Gc (GC, vitamin D binding protein)

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Gene: Gc (GC, vitamin D binding protein) Rattus norvegicus

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Symbol:

Name:

GC, vitamin D binding protein

RGD ID:

2667

Description:

Enables vitamin D binding activity. Involved in several processes, including female pregnancy; lactation; and response to estradiol. Located in axon; extracellular space; and perinuclear region of cytoplasm. Biomarker of brain ischemia and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Orthologous to human GC (GC vitamin D binding protein); INTERACTS WITH 1-naphthyl isothiocyanate; 2,6-dinitrotoluene; 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

DBP; DBP02; gc-globulin; group specific component; group-specific component; Group-specific component (vitamin D-binding protein); RATDBP02; VDB; Vdbp; vitamin D-binding protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GC (GC vitamin D binding protein)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Gc (vitamin D binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gc (GC vitamin D binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GC (GC vitamin D binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GC (GC vitamin D binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gc (GC vitamin D binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GC (GC vitamin D binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GC (GC vitamin D binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gc (GC vitamin D binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	STX6 (syntaxin 6)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Gc (vitamin D binding protein)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	GC (GC vitamin D binding protein)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gc (GC vitamin D binding protein)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gc	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Is Marker For:

QTLs: Scl11

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	18,916,255 - 18,951,670 (+)	NCBI		GRCr8
mRatBN7.2	14	18,632,146 - 18,667,563 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	18,632,135 - 18,667,567 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	18,622,611 - 18,658,030 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	19,941,501 - 19,976,920 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	18,653,131 - 18,688,560 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	20,267,023 - 20,302,577 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	20,266,891 - 20,302,581 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	20,173,467 - 20,209,021 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	20,166,243 - 20,197,060 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	20,166,180 - 20,201,613 (+)	NCBI
Celera	14	17,992,337 - 18,027,605 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

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Model

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gc	Rat	AIDS Dementia Complex		ISO	RDG:736902	5509882	associated with HIV Infections;protein:increased expression:cerebrospinal fluid:	RGD
Gc	Rat	arthritis	susceptibility	ISO	RDG:736902	5509918	associated with Spondylitis, Ankylosing;DNA:SNPs: :rs222016, rs222020,rs3733359(human)	RGD
Gc	Rat	asthma		ISO	RGD:10624	5509920		RGD
Gc	Rat	asthma		ISO	RDG:736902	5509920	protein, mRNA:increased expression:bronchoalveolar lavage fluid:	RGD
Gc	Rat	brain ischemia		IEP		1625796	protein:increased expression:urine	RGD
Gc	Rat	Carotid Artery Injuries		IEP		5509868	protein:decreased expression:plasma	RGD
Gc	Rat	Chronic Bronchitis	susceptibility	ISO	RDG:736902	5129516		RGD
Gc	Rat	chronic obstructive pulmonary disease		ISO	RDG:736902	5509932		RGD
Gc	Rat	Crohn's disease	susceptibility	ISO	RDG:736902	5509866	DNA:polymorphism:cds:p.T420K(human)	RGD
Gc	Rat	dengue disease		ISO	RDG:736902	5509870	protein:increased expression:plasma	RGD
Gc	Rat	diabetes mellitus		ISO	RDG:736902	5509921	protein:increased expression:ascitic fluid	RGD
Gc	Rat	diabetic retinopathy		ISO	RGD:736902	2315548	protein:increased expression:vitreous body	RGD
Gc	Rat	endometriosis	severity	ISO	RDG:736902	5509874		RGD
Gc	Rat	Experimental Diabetes Mellitus		IEP		2315540	protein:decreased expression:serum	RGD
Gc	Rat	Graves' disease	susceptibility	ISO	RDG:736902	5509883	DNA:polymorphism:cds:p.T420K(human)	RGD
Gc	Rat	Graves' disease	susceptibility	ISO	RDG:736902	5509886	DNA:repeats:intron	RGD
Gc	Rat	hepatic encephalopathy		ISO	RDG:736902	5509929		RGD
Gc	Rat	hepatocellular carcinoma		IEP		5509919	protein:increased expression:liver	RGD
Gc	Rat	hepatocellular carcinoma	susceptibility	ISO	RGD:736902	14402025	associated with Hepatitis B, Chronic;DNA:SNP: :rs7041(human)	RGD
Gc	Rat	human immunodeficiency virus infectious disease	disease_progression	ISO	RDG:736902	5509934		RGD
Gc	Rat	Intervertebral Disc Displacement		ISO	RDG:736902	5509883	protein:increased expression:cerebrospinal fluid	RGD
Gc	Rat	multiple sclerosis	no_association	ISO	RDG:736902	5509887	DNA:SNPs:exon:p.T420K, D416E(human)	RGD
Gc	Rat	multiple sclerosis	susceptibility	ISO	RDG:736902	5509885		RGD
Gc	Rat	multiple sclerosis		ISO	RDG:736902	5509922	protein:increased expression:plasma:	RGD
Gc	Rat	multiple sclerosis		ISO	RDG:736902	5509923	protein:decreased expression:cerebrospinal fluid	RGD
Gc	Rat	nephrotoxicity	treatment	IEP		329853759		RGD
Gc	Rat	neurodegenerative disease		ISO	RDG:736902	5509872		RGD
Gc	Rat	Pneumonia, Ventilator-Associated		ISO	RDG:736902	5509873	protein:increased expression:bronchoalveolar fluid:	RGD
Gc	Rat	pre-eclampsia		ISO	RGD:736902	401901078	mRNA:decreased expression:placenta (human)	RGD
Gc	Rat	Pregnancy in Diabetics		IEP		2315537	protein:decreased expression:plasma	RGD
Gc	Rat	primary progressive multiple sclerosis		ISO	RDG:736902	5509869	protein:increased expression:cerebrospinal fluid:	RGD
Gc	Rat	rheumatic fever		ISO	RDG:736902	5509933		RGD
Gc	Rat	rheumatoid arthritis		ISO	RDG:736902	5509931	protein:decreased expression:plasma	RGD
Gc	Rat	sciatic neuropathy		ISO	RDG:736902	2316214	protein:increased expression:nerve	RGD
Gc	Rat	type 1 diabetes mellitus		ISO	RGD:736902	2315558	DNA:polymorphism:exon:p.D416E(human)	RGD
Gc	Rat	ulcerative colitis	susceptibility	ISO	RDG:736902	5509866	DNA:polymorphism:cds:p.T420K(human)	RGD
Gc	Rat	uveitis	susceptibility	ISO	RDG:736902	5509918	associated with Spondylitis, Ankylosing;DNA:SNP: :rs4752(human)	RGD
Gc	Rat	Vitamin D Deficiency		ISO	RGD:736902	401901168	DNA:SNP:CDS:rs2282679) (human)	RGD
Gc	Rat	Wounds and Injuries	treatment	IEP		11041807	associated with Diabetes Mellitus, Experimental	RGD

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gc	Rat	chronic obstructive pulmonary disease		ISO	RGD:736902	8554872	ClinVar Annotator: match by term: Chronic obstructive pulmonary disease	ClinVar	PMID:28492532
Gc	Rat	periodontitis		ISO	RGD:736902	8554872	ClinVar Annotator: match by term: Periodontitis	ClinVar	PMID:1352271\|PMID:25741868

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gc	Rat	acute kidney failure		ISO	RGD:736902	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:28885000
Gc	Rat	Acute Liver Failure		ISO	RGD:736902	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:8666322\|PMID:17852808
Gc	Rat	Chemical and Drug Induced Liver Injury		ISO	RGD:736902	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:16099942
Gc	Rat	Drug-Related Side Effects and Adverse Reactions		ISO	RGD:736902	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:28885000
Gc	Rat	Experimental Liver Cirrhosis		ISO	RGD:736902	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:25380136
Gc	Rat	Graves' disease		ISO	RGD:736902	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:12050214
Gc	Rat	hepatic encephalopathy		ISO	RGD:736902	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:11510020
Gc	Rat	liver cirrhosis		ISO	RGD:736902	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:24381012
Gc	Rat	Lung Neoplasms		ISO	RGD:736902	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:17902193
Gc	Rat	Metabolic Bone Diseases		ISO	RGD:736902	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:24381012
Gc	Rat	multiple sclerosis		ISO	RGD:736902	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:25590278
Gc	Rat	rheumatoid arthritis		ISO	RGD:736902	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:3874814
Gc	Rat	schizophrenia		ISO	RGD:736902	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:25821032
Gc	Rat	toxic shock syndrome		ISO	RGD:736902	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:17852808
Gc	Rat	Wounds and Injuries		ISO	RGD:736902	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:17852808

