Fzd1 (frizzled class receptor 1) - Rat Genome Database

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Gene: Fzd1 (frizzled class receptor 1) Ictidomys tridecemlineatus
Analyze
Symbol: Fzd1
Name: frizzled class receptor 1
RGD ID: 12622673
Description: ENCODES a protein that exhibits identical protein binding (ortholog); protein heterodimerization activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); cell-cell signaling (ortholog); cellular response to growth factor stimulus (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH breast carcinoma (ortholog); pleomorphic xanthoastrocytoma (ortholog); FOUND IN cell surface (inferred); membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: frizzled family receptor 1; frizzled-1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511830,465,239 - 30,469,955 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366212,900,995 - 2,902,947 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366212,899,183 - 2,903,427 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
astrocyte-dopaminergic neuron signaling  (IEA)
autocrine signaling  (IEA)
canonical Wnt signaling pathway  (IEA,ISO)
cell surface receptor signaling pathway  (IEA)
cell-cell signaling  (IEA,ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to vitamin D  (ISO)
endothelial cell differentiation  (IEA,ISO)
G protein-coupled receptor signaling pathway  (IEA)
hard palate development  (IEA,ISO)
lung alveolus development  (ISO)
membranous septum morphogenesis  (IEA,ISO)
muscular septum morphogenesis  (IEA,ISO)
negative regulation of BMP signaling pathway  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (IEA)
non-canonical Wnt signaling pathway  (IEA)
obsolete planar cell polarity pathway involved in neural tube closure  (IEA,ISO)
outflow tract morphogenesis  (IEA,ISO)
positive regulation of DNA-binding transcription factor activity  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of neuron projection development  (ISO)
positive regulation of osteoblast differentiation  (IEA)
positive regulation of protein phosphorylation  (ISO)
regulation of mesenchymal stem cell differentiation  (IEA)
regulation of osteoblast differentiation  (ISO)
regulation of presynapse assembly  (IEA)
response to xenobiotic stimulus  (IEA)
ventricular septum morphogenesis  (IEA,ISO)
Wnt signaling pathway  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Fzd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511830,465,239 - 30,469,955 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366212,900,995 - 2,902,947 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366212,899,183 - 2,903,427 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FZD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38791,264,433 - 91,271,326 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl791,264,433 - 91,271,326 (+)EnsemblGRCh38hg38GRCh38
GRCh37790,893,748 - 90,900,641 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36790,731,719 - 90,736,068 (+)NCBINCBI36Build 36hg18NCBI36
Build 34790,538,433 - 90,542,783NCBI
Celera785,598,534 - 85,602,883 (+)NCBICelera
Cytogenetic Map7q21.13NCBI
HuRef785,501,893 - 85,506,245 (+)NCBIHuRef
CHM1_1790,823,675 - 90,828,024 (+)NCBICHM1_1
T2T-CHM13v2.0792,512,278 - 92,519,169 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2790,224,254 - 90,228,603 (+)NCBI
Fzd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3954,803,839 - 4,808,216 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl54,803,839 - 4,808,035 (-)EnsemblGRCm39 Ensembl
GRCm3854,753,839 - 4,758,216 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl54,753,839 - 4,758,035 (-)EnsemblGRCm38mm10GRCm38
MGSCv3754,753,839 - 4,758,216 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3654,759,845 - 4,763,977 (-)NCBIMGSCv36mm8
Celera54,685,028 - 4,689,405 (-)NCBICelera
Cytogenetic Map5A1NCBI
cM Map52.61NCBI
Fzd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8430,265,074 - 30,269,472 (+)NCBIGRCr8
mRatBN7.2429,310,303 - 29,314,701 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl429,310,091 - 29,312,643 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl429,310,091 - 29,312,643 (+)NCBImRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx434,270,999 - 34,275,397 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0430,197,106 - 30,201,504 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0428,605,179 - 28,609,577 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0426,470,864 - 26,475,262 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl426,470,864 - 26,475,262 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0426,377,857 - 26,382,255 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4425,994,423 - 25,998,821 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1426,006,310 - 26,010,460 (+)NCBI
Celera424,743,049 - 24,747,447 (+)NCBICelera
Cytogenetic Map4q13NCBI
FZD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26109,152,613 - 109,162,445 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17157,420,947 - 157,429,695 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0783,269,906 - 83,277,608 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1796,805,227 - 96,876,188 (+)NCBIpanpan1.1PanPan1.1panPan2
FZD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11417,046,911 - 17,050,515 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1417,047,382 - 17,049,337 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1416,617,442 - 16,624,391 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01416,853,072 - 16,860,019 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1416,853,171 - 16,855,126 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11417,015,222 - 17,022,169 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01416,732,649 - 16,739,601 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01417,018,787 - 17,025,738 (+)NCBIUU_Cfam_GSD_1.0
FZD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl971,349,988 - 71,352,104 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1971,346,994 - 71,356,488 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FZD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12157,695,000 - 57,702,666 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2157,699,468 - 57,701,417 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604246,532,184 - 46,537,450 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fzd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248092,021,124 - 2,025,589 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248092,021,118 - 2,025,826 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005334678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000013483   ⟹   ENSSTOP00000012081
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366212,900,995 - 2,902,947 (-)Ensembl
RefSeq Acc Id: XM_005334678   ⟹   XP_005334735
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511830,465,239 - 30,469,955 (+)NCBI
SpeTri2.0NW_0049366212,899,183 - 2,903,427 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005334735 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000012081.3
GenBank Protein KAG3277564 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005334735   ⟸   XM_005334678
- UniProtKB: I3ML35 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000012081   ⟸   ENSSTOT00000013483
Protein Domains
FZ   G-protein coupled receptors family 2 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000013482 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000013483.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.2000.10 UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro Frizzled/SFRP UniProtKB/TrEMBL
  Frizzled/Smoothened_TM UniProtKB/TrEMBL
  Frizzled_dom UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/TrEMBL
NCBI Gene Fzd1 ENTREZGENE
PANTHER FRIZZLED-1 UniProtKB/TrEMBL
  PTHR11309 UniProtKB/TrEMBL
Pfam Frizzled UniProtKB/TrEMBL
  PF01392 UniProtKB/TrEMBL
PRINTS FRIZZLED UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_4 UniProtKB/TrEMBL
  PS50038 UniProtKB/TrEMBL
SMART FRI UniProtKB/TrEMBL
  Frizzled UniProtKB/TrEMBL
Superfamily-SCOP SSF63501 UniProtKB/TrEMBL
UniProt I3ML35 ENTREZGENE, UniProtKB/TrEMBL