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Gene: Gc (GC, vitamin D binding protein) Rattus norvegicus
Symbol: Gc
Name: GC, vitamin D binding protein
RGD ID: 2667
Description: Exhibits vitamin D binding activity. Involved in several processes, including female pregnancy; lactation; and response to estradiol. Localizes to several cellular components, including axon; extracellular space; and perinuclear region of cytoplasm. Biomarker of brain ischemia and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Orthologous to human GC (GC vitamin D binding protein); INTERACTS WITH 1-naphthyl isothiocyanate; 2,6-dinitrotoluene; 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DBP; DBP02; gc-globulin; group specific component; group-specific component; Group-specific component (vitamin D-binding protein); RATDBP02; VDB; Vdbp; vitamin D-binding protein
Homo sapiens (human) : GC (GC vitamin D binding protein)  HGNC  Alliance
Mus musculus (house mouse) : Gc (vitamin D binding protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gc (GC vitamin D binding protein)
Pan paniscus (bonobo/pygmy chimpanzee) : GC (GC vitamin D binding protein)
Canis lupus familiaris (dog) : GC (GC vitamin D binding protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gc (GC vitamin D binding protein)
Sus scrofa (pig) : GC (GC vitamin D binding protein)
Chlorocebus sabaeus (African green monkey) : GC (GC vitamin D binding protein)
Heterocephalus glaber (naked mole-rat) : Gc (GC vitamin D binding protein)
more info ...
Is Marker For: QTLs:   Scl11  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01420,267,023 - 20,302,577 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1420,266,891 - 20,302,581 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01420,173,467 - 20,209,021 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41420,166,243 - 20,197,060 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11420,166,180 - 20,201,613 (+)NCBI
Celera1417,992,337 - 18,027,605 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Gc
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2667
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.