Imported Disease Annotations - GAD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gc	Rat	chronic obstructive pulmonary disease		ISO	RGD:736902	1331525		GAD

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gc	Rat	1-naphthyl isothiocyanate	decreases expression	EXP		6480464	1-Naphthylisothiocyanate results in decreased expression of GC mRNA	CTD	PMID:25380136
Gc	Rat	17alpha-ethynylestradiol	affects expression	ISO	RGD:10624	6480464	Ethinyl Estradiol affects the expression of GC mRNA	CTD	PMID:17555576
Gc	Rat	17alpha-ethynylestradiol	multiple interactions	ISO	RGD:10624	6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GC mRNA	CTD	PMID:17942748
Gc	Rat	17alpha-ethynylestradiol	increases expression	ISO	RGD:10624	6480464	Ethinyl Estradiol results in increased expression of GC mRNA	CTD	PMID:17942748
Gc	Rat	17beta-estradiol	decreases expression	ISO	RGD:10624	6480464	Estradiol results in decreased expression of GC mRNA	CTD	PMID:39298647
Gc	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	RGD:10624	6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GC mRNA	CTD	PMID:17942748
Gc	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	RGD:10624	6480464	Tetrachlorodibenzodioxin results in decreased expression of GC mRNA	CTD	PMID:29673856
Gc	Rat	2,4-dibromophenyl 2,4,5-tribromophenyl ether	affects expression	ISO	RGD:10624	6480464	2,2',4,4',5-brominated diphenyl ether affects the expression of GC mRNA	CTD	PMID:38648751
Gc	Rat	2,6-dinitrotoluene	affects expression	EXP		6480464	2,6-dinitrotoluene affects the expression of GC mRNA	CTD	PMID:21346803
Gc	Rat	2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile	affects expression	EXP		6480464	Verapamil affects the expression of GC protein	CTD	PMID:23533533
Gc	Rat	2-methoxyethanol	decreases expression	EXP		6480464	methyl cellosolve results in decreased expression of GC protein	CTD	PMID:15928459
Gc	Rat	4,4'-diaminodiphenylmethane	decreases expression	EXP		6480464	4,4'-diaminodiphenylmethane results in decreased expression of GC mRNA	CTD	PMID:25380136
Gc	Rat	4,4'-sulfonyldiphenol	decreases expression	ISO	RGD:10624	6480464	bisphenol S results in decreased expression of GC mRNA	CTD	PMID:39298647
Gc	Rat	7,12-dimethyltetraphene	increases expression	ISO	RGD:10624	6480464	9,10-Dimethyl-1,2-benzanthracene results in increased expression of GC protein	CTD	PMID:39910959
Gc	Rat	acetamide	decreases expression	EXP		6480464	acetamide results in decreased expression of GC mRNA	CTD	PMID:31881176
Gc	Rat	aflatoxin B1	affects expression	ISO	RGD:736902	6480464	Aflatoxin B1 affects the expression of GC protein	CTD	PMID:20106945
Gc	Rat	aflatoxin B1	decreases methylation	ISO	RGD:736902	6480464	Aflatoxin B1 results in decreased methylation of GC gene	CTD	PMID:27153756
Gc	Rat	aflatoxin B1	multiple interactions	EXP		6480464	[Aflatoxin B1 co-treated with Buthionine Sulfoximine] results in increased expression of GC mRNA	CTD	PMID:23288050
Gc	Rat	aflatoxin B1	increases expression	EXP		6480464	Aflatoxin B1 results in increased expression of GC mRNA	CTD	PMID:23288050
Gc	Rat	aldehydo-D-glucose	multiple interactions	ISO	RGD:10624	6480464	[lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] more ...	CTD	PMID:37567420
Gc	Rat	all-trans-retinoic acid	increases expression	ISO	RGD:736902	6480464	Tretinoin results in increased expression of GC mRNA	CTD	PMID:23830798
Gc	Rat	allethrin	multiple interactions	EXP		6480464	[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in more ...	CTD	PMID:34896426
Gc	Rat	ammonium chloride	affects expression	EXP		6480464	Ammonium Chloride affects the expression of GC mRNA	CTD	PMID:16483693
Gc	Rat	arsenite(3-)	increases expression	ISO	RGD:10624	6480464	arsenite results in increased expression of GC mRNA	CTD	PMID:18929588
Gc	Rat	arsenite(3-)	multiple interactions	ISO	RGD:10624	6480464	TRP53 protein affects the reaction [arsenite results in increased expression of GC mRNA]	CTD	PMID:18929588
Gc	Rat	benzo[a]pyrene	affects methylation	ISO	RGD:736902	6480464	Benzo(a)pyrene affects the methylation of GC promoter	CTD	PMID:27901495
Gc	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:736902	6480464	Benzo(a)pyrene results in decreased expression of GC mRNA	CTD	PMID:32234424
Gc	Rat	benzo[b]fluoranthene	increases expression	ISO	RGD:10624	6480464	benzo(b)fluoranthene results in increased expression of GC mRNA	CTD	PMID:26377693
Gc	Rat	bexarotene	decreases expression	EXP		6480464	bexarotene results in decreased expression of GC mRNA	CTD	PMID:16648578
Gc	Rat	bis(2-ethylhexyl) phthalate	increases expression	ISO	RGD:10624	6480464	Diethylhexyl Phthalate results in increased expression of GC mRNA	CTD	PMID:33754040
Gc	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of GC mRNA	CTD	PMID:25181051
Gc	Rat	bisphenol A	affects binding	ISO	RGD:736902	6480464	bisphenol A binds to GC protein	CTD	PMID:34706627
Gc	Rat	bisphenol A	increases expression	ISO	RGD:10624	6480464	bisphenol A results in increased expression of GC mRNA	CTD	PMID:30245210\|PMID:33221593\|PMID:34585602
Gc	Rat	bisphenol A	affects expression	EXP		6480464	bisphenol A affects the expression of GC mRNA	CTD	PMID:30903817
Gc	Rat	bleomycin A2	increases expression	EXP		6480464	Bleomycin results in increased expression of GC protein	CTD	PMID:25933445
Gc	Rat	bromobenzene	increases expression	EXP		6480464	bromobenzene results in increased expression of GC mRNA	CTD	PMID:15056800\|PMID:23288050
Gc	Rat	buta-1,3-diene	decreases expression	ISO	RGD:10624	6480464	1,3-butadiene results in decreased expression of GC mRNA	CTD	PMID:29038090
Gc	Rat	cadmium atom	increases expression	ISO	RGD:10624	6480464	Cadmium results in increased expression of GC mRNA	CTD	PMID:24067728
Gc	Rat	cadmium atom	affects binding	ISO	RGD:736902	6480464	GC protein binds to Cadmium	CTD	PMID:23896426
Gc	Rat	calcitriol	affects abundance	ISO	RGD:736902	6480464	GC protein affects the abundance of Calcitriol	CTD	PMID:6894152
Gc	Rat	calcitriol	affects binding	EXP		6480464	Calcitriol binds to GC protein	CTD	PMID:17444814
Gc	Rat	calcitriol	affects binding	ISO	RGD:736902	6480464	GC protein polymorphism binds to Calcitriol	CTD	PMID:8370586
Gc	Rat	calcitriol	affects transport	ISO	RGD:736902	6480464	GC protein affects the transport of Calcitriol	CTD	PMID:15820770
Gc	Rat	calcium atom	affects expression	EXP		6480464	Calcium affects the expression of GC mRNA	CTD	PMID:15913539
Gc	Rat	calcium silicate	increases expression	ISO	RGD:10624	6480464	calcium silicate results in increased expression of GC mRNA	CTD	PMID:29279043
Gc	Rat	calcium(0)	affects expression	EXP		6480464	Calcium affects the expression of GC mRNA	CTD	PMID:15913539
Gc	Rat	carbon atom	affects response to substance	ISO	RGD:736902	6480464	GC gene SNP affects the susceptibility to Carbon	CTD	PMID:21138591
Gc	Rat	carbon nanotube	affects expression	ISO	RGD:10624	6480464	Nanotubes, Carbon affects the expression of GC protein	CTD	PMID:21135415
Gc	Rat	carbon nanotube	increases secretion	ISO	RGD:10624	6480464	Nanotubes, Carbon results in increased secretion of GC protein	CTD	PMID:25598225
Gc	Rat	carbon nanotube	increases expression	ISO	RGD:10624	6480464	Nanotubes, Carbon analog results in increased expression of GC mRNA; Nanotubes, Carbon results in increased more ...	CTD	PMID:25554681
Gc	Rat	carnosic acid	decreases expression	ISO	RGD:10624	6480464	salvin results in decreased expression of GC protein	CTD	PMID:35926579
Gc	Rat	chromium trinitrate	decreases expression	ISO	RGD:10624	6480464	chromium nitrate results in decreased expression of GC protein	CTD	PMID:23618972
Gc	Rat	cisplatin	increases expression	ISO	RGD:10624	6480464	Cisplatin results in increased expression of GC protein	CTD	PMID:31493026
Gc	Rat	cisplatin	increases secretion	EXP		6480464	Cisplatin results in increased secretion of GC protein	CTD	PMID:28885000
Gc	Rat	clofibrate	decreases expression	EXP		6480464	Clofibrate results in decreased expression of GC mRNA	CTD	PMID:12851107
Gc	Rat	clofibric acid	multiple interactions	EXP		6480464	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GC mRNA	CTD	PMID:17602206
Gc	Rat	cobalt dichloride	decreases expression	EXP		6480464	cobaltous chloride results in decreased expression of GC mRNA	CTD	PMID:24386269
Gc	Rat	copper atom	affects binding	ISO	RGD:736902	6480464	GC protein binds to Copper	CTD	PMID:23896426
Gc	Rat	copper(0)	affects binding	ISO	RGD:736902	6480464	GC protein binds to Copper	CTD	PMID:23896426
Gc	Rat	cyclosporin A	decreases expression	ISO	RGD:736902	6480464	Cyclosporine results in decreased expression of GC mRNA	CTD	PMID:20106945\|PMID:27989131
Gc	Rat	cyclosporin A	increases expression	EXP		6480464	Cyclosporine results in increased expression of GC mRNA	CTD	PMID:21865292
Gc	Rat	cyclosporin A	decreases expression	EXP		6480464	Cyclosporine results in decreased expression of GC mRNA	CTD	PMID:21865292
Gc	Rat	cyhalothrin	multiple interactions	EXP		6480464	[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in more ...	CTD	PMID:34896426
Gc	Rat	cypermethrin	multiple interactions	EXP		6480464	[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in more ...	CTD	PMID:34896426
Gc	Rat	D-glucose	multiple interactions	ISO	RGD:10624	6480464	[lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] more ...	CTD	PMID:37567420
Gc	Rat	dibutyl phthalate	increases expression	ISO	RGD:10624	6480464	Dibutyl Phthalate results in increased expression of GC protein	CTD	PMID:34864091
Gc	Rat	diclofenac	multiple interactions	EXP		6480464	[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GC protein	CTD	PMID:25772430
Gc	Rat	diquat	increases expression	ISO	RGD:10624	6480464	Diquat results in increased expression of GC mRNA	CTD	PMID:36851058
Gc	Rat	doxorubicin	increases secretion	EXP		6480464	Doxorubicin results in increased secretion of GC protein	CTD	PMID:28885000
Gc	Rat	doxorubicin	increases expression	ISO	RGD:10624	6480464	Doxorubicin results in increased expression of GC mRNA	CTD	PMID:15033991
