Abcg5 (ATP binding cassette subfamily G member 5) - Rat Genome Database

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Gene: Abcg5 (ATP binding cassette subfamily G member 5) Rattus norvegicus
Analyze
Symbol: Abcg5
Name: ATP binding cassette subfamily G member 5
RGD ID: 620298
Description: Predicted to enable ATPase-coupled transmembrane transporter activity and protein heterodimerization activity. Predicted to contribute to ATP binding activity; ATP hydrolysis activity; and cholesterol transfer activity. Involved in several processes, including bile acid signaling pathway; cholesterol homeostasis; and triglyceride homeostasis. Predicted to be located in apical part of cell and membrane. Predicted to be part of ATP-binding activity cassette (ABC) transporter complex and receptor complex. Predicted to be active in apical plasma membrane. Used to study sitosterolemia. Biomarker of cholestasis; metabolic dysfunction-associated steatotic liver disease; and obesity. Human ortholog(s) of this gene implicated in arteriosclerosis and sitosterolemia. Orthologous to human ABCG5 (ATP binding cassette subfamily G member 5); PARTICIPATES IN bile acid signaling pathway; bile acid transport pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP-binding cassette sub-family G (WHITE) member 5 (sterolin 1); ATP-binding cassette sub-family G member 5; ATP-binding cassette, sub-family G (WHITE), member 5; ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1); ATP-binding cassette, subfamily G (WHITE), member 5; sterolin 1; sterolin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.269,965,118 - 9,990,563 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl69,965,118 - 9,990,563 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx610,253,680 - 10,285,836 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0610,563,072 - 10,595,227 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0610,084,742 - 10,110,340 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.067,935,771 - 7,961,207 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl67,935,771 - 7,961,207 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.067,871,269 - 7,896,799 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.468,027,647 - 8,064,425 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.168,027,646 - 8,064,425 (-)NCBI
Celera69,686,706 - 9,712,114 (+)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2,3-trilinolenoylglycerol  (ISO)
1,2,3-trilinoleoylglycerol  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7-ketocholesterol  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amiodarone  (EXP)
amitriptyline  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
androst-4-ene-3,17-dione  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
azathioprine  (EXP)
aztreonam  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bosentan  (EXP,ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
chenodeoxycholic acid  (ISO)
chlorohydrocarbon  (EXP)
cholate  (ISO)
cholesterol  (EXP,ISO)
cholic acid  (ISO)
chromium(6+)  (ISO)
clavulanic acid  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dehydroepiandrosterone  (ISO)
deoxycholic acid  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
diosgenin  (EXP,ISO)
disodium selenite  (ISO)
doxycycline  (EXP)
elemental selenium  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
fenofibrate  (EXP)
fenvalerate  (EXP)
fipronil  (EXP,ISO)
furan  (EXP)
genistein  (ISO)
glafenine  (EXP)
glyburide  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
guggulsterone  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
imipenem hydrate  (ISO)
indole-3-methanol  (EXP)
L-ethionine  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
loperamide  (ISO)
lovastatin  (ISO)
metformin  (EXP)
methimazole  (EXP)
methylmercury chloride  (EXP)
methyltestosterone  (ISO)
metronidazole  (ISO)
mirex  (EXP)
Muraglitazar  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP,ISO)
neomycin  (ISO)
O-methyleugenol  (ISO)
oltipraz  (ISO)
omeprazole  (EXP)
oxycodone  (EXP)
paracetamol  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
pravastatin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
pyrethrins  (EXP)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rotenone  (EXP,ISO)
selenium atom  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
spironolactone  (EXP)
stigmasterol  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
thioacetamide  (EXP)
tianeptine  (EXP)
toluene  (EXP)
triadimefon  (EXP)
trichloroethene  (EXP)
triolein  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Berge KE, etal., Science 2000 Dec 1;290(5497):1771-5.
2. Down-regulation of hepatic and intestinal Abcg5 and Abcg8 expression associated with altered sterol fluxes in rats with streptozotocin-induced diabetes. Bloks VW, etal., Diabetologia 2004 Jan;47(1):104-12. Epub 2003 Nov 14.
3. The missense mutation in Abcg5 gene in spontaneously hypertensive rats (SHR) segregates with phytosterolemia but not hypertension. Chen J, etal., BMC Genet. 2005 Jul 18;6:40.
4. Impaired VLDL assembly: a novel mechanism contributing to hepatic lipid accumulation following ovariectomy and high-fat/high-cholesterol diets? Côté I, etal., Br J Nutr. 2014 Nov 28;112(10):1592-600. doi: 10.1017/S0007114514002517. Epub 2014 Sep 29.
5. An atherogenic diet decreases liver FXR gene expression and causes severe hepatic steatosis and hepatic cholesterol accumulation: effect of endurance training. Côté I, etal., Eur J Nutr. 2013 Aug;52(5):1523-32. doi: 10.1007/s00394-012-0459-5. Epub 2012 Nov 2.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Effect of a high-fat diet on the hepatic expression of nuclear receptors and their target genes: relevance to drug disposition. Ghoneim RH, etal., Br J Nutr. 2015 Feb 14;113(3):507-16. doi: 10.1017/S0007114514003717. Epub 2015 Jan 23.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Diet induced regulation of genes involved in cholesterol metabolism in rat liver parenchymal and Kupffer cells. Hoekstra M, etal., J Hepatol. 2005 Mar;42(3):400-7.
10. The different effect of pioglitazone as compared to insulin on expression of hepatic and intestinal genes regulating post-prandial lipoproteins in diabetes. Lally S, etal., Atherosclerosis. 2006 Nov 14;.
11. Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Lee MH, etal., Nat Genet 2001 Jan;27(1):79-83.
12. Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively. Lu K, etal., Am J Hum Genet 2001 Aug;69(2):278-90.
13. Effect of maternal cholestasis and treatment with ursodeoxycholic acid on the expression of genes involved in the secretion of biliary lipids by the neonatal rat liver. Macias RI, etal., Life Sci. 2006 Aug 1;79(10):1014-9. Epub 2006 May 20.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. A missense mutation in the Abcg5 gene causes phytosterolemia in SHR, stroke-prone SHR, and WKY rats. Scoggan KA, etal., J Lipid Res 2003 May;44(5):911-6. Epub 2003 Mar 1.
22. Chronic Contamination with 137Cesium in Rat: Effect on Liver Cholesterol Metabolism. Souidi M, etal., Int J Toxicol. 2006 Nov-Dec;25(6):493-7.
23. (-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein E Knockout Mice: Involvement of TTC39B. Wang W, etal., Front Pharmacol. 2018 Mar 9;9:195. doi: 10.3389/fphar.2018.00195. eCollection 2018.
24. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Yu L, etal., Proc Natl Acad Sci U S A 2002 Dec 10;99(25):16237-42. Epub 2002 Nov 20.
Additional References at PubMed
PMID:12208867   PMID:12783625   PMID:14504269   PMID:15040800   PMID:16867993   PMID:16870176   PMID:16893193   PMID:18395092   PMID:19202267   PMID:19966468   PMID:20413720   PMID:22484926  
PMID:25912874   PMID:26192016   PMID:27144356   PMID:28982675  


