Gene: Kras (KRAS proto-oncogene, GTPase) Rattus norvegicus
Analyze
Symbol:
Kras
Name:
KRAS proto-oncogene, GTPase
Description:
Exhibits GDP binding activity; GMP binding activity; and LRR domain binding activity. Involved in several processes, including positive regulation of cellular senescence; positive regulation of nitric-oxide synthase activity; and response to corticosteroid. Localizes to the membrane raft and mitochondrion. Used to study bronchiolo-alveolar adenocarcinoma; endometrial adenocarcinoma; hepatocellular adenoma; hepatocellular carcinoma; and renal fibrosis. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); arteriovenous malformations of the brain; autoimmune lymphoproliferative syndrome type 4; gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; endometrial cancer pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,4-dinitrotoluene; 2-trans,6-trans-farnesyl diphosphate.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
c-K-ras; c-K-ras2 protein; c-Ki-ras; c-Kirsten-ras proto-oncogene; GTPase KRas; K-Ras 2; ki-Ras; Kirsten rat sarcoma viral oncogene; Kirsten rat sarcoma viral oncogene homolog; Kirsten rat sarcoma viral oncogene homologue 2 (active); Kras2; p21; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
KRAS (KRAS proto-oncogene, GTPase) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Kras (Kirsten rat sarcoma viral oncogene homolog) HGNC
Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Kras (KRAS proto-oncogene, GTPase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
KRAS (KRAS proto-oncogene, GTPase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
KRAS (KRAS proto-oncogene, GTPase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Kras (KRAS proto-oncogene, GTPase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
KRAS (KRAS proto-oncogene, GTPase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
KRAS (KRAS proto-oncogene, GTPase)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Kras (Kirsten rat sarcoma viral oncogene homolog)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
Ras85D
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Caenorhabditis elegans (roundworm):
let-60
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):
RAS1
Alliance
DIOPT (Ensembl Compara, OrthoFinder, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
RAS2
Alliance
DIOPT (Ensembl Compara, OrthoFinder, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 4 179,482,562 - 179,515,483 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 4 179,486,105 - 179,515,558 (-) Ensembl Rnor_5.0 4 243,667,912 - 243,696,325 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 4 182,869,242 - 182,895,106 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 4 183,114,365 - 183,140,230 (-) NCBI Celera 4 166,708,846 - 166,734,692 (-) NCBI Celera Cytogenetic Map 4 q44 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
acute myeloid leukemia ISO RGD:1350859 1600469 OMIM:601626 RGD acute myeloid leukemia ISO RGD:1350859 11060151 RGD astrocytoma susceptibility ISO RGD:1550157 13702858 DNA:mutation:cds:p.G12D(mouse) RGD astrocytoma ISO RGD:1350859 1600476 sporadic pilocytic astrocytoma, OMIM:137800 RGD breast cancer ISO RGD:1350859 2314909 RGD Breast Neoplasms ISO RGD:1350859 1600466 human breast adenocarcinoma cell line, OMIM:114480 RGD bronchiolo-alveolar adenocarcinoma IMP 11075076 DNA:mutations:cds: RGD cardiofaciocutaneous syndrome ISO RGD:1350859 1600471 DNA:missense mutations:CDS:p.G60R, p.D153V (human) RGD cardiomyopathy no_association ISO RGD:1550157 11568677 RGD colorectal cancer disease_progression ISO RGD:1350859 14398748 DNA:missense mutations:cds:p.GLY12ASP more ... RGD Colorectal Neoplasms ISO RGD:1350859 11060146 DNA:missense mutations: :p.G12C, p.G12D, p.G13D (human) RGD Colorectal Neoplasms ISO RGD:1550157 11568690 RGD dilated cardiomyopathy ISO RGD:1550157 1581757 RGD endometrial adenocarcinoma IAGP 1600499 DNA:point mutation:CDS:p.G12D, p.G12S, p.Q61H (rat) RGD endometrial hyperplasia ISO RGD:1350859 2314912 RGD Endometrial Neoplasms ISO RGD:1350859 4143515 ; 2314907 RGD Endometrioid Carcinomas ISO RGD:1350859 2314910 associated with Ovarian Neoplasms RGD Experimental Pancreatitis, Acute IEP 11062095 RGD Experimental Sarcoma IAGP 1598680 A to T transversion, Gln to His substitution RGD fibrillary astrocytoma ISO RGD:1350859 13702872 mRNA:decreased expression:brain RGD glioblastoma multiforme treatment ISO RGD:1550157 13702861 RGD glioblastoma multiforme ISO RGD:1350859 13702872 mRNA:decreased expression:brain RGD grade III astrocytoma ISO RGD:1350859 13702872 mRNA:decreased expression:brain RGD hepatocellular adenoma induced IAGP 11568697 aflatoxin B1 induced:DNA:transversion, transition mutations:cds: RGD hepatocellular carcinoma ISO RGD:1350859 14398750 mRNA, protein:increased expression:liver RGD hepatocellular carcinoma induced IAGP 11568697 aflatoxin B1 induced:DNA:transversion, transition mutations:cds: RGD hypertension ISO RGD:1550157 1581757 RGD intellectual disability ISO RGD:1350859 1600477 Costello syndrome, OMIM:218040 RGD intrahepatic cholangiocarcinoma disease_progression ISO RGD:1350859 14398746 DNA:mutations:: RGD Kidney Neoplasms IDA 11570401 RGD lung adenocarcinoma ISO RGD:1350859 1600465 DNA:point mutation:CDS:p.G12C (human) RGD Lung Neoplasms ISO RGD:1550157 11568678 RGD lung non-small cell carcinoma ISO RGD:1350859 5133242 RGD malignant glioma severity ISO RGD:1550157 13702860 RGD malignant glioma severity ISO RGD:1350859 13702477 RGD Multiple Abnormalities ISO RGD:1350859 1600477 Costello syndrome, OMIM:218040 RGD multiple myeloma ISO RGD:1350859 1581756 RGD myeloid neoplasm ISO RGD:1550157 11060138 DNA:missense mutation: :p.G12D (mouse) RGD myeloid sarcoma ISO RGD:1350859 11060142 associated with Leukemia, Myeloid, Acute, DNA:missense mutation:exon:p.G12C (human) RGD Neoplasm Metastasis ISO RGD:1550157 11570402 associated with Fibrosarcoma more ... RGD Neoplasm Metastasis treatment ISO RGD:1350859 11086960 associated with colorectal cancer, DNA:mutations: : RGD Neoplasm Metastasis treatment ISO RGD:1350859 14398751 associated with colorectal cancer, DNA:mutation:cds: RGD Neoplasm Metastasis disease_progression ISO RGD:1350859 14398745 associated with colorectal cancer, DNA:mutation: : RGD Noonan syndrome ISO RGD:1350859 1600472 Noonan syndrome type 3, OMIM:609942 RGD Noonan syndrome ISO RGD:1550157 11060134 DNA:missense mutation:exon:p.V14I (mouse) RGD Ovarian Neoplasms ISO RGD:1350859 2314911 RGD pancreatic cancer disease_progression ISO RGD:1350859 1581761 RGD pancreatic cancer ISO RGD:1350859 5490966 ; 5490965 RGD pancreatic mucinous cystadenoma severity ISO RGD:1350859 14398747 DNA:mutations:cds: RGD precursor lymphoblastic lymphoma/leukemia ISO RGD:1350859 11060148 RGD precursor lymphoblastic lymphoma/leukemia disease_progression ISO RGD:1350859 11060149 RGD precursor T-lymphoblastic lymphoma/leukemia ISO RGD:1550157 11060136 DNA:missense mutation: :p.G12D (mouse) RGD prostate carcinoma in situ ISO RGD:1550157 2314913 RGD Prostatic Neoplasms ISO RGD:1550157 2314913 RGD renal cell carcinoma ISO RGD:1350859 2314914 mRNA:increased expression:kidney RGD renal fibrosis treatment IMP 11060152 associated with Ureteral Obstruction RGD seminoma ISO RGD:1350859 2314915 RGD stomach carcinoma ISO RGD:1350859 1600468 gastric cancer, OMIM:137215 RGD transitional cell carcinoma ISO RGD:1350859 2314836 mRNA:increased expression:urinary bladder RGD urinary bladder cancer ISO RGD:1350859 1600467 transitional cell bladder carcinoma, OMIM:109800 RGD Uterine Cervical Neoplasms ISO RGD:1350859 2314838 DNA:point mutation:exon (human) RGD
Imported Annotations - ClinVar
