1,2-dimethylhydrazine decreases expression ISO RGD:62332 6480464 1, 2-Dimethylhydrazine results in decreased expression of HPX mRNA CTD PMID:22206623 17alpha-ethynylestradiol affects expression ISO RGD:62332 6480464 Ethinyl Estradiol affects the expression of HPX mRNA CTD PMID:17555576 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of HPX mRNA CTD PMID:16940010 , PMID:17108234 17alpha-ethynylestradiol multiple interactions ISO RGD:62332 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HPX mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:62332 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HPX mRNA, Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HPX gene] CTD PMID:17942748 , PMID:28213091 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of HPX mRNA CTD PMID:33387578 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:62332 6480464 Tetrachlorodibenzodioxin results in decreased expression of HPX mRNA, Tetrachlorodibenzodioxin results in decreased expression of HPX protein CTD PMID:28213091 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:62332 6480464 Tetrachlorodibenzodioxin affects the expression of HPX mRNA CTD PMID:28922406 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:737150 6480464 Tetrachlorodibenzodioxin results in decreased expression of HPX mRNA CTD PMID:21632981 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of HPX mRNA CTD PMID:21346803 3,3',5,5'-tetrabromobisphenol A decreases expression ISO RGD:737150 6480464 tetrabromobisphenol A results in decreased expression of HPX protein CTD PMID:31675489 3,7-dihydropurine-6-thione increases expression EXP 6480464 Mercaptopurine results in increased expression of HPX mRNA CTD PMID:23358152 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin analog results in decreased expression of HPX protein, alpha-Chlorohydrin results in decreased expression of HPX protein CTD PMID:26597043 3-chloropropane-1,2-diol increases expression EXP 6480464 alpha-Chlorohydrin analog results in increased expression of HPX protein, alpha-Chlorohydrin results in increased expression of HPX protein CTD PMID:26072098 4-hydroxyphenyl retinamide increases expression ISO RGD:62332 6480464 Fenretinide results in increased expression of HPX mRNA CTD PMID:28973697 5-fluorouracil multiple interactions ISO RGD:737150 6480464 TP53 protein affects the reaction [Fluorouracil results in decreased expression of HPX mRNA] CTD PMID:15016801 acrylamide increases expression ISO RGD:737150 6480464 Acrylamide results in increased expression of HPX mRNA CTD PMID:32763439 aflatoxin B1 affects expression ISO RGD:737150 6480464 Aflatoxin B1 affects the expression of HPX protein CTD PMID:20106945 aflatoxin B1 increases methylation ISO RGD:737150 6480464 Aflatoxin B1 results in increased methylation of HPX gene CTD PMID:28458013 all-trans-retinoic acid affects expression ISO RGD:737150 6480464 Tretinoin affects the expression of HPX mRNA CTD PMID:31600526 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of HPX mRNA CTD PMID:16483693 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:62332 6480464 pyrazolanthrone inhibits the reaction [Ozone results in increased expression of HPX mRNA] CTD PMID:17460151 aristolochic acid A increases expression ISO RGD:737150 6480464 aristolochic acid I results in increased expression of HPX mRNA CTD PMID:33212167 atazanavir sulfate multiple interactions ISO RGD:737150 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of HPX mRNA CTD PMID:33819548 bathocuproine disulfonic acid multiple interactions ISO RGD:62332 6480464 bathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] affects the localization of MTF1 protein] more ... CTD PMID:11213479 belinostat decreases expression ISO RGD:737150 6480464 belinostat results in decreased expression of HPX mRNA CTD PMID:27188386 benzo[a]pyrene increases methylation ISO RGD:737150 6480464 Benzo(a)pyrene results in increased methylation of HPX promoter CTD PMID:27901495 benzo[a]pyrene decreases expression ISO RGD:737150 6480464 Benzo(a)pyrene results in decreased expression of HPX mRNA CTD PMID:32234424 beta-naphthoflavone decreases expression ISO RGD:737150 6480464 beta-Naphthoflavone results in decreased expression of HPX mRNA CTD PMID:19737606 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of HPX mRNA CTD PMID:25181051 , PMID:30903817 bisphenol A decreases expression ISO RGD:737150 6480464 bisphenol A results in decreased expression of HPX protein CTD PMID:31675489 bisphenol A increases expression ISO RGD:62332 6480464 bisphenol A results in increased expression of HPX mRNA CTD PMID:30245210 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of HPX mRNA CTD PMID:30816183 , PMID:32528016 bleomycin A2 increases expression EXP 6480464 Bleomycin results in increased expression of HPX protein CTD PMID:25933445 