL
	ENSCAFT00030017876.1	UniProtKB/TrEMBL
	ENSCAFT00040031394.1	UniProtKB/TrEMBL
	ENSCAFT00845021501	ENTREZGENE
	ENSCAFT00845021501.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.2000.10	UniProtKB/TrEMBL
	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	Frizzled/SFRP	UniProtKB/TrEMBL
	Frizzled/Smoothened_TM	UniProtKB/TrEMBL
	Frizzled_dom	UniProtKB/TrEMBL
	Frizzled_dom_sf	UniProtKB/TrEMBL
	GPCR_2-like	UniProtKB/TrEMBL
NCBI Gene	FZD1	ENTREZGENE
PANTHER	FRIZZLED-1	UniProtKB/TrEMBL
	PTHR11309	UniProtKB/TrEMBL
Pfam	Frizzled	UniProtKB/TrEMBL
	PF01392	UniProtKB/TrEMBL
PRINTS	FRIZZLED	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F2_4	UniProtKB/TrEMBL
	PS50038	UniProtKB/TrEMBL
SMART	FRI	UniProtKB/TrEMBL
	Frizzled	UniProtKB/TrEMBL
Superfamily-SCOP	SSF63501	UniProtKB/TrEMBL
UniProt	A0A8C0R260	ENTREZGENE
	A0A8C0Z0A4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3NK38	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0S7Z1_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:41028	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

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Imported Disease Annotations - ClinVar

RGD Manual Annotations