acute myeloid leukemia ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Acute myelogenous leukemia ClinVar PMID:15696205 more ... acute myeloid leukemia ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Acute myelogenous leukemia ClinVar PMID:12460918 more ... acute myeloid leukemia ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Leukemia, acute myelogenous ClinVar PMID:12460918 more ... acute myeloid leukemia ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Leukemia, acute myelogenous ClinVar PMID:12460918 more ... acute myeloid leukemia ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Acute myeloid leukemia ClinVar PMID:12460918 more ... acute myeloid leukemia ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Leukemia, acute myeloid, UMLS MESH term: Acute Myelogenous Leukemia ClinVar PMID:8955068 adenoid cystic carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Adenoid cystic carcinoma ClinVar PMID:12460918 more ... angiosarcoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Angiosarcoma ClinVar PMID:24740626 more ... angiosarcoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Angiosarcoma ClinVar PMID:24740626 , PMID:25157968 Aplasia Cutis Congenita with Epibulbar Dermoids ISO RGD:1350859 8554872 ClinVar Annotator: match by term: OCULOECTODERMAL SYNDROME, SOMATIC ClinVar PMID:16361624 more ... Aplasia Cutis Congenita with Epibulbar Dermoids ISO RGD:1350859 8554872 ClinVar Annotator: match by term: OCULOECTODERMAL SYNDROME, SOMATIC ClinVar PMID:16361624 more ... Aplasia Cutis Congenita with Epibulbar Dermoids ISO RGD:1350859 8554872 ClinVar Annotator: match by term: OCULOECTODERMAL SYNDROME, SOMATIC ClinVar PMID:12460918 more ... Aplasia Cutis Congenita with Epibulbar Dermoids ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Oculoectodermal syndrome ClinVar PMID:24740626 more ... arteriovenous malformations of the brain ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Arteriovenous malformations of the brain ClinVar PMID:12460918 more ... arteriovenous malformations of the brain ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Arteriovenous malformations of the brain ClinVar PMID:15696205 more ... autoimmune lymphoproliferative syndrome type 4 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IV ClinVar PMID:12460918 more ... autoimmune lymphoproliferative syndrome type 4 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: RAS-associated autoimmune leukoproliferative disorder ClinVar PMID:12460918 more ... autoimmune lymphoproliferative syndrome type 4 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: RAS-associated autoimmune leukoproliferative disorder ClinVar PMID:12460918 more ... B-Cell Chronic Lymphocytic Leukemia ISO RGD:1350859 8554872 ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia ClinVar PMID:12460918 more ... bladder urothelial carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Transitional cell bladder carcinoma ClinVar PMID:12460918 more ... breast adenocarcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Breast adenocarcinoma, somatic ClinVar PMID:12460918 more ... breast cancer ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Breast cancer, somatic ClinVar PMID:12460918 more ... Breast Cancer, Familial ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Familial cancer of breast ClinVar PMID:16474404 more ... cardiofaciocutaneous syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Cardio-facio-cutaneous syndrome ClinVar PMID:16474404 more ... cardiofaciocutaneous syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Cardiofaciocutaneous syndrome 1 ClinVar PMID:20186801 more ... cardiofaciocutaneous syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Cardio-facio-cutaneous syndrome ClinVar PMID:16474405 more ... cardiofaciocutaneous syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Cardio-facio-cutaneous syndrome ClinVar PMID:24033266 , PMID:25741868 cardiofaciocutaneous syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Cardio-facio-cutaneous syndrome ClinVar PMID:24033266 more ... cardiofaciocutaneous syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Cardio-facio-cutaneous syndrome ClinVar PMID:24033266 cardiofaciocutaneous syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Cardio-facio-cutaneous syndrome ClinVar PMID:18922928 cardiofaciocutaneous syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Cardio-facio-cutaneous syndrome ClinVar cardiofaciocutaneous syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Cardio-facio-cutaneous syndrome ClinVar PMID:22980975 more ... cardiofaciocutaneous syndrome 1 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Cardiofaciocutaneous syndrome 1 ClinVar PMID:20186801 more ... cardiofaciocutaneous syndrome 2 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Cardiofaciocutaneous syndrome 2 ClinVar PMID:16474404 more ... cardiofaciocutaneous syndrome 2 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Cardiofaciocutaneous syndrome 2 ClinVar PMID:16474404 more ... cardiofaciocutaneous syndrome 2 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Cardiofaciocutaneous syndrome 2 ClinVar PMID:16773572 more ... cardiofaciocutaneous syndrome 2 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Cardiofaciocutaneous syndrome 2 ClinVar PMID:16474405 more ... cardiofaciocutaneous syndrome 2 ISO RGD:1350859 8554872 ClinVar Annotator: match by OMIM:615278 ClinVar PMID:21797849 , PMID:23059812 cardiofaciocutaneous syndrome 2 ISO RGD:1350859 8554872 ClinVar Annotator: match by OMIM:615278 ClinVar PMID:17056636 , PMID:18386799 chronic lymphocytic leukemia ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Chronic lymphocytic leukemia ClinVar PMID:12460918 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:16361624 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:15696205 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal cancer, susceptibility to, 12 ClinVar PMID:12460918 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:16361624 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:16361624 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:12460918 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:12460918 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:12460918 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:12460918 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:12460918 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:12460918 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:12460918 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:12460918 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:12460918 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:16361624 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:12460918 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:12460918 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:12460918 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:11745231 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:25157968 Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:17384584 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:16361624 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:1553789 more ... Colorectal Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:12460918 more ... craniopharyngioma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Craniopharyngioma ClinVar PMID:25741868 , PMID:28492532 endometrial cancer ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Endometrial cancer ClinVar PMID:11745231 more ... endometrial carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Endometrial carcinoma ClinVar PMID:11745231 more ... endometrial carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Endometrial carcinoma ClinVar PMID:16474405 more ... epidermal nevus ISO RGD:1350859 8554872 ClinVar Annotator: match by term: NEVUS, KERATINOCYTIC, NONEPIDERMOLYTIC ClinVar PMID:12460918 more ... epidermal nevus ISO RGD:1350859 8554872 ClinVar Annotator: match by term: NEVUS, KERATINOCYTIC, NONEPIDERMOLYTIC ClinVar PMID:15696205 more ... esophageal carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Esophageal carcinoma ClinVar PMID:16361624 more ... gastric adenocarcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:12460918 more ... gastric adenocarcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:16361624 more ... gastrointestinal stromal tumor ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Gastrointestinal stromal tumor ClinVar PMID:12460918 more ... genetic disease ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:16773572 more ... hepatocellular carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: LIVER CELL CARCINOMA ClinVar PMID:12460918 more ... hepatocellular carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: LIVER CELL CARCINOMA ClinVar PMID:16361624 more ... juvenile myelomonocytic leukemia ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Juvenile myelomonocytic leukemia ClinVar PMID:15696205 more ... juvenile myelomonocytic leukemia ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Juvenile myelomonocytic leukemia ClinVar PMID:12460918 more ... juvenile myelomonocytic leukemia ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Juvenile myelomonocytic leukemia ClinVar PMID:12460918 more ... juvenile myelomonocytic leukemia ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Juvenile myelomonocytic leukemia ClinVar PMID:12460918 more ... linear nevus sebaceous syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Nevus, Sebaceous of Jadassohn ClinVar PMID:12460918 more ... liver cancer ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Liver cancer ClinVar PMID:12460918 more ... liver cancer ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Liver cancer ClinVar PMID:16361624 more ... lung adenocarcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Adenocarcinoma of lung ClinVar PMID:12460918 more ... lung adenocarcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Adenocarcinoma of lung, somatic ClinVar PMID:12460918 more ... lung adenocarcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Adenocarcinoma