Gc	Rat	elemental carbon	affects response to substance	ISO	RGD:736902	6480464	GC gene SNP affects the susceptibility to Carbon	CTD	PMID:21138591
Gc	Rat	ethanol	decreases expression	ISO	RGD:736902	6480464	Ethanol results in decreased expression of GC mRNA	CTD	PMID:31059573
Gc	Rat	fenvalerate	multiple interactions	EXP		6480464	[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in more ...	CTD	PMID:34896426
Gc	Rat	folic acid	increases expression	ISO	RGD:10624	6480464	Folic Acid results in increased expression of GC mRNA	CTD	PMID:25629700
Gc	Rat	fructose	multiple interactions	ISO	RGD:10624	6480464	[lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] more ...	CTD	PMID:37567420
Gc	Rat	furan	affects binding	EXP		6480464	furan binds to GC protein	CTD	PMID:22240984
Gc	Rat	furan	increases methylation	EXP		6480464	furan results in increased methylation of GC gene	CTD	PMID:22079235
Gc	Rat	genistein	increases expression	EXP		6480464	Genistein results in increased expression of GC protein	CTD	PMID:22649256
Gc	Rat	glucose	multiple interactions	ISO	RGD:10624	6480464	[lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] more ...	CTD	PMID:37567420
Gc	Rat	glyphosate	increases expression	ISO	RGD:10624	6480464	Glyphosate results in increased expression of GC protein	CTD	PMID:37208198
Gc	Rat	lead diacetate	increases expression	EXP		6480464	lead acetate results in increased expression of GC mRNA	CTD	PMID:22641619
Gc	Rat	lead(0)	affects binding	ISO	RGD:736902	6480464	GC protein binds to Lead	CTD	PMID:23896426
Gc	Rat	lipopolysaccharide	multiple interactions	ISO	RGD:736902	6480464	[S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of GC mRNA	CTD	PMID:35811015
Gc	Rat	methidathion	decreases expression	ISO	RGD:10624	6480464	methidathion results in decreased expression of GC mRNA	CTD	PMID:34813904
Gc	Rat	methylmercury(1+)	decreases expression	EXP		6480464	methylmercury II results in decreased expression of GC mRNA	CTD	PMID:17905399
Gc	Rat	N-nitrosodiethylamine	multiple interactions	EXP		6480464	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GC mRNA; [Diethylnitrosamine more ...	CTD	PMID:17602206\|PMID:20360939
Gc	Rat	N-nitrosodimethylamine	decreases expression	EXP		6480464	Dimethylnitrosamine results in decreased expression of GC mRNA	CTD	PMID:25380136
Gc	Rat	N-nitrosomorpholine	increases expression	EXP		6480464	N-nitrosomorpholine results in increased expression of GC mRNA	CTD	PMID:23288050
Gc	Rat	N-Nitrosopyrrolidine	decreases expression	ISO	RGD:736902	6480464	N-Nitrosopyrrolidine results in decreased expression of GC mRNA	CTD	PMID:32234424
Gc	Rat	nefazodone	decreases expression	EXP		6480464	nefazodone results in decreased expression of GC mRNA	CTD	PMID:24136188
Gc	Rat	nickel atom	affects binding	ISO	RGD:736902	6480464	GC protein binds to Nickel	CTD	PMID:23896426
Gc	Rat	nimesulide	decreases expression	EXP		6480464	nimesulide results in decreased expression of GC mRNA	CTD	PMID:24136188
Gc	Rat	nitrofen	increases expression	EXP		6480464	nitrofen results in increased expression of GC mRNA	CTD	PMID:33484710
Gc	Rat	nitrofen	multiple interactions	EXP		6480464	Vitamin D affects the reaction [nitrofen results in increased expression of GC mRNA]	CTD	PMID:33484710
Gc	Rat	O-methyleugenol	decreases expression	ISO	RGD:736902	6480464	methyleugenol results in decreased expression of GC mRNA	CTD	PMID:32234424
Gc	Rat	ochratoxin A	decreases expression	EXP		6480464	ochratoxin A results in decreased expression of GC mRNA	CTD	PMID:18417182\|PMID:30449730
Gc	Rat	okadaic acid	decreases expression	ISO	RGD:736902	6480464	Okadaic Acid results in decreased expression of GC mRNA	CTD	PMID:38832940
Gc	Rat	olanzapine	affects phosphorylation	ISO	RGD:736902	6480464	olanzapine affects the phosphorylation of GC protein	CTD	PMID:25821032
Gc	Rat	ouabain	affects expression	ISO	RGD:736902	6480464	Ouabain affects the expression of GC protein	CTD	PMID:17268060
Gc	Rat	p-toluidine	increases expression	EXP		6480464	4-toluidine results in increased expression of GC mRNA	CTD	PMID:27638505
Gc	Rat	paracetamol	affects expression	ISO	RGD:10624	6480464	Acetaminophen affects the expression of GC mRNA	CTD	PMID:17562736
Gc	Rat	paracetamol	increases expression	EXP		6480464	Acetaminophen results in increased expression of GC mRNA; Acetaminophen results in increased expression of GC more ...	CTD	PMID:16687475\|PMID:23288050
Gc	Rat	paracetamol	affects expression	EXP		6480464	Acetaminophen affects the expression of GC protein	CTD	PMID:16099942
Gc	Rat	paracetamol	decreases expression	ISO	RGD:736902	6480464	Acetaminophen results in decreased expression of GC mRNA; Acetaminophen results in decreased expression of GC more ...	CTD	PMID:11510020\|PMID:29067470
Gc	Rat	parathion	affects response to substance	ISO	RGD:736902	6480464	GC gene SNP affects the susceptibility to Parathion	CTD	PMID:23833127
Gc	Rat	perfluorododecanoic acid	decreases expression	EXP		6480464	perfluorododecanoic acid results in decreased expression of GC protein	CTD	PMID:26168851
Gc	Rat	perfluorooctane-1-sulfonic acid	multiple interactions	ISO	RGD:10624	6480464	[perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of GC mRNA	CTD	PMID:36331819
Gc	Rat	phenethyl caffeate	multiple interactions	EXP		6480464	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GC mRNA	CTD	PMID:20360939
Gc	Rat	pirinixic acid	multiple interactions	ISO	RGD:10624	6480464	[pirinixic acid co-treated with PPARA] results in decreased expression of GC mRNA	CTD	PMID:20813756
Gc	Rat	pirinixic acid	decreases expression	ISO	RGD:10624	6480464	pirinixic acid results in decreased expression of GC mRNA	CTD	PMID:20813756
Gc	Rat	potassium chromate	decreases expression	ISO	RGD:10624	6480464	potassium chromate(VI) results in decreased expression of GC protein	CTD	PMID:23618972
Gc	Rat	potassium dichromate	decreases expression	ISO	RGD:10624	6480464	Potassium Dichromate results in decreased expression of GC mRNA	CTD	PMID:23608068
Gc	Rat	pyrethrins	decreases expression	EXP		6480464	Pyrethrins results in decreased expression of GC protein	CTD	PMID:34896426
Gc	Rat	S-(1,2-dichlorovinyl)-L-cysteine	multiple interactions	ISO	RGD:736902	6480464	[S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of GC mRNA	CTD	PMID:35811015
Gc	Rat	S-butyl-DL-homocysteine (S,R)-sulfoximine	multiple interactions	EXP		6480464	[Aflatoxin B1 co-treated with Buthionine Sulfoximine] results in increased expression of GC mRNA	CTD	PMID:23288050
Gc	Rat	sarin	increases expression	EXP		6480464	Sarin results in increased expression of GC protein	CTD	PMID:26778279
Gc	Rat	senecionine	decreases expression	ISO	RGD:10624	6480464	senecionine results in decreased expression of GC protein	CTD	PMID:35357534
Gc	Rat	silicon dioxide	increases expression	EXP		6480464	Silicon Dioxide results in increased expression of GC mRNA	CTD	PMID:22431001
Gc	Rat	silicon dioxide	increases expression	ISO	RGD:10624	6480464	Silicon Dioxide results in increased expression of GC mRNA	CTD	PMID:38811393
Gc	Rat	sodium arsenite	affects expression	ISO	RGD:10624	6480464	sodium arsenite affects the expression of GC mRNA	CTD	PMID:17450228
Gc	Rat	sodium arsenite	decreases expression	ISO	RGD:10624	6480464	sodium arsenite results in decreased expression of GC mRNA	CTD	PMID:37682722
Gc	Rat	sodium arsenite	decreases expression	EXP		6480464	sodium arsenite results in decreased expression of GC protein	CTD	PMID:31874112
Gc	Rat	sodium arsenite	decreases expression	ISO	RGD:736902	6480464	sodium arsenite results in decreased expression of GC mRNA	CTD	PMID:29301061
Gc	Rat	tacrolimus hydrate	decreases expression	EXP		6480464	Tacrolimus results in decreased expression of GC mRNA	CTD	PMID:21865292
Gc	Rat	tacrolimus hydrate	increases expression	ISO	RGD:10624	6480464	Tacrolimus results in increased expression of GC mRNA	CTD	PMID:29362864
Gc	Rat	terbufos	affects response to substance	ISO	RGD:736902	6480464	GC gene SNP affects the susceptibility to terbufos	CTD	PMID:23833127
Gc	Rat	tetrachloromethane	affects expression	ISO	RGD:10624	6480464	Carbon Tetrachloride affects the expression of GC mRNA	CTD	PMID:17484886
Gc	Rat	tetrachloromethane	decreases expression	ISO	RGD:10624	6480464	Carbon Tetrachloride results in decreased expression of GC mRNA	CTD	PMID:24381012
Gc	Rat	thapsigargin	increases expression	EXP		6480464	Thapsigargin results in increased expression of GC protein	CTD	PMID:35544339
Gc	Rat	thioacetamide	increases expression	EXP		6480464	Thioacetamide results in increased expression of GC mRNA	CTD	PMID:23288050
Gc	Rat	thioacetamide	decreases expression	EXP		6480464	Thioacetamide results in decreased expression of GC mRNA	CTD	PMID:34492290
Gc	Rat	titanium dioxide	decreases expression	ISO	RGD:10624	6480464	titanium dioxide results in decreased expression of GC mRNA	CTD	PMID:23557971
Gc	Rat	tremolite asbestos	increases expression	ISO	RGD:10624	6480464	tremolite results in increased expression of GC mRNA	CTD	PMID:29279043
Gc	Rat	valproic acid	increases expression	EXP		6480464	Valproic Acid results in increased expression of GC mRNA	CTD	PMID:35594946
Gc	Rat	verapamil	affects expression	EXP		6480464	Verapamil affects the expression of GC protein	CTD	PMID:23533533
Gc	Rat	vitamin D	affects binding	ISO	RGD:736902	6480464	GC protein polymorphism binds to Vitamin D metabolite; Vitamin D binds to GC protein	CTD	PMID:25590278\|PMID:8370586
Gc	Rat	vitamin D	multiple interactions	EXP		6480464	Vitamin D affects the reaction [nitrofen results in increased expression of GC mRNA]	CTD	PMID:33484710
Gc	Rat	vitamin D	affects binding	ISO	RGD:10624	6480464	Vitamin D binds to GC protein	CTD	PMID:10052453
Gc	Rat	vitamin D	multiple interactions	ISO	RGD:10624	6480464	LRP2 protein binds to and results in increased uptake of [Vitamin D binds to GC more ...	CTD	PMID:10052453
Gc	Rat	zoledronic acid	increases expression	ISO	RGD:736902	6480464	zoledronic acid results in increased expression of GC protein	CTD	PMID:28871336