Brodifacoum increases expression EXP 6480464 bromfenacoum results in increased expression of HPX protein CTD PMID:28903499 buta-1,3-diene decreases expression ISO RGD:62332 6480464 1, 3-butadiene results in decreased expression of HPX mRNA CTD PMID:29038090 butanal decreases expression ISO RGD:737150 6480464 butyraldehyde results in decreased expression of HPX mRNA CTD PMID:26079696 cadmium atom affects binding ISO RGD:737150 6480464 HPX protein binds to Cadmium CTD PMID:23896426 carbon nanotube affects expression ISO RGD:62332 6480464 Nanotubes, Carbon affects the expression of HPX mRNA CTD PMID:23845593 carbon nanotube increases expression ISO RGD:62332 6480464 Nanotubes more ... CTD PMID:25554681 , PMID:25620056 chenodeoxycholic acid multiple interactions ISO RGD:737150 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of HPX mRNA more ... CTD PMID:33819548 chloroprene increases expression ISO RGD:62332 6480464 Chloroprene results in increased expression of HPX mRNA CTD PMID:23125180 ciguatoxin CTX1B affects expression ISO RGD:62332 6480464 Ciguatoxins affects the expression of HPX mRNA CTD PMID:18353800 cisplatin increases secretion EXP 6480464 Cisplatin results in increased secretion of HPX protein CTD PMID:28885000 cisplatin increases expression ISO RGD:737150 6480464 Cisplatin results in increased expression of HPX mRNA CTD PMID:27392435 copper atom decreases expression EXP 6480464 Copper results in decreased expression of HPX mRNA CTD PMID:22465980 copper atom affects binding ISO RGD:737150 6480464 HPX protein binds to Copper CTD PMID:23896426 copper atom multiple interactions ISO RGD:62332 6480464 Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein] more ... CTD PMID:19039664 copper(0) decreases expression EXP 6480464 Copper results in decreased expression of HPX mRNA CTD PMID:22465980 copper(0) affects binding ISO RGD:737150 6480464 HPX protein binds to Copper CTD PMID:23896426 copper(0) multiple interactions ISO RGD:62332 6480464 Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein] more ... CTD PMID:19039664 copper(II) sulfate decreases expression ISO RGD:737150 6480464 Copper Sulfate results in decreased expression of HPX mRNA CTD PMID:19549813 cyclosporin A decreases expression ISO RGD:737150 6480464 Cyclosporine results in decreased expression of HPX mRNA CTD PMID:20106945 cyclosporin A multiple interactions ISO RGD:737150 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine] results in decreased expression of HPX mRNA CTD PMID:33819548 cylindrospermopsin increases expression ISO RGD:62332 6480464 cylindrospermopsin results in increased expression of HPX mRNA CTD PMID:20936652 decabromodiphenyl ether multiple interactions EXP 6480464 [Flame Retardants co-treated with pentabromodiphenyl ether co-treated with decabromobiphenyl ether co-treated with hexabromocyclododecane] results in decreased expression of HPX mRNA CTD PMID:32207525 decabromodiphenyl ether decreases expression ISO RGD:737150 6480464 decabromobiphenyl ether results in decreased expression of HPX protein CTD PMID:31675489 deoxycholic acid multiple interactions ISO RGD:737150 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of HPX mRNA more ... CTD PMID:33819548 dichloroacetic acid decreases expression ISO RGD:62332 6480464 Dichloroacetic Acid results in decreased expression of HPX mRNA CTD PMID:28962523 doxorubicin increases secretion EXP 6480464 Doxorubicin results in increased secretion of HPX protein CTD PMID:28885000 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of HPX mRNA CTD PMID:29391264 entinostat decreases expression ISO RGD:737150 6480464 entinostat results in decreased expression of HPX mRNA CTD PMID:27188386 enzyme inhibitor multiple interactions ISO RGD:737150 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HPX protein CTD PMID:23301498 ethanol increases expression EXP 6480464 Ethanol results in increased expression of HPX protein CTD PMID:19609968 fenvalerate decreases expression EXP 6480464 fenvalerate results in decreased expression of HPX protein CTD PMID:33656234 ferroheme b multiple interactions ISO RGD:62332 6480464 [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein] more ... CTD PMID:11213479 , PMID:19039664 ferroheme b affects binding ISO RGD:62332 6480464 Heme binds to HPX protein CTD PMID:19039664 fluoxetine decreases expression EXP 6480464 Fluoxetine results in decreased expression of HPX mRNA CTD PMID:21852994 fumonisin B1 increases expression ISO RGD:62332 6480464 fumonisin B1 results in increased expression of HPX mRNA CTD PMID:16221962 furan decreases expression EXP 6480464 furan results in decreased expression of HPX mRNA CTD PMID:25539665 , PMID:26194646 genistein increases expression EXP 6480464 Genistein results in increased expression of HPX protein CTD PMID:22649256 genistein decreases expression ISO RGD:62332 