of lung, somatic ClinVar PMID:11745231 more ... lung cancer ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Lung cancer ClinVar PMID:11745231 more ... lung cancer ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Lung cancer, somatic ClinVar PMID:12460918 more ... lung non-small cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Non-small cell lung carcinoma ClinVar PMID:15696205 more ... lung non-small cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Non-small cell lung cancer ClinVar PMID:16474404 more ... lung non-small cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Non-small cell lung cancer ClinVar PMID:16361624 more ... lung non-small cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Non-small cell lung cancer ClinVar PMID:12460918 more ... lung non-small cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Non-small cell lung carcinoma ClinVar PMID:16361624 more ... lung non-small cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Non-small cell lung carcinoma ClinVar PMID:12460918 more ... lung non-small cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Non-small cell lung cancer ClinVar PMID:12460918 more ... lung non-small cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Non-small cell lung cancer ClinVar PMID:12460918 more ... lung non-small cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Non-small cell lung cancer ClinVar PMID:12460918 more ... lung non-small cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Non-small cell lung cancer ClinVar PMID:12460918 more ... lung non-small cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Non-small cell lung cancer ClinVar PMID:12460918 more ... lung non-small cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Non-small cell lung cancer ClinVar PMID:12460918 more ... lung non-small cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Non-small cell lung cancer ClinVar PMID:12460918 more ... lung non-small cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Non-small cell lung cancer ClinVar PMID:12460918 more ... lung non-small cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Non-small cell lung cancer ClinVar PMID:12460918 more ... lung non-small cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Non-small cell lung cancer ClinVar PMID:12460918 more ... lung non-small cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Non-small cell lung cancer ClinVar PMID:12460918 more ... lung non-small cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Non-small cell lung cancer ClinVar PMID:11745231 more ... lung non-small cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Non-small cell lung cancer ClinVar PMID:12460918 more ... lung non-small cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by synonym: Non-small cell lung cancer ClinVar lung non-small cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Non-small cell lung cancer ClinVar PMID:24033266 lung squamous cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Squamous cell carcinoma of lung ClinVar PMID:12460918 more ... lung squamous cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Squamous cell carcinoma of lung ClinVar PMID:12460918 more ... melanoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: MELANOMA, MALIGNANT, SOMATIC ClinVar PMID:16361624 more ... melanoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: MELANOMA, MALIGNANT, SOMATIC ClinVar PMID:12460918 more ... multiple myeloma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Multiple myeloma ClinVar PMID:12460918 more ... multiple myeloma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Multiple myeloma ClinVar PMID:16361624 more ... Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome ClinVar PMID:17056636 more ... Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome ClinVar PMID:17056636 , PMID:24033266 Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome ClinVar PMID:16474404 more ... Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome ClinVar PMID:16474404 more ... Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome ClinVar PMID:16474404 more ... Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome ClinVar PMID:16773572 more ... Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome ClinVar PMID:16474405 more ... Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome ClinVar PMID:16474405 more ... Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome ClinVar PMID:16474405 more ... Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome ClinVar PMID:12110640 more ... Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan's syndrome ClinVar PMID:16474404 more ... Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome ClinVar PMID:16474405 more ... Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome ClinVar PMID:17056636 more ... Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome ClinVar PMID:24033266 , PMID:25741868 Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome ClinVar PMID:24033266 more ... Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan's syndrome, UMLS OMIM term: NOONAN SYNDROME ClinVar PMID:12460918 more ... Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome ClinVar PMID:18922928 Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome ClinVar Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome ClinVar PMID:22980975 more ... Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan's syndrome, UMLS OMIM term: NOONAN SYNDROME ClinVar PMID:16773572 , PMID:24033266 Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome ClinVar PMID:17056636 more ... Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome ClinVar PMID:22488932 , PMID:24033266 Noonan syndrome ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome ClinVar PMID:24033266 Noonan syndrome 3 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome 3 ClinVar PMID:17056636 more ... Noonan syndrome 3 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome 3 ClinVar PMID:17056636 , PMID:24033266 Noonan syndrome 3 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome 3 ClinVar PMID:16474404 more ... Noonan syndrome 3 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome 3 ClinVar PMID:16474404 more ... Noonan syndrome 3 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome 3 ClinVar PMID:16474404 more ... Noonan syndrome 3 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome 3 ClinVar PMID:16474405 more ... Noonan syndrome 3 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome 3 ClinVar PMID:16474405 more ... Noonan syndrome 3 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome 3 ClinVar PMID:20186801 more ... Noonan syndrome 3 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome 3 ClinVar PMID:19396835 , PMID:28492532 Noonan syndrome 3 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome 3 ClinVar PMID:16474405 more ... Noonan syndrome 3 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome 3 ClinVar PMID:25326635 more ... Noonan syndrome 3 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome 3 ClinVar PMID:12110640 more ... Noonan syndrome 3 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome 3 ClinVar PMID:16474404 more ... Noonan syndrome 3 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome 3 ClinVar PMID:16474405 more ... Noonan syndrome 3 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome 3 ClinVar PMID:17056636 more ... Noonan syndrome 3 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome 3 ClinVar PMID:25741868 Noonan syndrome 3 ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Noonan syndrome 3 ClinVar PMID:12460918 more ... Noonan syndrome 3 ISO RGD:1350859 8554872 ClinVar Annotator: match by OMIM:609942 ClinVar PMID:16773572 Noonan syndrome 3 ISO RGD:1350859 8554872 ClinVar Annotator: match by OMIM:609942 ClinVar PMID:17056636 more ... Noonan syndrome 3 ISO RGD:1350859 8554872 ClinVar Annotator: match by OMIM:609942 ClinVar PMID:16773572 , PMID:24033266 Noonan syndrome 3 ISO RGD:1350859 8554872 ClinVar Annotator: match by OMIM:609942 ClinVar PMID:22488932 , PMID:24033266 ovarian cancer ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Ovarian neoplasm ClinVar PMID:12460918 more ... ovarian cancer ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Ovarian cancer ClinVar PMID:12460918 more ... Ovarian Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Ovarian Neoplasms ClinVar PMID:15696205 more ... Ovarian Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Ovarian neoplasm ClinVar PMID:12460918 more ... Ovarian Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Ovarian neoplasm ClinVar PMID:12460918 more ... Ovarian Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Ovarian Neoplasms ClinVar PMID:12460918 more ... Ovarian Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Ovarian Neoplasms ClinVar PMID:12460918 more ... Ovarian Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Ovarian Neoplasms ClinVar PMID:11745231 more ... Ovarian Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Ovarian Neoplasms ClinVar PMID:12460918 more ... pancreatic adenocarcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Pancreatic adenocarcinoma ClinVar PMID:12460918 more ... pancreatic cancer ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Pancreatic cancer ClinVar PMID:15696205 more ... pancreatic cancer ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Pancreatic cancer ClinVar PMID:12460918 more ... pancreatic carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: PANCREATIC CARCINOMA ClinVar PMID:15696205 more ... pancreatic carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: PANCREATIC CARCINOMA ClinVar PMID:12460918 more ... pilocytic astrocytoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Pilocytic astrocytoma ClinVar PMID:12460918 more ... plasmacytoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Plasmocytoma ClinVar PMID:12460918 more ... plasmacytoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Plasmocytoma ClinVar PMID:16361624 more ... RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:28492532 RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:17056636 , PMID:24033266 RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:27450488 , PMID:28492532 RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:15696205 more ... RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:25741868 , PMID:28492532 RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:16474404 more ... RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:17056636 more ... RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:24033266 more ... RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:16474404 more ... RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:16474404 more ... RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:16474405 more ... RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:16474405 more ... RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:19396835 , PMID:28492532 RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:16474405 more ... RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:20147967 more ... RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: rasopathies ClinVar PMID:12460918 more ... RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:25326635 more ... RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:12110640 more ... RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:16474404 more ... RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:16474405 more ... RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:17056636 more ... RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:17056636 more ... RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:24033266 more ... RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:25741868 RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:24033266 , PMID:25741868 RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:17056636 , PMID:18386799 RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:17056636 more ... RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:24033266 RASopathies ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Rasopathy ClinVar PMID:17409930 more ... Sebaceous Nevus Syndrome and Hemimegalencephaly ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Sebaceous nevus syndrome and hemimegalencephaly ClinVar PMID:12460918 more ... stomach cancer ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Gastric cancer ClinVar PMID:12460918 more ... stomach cancer ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Gastric cancer ClinVar PMID:12460918 more ... thyroid gland medullary carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Medullary Thyroid Cancer ClinVar PMID:12460918 more ... Thyroid Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Neoplasm of the thyroid gland ClinVar PMID:12460918 more ... Thyroid Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Neoplasm of the thyroid gland ClinVar PMID:15696205 more ... Thyroid Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Neoplasm of the thyroid gland ClinVar PMID:16361624 more ... Thyroid Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Neoplasm of the thyroid gland ClinVar PMID:12460918 more ... Thyroid Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Neoplasm of the thyroid gland ClinVar PMID:16361624 more ... Thyroid Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Neoplasm of the thyroid gland ClinVar PMID:12460918 more ... Thyroid Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Neoplasm of the thyroid gland ClinVar PMID:12460918 more ... Thyroid Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Neoplasm of the thyroid gland ClinVar PMID:12460918 more ... Thyroid Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Neoplasm of the thyroid gland ClinVar PMID:17384584 more ... Thyroid Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Neoplasm of the thyroid gland ClinVar PMID:12460918 more ... Thyroid Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Neoplasm of the thyroid gland ClinVar PMID:12460918 more ... Thyroid Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Neoplasm of the thyroid gland ClinVar PMID:11745231 more ... Thyroid Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Neoplasm of the thyroid gland ClinVar PMID:12460918 more ... Thyroid Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Neoplasm of the thyroid gland ClinVar PMID:12460918 more ... Thyroid Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Neoplasm of the thyroid gland ClinVar PMID:12460918 more ... transitional cell carcinoma ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder ClinVar PMID:12460918 more ... urinary bladder cancer ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Bladder cancer ClinVar PMID:12460918 more ... urinary bladder cancer ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Bladder cancer, transitional cell, somatic ClinVar PMID:1553789 more ... Urinary Bladder Neoplasm ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Urinary Bladder Neoplasms ClinVar PMID:12460918 more ... Uterine Neoplasms ISO RGD:1350859 8554872 ClinVar Annotator: match by term: Malignant neoplasm of body of uterus ClinVar PMID:12460918 more ...
Imported Annotations - CTD
adenocarcinoma ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:11745231 more ... adenoma ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:8761429 more ... anemia ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27725143 angiosarcoma ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:10930038 more ... Animal Disease Models ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26390243 , PMID:27588471 astrocytoma ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23817572 Breast Neoplasms ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD Carcinogenesis ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26595770 , PMID:29247004 carcinoma ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:10545420 , PMID:20565773 cardiofaciocutaneous syndrome ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17703371 Cecal Neoplasms ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14688030 cholangiocarcinoma ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:8968066 , PMID:22561520 Colonic Neoplasms ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:10813127 more ... Colorectal Neoplasms ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20565773 more ... Costello syndrome ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17468812 , PMID:17703371 disease of cellular proliferation ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:10673434 , PMID:26595770 Disease Progression ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30654191 endometriosis ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23284138 Experimental Liver Neoplasms ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:8603461 Experimental Neoplasms ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9205081 more ... Gallbladder Neoplasms ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24997986 hepatocellular carcinoma ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:11286481 , PMID:11563603 juvenile myelomonocytic leukemia ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26457647 juvenile rheumatoid arthritis ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19565504 Leukocytosis ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27725143 linear nevus sebaceous syndrome ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22683711 Liver Neoplasms ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:10629081 , PMID:12211074 Lung Neoplasms ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:7614698 more ... lung non-small cell carcinoma ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21336183 more ... lymphoma ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9205081 Mouth Neoplasms ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19435901 myelodysplastic syndrome ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27992414 Neoplasm Metastasis ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:8635384 Neoplastic Cell Transformation ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27510461 neuroblastoma ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26121086 Noonan syndrome ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17468812 more ... Ovarian Neoplasms ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21372221 pancreatic cancer ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14520703 more ... pancreatic ductal carcinoma ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25347530 , PMID:30654191 Parasitic Liver Diseases ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22561520 penile neoplasm ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18355852 Prostatic Neoplasms ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29610475 Recurrence ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26121086 Splenomegaly ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27725143 squamous cell carcinoma ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19435901 , PMID:25125259 Stomach Neoplasms ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:10874023 , PMID:11397402 thyroid gland follicular carcinoma ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27440272 Thyroid Neoplasms ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:3078959 Triple Negative Breast Neoplasms ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30654191 urinary bladder cancer ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29644616 Uterine Neoplasms ISO RGD:1350859 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17325976 Imported Annotations - MGI
intrahepatic cholangiocarcinoma ISS RGD:1550157 13592920 MouseDO lung cancer ISS RGD:1550157 13592920 OMIM:211980 more ... MouseDO pancreatic carcinoma ISS RGD:1550157 13592920 OMIM:260350 MouseDO prostate cancer ISS RGD:1550157 13592920 OMIM:176807 more ... MouseDO stomach cancer ISS RGD:1350859 13592920 OMIM:137215 , OMIM:613659MouseDO Imported Annotations - OMIM
acute myeloid leukemia ISO RGD:1350859 7240710 OMIM Aplasia Cutis Congenita with Epibulbar Dermoids ISO RGD:1350859 7240710 OMIM arteriovenous malformations of the brain ISO RGD:1350859 7240710 OMIM autoimmune lymphoproliferative syndrome type 4 ISO RGD:1350859 7240710 OMIM breast cancer ISO RGD:1350859 7240710 OMIM cardiofaciocutaneous syndrome 2 ISO RGD:1350859 7240710 OMIM linear nevus sebaceous syndrome ISO RGD:1350859 7240710 OMIM Lung Neoplasms ISO RGD:1350859 7240710 OMIM Noonan syndrome 3 ISO RGD:1350859 7240710 OMIM pancreatic cancer ISO RGD:1350859 7240710 OMIM Stomach Neoplasms ISO RGD:1350859 7240710 OMIM urinary bladder cancer ISO RGD:1350859 7240710 OMIM
(trichloromethyl)benzene increases mutagenesis ISO RGD:1550157 6480464 benzotrichloride results in increased mutagenesis of KRAS gene CTD PMID:8508514 1,1-dichloroethene increases expression ISO RGD:1550157 6480464 vinylidene chloride results in increased expression of KRAS mRNA CTD PMID:26682919 1-nitropyrene increases mutagenesis ISO RGD:1550157 6480464 1-nitropyrene results in increased mutagenesis of KRAS gene CTD PMID:10396879 more ... 1-nitropyrene multiple interactions ISO RGD:1550157 6480464 [1-nitropyrene co-treated with KC 400] results in increased mutagenesis of KRAS gene more ... CTD PMID:10396879 more ... 17alpha-ethynylestradiol multiple interactions ISO RGD:1550157 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KRAS mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of KRAS mRNA CTD PMID:29097150 17beta-estradiol decreases expression ISO RGD:1350859 6480464 Estradiol results in decreased expression of KRAS mRNA CTD PMID:16474171 17beta-estradiol increases expression ISO RGD:1350859 6480464 Estradiol results in increased expression of KRAS mRNA CTD PMID:23094148 2,2-Bis(bromomethyl)propane-1,3-diol increases mutagenesis ISO RGD:1550157 6480464 2 more ... CTD PMID:14713543 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1350859 6480464 Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of KRAS mRNA] CTD PMID:11007951 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1550157 6480464 Tetrachlorodibenzodioxin affects the expression of KRAS mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1350859 6480464 Tetrachlorodibenzodioxin results in increased expression of KRAS mRNA CTD PMID:11007951 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1350859 6480464 Tetrachlorodibenzodioxin affects the expression of KRAS mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1550157 6480464 Tetrachlorodibenzodioxin results in decreased expression of KRAS mRNA CTD PMID:14708085 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1550157 6480464 Tetrachlorodibenzodioxin results in increased expression of KRAS mRNA CTD PMID:19465110 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1550157 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KRAS mRNA more ... CTD PMID:11884234 more ... 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of KRAS mRNA CTD PMID:21346803 2,6-di-tert-butyl-4-methylphenol increases mutagenesis ISO RGD:1550157 6480464 Butylated Hydroxytoluene results in increased mutagenesis of KRAS gene CTD PMID:20101149 2-trans,6-trans-farnesyl diphosphate multiple interactions EXP 6480464 [FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein] CTD PMID:10673434 3-methyl-3H-imidazo[4,5-f]quinolin-2-amine increases mutagenesis EXP 6480464 2-amino-3-methylimidazo(4, 5-f)quinoline results in increased mutagenesis of KRAS gene CTD PMID:8844820 3-methylcholanthrene multiple interactions ISO RGD:1550157 6480464 Methylcholanthrene promotes the reaction [GATA6 protein binds to KRAS exon], Methylcholanthrene promotes the reaction [NFYA protein binds to KRAS exon] CTD PMID:16271038 3-methylcholanthrene increases mutagenesis ISO RGD:1550157 6480464 Methylcholanthrene results in increased mutagenesis of KRAS gene CTD PMID:11195466 , PMID:20101149 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases mutagenesis EXP 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased mutagenesis of KRAS gene CTD PMID:18271921 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one multiple interactions ISO RGD:1550157 6480464 [Lipopolysaccharides co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased mutagenesis of KRAS gene CTD PMID:21868532 4-vinylcyclohexene dioxide affects expression ISO RGD:1550157 6480464 4-vinyl-1-cyclohexene dioxide affects the expression of KRAS mRNA CTD PMID:20829426 5-aza-2'-deoxycytidine multiple interactions ISO RGD:1350859 6480464 Decitabine inhibits the reaction [arsenite results in increased expression of KRAS protein] CTD PMID:24704393 5-fluorouracil decreases expression ISO RGD:1350859 6480464 Fluorouracil results in decreased expression of KRAS protein CTD PMID:15585135 , PMID:16803524 5-Methylchrysene increases mutagenesis ISO RGD:1550157 6480464 5-methylchrysene results in increased mutagenesis of KRAS gene CTD PMID:8571376 , PMID:9659573 acrolein decreases expression ISO RGD:1350859 6480464 Acrolein results in decreased expression of KRAS protein CTD PMID:24812010 actinomycin D multiple interactions ISO RGD:1350859 6480464 Dactinomycin inhibits the reaction [[KRAS protein mutant form affects the susceptibility to vemurafenib] which results in increased expression of TNFRSF10B mRNA] CTD PMID:27222248 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of KRAS mRNA CTD PMID:16483693 amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of KRAS mRNA CTD PMID:30779732 antirheumatic drug decreases expression ISO RGD:1350859 6480464 Antirheumatic Agents results in decreased expression of KRAS mRNA CTD PMID:24449571 aristolochic acid increases mutagenesis EXP 6480464 aristolochic acid I results in increased mutagenesis of KRAS gene CTD PMID:21642617 Aroclor 1254 decreases expression ISO RGD:1550157 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of KRAS mRNA, Chlorodiphenyl (54% Chlorine) results in decreased expression of KRAS protein CTD PMID:23650126 Aroclor 1254 affects localization ISO RGD:1550157 6480464 Chlorodiphenyl (54% Chlorine) affects the localization of KRAS protein CTD PMID:9525281 arsane multiple interactions ISO RGD:1350859 6480464 KRAS affects the reaction [Arsenic results in increased phosphorylation of MAPK1 protein] more ... CTD PMID:25273566 arsane affects response to substance ISO RGD:1350859 6480464 KRAS affects the susceptibility to Arsenic CTD PMID:25273566 arsenic atom multiple interactions ISO RGD:1350859 6480464 KRAS affects the reaction [Arsenic results in increased