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gc	Rat	female pregnancy		IEP		2315536		RGD
Gc	Rat	lactation		IEP		2315536		RGD
Gc	Rat	response to estradiol		IEP		2315533		RGD
Gc	Rat	response to nutrient levels		IEP		2315500		RGD
Gc	Rat	response to steroid hormone		IEP		2315536		RGD
Gc	Rat	vitamin D metabolic process	involved_in	IBA	MGI:95669\|PANTHER:PTN002604574	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Gc	Rat	vitamin D metabolic process	acts_upstream_of_or_within	IEA	UniProtKB:P21614\|ensembl:ENSMUSP00000046636	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gc	Rat	vitamin D metabolic process	acts_upstream_of_or_within	ISO	RGD:10624	1624291	PMID:15225763	RGD	PMID:15225763
Gc	Rat	vitamin transmembrane transport	involved_in	IEA	GO:0090482	1600115	GO_REF:0000108	GOC	GO_REF:0000108
Gc	Rat	vitamin transport	involved_in	IEA	InterPro:IPR000213	1600115	GO_REF:0000002	InterPro	GO_REF:0000002

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gc	Rat	axon		IDA		2315499		RGD
Gc	Rat	cytoplasm	is_active_in	IBA	MGI:87951\|MGI:87991\|PANTHER:PTN000147344\|RGD:2667\|UniProtKB:P02768\|UniProtKB:P19121	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Gc	Rat	extracellular region	located_in	IEA	UniProtKB-KW:KW-0964	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Gc	Rat	extracellular region	located_in	IEA	UniProtKB-SubCell:SL-0243	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Gc	Rat	extracellular space	located_in	IEA	InterPro:IPR000213\|InterPro:IPR000264\|InterPro:IPR014760\|InterPro:IPR020858	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Gc	Rat	extracellular space		IDA		2315530		RGD
Gc	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Gc	Rat	perinuclear region of cytoplasm		IDA		2315499		RGD