6480464 Genistein results in decreased expression of HPX mRNA CTD PMID:32186404 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of HPX mRNA CTD PMID:33387578 glycochenodeoxycholic acid multiple interactions ISO RGD:737150 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of HPX mRNA more ... CTD PMID:33819548 glycocholic acid multiple interactions ISO RGD:737150 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of HPX mRNA more ... CTD PMID:33819548 glycodeoxycholic acid multiple interactions ISO RGD:737150 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of HPX mRNA more ... CTD PMID:33819548 glyphosate decreases expression ISO RGD:62332 6480464 glyphosate results in decreased expression of HPX protein CTD PMID:36173347 graphite affects expression EXP 6480464 Graphite affects the expression of HPX mRNA CTD PMID:29933104 heme b multiple interactions ISO RGD:62332 6480464 [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein] more ... CTD PMID:11213479 , PMID:19039664 heme b affects binding ISO RGD:62332 6480464 Heme binds to HPX protein CTD PMID:19039664 hydrazine increases expression ISO RGD:62332 6480464 hydrazine results in increased expression of HPX mRNA CTD PMID:15282401 lactacystin multiple interactions ISO RGD:62332 6480464 lactacystin inhibits the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased degradation of CCS protein], lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein] CTD PMID:19039664 lead(0) affects binding ISO RGD:737150 6480464 HPX protein binds to Lead CTD PMID:23896426 lead(2+) affects binding ISO RGD:737150 6480464 HPX protein binds to Lead CTD PMID:23896426 Licochalcone B increases expression ISO RGD:737150 6480464 licochalcone B results in increased expression of HPX mRNA CTD PMID:33647349 manganese(II) chloride decreases expression EXP 6480464 manganese chloride results in decreased expression of HPX mRNA CTD PMID:28801915 mercaptopurine increases expression EXP 6480464 Mercaptopurine results in increased expression of HPX mRNA CTD PMID:23358152 mercury atom affects expression ISO RGD:737150 6480464 Mercury affects the expression of HPX protein CTD PMID:22030286 mercury(0) affects expression ISO RGD:737150 6480464 Mercury affects the expression of HPX protein CTD PMID:22030286 mesoporphyrin IX multiple interactions ISO RGD:62332 6480464 [mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA more ... CTD PMID:12042074 microcystin-LR increases expression ISO RGD:62332 6480464 cyanoginosin LR results in increased expression of HPX protein CTD PMID:26984711 N-(6-acetamidohexyl)acetamide multiple interactions ISO RGD:62332 6480464 hexamethylene bisacetamide inhibits the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA] more ... CTD PMID:12042074 N-nitrosomorpholine decreases expression EXP 6480464 N-nitrosomorpholine results in decreased expression of HPX protein CTD PMID:19716841 N-Nitrosopyrrolidine decreases expression ISO RGD:737150 6480464 N-Nitrosopyrrolidine results in decreased expression of HPX mRNA CTD PMID:32234424 nefazodone multiple interactions ISO RGD:737150 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with nefazodone] results in decreased expression of HPX mRNA CTD PMID:33819548 nickel atom affects binding ISO RGD:737150 6480464 HPX protein binds to Nickel CTD PMID:23896426 nitrofen increases expression EXP 6480464 nitrofen results in increased expression of HPX mRNA CTD PMID:33484710 O-methyleugenol decreases expression ISO RGD:737150 6480464 methyleugenol results in decreased expression of HPX mRNA CTD PMID:32234424 olanzapine affects phosphorylation ISO RGD:737150 6480464 olanzapine affects the phosphorylation of HPX protein CTD PMID:25821032 ozone multiple interactions ISO RGD:62332 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of HPX mRNA more ... CTD PMID:17460151 more ... ozone increases expression ISO RGD:62332 6480464 Ozone results in increased expression of HPX mRNA CTD PMID:17460151 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of HPX protein CTD PMID:16099942 paracetamol multiple interactions ISO RGD:737150 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of HPX mRNA CTD PMID:33819548 paracetamol decreases expression ISO RGD:737150 6480464 Acetaminophen results in decreased expression of HPX mRNA CTD PMID:29067470 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of HPX protein CTD PMID:16687475 paracetamol affects expression ISO RGD:62332 6480464 Acetaminophen affects the expression of HPX mRNA CTD PMID:17562736 pentanal decreases expression ISO RGD:737150 6480464 pentanal results in decreased expression of HPX mRNA CTD PMID:26079696 perfluorododecanoic acid increases expression EXP 6480464 perfluorododecanoic acid results in increased expression of HPX protein CTD PMID:26168851 pirinixic acid multiple interactions ISO RGD:62332 