phosphorylation of MAPK1 protein] more ... CTD PMID:25273566 arsenic atom affects response to substance ISO RGD:1350859 6480464 KRAS affects the susceptibility to Arsenic CTD PMID:25273566 arsenite(3-) multiple interactions ISO RGD:1350859 6480464 decitabine inhibits the reaction [arsenite results in increased expression of KRAS protein], MIRLET7C mRNA inhibits the reaction [arsenite results in increased expression of KRAS protein] CTD PMID:24704393 arsenite(3-) increases expression ISO RGD:1350859 6480464 arsenite results in increased expression of KRAS protein CTD PMID:24704393 asbestos increases mutagenesis ISO RGD:1350859 6480464 Asbestos results in increased mutagenesis of KRAS gene CTD PMID:12725029 Benz[j]aceanthrylene increases mutagenesis ISO RGD:1550157 6480464 benz(j)aceanthrylene results in increased mutagenesis of KRAS gene CTD PMID:9659573 benzene increases response to substance ISO RGD:1550157 6480464 KRAS gene polymorphism results in increased susceptibility to Benzene CTD PMID:12807761 benzo[a]pyrene increases expression ISO RGD:1550157 6480464 Benzo(a)pyrene results in increased expression of KRAS mRNA CTD PMID:22228805 benzo[a]pyrene increases mutagenesis ISO RGD:1550157 6480464 Benzo(a)pyrene results in increased mutagenesis of KRAS gene CTD PMID:19658153 more ... benzo[a]pyrene diol epoxide I increases expression ISO RGD:1350859 6480464 7 more ... CTD PMID:18567617 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1350859 6480464 7 more ... CTD PMID:19150397 , PMID:20018196 benzo[b]fluoranthene increases mutagenesis ISO RGD:1550157 6480464 benzo(b)fluoranthene results in increased mutagenesis of KRAS gene CTD PMID:8571376 , PMID:9659573 bisphenol A decreases expression ISO RGD:1350859 6480464 bisphenol A results in decreased expression of KRAS mRNA CTD PMID:16474171 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of KRAS gene CTD PMID:28505145 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of KRAS mRNA CTD PMID:29097150 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of KRAS mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:1550157 6480464 bisphenol A results in increased expression of KRAS mRNA CTD PMID:26063408 bisphenol A increases mutagenesis ISO RGD:1350859 6480464 bisphenol A results in increased mutagenesis of KRAS gene CTD PMID:11342245 bleomycin A2 multiple interactions ISO RGD:1550157 6480464 [Bleomycin co-treated with 1-nitropyrene] results in increased mutagenesis of KRAS gene CTD PMID:12616606 buta-1,3-diene increases mutagenesis ISO RGD:1550157 6480464 1, 3-butadiene results in increased mutagenesis of KRAS gene CTD PMID:11397402 cadmium atom increases expression ISO RGD:1350859 6480464 Cadmium results in increased expression of KRAS mRNA, Cadmium results in increased expression of KRAS protein CTD PMID:20049202 cadmium atom decreases expression ISO RGD:1350859 6480464 Cadmium results in decreased expression of KRAS mRNA CTD PMID:21120746 cadmium dichloride increases expression ISO RGD:1350859 6480464 Cadmium Chloride results in increased expression of KRAS mRNA, Cadmium Chloride results in increased expression of KRAS protein CTD PMID:23811327 more ... cadmium dichloride multiple interactions ISO RGD:1350859 6480464 KRAS protein inhibits the reaction [Cadmium Chloride results in decreased expression of MIR155 mRNA] more ... CTD PMID:27510461 carbamazepine affects expression ISO RGD:1350859 6480464 Carbamazepine affects the expression of KRAS mRNA CTD PMID:24752500 carbon nanotube increases mutagenesis ISO RGD:1550157 6480464 Nanotubes, Carbon results in increased mutagenesis of KRAS gene CTD PMID:24213921 ceruletide multiple interactions ISO RGD:1550157 6480464 (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein] more ... CTD PMID:26390243 chloroethene multiple interactions ISO RGD:1350859 6480464 CYP2E1 gene polymorphism promotes the reaction [Vinyl Chloride affects the mutagenesis of KRAS gene] more ... CTD PMID:12705718 more ... chloroethene increases mutagenesis ISO RGD:1350859 6480464 Vinyl Chloride results in increased mutagenesis of KRAS gene CTD PMID:10629081 more ... chloroethene increases response to substance ISO RGD:1550157 6480464 KRAS gene polymorphism results in increased susceptibility to Vinyl Chloride CTD PMID:12807761 chloroprene increases mutagenesis ISO RGD:1550157 6480464 Chloroprene results in increased mutagenesis of KRAS gene CTD PMID:10223196 , PMID:11397402 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of KRAS mRNA CTD PMID:18668222 cisplatin multiple interactions ISO RGD:1350859 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of KRAS mRNA CTD PMID:27392435 cisplatin decreases expression ISO RGD:1350859 6480464 Cisplatin results in decreased expression of KRAS mRNA CTD PMID:27392435 clofibrate increases expression ISO RGD:1550157 6480464 Clofibrate results in increased expression of KRAS mRNA CTD PMID:23811191 copper atom increases expression EXP 6480464 Copper deficiency results in increased expression of KRAS mRNA, Copper results in increased expression of KRAS mRNA CTD PMID:17418555 , PMID:22465980 copper(0) increases expression EXP 6480464 Copper deficiency results in increased expression of KRAS mRNA, Copper results in increased expression of KRAS mRNA CTD PMID:17418555 , PMID:22465980 coumestrol decreases expression ISO RGD:1350859 6480464 Coumestrol results in decreased expression of KRAS mRNA CTD PMID:19167446 crizotinib decreases response to substance ISO RGD:1350859 6480464 KRAS protein mutant form results in decreased susceptibility to crizotinib CTD PMID:22235099 cumene multiple interactions ISO RGD:1550157 6480464 [cumene co-treated with KRAS gene mutant form] results in decreased expression of CCN1 mRNA more ... CTD PMID:18648096 curcumin decreases expression ISO RGD:1350859 6480464 Curcumin analog results in decreased expression of KRAS mRNA, Curcumin results in decreased expression of KRAS mRNA CTD PMID:17041101 curcumin multiple interactions ISO RGD:1550157 6480464 Curcumin affects the reaction [KRAS protein affects the localization of TRP53 protein], Curcumin inhibits the reaction [KRAS protein results in decreased expression of XPO1 protein] CTD PMID:21519798 cycloheximide multiple interactions ISO RGD:1350859 6480464 Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of KRAS mRNA] CTD PMID:11007951 Cyclopenta[cd]pyrene increases mutagenesis ISO RGD:1550157 6480464 cyclopenta(c, d)pyrene results in increased mutagenesis of KRAS gene CTD PMID:9659573 dabrafenib multiple interactions ISO RGD:1350859 6480464 [KRAS protein affects the susceptibility to dabrafenib] which affects the expression of TNFRSF10B protein more ... CTD PMID:27222248 dabrafenib affects response to substance ISO RGD:1350859 6480464 KRAS protein affects the susceptibility to dabrafenib CTD PMID:27222248 dextran sulfate multiple interactions ISO RGD:1550157 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of KRAS mRNA CTD PMID:29950665 dibenzo[a,l]pyrene increases mutagenesis ISO RGD:1550157 6480464 dibenzo(a, l)pyrene results in increased mutagenesis of KRAS gene CTD PMID:9659573 dichlorine multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in decreased expression of KRAS mRNA CTD PMID:18636392 diclofenac affects expression ISO RGD:1350859 6480464 Diclofenac affects the expression of KRAS mRNA CTD PMID:24752500 dorsomorphin multiple interactions ISO RGD:1350859 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin decreases expression ISO RGD:1350859 6480464 Doxorubicin results in decreased expression of KRAS mRNA CTD PMID:29803840 erlotinib hydrochloride increases response to substance ISO RGD:1350859 6480464 KRAS protein results in increased susceptibility to Erlotinib Hydrochloride CTD PMID:20705357 ethanol affects splicing ISO RGD:1550157 6480464 Ethanol affects the splicing of KRAS mRNA CTD PMID:30319688 farnesyl diphosphate multiple interactions EXP 6480464 [FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein] CTD PMID:10673434 flutamide increases expression EXP 6480464 Flutamide results in increased expression of KRAS mRNA CTD PMID:24136188 folic acid increases expression ISO RGD:1550157 6480464 Folic Acid results in increased expression of KRAS mRNA CTD PMID:2566606 GDP multiple interactions ISO RGD:1350859 6480464 KRAS protein mutant form inhibits the reaction [SOS1 protein inhibits the reaction [Guanosine Diphosphate binds to KRAS protein]], SOS1 protein inhibits the reaction [Guanosine Diphosphate binds to KRAS protein] CTD PMID:28154176 GDP affects binding ISO RGD:1350859 6480464 Guanosine Diphosphate binds to KRAS protein, Guanosine Diphosphate binds to KRAS protein mutant form CTD PMID:28154176 gefitinib affects response to substance ISO RGD:1350859 6480464 KRAS protein mutant form affects the susceptibility to gefitinib CTD PMID:17270025 gefitinib decreases response to substance ISO RGD:1350859 6480464 KRAS