Gene: Gc (GC, vitamin D binding protein) Rattus norvegicus
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Symbol:
Gc
Name:
GC, vitamin D binding protein
Description:
Exhibits vitamin D binding activity. Involved in several processes, including female pregnancy; lactation; and response to estradiol. Localizes to several cellular components, including the axon; extracellular space; and perinuclear region of cytoplasm. Biomarker of brain ischemia and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); hepatocellular carcinoma; human immunodeficiency virus infectious disease; inflammatory bowel disease (multiple); and rheumatic fever. Orthologous to human GC (GC vitamin D binding protein); INTERACTS WITH 1-naphthyl isothiocyanate; 2,6-dinitrotoluene; 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
DBP; DBP02; gc-globulin; group specific component; group-specific component; Group-specific component (vitamin D-binding protein); RATDBP02; VDB; Vdbp; vitamin D-binding protein
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
GC (GC vitamin D binding protein) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Gc (vitamin D binding protein) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Gc (GC vitamin D binding protein) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
GC (GC vitamin D binding protein) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
GC (GC vitamin D binding protein) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Gc (GC vitamin D binding protein) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
GC (GC vitamin D binding protein) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Gc (vitamin D binding protein)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
GC (GC vitamin D binding protein)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
gc (GC vitamin D binding protein)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Is Marker For:
QTLs:
Scl11
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 14 20,267,023 - 20,302,577 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 14 20,266,891 - 20,302,581 (+) Ensembl Rnor_5.0 14 20,173,467 - 20,209,021 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 14 20,166,243 - 20,197,060 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 14 20,166,180 - 20,201,613 (+) NCBI Celera 14 17,992,337 - 18,027,605 (+) NCBI Celera Cytogenetic Map 14 p22 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
AIDS Dementia Complex ISO RDG:736902 5509882 associated with HIV Infections, protein:increased expression:cerebrospinal fluid: RGD arthritis susceptibility ISO RDG:736902 5509918 associated with Spondylitis, Ankylosing more ... RGD asthma ISO RGD:10624 5509920 RGD asthma ISO RDG:736902 5509920 protein, mRNA:increased expression:bronchoalveolar lavage fluid: RGD brain ischemia IEP 1625796 protein:increased expression:urine RGD Bronchitis, Chronic susceptibility ISO RDG:736902 5129516 RGD Carotid Artery Injuries IEP 5509868 protein:decreased expression:plasma RGD chronic obstructive pulmonary disease ISO RDG:736902 5509932 RGD Crohn's disease susceptibility ISO RDG:736902 5509866 DNA:polymorphism:cds:p.T420K(human) RGD dengue disease ISO RDG:736902 5509870 protein:increased expression:plasma RGD diabetes mellitus ISO RDG:736902 5509921 protein:increased expression:ascitic fluid RGD Diabetes Mellitus, Experimental IEP 2315540 protein:decreased expression:serum RGD diabetic retinopathy ISO RGD:736902 2315548 protein:increased expression:vitreous body RGD endometriosis severity ISO RDG:736902 5509874 RGD Graves' disease susceptibility ISO RDG:736902 5509883 DNA:polymorphism:cds:p.T420K(human) RGD Graves' disease susceptibility ISO RDG:736902 5509886 DNA:repeats:intron RGD hepatic encephalopathy ISO RDG:736902 5509929 RGD hepatocellular carcinoma IEP 5509919 protein:increased expression:liver RGD hepatocellular carcinoma susceptibility ISO RGD:736902 14402025 associated with Hepatitis B, Chronic, DNA:SNP: :rs7041(human) RGD human immunodeficiency virus infectious disease disease_progression ISO RDG:736902 5509934 RGD Intervertebral Disc Displacement ISO RDG:736902 5509883 protein:increased expression:cerebrospinal fluid RGD multiple sclerosis no_association ISO RDG:736902 5509887 DNA:SNPs:exon:p.T420K, D416E(human) RGD multiple sclerosis susceptibility ISO RDG:736902 5509885 RGD multiple sclerosis ISO RDG:736902 5509922 protein:increased expression:plasma: RGD multiple sclerosis ISO RDG:736902 5509923 protein:decreased expression:cerebrospinal fluid RGD neurodegenerative disease ISO RDG:736902 5509872 RGD Pneumonia, Ventilator-Associated ISO RDG:736902 5509873 protein:increased expression:bronchoalveolar fluid: RGD Pregnancy in Diabetics IEP 2315537 protein:decreased expression:plasma RGD primary progressive multiple sclerosis ISO RDG:736902 5509869 protein:increased expression:cerebrospinal fluid: RGD rheumatic fever ISO RDG:736902 5509933 RGD rheumatoid arthritis ISO RDG:736902 5509931 protein:decreased expression:plasma RGD sciatic neuropathy ISO RDG:736902 2316214 protein:increased expression:nerve RGD type 1 diabetes mellitus ISO RGD:736902 2315558 DNA:polymorphism:exon:p.D416E(human) RGD ulcerative colitis susceptibility ISO RDG:736902 5509866 DNA:polymorphism:cds:p.T420K(human) RGD uveitis susceptibility ISO RDG:736902 5509918 associated with Spondylitis, Ankylosing, DNA:SNP: :rs4752(human) RGD Wounds and Injuries treatment IEP 11041807 associated with Diabetes Mellitus, Experimental RGD