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gc	Rat	actin binding	enables	IEA	UniProtKB-KW:KW-0009	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Gc	Rat	actin binding	enables	ISO	RGD:736902	1624291	UniProtKB:P62740 PMID:12119014	RGD	PMID:12119014
Gc	Rat	actin binding	enables	IEA	UniProtKB:P02774\|ensembl:ENSP00000273951	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gc	Rat	actin binding	enables	ISS	UniProtKB:P02774	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Gc	Rat	calcidiol binding	enables	ISO	RGD:736902	1624291	PMID:11799400	RGD	PMID:11799400
Gc	Rat	calcidiol binding	enables	IEA	UniProtKB:P02774\|ensembl:ENSP00000273951	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gc	Rat	protein binding		IPI	UniProtKB:P68135\|UniProtKB:P00639	2315530		RGD
Gc	Rat	vitamin D binding		TAS		731145		RGD
Gc	Rat	vitamin D binding	enables	IEA	InterPro:IPR000213	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Gc	Rat	vitamin D binding	enables	IBA	PANTHER:PTN002604574\|RGD:2667\|UniProtKB:P02774	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Gc	Rat	vitamin D binding	enables	IEA	UniProtKB-KW:KW-0848	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Gc	Rat	vitamin D binding		IDA		2315532		RGD
Gc	Rat	vitamin transmembrane transporter activity	enables	IEA	InterPro:IPR000213	1600115	GO_REF:0000002	InterPro	GO_REF:0000002

Disease Annotations Click to see Annotation Detail View

acute kidney failure (ISO)

Acute Liver Failure (ISO)

AIDS Dementia Complex (ISO)

arthritis (ISO)

asthma (ISO)

brain ischemia (IEP)

Carotid Artery Injuries (IEP)

Chemical and Drug Induced Liver Injury (ISO)

Chronic Bronchitis (ISO)

chronic obstructive pulmonary disease (ISO)

Crohn's disease (ISO)

dengue disease (ISO)

diabetes mellitus (ISO)

diabetic retinopathy (ISO)

endometriosis (ISO)

Experimental Diabetes Mellitus (IEP)

Experimental Liver Cirrhosis (ISO)

Graves' disease (ISO)

hepatic encephalopathy (ISO)

hepatocellular carcinoma (IEP,ISO)

human immunodeficiency virus infectious disease (ISO)

Intervertebral Disc Displacement (ISO)

liver cirrhosis (ISO)

Lung Neoplasms (ISO)

Metabolic Bone Diseases (ISO)

multiple sclerosis (ISO)

nephrotoxicity (IEP)

neurodegenerative disease (ISO)

periodontitis (ISO)

Pneumonia, Ventilator-Associated (ISO)

pre-eclampsia (ISO)

Pregnancy in Diabetics (IEP)

primary progressive multiple sclerosis (ISO)

rheumatic fever (ISO)

rheumatoid arthritis (ISO)

schizophrenia (ISO)

sciatic neuropathy (ISO)

toxic shock syndrome (ISO)

type 1 diabetes mellitus (ISO)

ulcerative colitis (ISO)

uveitis (ISO)

Vitamin D Deficiency (ISO)

Wounds and Injuries (IEP,ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,6-dinitrotoluene (EXP)

2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile (EXP)

2-methoxyethanol (EXP)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

7,12-dimethyltetraphene (ISO)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

allethrin (EXP)

ammonium chloride (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bexarotene (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bleomycin A2 (EXP)

bromobenzene (EXP)

buta-1,3-diene (ISO)

cadmium atom (ISO)

calcitriol (EXP,ISO)

calcium atom (EXP)

calcium silicate (ISO)

calcium(0) (EXP)

carbon atom (ISO)

carbon nanotube (ISO)

carnosic acid (ISO)

chromium trinitrate (ISO)

cisplatin (EXP,ISO)

clofibrate (EXP)

clofibric acid (EXP)

cobalt dichloride (EXP)

copper atom (ISO)

copper(0) (ISO)

cyclosporin A (EXP,ISO)

cyhalothrin (EXP)

cypermethrin (EXP)

D-glucose (ISO)

dibutyl phthalate (ISO)

diclofenac (EXP)

diquat (ISO)

doxorubicin (EXP,ISO)

elemental carbon (ISO)

ethanol (ISO)

fenvalerate (EXP)

folic acid (ISO)

fructose (ISO)

furan (EXP)

genistein (EXP)

glucose (ISO)

glyphosate (ISO)

lead diacetate (EXP)

lead(0) (ISO)

lipopolysaccharide (ISO)

methidathion (ISO)

methylmercury(1+) (EXP)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

N-nitrosomorpholine (EXP)

N-Nitrosopyrrolidine (ISO)

nefazodone (EXP)

nickel atom (ISO)

nimesulide (EXP)

nitrofen (EXP)

O-methyleugenol (ISO)

ochratoxin A (EXP)

okadaic acid (ISO)

olanzapine (ISO)

ouabain (ISO)

p-toluidine (EXP)

paracetamol (EXP,ISO)

parathion (ISO)

perfluorododecanoic acid (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenethyl caffeate (EXP)

pirinixic acid (ISO)

potassium chromate (ISO)

potassium dichromate (ISO)

pyrethrins (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

S-butyl-DL-homocysteine (S,R)-sulfoximine (EXP)

sarin (EXP)

senecionine (ISO)

silicon dioxide (EXP,ISO)

sodium arsenite (EXP,ISO)

tacrolimus hydrate (EXP,ISO)

terbufos (ISO)

tetrachloromethane (ISO)

thapsigargin (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

tremolite asbestos (ISO)

valproic acid (EXP)

verapamil (EXP)

vitamin D (EXP,ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

female pregnancy (IEP)

lactation (IEP)

response to estradiol (IEP)

response to nutrient levels (IEP)

response to steroid hormone (IEP)

vitamin D metabolic process (IBA,IEA,ISO)

vitamin transmembrane transport (IEA)

vitamin transport (IEA)

Cellular Component

axon (IDA)

cytoplasm (IBA)

extracellular region (IEA)

extracellular space (IDA,IEA)

membrane (IEA)

perinuclear region of cytoplasm (IDA)

Molecular Function

actin binding (IEA,ISO,ISS)

calcidiol binding (IEA,ISO)

protein binding (IPI)

vitamin D binding (IBA,IDA,IEA,TAS)