protein results in decreased susceptibility to gefitinib CTD PMID:28739874 gefitinib multiple interactions ISO RGD:1350859 6480464 KRAS protein affects the reaction [EGFR protein affects the susceptibility to gefitinib] CTD PMID:28739874 genistein decreases expression ISO RGD:1350859 6480464 Genistein results in decreased expression of KRAS mRNA CTD PMID:15256057 , PMID:16474171 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of KRAS mRNA CTD PMID:22061828 geraniol multiple interactions EXP 6480464 geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of KRAS mRNA] CTD PMID:28428697 GTP multiple interactions ISO RGD:1350859 6480464 KRAS protein mutant form inhibits the reaction [RASA1 protein promotes the reaction [KRAS protein results in increased hydrolysis of Guanosine Triphosphate]], RASA1 protein promotes the reaction [KRAS protein results in increased hydrolysis of Guanosine Triphosphate] CTD PMID:28154176 GTP affects binding ISO RGD:1350859 6480464 Guanosine Triphosphate binds to KRAS protein, Guanosine Triphosphate binds to KRAS protein mutant form CTD PMID:28154176 GTP increases hydrolysis ISO RGD:1350859 6480464 KRAS protein mutant form results in increased hydrolysis of Guanosine Triphosphate, KRAS protein results in increased hydrolysis of Guanosine Triphosphate CTD PMID:28154176 guanosine multiple interactions ISO RGD:1350859 6480464 Guanosine inhibits the reaction [tiazofurin results in decreased expression of KRAS] CTD PMID:9381980 haloperidol increases expression EXP 6480464 Haloperidol results in increased expression of KRAS mRNA CTD PMID:15860345 hydroquinone multiple interactions ISO RGD:1350859 6480464 [PARP1 protein affects the susceptibility to hydroquinone] which affects the expression of KRAS protein CTD PMID:28444915 hydroxyurea decreases expression ISO RGD:1550157 6480464 Hydroxyurea results in decreased expression of KRAS mRNA CTD PMID:12929121 ionomycin multiple interactions ISO RGD:1350859 6480464 Methohexital inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of KRAS protein] more ... CTD PMID:15263067 isoprenaline increases expression ISO RGD:1550157 6480464 Isoproterenol results in increased expression of KRAS mRNA CTD PMID:21335049 isoprene increases mutagenesis ISO RGD:1550157 6480464 isoprene results in increased mutagenesis of KRAS gene CTD PMID:11397402 , PMID:9111215 isotretinoin decreases expression ISO RGD:1350859 6480464 Isotretinoin results in decreased expression of KRAS mRNA CTD PMID:20436886 kainic acid increases expression EXP 6480464 Kainic Acid results in increased expression of KRAS mRNA CTD PMID:19700661 lapatinib multiple interactions ISO RGD:1350859 6480464 KRAS protein affects the reaction [EGFR protein affects the susceptibility to lapatinib] CTD PMID:28739874 lapatinib decreases response to substance ISO RGD:1350859 6480464 KRAS protein results in decreased susceptibility to lapatinib CTD PMID:28739874 lead diacetate decreases expression ISO RGD:1550157 6480464 lead acetate results in decreased expression of KRAS mRNA CTD PMID:21829687 lead diacetate multiple interactions ISO RGD:1350859 6480464 [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of KRAS mRNA CTD PMID:22839698 lead diacetate increases expression ISO RGD:1550157 6480464 lead acetate results in increased expression of KRAS mRNA CTD PMID:25270620 lead(0) increases expression ISO RGD:1550157 6480464 Lead results in increased expression of KRAS protein CTD PMID:19727529 lead(2+) increases expression ISO RGD:1550157 6480464 Lead results in increased expression of KRAS protein CTD PMID:19727529 lipopolysaccharide multiple interactions ISO RGD:1550157 6480464 [Lipopolysaccharides co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased mutagenesis of KRAS gene CTD PMID:21868532 lovastatin decreases prenylation ISO RGD:1350859 6480464 Lovastatin results in decreased prenylation of KRAS protein CTD PMID:16156861 lovastatin increases expression ISO RGD:1550157 6480464 Lovastatin results in increased expression of KRAS protein CTD PMID:12907238 lovastatin affects localization ISO RGD:1550157 6480464 Lovastatin affects the localization of KRAS protein CTD PMID:12106604 lovastatin increases activity ISO RGD:1550157 6480464 Lovastatin results in increased activity of KRAS protein CTD PMID:17005160 Manumycin A multiple interactions ISO RGD:1350859 6480464 Acetylcysteine inhibits the reaction [manumycin results in decreased activity of KRAS protein] CTD PMID:19409983 Manumycin A decreases activity ISO RGD:1350859 6480464 manumycin results in decreased activity of KRAS protein CTD PMID:19409983 MeIQx increases mutagenesis EXP 6480464 2-amino-3 more ... CTD PMID:18271921 mercury dibromide decreases expression ISO RGD:1350859 6480464 mercuric bromide results in decreased expression of KRAS mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO RGD:1350859 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KRAS mRNA CTD PMID:27188386 metformin multiple interactions ISO RGD:1350859 6480464 [Paclitaxel co-treated with Metformin] results in decreased expression of KRAS mRNA CTD PMID:29309887 methohexital multiple interactions ISO RGD:1350859 6480464 Methohexital inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of KRAS protein] CTD PMID:15263067 methotrexate increases response to substance ISO RGD:1350859 6480464 KRAS gene mutant form results in increased susceptibility to Methotrexate CTD PMID:24688052 methotrexate decreases expression ISO RGD:1350859 6480464 Methotrexate results in decreased expression of KRAS mRNA more ... CTD PMID:24688052 N,N-bis(2-hydroxypropyl)nitrosamine increases mutagenesis EXP 6480464 diisopropanolnitrosamine results in increased mutagenesis of KRAS gene CTD PMID:18271921 N-acetyl-L-cysteine multiple interactions ISO RGD:1350859 6480464 Acetylcysteine inhibits the reaction [manumycin results in decreased activity of KRAS protein] CTD PMID:19409983 N-ethyl-N-nitrosourea multiple interactions ISO RGD:1550157 6480464 Ethylnitrosourea promotes the reaction [GATA6 protein binds to KRAS exon], Ethylnitrosourea promotes the reaction [NFYA protein binds to KRAS exon] CTD PMID:16271038 N-ethyl-N-nitrosourea increases mutagenesis ISO RGD:1550157 6480464 Ethylnitrosourea results in increased mutagenesis of KRAS gene CTD PMID:15790496 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions EXP 6480464 geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of KRAS mRNA] CTD PMID:28428697 N-methyl-N'-nitro-N-nitrosoguanidine increases expression EXP 6480464 Methylnitronitrosoguanidine results in increased expression of KRAS mRNA CTD PMID:28428697 N-methyl-N-nitrosourea decreases response to substance EXP 6480464 KRAS protein results in decreased susceptibility to Methylnitrosourea CTD PMID:11973638 N-methyl-N-nitrosourea increases mutagenesis ISO RGD:1550157 6480464 Methylnitrosourea results in increased mutagenesis of KRAS gene CTD PMID:12483526 , PMID:18062963 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of KRAS mRNA CTD PMID:7910516 N-nitrosodiethylamine increases expression ISO RGD:1550157 6480464 Diethylnitrosamine results in increased expression of KRAS mRNA CTD PMID:26464624 N-nitrosodimethylamine affects localization ISO RGD:1550157 6480464 Dimethylnitrosamine affects the localization of KRAS protein CTD PMID:11884234 N-nitrosodimethylamine multiple interactions ISO RGD:1550157 6480464 Dimethylnitrosamine results in decreased expression of and affects the localization of KRAS protein more ... CTD PMID:11884234 , PMID:19555203 nicotinic acid affects localization ISO RGD:1550157 6480464 Niacin affects the localization of KRAS protein CTD PMID:12106604 ochratoxin A decreases expression ISO RGD:1350859 6480464 ochratoxin A results in decreased expression of KRAS mRNA CTD PMID:30559759 oxirane increases mutagenesis ISO RGD:1550157 6480464 Ethylene Oxide results in increased mutagenesis of KRAS gene CTD PMID:24029818 ozone multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in decreased expression of KRAS mRNA CTD PMID:18636392 ozone increases expression EXP 6480464 Ozone results in increased expression of KRAS mRNA CTD PMID:16330353 p-chloromercuribenzoic acid decreases expression ISO RGD:1350859 6480464 p-Chloromercuribenzoic Acid results in decreased expression of KRAS mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions ISO RGD:1350859 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KRAS mRNA CTD PMID:27188386 paclitaxel multiple interactions ISO RGD:1350859 6480464 [Paclitaxel co-treated with Metformin] results in decreased expression of KRAS mRNA CTD PMID:29309887 paracetamol affects expression ISO RGD:1550157 6480464 Acetaminophen affects the expression of KRAS mRNA CTD PMID:17562736 pemetrexed increases response to substance ISO RGD:1350859 6480464 KRAS gene mutant form results in increased susceptibility to Pemetrexed CTD PMID:24688052 pemetrexed decreases expression