6480464 [pirinixic acid co-treated with PPARA] results in decreased expression of HPX mRNA CTD PMID:20813756 pirinixic acid decreases expression ISO RGD:62332 6480464 pirinixic acid results in decreased expression of HPX mRNA CTD PMID:16221962 , PMID:20813756 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of HPX mRNA CTD PMID:16940010 pirinixic acid affects expression EXP 6480464 pirinixic acid affects the expression of HPX protein CTD PMID:16099942 potassium dichromate decreases expression ISO RGD:62332 6480464 Potassium Dichromate results in decreased expression of HPX mRNA CTD PMID:23608068 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:62332 6480464 Pregnenolone Carbonitrile results in increased expression of HPX mRNA CTD PMID:28903501 propanal decreases expression ISO RGD:737150 6480464 propionaldehyde results in decreased expression of HPX mRNA CTD PMID:26079696 purine-6-thiol increases expression EXP 6480464 Mercaptopurine results in increased expression of HPX mRNA CTD PMID:23358152 resveratrol multiple interactions ISO RGD:62332 6480464 Resveratrol promotes the reaction [titanium dioxide results in increased expression of HPX mRNA] CTD PMID:31298478 sarin decreases expression EXP 6480464 Sarin results in decreased expression of HPX protein CTD PMID:26778279 silicon dioxide decreases expression ISO RGD:737150 6480464 Silicon Dioxide analog results in decreased expression of HPX mRNA CTD PMID:25895662 silicon dioxide increases expression EXP 6480464 Silicon Dioxide results in increased expression of HPX mRNA CTD PMID:22431001 sodium arsenite affects expression ISO RGD:62332 6480464 sodium arsenite affects the expression of HPX mRNA CTD PMID:17450228 sodium arsenite decreases expression ISO RGD:62332 6480464 sodium arsenite results in decreased expression of HPX mRNA CTD PMID:36209798 sodium arsenite decreases expression ISO RGD:737150 6480464 sodium arsenite results in decreased expression of HPX mRNA CTD PMID:29301061 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of HPX protein CTD PMID:29459688 sodium fluoride decreases expression EXP 6480464 Sodium Fluoride results in decreased expression of HPX protein CTD PMID:29653260 Sunset Yellow FCF multiple interactions ISO RGD:737150 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of HPX mRNA CTD PMID:33819548 tamoxifen affects expression ISO RGD:62332 6480464 Tamoxifen affects the expression of HPX mRNA CTD PMID:17555576 tartrazine multiple interactions ISO RGD:737150 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine] results in decreased expression of HPX mRNA CTD PMID:33819548 tetrachloromethane affects expression ISO RGD:62332 6480464 Carbon Tetrachloride affects the expression of HPX mRNA CTD PMID:17484886 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of HPX mRNA CTD PMID:16239168 titanium dioxide multiple interactions ISO RGD:62332 6480464 Resveratrol promotes the reaction [titanium dioxide results in increased expression of HPX mRNA] CTD PMID:31298478 titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of HPX mRNA CTD PMID:30012374 titanium dioxide increases expression ISO RGD:62332 6480464 titanium dioxide results in increased expression of HPX mRNA CTD PMID:23557971 more ... Tributyltin oxide increases expression ISO RGD:62332 6480464 bis(tri-n-butyltin)oxide results in increased expression of HPX mRNA CTD PMID:18958704 triclosan increases expression ISO RGD:737150 6480464 Triclosan results in increased expression of HPX mRNA CTD PMID:30510588 Triptolide increases expression EXP 6480464 triptolide results in increased expression of HPX protein CTD PMID:32519852 triptonide increases expression ISO RGD:62332 6480464 triptonide results in increased expression of HPX mRNA CTD PMID:33045310 Tris(1-aziridinyl)phosphine oxide multiple interactions ISO RGD:62332 6480464 [cobaltiprotoporphyrin binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein] more ... CTD PMID:19039664 tris(2-chloroethyl) phosphate decreases expression ISO RGD:737150 6480464 tris(chloroethyl)phosphate results in decreased expression of HPX mRNA CTD PMID:29143341 troglitazone decreases expression ISO RGD:737150 6480464 troglitazone results in decreased expression of HPX mRNA CTD PMID:25572481 valproic acid decreases expression ISO RGD:737150 6480464 Valproic Acid results in decreased expression of HPX mRNA CTD PMID:29154799 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of HPX mRNA CTD PMID:35594946 valproic acid affects expression ISO RGD:737150 6480464 Valproic Acid affects the expression of HPX mRNA CTD PMID:25979313 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of HPX mRNA CTD PMID:22570695 zinc atom affects binding ISO RGD:737150 6480464 HPX protein binds to Zinc CTD PMID:23896426 zinc(0) affects binding ISO RGD:737150 6480464 HPX protein binds to Zinc CTD PMID:23896426