vitamin transmembrane transporter activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Gel-based proteomics of liver cancer progression in rat.	Albrethsen J, etal., Biochim Biophys Acta. 2011 Oct;1814(10):1367-76. Epub 2011 Jun 6.
2.	Two-dimensional difference gel electrophoresis (DiGE) analysis of plasmas from dengue fever patients.	Albuquerque LM, etal., J Proteome Res. 2009 Dec;8(12):5431-41.
3.	An association between Gc (vitamin D-binding protein) alleles and susceptibility to rheumatic fever.	Bahr GM, etal., Immunology. 1989 May;67(1):126-8.
4.	The genetic association database.	Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
5.	Serum and peritoneal evaluation of vitamin D-binding protein in women with endometriosis.	Borkowski J, etal., Postepy Hig Med Dosw (Online). 2008 Mar 3;62:103-9.
6.	Immunochemical measurement of the vitamin D-binding protein in rat serum.	Bouillon R, etal., Endocrinology. 1978 Jun;102(6):1710-5.
7.	Rat vitamin D binding protein. Determination of the full-length primary structure from cloned cDNA.	Cooke NE J Biol Chem 1986 Mar 5;261(7):3441-50.
8.	Group-specific component (Gc) proteins bind vitamin D and 25-hydroxyvitamin D.	Daiger SP, etal., Proc Natl Acad Sci U S A. 1975 Jun;72(6):2076-80.
9.	Bayesian approach to searching for susceptibility genes: Gc2 and EsD1 alleles and multiple sclerosis.	Di Bacco M, etal., Coll Antropol. 2002 Jun;26(1):77-84.
10.	Analysis of changes in acute-phase plasma proteins in an acute inflammatory response and in rheumatoid arthritis using two-dimensional gel electrophoresis.	Doherty NS, etal., Electrophoresis. 1998 Feb;19(2):355-63.
11.	Association of different allelic forms of group specific component with susceptibility to and clinical manifestation of human immunodeficiency virus infection.	Eales LJ, etal., Lancet. 1987 May 2;1(8540):999-1002.
12.	Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease.	Eloranta JJ, etal., Pharmacogenet Genomics. 2011 Sep;21(9):559-64.
13.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
15.	Questioning the role of actinfree Gc-Globulin as actin scavenger in neurodegenerative central nervous system disease: relationship to S-100B levels and blood-brain barrier function.	Gressner OA, etal., Clin Chim Acta. 2009 Feb;400(1-2):86-90. Epub 2008 Oct 30.
16.	Proteomic identification of biomarkers of vascular injury.	Huang NF, etal., Am J Transl Res. 2011 Feb;3(2):139-48. Epub 2010 Nov 21.
17.	Genetic-biochemical criteria for individual sensitivity in development of occupational bronchopulmonary diseases.	Izmerov NF, etal., Cent Eur J Public Health. 2002 Jun;10(1-2):35-41.
18.	Proteomics of the injured rat sciatic nerve reveals protein expression dynamics during regeneration.	Jimenez CR, etal., Mol Cell Proteomics. 2005 Feb;4(2):120-32. Epub 2004 Oct 25.
19.	Distribution of vitamin D binding protein expressing neurons in the rat hypothalamus.	Jirikowski GF, etal., Histochem Cell Biol. 2009 Mar;131(3):365-70. Epub 2008 Nov 26.
20.	Associations of vitamin d binding protein gene polymorphisms with the development of peripheral arthritis and uveitis in ankylosing spondylitis.	Jung KH, etal., J Rheumatol. 2011 Oct;38(10):2224-9. Epub 2011 Aug 15.
21.	Vitamin D-binding protein (DBP) gene polymorphism is associated with Graves' disease and the vitamin D status in a Polish population study.	Kurylowicz A, etal., Exp Clin Endocrinol Diabetes. 2006 Jun;114(6):329-35.
22.	Association of circulating 25-hydroxyvitamin D levels with hypertension and blood pressure values in Korean adults: A Mendelian randomization study on a subset of the Korea National Health and Nutrition Survey 2011-2012 population.	Kwak SY, etal., Nutr Res Pract. 2019 Dec;13(6):498-508. doi: 10.4162/nrp.2019.13.6.498. Epub 2019 Aug 13.
23.	Changes with malnutrition in the concentration of plasma vitamin D binding protein in growing rats.	Laing CJ and Fraser DR, Br J Nutr. 2002 Aug;88(2):133-9.
24.	Relationship between group-specific component protein and the development of asthma.	Lee SH, etal., Am J Respir Crit Care Med. 2011 Sep 1;184(5):528-36.
25.	Induction of cytosolic receptors for 1 alpha, 25-dihydroxyvitamin D3 in the immature rat uterus by oestradiol.	Levy J, etal., J Endocrinol. 1984 Mar;100(3):265-9.
26.	Proteomic profiles of bronchoalveolar lavage fluid from patients with ventilator-associated pneumonia by gel-assisted digestion and 2-D-LC/MS/MS.	Lu YT, etal., Proteomics Clin Appl. 2008 Sep;2(9):1208-22. doi: 10.1002/prca.200800069. Epub 2008 Aug 7.
27.	Vitamin-D dysregulation in early- and late-onset preeclampsia: A gestational-age matched study.	Martin CB, etal., J Steroid Biochem Mol Biol. 2020 Oct;203:105729. doi: 10.1016/j.jsbmb.2020.105729. Epub 2020 Jul 15.
28.	The vitamin D-binding protein, alpha-fetoprotein, albumin multigene family: detection of transcripts in multiple tissues.	McLeod JF and Cooke NE, J Biol Chem 1989 Dec 25;264(36):21760-9.
29.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
30.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
31.	No association of vitamin D-binding protein gene polymorphisms in Japanese patients with MS.	Niino M, etal., J Neuroimmunol. 2002 Jun;127(1-2):177-9.
32.	1,25-Dihydroxyvitamin D and vitamin D-binding protein are both decreased in streptozotocin-diabetic rats.	Nyomba BL, etal., Endocrinology. 1985 Jun;116(6):2483-8.
33.	Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative and anti-inflammatory activities in rat.	Obaid AA, etal., J Trace Elem Med Biol. 2023 May 24;79:127221. doi: 10.1016/j.jtemb.2023.127221.
34.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
35.	The HLA-DQB alleles and amino acid variants of the vitamin D-binding protein in diabetic patients in Alsace.	Ongagna JC, etal., Clin Biochem. 2001 Feb;34(1):59-63.
36.	Multiple sclerosis: Identification and clinical evaluation of novel CSF biomarkers.	Ottervald J, etal., J Proteomics. 2010 Apr 18;73(6):1117-32. Epub 2010 Jan 20.
37.	Proteomic analysis of vitreous from diabetic macular edema.	Ouchi M, etal., Exp Eye Res. 2005 Aug;81(2):176-82.
38.	A polymorphism within the vitamin D-binding protein gene is associated with Graves' disease but not with Hashimoto's thyroiditis.	Pani MA, etal., J Clin Endocrinol Metab. 2002 Jun;87(6):2564-7.
39.	Association of single nucleotide polymorphisms in VDR and DBP genes with HBV-related hepatocellular carcinoma risk in a Chinese population.	Peng Q, etal., PLoS One. 2014 Dec 26;9(12):e116026. doi: 10.1371/journal.pone.0116026. eCollection 2014.
40.	Alteration of DBP levels in CSF of patients with MS by proteomics analysis.	Qin Z, etal., Cell Mol Neurobiol. 2009 Mar;29(2):203-10. Epub 2008 Sep 19.
41.	The rat vitamin D binding protein (Gc-globulin) gene. Structural analysis, functional and evolutionary correlations.	Ray K, etal., J Biol Chem 1991 Apr 5;266(10):6221-9.
42.	GOA pipeline	RGD automated data pipeline
43.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
45.	Protein expression profiles in pediatric multiple sclerosis: potential biomarkers.	Rithidech KN, etal., Mult Scler. 2009 Apr;15(4):455-64.
46.	Cerebrospinal fluid proteomic profiling of HIV-1-infected patients with cognitive impairment.	Rozek W, etal., J Proteome Res. 2007 Nov;6(11):4189-99. Epub 2007 Oct 12.
47.	Vitamin D binding protein variants and the risk of COPD.	Schellenberg D, etal., Am J Respir Crit Care Med. 1998 Mar;157(3 Pt 1):957-61.
48.	Increased turnover of Gc-globulin in patients with hepatic encephalopathy.	Schiodt FV, etal., Scand J Gastroenterol. 2001 Sep;36(9):998-1003.
49.	Acute-phase proteins before cerebral ischemia in stroke-prone rats: identification by proteomics.	Sironi L, etal., Stroke. 2001 Mar;32(3):753-60.
50.	Vitamin D-binding protein gene transcription is regulated by the relative abundance of hepatocyte nuclear factors 1alpha and 1beta.	Song YH, etal., J Biol Chem 1998 Oct 23;273(43):28408-18.
51.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
52.	Electrophoretic mobility shift assay identifies vitamin D binding protein (Gc-globulin) in human, rat, and mouse sera.	Tang WX, etal., Anal Biochem. 1996 Jun 1;237(2):245-51.
53.	Vitamin D and bone mineral homeostasis during pregnancy in the diabetic BB rat.	Verhaeghe J, etal., Endocrinology. 1986 Mar;118(3):1019-25.
54.	Differential proteomic characterization between normal peritoneal fluid and diabetic peritoneal dialysate.	Wang HY, etal., Nephrol Dial Transplant. 2010 Jun;25(6):1955-63. Epub 2010 Jan 6.
55.	Serum proteomic analysis of extracorporeal shock wave therapy-enhanced diabetic wound healing in a streptozotocin-induced diabetes model.	Yang MY, etal., Plast Reconstr Surg. 2014 Jan;133(1):59-68. doi: 10.1097/01.prs.0000439050.08733.cf.