Imported Annotations - CTD
acute kidney failure ISO RGD:736902 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28885000 Acute Liver Failure ISO RGD:736902 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:8666322 , PMID:17852808 Chemical and Drug Induced Liver Injury ISO RGD:736902 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16099942 Drug-Related Side Effects and Adverse Reactions ISO RGD:736902 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28885000 Experimental Liver Cirrhosis ISO RGD:736902 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25380136 Graves' disease ISO RGD:736902 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12050214 hepatic encephalopathy ISO RGD:736902 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:11510020 liver cirrhosis ISO RGD:736902 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24381012 Lung Neoplasms ISO RGD:736902 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17902193 Metabolic Bone Diseases ISO RGD:736902 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24381012 multiple sclerosis ISO RGD:736902 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25590278 rheumatoid arthritis ISO RGD:736902 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:3874814 schizophrenia ISO RGD:736902 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25821032 toxic shock syndrome ISO RGD:736902 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17852808 Wounds and Injuries ISO RGD:736902 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17852808
Imported Annotations - Genetic Association Database
chronic obstructive pulmonary disease ISO RGD:736902 1331525 GAD Imported Annotations - OMIM
Graves' disease ISO RGD:736902 7240710 OMIM
1-naphthyl isothiocyanate decreases expression EXP 6480464 1-Naphthylisothiocyanate results in decreased expression of GC mRNA CTD PMID:25380136 17alpha-ethynylestradiol affects expression ISO RGD:10624 6480464 Ethinyl Estradiol affects the expression of GC mRNA CTD PMID:17555576 17alpha-ethynylestradiol multiple interactions ISO RGD:10624 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GC mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression ISO RGD:10624 6480464 Ethinyl Estradiol results in increased expression of GC mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10624 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GC mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10624 6480464 Tetrachlorodibenzodioxin results in decreased expression of GC mRNA CTD PMID:29673856 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of GC mRNA CTD PMID:21346803 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile affects expression EXP 6480464 Verapamil affects the expression of GC protein CTD PMID:23533533 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of GC mRNA CTD PMID:25380136 aflatoxin B1 affects expression ISO RGD:736902 6480464 Aflatoxin B1 affects the expression of GC protein CTD PMID:20106945 aflatoxin B1 decreases methylation ISO RGD:736902 6480464 Aflatoxin B1 results in decreased methylation of GC gene CTD PMID:27153756 aflatoxin B1 multiple interactions EXP 6480464 [Aflatoxin B1 co-treated with Buthionine Sulfoximine] results in increased expression of GC mRNA CTD PMID:23288050 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of GC mRNA CTD PMID:23288050 all-trans-retinoic acid increases expression ISO RGD:736902 6480464 Tretinoin results in increased expression of GC mRNA CTD PMID:23830798 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of GC mRNA CTD PMID:16483693 arsenite(3-) increases expression ISO RGD:10624 6480464 arsenite results in increased expression of GC mRNA CTD PMID:18929588 arsenite(3-) multiple interactions ISO RGD:10624 6480464 TRP53 protein affects the reaction [arsenite results in increased expression of GC mRNA] CTD PMID:18929588 benzo[b]fluoranthene increases expression ISO RGD:10624 6480464 benzo(b)fluoranthene results in increased expression of GC mRNA CTD PMID:26377693 bexarotene decreases expression EXP 6480464 bexarotene results in decreased