Genomics

Comparative Map Data
Abcg5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.269,965,118 - 9,990,563 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl69,965,118 - 9,990,563 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx610,253,680 - 10,285,836 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0610,563,072 - 10,595,227 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0610,084,742 - 10,110,340 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.067,935,771 - 7,961,207 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl67,935,771 - 7,961,207 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.067,871,269 - 7,896,799 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.468,027,647 - 8,064,425 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.168,027,646 - 8,064,425 (-)NCBI
Celera69,686,706 - 9,712,114 (+)NCBICelera
Cytogenetic Map6q12NCBI
ABCG5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38243,806,211 - 43,839,231 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl243,812,472 - 43,838,865 (-)EnsemblGRCh38hg38GRCh38
GRCh37244,039,611 - 44,065,978 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36243,893,115 - 43,919,462 (-)NCBINCBI36Build 36hg18NCBI36
Build 34243,951,261 - 43,977,609NCBI
Celera243,878,347 - 43,904,690 (-)NCBICelera
Cytogenetic Map2p21NCBI
HuRef243,776,307 - 43,802,654 (-)NCBIHuRef
CHM1_1243,969,007 - 43,995,357 (-)NCBICHM1_1
T2T-CHM13v2.0243,810,586 - 43,844,196 (-)NCBIT2T-CHM13v2.0
Abcg5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391784,965,602 - 84,990,439 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1784,965,662 - 84,990,439 (-)EnsemblGRCm39 Ensembl
GRCm381784,658,174 - 84,683,011 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1784,658,234 - 84,683,011 (-)EnsemblGRCm38mm10GRCm38
MGSCv371785,057,574 - 85,082,263 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361784,566,560 - 84,591,249 (-)NCBIMGSCv36mm8
Celera1789,024,999 - 89,050,375 (-)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1755.02NCBI
Abcg5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544110,964,858 - 10,986,967 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544110,964,588 - 10,987,771 (-)NCBIChiLan1.0ChiLan1.0
ABCG5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12A82,589,317 - 82,617,174 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A43,896,188 - 43,922,756 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A44,745,183 - 44,771,012 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A44,745,183 - 44,771,012 (-)Ensemblpanpan1.1panPan2
ABCG5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11046,261,747 - 46,300,084 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1046,271,772 - 46,299,773 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1046,123,805 - 46,173,246 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01047,140,680 - 47,190,102 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1047,151,472 - 47,178,440 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11046,849,037 - 46,898,531 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01047,138,987 - 47,188,120 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01047,322,375 - 47,371,811 (-)NCBIUU_Cfam_GSD_1.0
Abcg5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629236,665,097 - 36,688,553 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365088,093,804 - 8,116,877 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365088,093,804 - 8,117,467 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCG5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl396,616,246 - 96,656,889 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1396,616,304 - 96,656,893 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23102,776,822 - 102,782,661 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCG5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11463,414,241 - 63,439,193 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1463,413,691 - 63,438,917 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604548,447,921 - 48,472,592 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcg5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473825,287,841 - 25,309,828 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473825,287,574 - 25,310,643 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Abcg5
177 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:115
Count of miRNA genes:91
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000007174
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6507449719988050Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6984331220338915Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6984331220338915Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 13 13 13 4
Low 1 27 22 3 22 1 1 55 22 26 1
Below cutoff 1 42 14 4 15 4 3 3 19 9 11 9 3