Additional References at PubMed

PMID:3713442	PMID:11799400	PMID:12119014	PMID:15225763	PMID:16502470	PMID:22516433	PMID:23339019	PMID:23376485	PMID:23533145	PMID:31792309

Genomics

Comparative Map Data

Gc
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	18,916,255 - 18,951,670 (+)	NCBI		GRCr8
mRatBN7.2	14	18,632,146 - 18,667,563 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	18,632,135 - 18,667,567 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	18,622,611 - 18,658,030 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	19,941,501 - 19,976,920 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	18,653,131 - 18,688,560 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	20,267,023 - 20,302,577 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	20,266,891 - 20,302,581 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	20,173,467 - 20,209,021 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	20,166,243 - 20,197,060 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	20,166,180 - 20,201,613 (+)	NCBI
Celera	14	17,992,337 - 18,027,605 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

GC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	71,741,693 - 71,805,520 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	71,741,696 - 71,804,041 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	72,607,410 - 72,671,237 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	72,826,274 - 72,868,752 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	72,972,446 - 73,014,923	NCBI
Celera	4	69,964,129 - 70,006,624 (-)	NCBI		Celera
Cytogenetic Map	4	q13.3	NCBI
HuRef	4	68,412,706 - 68,476,557 (-)	NCBI		HuRef
CHM1_1	4	72,643,398 - 72,707,216 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	75,084,117 - 75,147,957 (-)	NCBI		T2T-CHM13v2.0

Gc
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	89,565,370 - 89,605,757 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	89,565,381 - 89,605,757 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	89,417,511 - 89,457,898 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	89,417,522 - 89,457,898 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	89,846,547 - 89,886,790 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	90,492,721 - 90,532,964 (-)	NCBI		MGSCv36	mm8
Celera	5	87,554,559 - 87,593,435 (-)	NCBI		Celera
Cytogenetic Map	5	E1	NCBI
cM Map	5	44.32	NCBI

Gc
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955447	1,361,566 - 1,402,491 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955447	1,361,698 - 1,400,633 (+)	NCBI	ChiLan1.0	ChiLan1.0

GC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	58,270,055 - 58,332,433 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	58,466,887 - 58,529,283 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	52,431,196 - 52,473,762 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	58,749,384 - 58,792,073 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	58,729,236 - 58,792,073 (+)	Ensembl	panpan1.1		panPan2

GC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	60,795,305 - 60,828,038 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	60,795,305 - 60,827,929 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	60,528,533 - 60,561,906 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	61,603,086 - 61,636,545 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	61,603,088 - 61,652,533 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	61,215,897 - 61,249,598 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	60,708,804 - 60,742,244 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	61,856,182 - 61,889,922 (-)	NCBI		UU_Cfam_GSD_1.0

Gc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	14,767,874 - 14,809,615 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936598	3,219,991 - 3,261,629 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936598	3,220,029 - 3,256,091 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	68,326,299 - 68,360,262 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	68,326,293 - 68,360,262 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	72,227,896 - 72,261,806 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	20,254,604 - 20,298,384 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	20,253,879 - 20,298,265 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666084	2,553,410 - 2,596,840 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gc
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624890	3,226,900 - 3,318,316 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624890	3,274,239 - 3,318,281 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gc
387 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	17
Count of miRNA genes:	17
Interacting mature miRNAs:	17
Transcripts:	ENSRNOT00000004174
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300114	Srn2	Serum renin concentration QTL 2	3.27		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	3813074	21217635	Rat
631528	Scl11	Serum cholesterol level QTL 11	4.9		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	14	17573412	19726296	Rat
1581500	Renag1	Renal agenesis QTL 1			kidney development trait (VT:0000527)	percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)	14	8170668	68298175	Rat
731183	Pia20	Pristane induced arthritis QTL 20	3.55		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	9088978	39057237	Rat
631212	Bw5	Body weight QTL5	5.43		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	14	11030812	30320092	Rat
2302277	Gluco38	Glucose level QTL 38	5.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	28035204	Rat
1331740	Bw26	Body weight QTL 26	3.028		body mass (VT:0001259)	body weight (CMO:0000012)	14	3813074	30767156	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
1358296	Ael3	Aortic elastin QTL 3	3.7	0.00051	aorta elastin amount (VT:0003905)	aortic elastin	14	8267090	53267090	Rat
71117	Niddm17	Non-insulin dependent diabetes mellitus QTL 17	2.35		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	17593761	42336881	Rat
61420	Pia6	Pristane induced arthritis QTL 6	4.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	14	18631345	42337007	Rat
70195	Mcs8	Mammary carcinoma susceptibility QTL 8	4.28		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	14	3813074	24531477	Rat
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	95876975	Rat
2313397	Coatc1	Coat color QTL1			coat/hair pigmentation trait (VT:0010463)	coat/hair color measurement (CMO:0001808)	14	18541332	63541332	Rat
631262	Tcas4	Tongue tumor susceptibility QTL 4	7.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	14	17622561	42337007	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
2302045	Pia39	Pristane induced arthritis QTL 39	4.9	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G2a level (CMO:0002116)	14	8267090	53267090	Rat
1300140	Srn3	Serum renin concentration QTL 3	3.19		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	14875168	30883947	Rat

Markers in Region

D14Mgh3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	14	18,915,454 - 18,915,579 (+)	Marker Load Pipeline
mRatBN7.2	14	18,631,345 - 18,631,470 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	20,266,223 - 20,266,347	NCBI	Rnor6.0
Rnor_5.0	14	20,172,667 - 20,172,791	UniSTS	Rnor5.0
RGSC_v3.4	14	20,165,393 - 20,165,518	RGD	RGSC3.4
RGSC_v3.4	14	20,165,394 - 20,165,518	UniSTS	RGSC3.4
RGSC_v3.1	14	20,165,393 - 20,165,518	RGD
Celera	14	17,991,537 - 17,991,661	UniSTS
RH 3.4 Map	14	265.8	UniSTS
RH 3.4 Map	14	265.8	RGD
RH 2.0 Map	14	260.2	RGD
Cytogenetic Map	14	p22	UniSTS

D14Wox12

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	14	18,928,152 - 18,928,341 (+)	Marker Load Pipeline
mRatBN7.2	14	18,644,043 - 18,644,232 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	20,278,921 - 20,279,109	NCBI	Rnor6.0
Rnor_5.0	14	20,185,365 - 20,185,553	UniSTS	Rnor5.0
RGSC_v3.4	14	20,178,092 - 20,178,280	UniSTS	RGSC3.4
RGSC_v3.4	14	20,178,091 - 20,178,280	RGD	RGSC3.4
RGSC_v3.1	14	20,178,091 - 20,178,280	RGD
Celera	14	18,004,268 - 18,004,454	UniSTS
RH 3.4 Map	14	264.4	RGD
RH 3.4 Map	14	264.4	UniSTS
RH 2.0 Map	14	263.7	RGD
Cytogenetic Map	14	p22	UniSTS

D14Arb17

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	14	18,928,121 - 18,928,342 (+)	Marker Load Pipeline
mRatBN7.2	14	18,644,012 - 18,644,233 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	20,278,890 - 20,279,110	NCBI	Rnor6.0
Rnor_5.0	14	20,185,334 - 20,185,554	UniSTS	Rnor5.0
RGSC_v3.4	14	20,178,061 - 20,178,281	UniSTS	RGSC3.4
RGSC_v3.4	14	20,178,060 - 20,178,281	RGD	RGSC3.4
RGSC_v3.1	14	20,178,060 - 20,178,281	RGD
Celera	14	18,004,237 - 18,004,455	UniSTS
SHRSP x BN Map	14	6.9	UniSTS
SHRSP x BN Map	14	6.9	RGD
Cytogenetic Map	14	p22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
8	9	16	60	89	88	59	24	59	6	179	59	41	45	54	29

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012564	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AH002167	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078891	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474060	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ209523	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ209578	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ209652	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ209764	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ209886	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ209967	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210204	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210565	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210683	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210734	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210808	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210855	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211064	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211277	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211757	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217370	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218130	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218396	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218587	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218742	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219041	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219081	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219132	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219314	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219497	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219502	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	J05148	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M12450	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000004174 ⟹ ENSRNOP00000004174

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	18,632,135 - 18,667,567 (+)	Ensembl
Rnor_6.0 Ensembl	14	20,266,891 - 20,302,581 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098849 ⟹ ENSRNOP00000083512

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	18,642,699 - 18,658,586 (+)	Ensembl

RefSeq Acc Id:

NM_012564 ⟹ NP_036696

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	18,916,255 - 18,951,670 (+)	NCBI
mRatBN7.2	14	18,632,146 - 18,667,563 (+)	NCBI
Rnor_6.0	14	20,267,023 - 20,302,577 (+)	NCBI
Rnor_5.0	14	20,173,467 - 20,209,021 (+)	NCBI
RGSC_v3.4	14	20,166,243 - 20,197,060 (+)	RGD
Celera	14	17,992,337 - 18,027,605 (+)	NCBI

Sequence:

show sequence

CGGTGTCCTGTGGGTGAGAGGAGGTGCTGCAGGACTCCCTGGACGCAAAATGAAGAGGGTTCTG
GTTCTCCTGCTGGCCTTAGCCTTTGGGCATGCCCTAGAGAGAGGCCGAGATTATGAGAAGGATA
AAGTTTGCCAGGAACTCTCCACGCTGGGGAAAGATGACTTCAGATCTCTATCACTAATCCTATA
CAGCAGGAAGTTTCCCAGTAGCACCTTTGAACAGGTCAGTCAGCTTGTGAAGGAAGTTGTCTCC
TTAACTGAGGAATGCTGTGCTGAGGGAGCAGATCCCAACTGCTATGACACCAGGACTTCAGAGC
TGTCTATTAAGTCCTGTGAAAGTGACGCCCCCTTTCCCGTTCACCCCGGGACTTCCGAGTGTTG
CACGAAGGAGGGGCTAGAGCGGAAACTCTGCATGGCTGCCCTCAGTCACCAGCCACAGGAATTT
CCCGCCTATGTGGAGCCGACGAATGATGAGATCTGTGAGGCGTTCAGGAAGGATCCAAAGGGAT
TTGCCGATCAGTTTCTATTCGAATATTCCAGCAATTACGGACAAGCTCCTCTGCCACTTTTAGT
TGGTTACACCAAGAGTTATCTCTCTATGGTTGGCTCCTGCTGTACTTCTGCAAAACCAACTGTG
TGCTTTTTGAAGGAGAGACTCCAGATGAAACAGTTATCACTTCTCACCACTATGTCAAACAGAG
TCTGCTCACAATATGCTGCATATGGAAAGGAAAAATCAAGGATGAGCCATCTCATAAAACTAGC
CCAAAAAGTACCAACTGCTAACCTGGAGGATGTTCTGCCACTCGCTGAAGACCTTACTGAAATC
CTGTCCAGATGTTGTAAGTCTACCTCAGAGGACTGCATGGCCAGAGAGCTGCCTGAACACACAT
TAAAAATCTGTGGAAACTTATCCAAAAAGAATTCAAAGTTTGAAGAGTGCTGTTACGAAACAAC
ACCCATGGGCATTTTTATGTGTAGCTACTTCATGCCAACTGCTGAACCACTTCAATTGCCAGCC
ATCAAGCTGCCAACCAGCAAAGACCTCTGTGGTCAGAGTGCCACACAAGCCATGGACCAGTATA
CATTTGAACTAAGCAGAAGGACCCAGGTTCCAGAAGTGTTCCTCAGCAAAGTTCTGGATACGAC
CCTGAAAACCCTTAGGGAATGCTGCGACACTCAGGACTCTGTCTCCTGTTTCAGCACTCAGAGT
CCCCTGATGAAGAGGCAACTAACTTCTTTCATTGAAAAGGGGCAAGAAATGTGTGCAGATTATT
CCGAGAACACATTTACTGAGTACAAGAAAAAATTGGCGGAACGACTGAGGACAAAAATGCCCAA
TGCCTCCCCGGAAGAGCTGGCAGACATGGTGGCCAAGCACTCAGACTTTGCCTCCAAGTGCTGC
TCCATAAACTCTCCTCCACGCTACTGTAGCTCACAGATTGATGCAGAAATGAGAGACATCCTGC
AGTCCTGATGCAGGGTATATGCAATGCCTTGGACCTAGAACTGGACCACTCTGGAAAATTGCCA
GATAACAAAATCAAGCAAATACCACAGAGATGGCCTTCCAAGAAGACCACCAAGATAATTCCAT
TTTTCCCATCTACAATGTTTTTTGATGAATTATAAAAATAAATTGAAATATAGTGCAAAAAAAA
AAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_036696	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41080	(Get FASTA)	NCBI Sequence Viewer
	AAA41081	(Get FASTA)	NCBI Sequence Viewer
	AAA41082	(Get FASTA)	NCBI Sequence Viewer
	AAH78891	(Get FASTA)	NCBI Sequence Viewer
	EDL88537	(Get FASTA)	NCBI Sequence Viewer
	EDL88538	(Get FASTA)	NCBI Sequence Viewer
	EDL88539	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000004174
GenBank Protein	P04276	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_036696 ⟸ NM_012564
- Peptide Label:	precursor
- UniProtKB:	P04276 (UniProtKB/Swiss-Prot), Q68FY4 (UniProtKB/TrEMBL), A6KKH1 (UniProtKB/TrEMBL), F7FJ08 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKRVLVLLLALAFGHALERGRDYEKDKVCQELSTLGKDDFRSLSLILYSRKFPSSTFEQVSQLV KEVVSLTEECCAEGADPNCYDTRTSELSIKSCESDAPFPVHPGTSECCTKEGLERKLCMAALSH QPQEFPAYVEPTNDEICEAFRKDPKGFADQFLFEYSSNYGQAPLPLLVGYTKSYLSMVGSCCTS AKPTVCFLKERLQMKQLSLLTTMSNRVCSQYAAYGKEKSRMSHLIKLAQKVPTANLEDVLPLAE DLTEILSRCCKSTSEDCMARELPEHTLKICGNLSKKNSKFEECCYETTPMGIFMCSYFMPTAEP LQLPAIKLPTSKDLCGQSATQAMDQYTFELSRRTQVPEVFLSKVLDTTLKTLRECCDTQDSVSC FSTQSPLMKRQLTSFIEKGQEMCADYSENTFTEYKKKLAERLRTKMPNASPEELADMVAKHSDF ASKCCSINSPPRYCSSQIDAEMRDILQS hide sequence

Ensembl Acc Id:

ENSRNOP00000004174 ⟸ ENSRNOT00000004174

Ensembl Acc Id:

ENSRNOP00000083512 ⟸ ENSRNOT00000098849

Protein Domains

Albumin

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P04276-F1-model_v2	AlphaFold	P04276	1-476	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699237

Promoter ID:

EPDNEW_R9761

Type:

initiation region

Name:

Gc_1

Description:

GC, vitamin D binding protein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	20,267,014 - 20,267,074	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2667	AgrOrtholog
BioCyc Gene	G2FUF-16172	BioCyc
Ensembl Genes	ENSRNOG00000003119	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000004174	ENTREZGENE
Gene3D-CATH	1.10.246.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7130137	IMAGE-MGC_LOAD
InterPro	ALB/AFP/VDB	UniProtKB/Swiss-Prot
	Serum_albumin-like	UniProtKB/Swiss-Prot
	Serum_albumin_CS	UniProtKB/Swiss-Prot
	Serum_albumin_N	UniProtKB/Swiss-Prot
	VitD-bd	UniProtKB/Swiss-Prot
	VitD-bind_III	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93612	IMAGE-MGC_LOAD
NCBI Gene	24384	ENTREZGENE
PANTHER	PTHR11385	UniProtKB/Swiss-Prot
	PTHR11385:SF11	UniProtKB/Swiss-Prot
Pfam	Serum_albumin	UniProtKB/Swiss-Prot
	VitD-bind_III	UniProtKB/Swiss-Prot
PhenoGen	Gc	PhenoGen
PRINTS	SERUMALBUMIN	UniProtKB/Swiss-Prot
	VITAMNDBNDNG	UniProtKB/Swiss-Prot
PROSITE	ALBUMIN_1	UniProtKB/Swiss-Prot
	ALBUMIN_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000003119	RatGTEx
SMART	ALBUMIN	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48552	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZW66_RAT	UniProtKB/TrEMBL
	A6KKH1	ENTREZGENE, UniProtKB/TrEMBL
	A6KKH2_RAT	UniProtKB/TrEMBL
	A6KKH3_RAT	UniProtKB/TrEMBL
	F7FJ08	ENTREZGENE, UniProtKB/TrEMBL
	P04276	ENTREZGENE
	Q68FY4	ENTREZGENE
	VTDB_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-03-07	Gc	GC, vitamin D binding protein	Gc	group specific component	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Gc	Group-specific component (vitamin D-binding protein)			Symbol and Name status set to approved	70586	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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