expression of GC mRNA CTD PMID:16648578 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of GC mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:10624 6480464 bisphenol A results in increased expression of GC mRNA CTD PMID:30245210 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of GC mRNA CTD PMID:30903817 bleomycin A2 increases expression EXP 6480464 Bleomycin results in increased expression of GC protein CTD PMID:25933445 bromobenzene increases expression EXP 6480464 bromobenzene results in increased expression of GC mRNA CTD PMID:15056800 , PMID:23288050 buta-1,3-diene decreases expression ISO RGD:10624 6480464 1, 3-butadiene results in decreased expression of GC mRNA CTD PMID:29038090 cadmium atom increases expression ISO RGD:10624 6480464 Cadmium results in increased expression of GC mRNA CTD PMID:24067728 cadmium atom affects binding ISO RGD:736902 6480464 GC protein binds to Cadmium CTD PMID:23896426 calcitriol affects abundance ISO RGD:736902 6480464 GC protein affects the abundance of Calcitriol CTD PMID:6894152 calcitriol affects binding EXP 6480464 Calcitriol binds to GC protein CTD PMID:17444814 calcitriol affects binding ISO RGD:736902 6480464 GC protein polymorphism binds to Calcitriol CTD PMID:8370586 calcitriol affects transport ISO RGD:736902 6480464 GC protein affects the transport of Calcitriol CTD PMID:15820770 calcium atom affects expression EXP 6480464 Calcium affects the expression of GC mRNA CTD PMID:15913539 calcium(0) affects expression EXP 6480464 Calcium affects the expression of GC mRNA CTD PMID:15913539 carbon atom affects response to substance ISO RGD:736902 6480464 GC gene SNP affects the susceptibility to Carbon CTD PMID:21138591 carbon nanotube affects expression ISO RGD:10624 6480464 Nanotubes, Carbon affects the expression of GC protein CTD PMID:21135415 carbon nanotube increases secretion ISO RGD:10624 6480464 Nanotubes, Carbon results in increased secretion of GC protein CTD PMID:25598225 carbon nanotube increases expression ISO RGD:10624 6480464 Nanotubes, Carbon analog results in increased expression of GC mRNA, Nanotubes, Carbon results in increased expression of GC mRNA CTD PMID:25554681 chromium trinitrate decreases expression ISO RGD:10624 6480464 chromium nitrate results in decreased expression of GC protein CTD PMID:23618972 cisplatin increases secretion EXP 6480464 Cisplatin results in increased secretion of GC protein CTD PMID:28885000 clofibrate decreases expression EXP 6480464 Clofibrate results in decreased expression of GC mRNA CTD PMID:12851107 clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GC mRNA CTD PMID:17602206 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of GC mRNA CTD PMID:24386269 copper atom affects binding ISO RGD:736902 6480464 GC protein binds to Copper CTD PMID:23896426 copper(0) affects binding ISO RGD:736902 6480464 GC protein binds to Copper CTD PMID:23896426 cyclosporin A decreases expression ISO RGD:736902 6480464 Cyclosporine results in decreased expression of GC mRNA CTD PMID:20106945 , PMID:27989131 cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of GC mRNA CTD PMID:21865292 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of GC mRNA CTD PMID:21865292 diclofenac multiple interactions EXP 6480464 [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GC protein CTD PMID:25772430 doxorubicin increases secretion EXP 6480464 Doxorubicin results in increased secretion of GC protein CTD PMID:28885000 doxorubicin increases expression ISO RGD:10624 6480464 Doxorubicin results in increased expression of GC mRNA CTD PMID:15033991 elemental carbon affects response to substance ISO RGD:736902 6480464 GC gene SNP affects the susceptibility to Carbon CTD PMID:21138591 ethanol decreases expression ISO RGD:736902 6480464 Ethanol results in decreased expression of GC mRNA CTD PMID:31059573 furan affects binding EXP 6480464 furan binds to GC protein CTD PMID:22240984 furan increases methylation EXP 6480464 furan results in increased methylation of GC gene CTD PMID:22079235 genistein increases expression EXP 6480464 Genistein results in increased expression of GC protein CTD PMID:22649256 lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of GC mRNA CTD PMID:22641619 lead(0) affects binding ISO RGD:736902 6480464 GC protein binds to Lead CTD PMID:23896426 lead(2+) affects binding ISO RGD:736902 6480464 GC protein binds to Lead CTD PMID:23896426 methylmercury(1+) decreases expression EXP 6480464 methylmercury II results in decreased expression of GC mRNA CTD PMID:17905399 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GC mRNA, [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GC mRNA CTD PMID:17602206 , PMID:20360939 N-nitrosodimethylamine decreases expression EXP 6480464 Dimethylnitrosamine results