Sequence


RefSeq Acc Id: ENSRNOT00000007174   ⟹   ENSRNOP00000007174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl69,965,118 - 9,990,563 (+)Ensembl
Rnor_6.0 Ensembl67,935,771 - 7,961,207 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101271   ⟹   ENSRNOP00000093553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl69,965,118 - 9,990,563 (+)Ensembl
RefSeq Acc Id: NM_053754   ⟹   NP_446206
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.269,965,118 - 9,990,563 (+)NCBI
Rnor_6.067,935,771 - 7,961,207 (-)NCBI
Rnor_5.067,871,269 - 7,896,799 (-)NCBI
RGSC_v3.468,027,647 - 8,064,425 (-)RGD
Celera69,686,706 - 9,712,114 (+)RGD
Sequence:
RefSeq Acc Id: NP_446206   ⟸   NM_053754
- UniProtKB: Q8CIQ4 (UniProtKB/Swiss-Prot),   Q99PE7 (UniProtKB/Swiss-Prot),   A6H9I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007174   ⟸   ENSRNOT00000007174
RefSeq Acc Id: ENSRNOP00000093553   ⟸   ENSRNOT00000101271
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99PE7-F1-model_v2 AlphaFold Q99PE7 1-652 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694375
Promoter ID:EPDNEW_R4900
Type:initiation region
Name:Abcg5_1
Description:ATP binding cassette subfamily G member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.067,961,163 - 7,961,223EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620298 AgrOrtholog
BioCyc Gene G2FUF-38644 BioCyc
Ensembl Genes ENSRNOG00000005250 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00065015140 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007174 ENTREZGENE
  ENSRNOT00000007174.3 UniProtKB/Swiss-Prot
  ENSRNOT00000101271.1 UniProtKB/TrEMBL
  ENSRNOT00065025097 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_2_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like_CS UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  ABCG_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114628 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 114628 ENTREZGENE
PANTHER ABC TRANSPORTER G FAMILY MEMBER 28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ABC2_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC2_membrane_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Abcg5 PhenoGen
PROSITE ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005250 RatGTEx
  ENSRNOG00065015140 RatGTEx
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AHT3_RAT UniProtKB/TrEMBL
  A6H9I9 ENTREZGENE, UniProtKB/TrEMBL
  A6H9J0_RAT UniProtKB/TrEMBL
  ABCG5_RAT UniProtKB/Swiss-Prot
  Q8CIQ4 ENTREZGENE
  Q923R8_RAT UniProtKB/TrEMBL
  Q99PE7 ENTREZGENE
UniProt Secondary Q8CIQ4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Abcg5  ATP binding cassette subfamily G member 5  Abcg5  ATP-binding cassette, subfamily G (WHITE), member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abcg5  ATP-binding cassette, subfamily G (WHITE), member 5  Abcg5  ATP-binding cassette, sub-family G (WHITE), member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Abcg5  ATP-binding cassette, sub-family G (WHITE), member 5    ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1)  Name updated 1299863 APPROVED
2002-08-07 Abcg5  ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile 724707