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Gene: Gc (GC, vitamin D binding protein) Rattus norvegicus
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Symbol: Gc
Name: GC, vitamin D binding protein
Description: Exhibits vitamin D binding activity. Involved in several processes, including female pregnancy; lactation; and response to estradiol. Localizes to several cellular components, including the axon; extracellular space; and perinuclear region of cytoplasm. Biomarker of brain ischemia and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); hepatocellular carcinoma; human immunodeficiency virus infectious disease; inflammatory bowel disease (multiple); and rheumatic fever. Orthologous to human GC (GC vitamin D binding protein); INTERACTS WITH 1-naphthyl isothiocyanate; 2,6-dinitrotoluene; 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DBP; DBP02; gc-globulin; group specific component; group-specific component; Group-specific component (vitamin D-binding protein); RATDBP02; VDB; Vdbp; vitamin D-binding protein
Orthologs:
Homo sapiens (human) : GC (GC vitamin D binding protein)  HGNC  Alliance
Mus musculus (house mouse) : Gc (vitamin D binding protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gc (GC vitamin D binding protein)
Pan paniscus (bonobo/pygmy chimpanzee) : GC (GC vitamin D binding protein)
Canis lupus familiaris (dog) : GC (GC vitamin D binding protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gc (GC vitamin D binding protein)
Sus scrofa (pig) : GC (GC vitamin D binding protein)
more info ...
Is Marker For: QTLs:   Scl11  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01420,267,023 - 20,302,577 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1420,266,891 - 20,302,581 (+)Ensembl
Rnor_5.01420,173,467 - 20,209,021 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41420,166,243 - 20,197,060 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11420,166,180 - 20,201,613 (+)NCBI
Celera1417,992,337 - 18,027,605 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Gc
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2667
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.