ISO RGD:1350859 6480464 Pemetrexed results in decreased expression of KRAS mRNA more ... CTD PMID:24688052 pentobarbital multiple interactions ISO RGD:1350859 6480464 Pentobarbital inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of KRAS protein] CTD PMID:15263067 phlorizin decreases expression ISO RGD:1550157 6480464 Phlorhizin results in decreased expression of KRAS mRNA CTD PMID:22538082 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:1350859 6480464 Methohexital inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of KRAS protein] more ... CTD PMID:15263067 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:1550157 6480464 [sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of KRAS mRNA, [sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of KRAS protein CTD PMID:16368122 picrotoxin decreases expression EXP 6480464 Picrotoxin results in decreased expression of KRAS mRNA CTD PMID:15170462 piperonyl butoxide increases mutagenesis ISO RGD:1350859 6480464 Piperonyl Butoxide results in increased mutagenesis of KRAS gene CTD PMID:7565889 pirinixic acid multiple interactions ISO RGD:1350859 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of KRAS mRNA CTD PMID:19710929 quercetin multiple interactions ISO RGD:1350859 6480464 Quercetin inhibits the reaction [KRAS protein affects the activity of TP53 protein] CTD PMID:19424582 quercetin decreases expression ISO RGD:1350859 6480464 Quercetin results in decreased expression of KRAS mRNA, Quercetin results in decreased expression of KRAS protein CTD PMID:10652438 , PMID:9381980 Rebamipide increases expression EXP 6480464 rebamipide results in increased expression of KRAS mRNA CTD PMID:18299717 resveratrol decreases expression ISO RGD:1350859 6480464 resveratrol results in decreased expression of KRAS mRNA, resveratrol results in decreased expression of KRAS protein CTD PMID:12002526 more ... resveratrol decreases expression ISO RGD:1550157 6480464 resveratrol results in decreased expression of KRAS protein mutant form CTD PMID:25280562 riddelliine increases mutagenesis ISO RGD:1550157 6480464 riddelliine results in increased mutagenesis of KRAS gene CTD PMID:13678655 , PMID:20737008 SB 431542 multiple interactions ISO RGD:1350859 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 secobarbital multiple interactions ISO RGD:1350859 6480464 Secobarbital inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of KRAS protein] CTD PMID:15263067 selumetinib multiple interactions ISO RGD:1350859 6480464 AZD 6244 inhibits the reaction [[KRAS protein mutant form affects the susceptibility to vemurafenib] promotes the reaction [TNFRSF10B protein results in increased cleavage of CASP3 protein]] more ... CTD PMID:27222248 simvastatin decreases prenylation ISO RGD:1350859 6480464 Simvastatin results in decreased prenylation of KRAS protein CTD PMID:8063617 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of KRAS mRNA CTD PMID:11241755 sodium arsenite multiple interactions ISO RGD:1550157 6480464 [sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of KRAS mRNA, [sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of KRAS protein CTD PMID:16368122 sodium arsenite affects expression ISO RGD:1350859 6480464 sodium arsenite affects the expression of KRAS protein CTD PMID:17384772 sodium arsenite affects expression ISO RGD:1550157 6480464 sodium arsenite affects the expression of KRAS mRNA CTD PMID:16507464 sodium arsenite increases expression ISO RGD:1350859 6480464 sodium arsenite results in increased expression of KRAS protein CTD PMID:24431212 , PMID:25804888 sodium arsenite increases expression ISO RGD:1550157 6480464 sodium arsenite results in increased expression of KRAS mRNA, sodium arsenite results in increased expression of KRAS protein CTD PMID:16014739 , PMID:16507464 Soman increases expression EXP 6480464 Soman results in increased expression of KRAS mRNA CTD PMID:19281266 styrene increases response to substance ISO RGD:1550157 6480464 KRAS gene polymorphism results in increased susceptibility to Styrene CTD PMID:12807761 sulfur dioxide increases expression EXP 6480464 Sulfur Dioxide results in increased expression of KRAS mRNA, Sulfur Dioxide results in increased expression of KRAS protein CTD PMID:19434695 sulindac affects response to substance ISO RGD:1350859 6480464 KRAS protein affects the susceptibility to Sulindac CTD PMID:11751493 tacrolimus hydrate increases expression ISO RGD:1550157 6480464 Tacrolimus results in increased expression of KRAS mRNA CTD PMID:25270620 testosterone enanthate affects expression ISO RGD:1350859 6480464 testosterone enanthate affects the expression of KRAS mRNA CTD PMID:17440010 tetrachloromethane affects expression ISO RGD:1550157 6480464 Carbon Tetrachloride affects the expression of KRAS mRNA CTD PMID:17484886 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of KRAS mRNA CTD PMID:31150632 , PMID:8847708 Tetranitromethane increases mutagenesis ISO RGD:1550157 6480464 Tetranitromethane results in increased mutagenesis of KRAS gene CTD PMID:14713543 thiamylal multiple interactions ISO RGD:1350859 6480464 Thiamylal inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of KRAS protein] CTD PMID:15263067 thimerosal decreases expression ISO RGD:1350859 6480464 Thimerosal results in decreased expression of KRAS mRNA CTD PMID:27188386 tiazofurine multiple interactions ISO RGD:1350859 6480464 Guanosine inhibits the reaction [tiazofurin results in decreased expression of KRAS] CTD PMID:9381980 tiazofurine decreases expression ISO RGD:1350859 6480464 tiazofurin results in decreased expression of KRAS CTD PMID:9381980 tipifarnib increases expression EXP 6480464 tipifarnib results in increased expression of KRAS mRNA CTD PMID:16403772 titanium dioxide decreases expression ISO RGD:1550157 6480464 titanium dioxide results in decreased expression of KRAS mRNA CTD PMID:23557971 titanium dioxide multiple interactions ISO RGD:1550157 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of KRAS mRNA CTD PMID:29950665 titanium dioxide affects expression ISO RGD:1550157 6480464 titanium dioxide affects the expression of KRAS mRNA CTD PMID:17656681 toluene affects expression EXP 6480464 Toluene affects the expression of KRAS mRNA CTD PMID:21827849 trimetrexate increases response to substance ISO RGD:1350859 6480464 KRAS gene mutant form results in increased susceptibility to Trimetrexate CTD PMID:24688052 Triptolide increases expression EXP 6480464 triptolide results in increased expression of KRAS mRNA CTD PMID:23639586 urethane affects response to substance ISO RGD:1550157 6480464 KRAS gene affects the susceptibility to Urethane CTD PMID:11807781 urethane decreases expression ISO RGD:1350859 6480464 Urethane results in decreased expression of KRAS mRNA CTD PMID:28818685 urethane increases mutagenesis ISO RGD:1550157 6480464 Urethane results in increased mutagenesis of KRAS gene CTD PMID:10779650 urethane increases mutagenesis EXP 6480464 Urethane results in increased mutagenesis of KRAS gene CTD PMID:18271921 urethane decreases expression ISO RGD:1550157 6480464 Urethane results in decreased expression of KRAS mRNA CTD PMID:16289808 ursodeoxycholic acid multiple interactions EXP 6480464 Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased mutagenesis of KRAS gene] CTD PMID:12839936 valproic acid increases expression ISO RGD:1350859 6480464 Valproic Acid results in increased expression of KRAS mRNA CTD PMID:28001369 vemurafenib affects response to substance ISO RGD:1350859 6480464 KRAS protein mutant form affects the susceptibility to vemurafenib CTD PMID:27222248 vemurafenib multiple interactions ISO RGD:1350859 6480464 [KRAS protein mutant form affects the susceptibility to vemurafenib] promotes the reaction [TNFRSF10B protein results in increased cleavage of CASP3 protein] more ... CTD PMID:27222248 vinyl carbamate multiple interactions ISO RGD:1550157 6480464 diallyl sulfone inhibits the reaction [vinyl carbamate results in increased mutagenesis of KRAS gene] CTD PMID:20205516 vinyl carbamate increases mutagenesis ISO RGD:1550157 6480464 vinyl carbamate results in increased mutagenesis of KRAS gene CTD PMID:20205516 zearalenone decreases expression ISO RGD:1550157 6480464 Zearalenone results in decreased expression of KRAS mRNA CTD PMID:30717214 zearalenone increases expression ISO RGD:1550157 6480464 Zearalenone results in increased expression of KRAS mRNA CTD PMID:29758222 zidovudine increases mutagenesis ISO RGD:1550157 6480464 Zidovudine results in increased mutagenesis of KRAS gene CTD PMID:18800350 zinc protoporphyrin multiple interactions ISO RGD:1350859 6480464 [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of KRAS mRNA CTD PMID:22839698 zoledronic acid increases expression ISO RGD:1350859 6480464 zoledronic acid results in increased expression of KRAS protein CTD PMID:28871336
Gene-Chemical Interaction Annotations