in decreased expression of GC mRNA CTD PMID:25380136 N-nitrosomorpholine increases expression EXP 6480464 N-nitrosomorpholine results in increased expression of GC mRNA CTD PMID:23288050 nefazodone decreases expression EXP 6480464 nefazodone results in decreased expression of GC mRNA CTD PMID:24136188 nickel atom affects binding ISO RGD:736902 6480464 GC protein binds to Nickel CTD PMID:23896426 nimesulide decreases expression EXP 6480464 nimesulide results in decreased expression of GC mRNA CTD PMID:24136188 ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of GC mRNA CTD PMID:18417182 , PMID:30449730 olanzapine affects phosphorylation ISO RGD:736902 6480464 olanzapine affects the phosphorylation of GC protein CTD PMID:25821032 ouabain affects expression ISO RGD:736902 6480464 Ouabain affects the expression of GC protein CTD PMID:17268060 p-toluidine increases expression EXP 6480464 4-toluidine results in increased expression of GC mRNA CTD PMID:27638505 paracetamol affects expression ISO RGD:10624 6480464 Acetaminophen affects the expression of GC mRNA CTD PMID:17562736 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of GC mRNA, Acetaminophen results in increased expression of GC protein CTD PMID:16687475 , PMID:23288050 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of GC protein CTD PMID:16099942 paracetamol decreases expression ISO RGD:736902 6480464 Acetaminophen results in decreased expression of GC mRNA, Acetaminophen results in decreased expression of GC protein CTD PMID:11510020 , PMID:29067470 parathion affects response to substance ISO RGD:736902 6480464 GC gene SNP affects the susceptibility to Parathion CTD PMID:23833127 perfluorododecanoic acid decreases expression EXP 6480464 perfluorododecanoic acid results in decreased expression of GC protein CTD PMID:26168851 phenethyl caffeate multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GC mRNA CTD PMID:20360939 pirinixic acid multiple interactions ISO RGD:10624 6480464 [pirinixic acid co-treated with PPARA] results in decreased expression of GC mRNA CTD PMID:20813756 pirinixic acid decreases expression ISO RGD:10624 6480464 pirinixic acid results in decreased expression of GC mRNA CTD PMID:20813756 potassium chromate decreases expression ISO RGD:10624 6480464 potassium chromate(VI) results in decreased expression of GC protein CTD PMID:23618972 potassium dichromate decreases expression ISO RGD:10624 6480464 Potassium Dichromate results in decreased expression of GC mRNA CTD PMID:23608068 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions EXP 6480464 [Aflatoxin B1 co-treated with Buthionine Sulfoximine] results in increased expression of GC mRNA CTD PMID:23288050 sarin increases expression EXP 6480464 Sarin results in increased expression of GC protein CTD PMID:26778279 silicon dioxide increases expression EXP 6480464 Silicon Dioxide results in increased expression of GC mRNA CTD PMID:22431001 sodium arsenite affects expression ISO RGD:10624 6480464 sodium arsenite affects the expression of GC mRNA CTD PMID:17450228 sodium arsenite decreases expression ISO RGD:736902 6480464 sodium arsenite results in decreased expression of GC mRNA CTD PMID:29301061 tacrolimus hydrate decreases expression EXP 6480464 Tacrolimus results in decreased expression of GC mRNA CTD PMID:21865292 tacrolimus hydrate increases expression ISO RGD:10624 6480464 Tacrolimus results in increased expression of GC mRNA CTD PMID:29362864 terbufos affects response to substance ISO RGD:736902 6480464 GC gene SNP affects the susceptibility to terbufos CTD PMID:23833127 tetrachloromethane affects expression ISO RGD:10624 6480464 Carbon Tetrachloride affects the expression of GC mRNA CTD PMID:17484886 tetrachloromethane decreases expression ISO RGD:10624 6480464 Carbon Tetrachloride results in decreased expression of GC mRNA CTD PMID:24381012 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of GC mRNA CTD PMID:23288050 titanium dioxide decreases expression ISO RGD:10624 6480464 titanium dioxide results in decreased expression of GC mRNA CTD PMID:23557971 verapamil affects expression EXP 6480464 Verapamil affects the expression of GC protein CTD PMID:23533533 vitamin D affects binding ISO RGD:736902 6480464 GC protein polymorphism binds to Vitamin D metabolite, Vitamin D binds to GC protein CTD PMID:25590278 , PMID:8370586 vitamin D affects binding ISO RGD:10624 6480464 Vitamin D binds to GC protein CTD PMID:10052453 vitamin D multiple interactions ISO RGD:10624 6480464 LRP2 protein binds to and results in increased uptake of [Vitamin D binds to GC protein] CTD PMID:10052453 zoledronic acid increases expression ISO RGD:736902 6480464 zoledronic acid results in increased expression of GC protein CTD PMID:28871336
Gene-Chemical Interaction Annotations
